{"id":"https://openalex.org/W4415325345","doi":"https://doi.org/10.2139/ssrn.5609132","title":"Structural investigation of benzo[1,2,4]thiadiazine-1,1-dioxide chemotype as CD73 ectonucleotidase inhibitors","display_name":"Structural investigation of benzo[1,2,4]thiadiazine-1,1-dioxide chemotype as CD73 ectonucleotidase inhibitors","publication_year":2025,"publication_date":"2025-01-01","ids":{"openalex":"https://openalex.org/W4415325345","doi":"https://doi.org/10.2139/ssrn.5609132"},"language":"en","primary_location":{"id":"doi:10.2139/ssrn.5609132","doi":"https://doi.org/10.2139/ssrn.5609132","is_oa":true,"landing_page_url":"https://doi.org/10.2139/ssrn.5609132","pdf_url":null,"source":{"id":"https://openalex.org/S4210172589","display_name":"SSRN Electronic Journal","issn_l":"1556-5068","issn":["1556-5068"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1318003438","host_organization_name":"RELX Group (Netherlands)","host_organization_lineage":["https://openalex.org/I1318003438"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.2139/ssrn.5609132","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Giulia Vagnoni","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Giulia Vagnoni","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000990423","display_name":"Flavia Varano","orcid":"https://orcid.org/0000-0002-4342-9427","observed_orcids":["https://orcid.org/0000-0002-4342-9427"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Flavia Varano","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016294244","display_name":"Daniela Catarzi","orcid":"https://orcid.org/0000-0002-8821-928X","observed_orcids":["https://orcid.org/0000-0002-8821-928X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daniela Catarzi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091275546","display_name":"Erica Vigiani","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Erica Vigiani","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077903747","display_name":"Sara Calenda","orcid":"https://orcid.org/0009-0007-2255-9250","observed_orcids":["https://orcid.org/0009-0007-2255-9250"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sara Calenda","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042943825","display_name":"Costanza Ceni","orcid":"https://orcid.org/0000-0002-6832-1703","observed_orcids":["https://orcid.org/0000-0002-6832-1703"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Costanza Ceni","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5120053587","display_name":"Radu Turcitu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Radu Turcitu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5120053588","display_name":"Sina Rahimi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sina Rahimi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067657116","display_name":"Daniela Bitencourt Rosa Leal","orcid":"https://orcid.org/0000-0003-2618-9801","observed_orcids":["https://orcid.org/0000-0003-2618-9801"]},"institutions":[{"id":"https://openalex.org/I33501960","display_name":"Universidade Federal de Santa Maria","ror":"https://ror.org/01b78mz79","country_code":"BR","type":"education","lineage":["https://openalex.org/I33501960"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Daniela Leal","raw_affiliation_strings":["Federal University of Santa Maria","Federal University of Santa Maria, Santa Maria, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Federal University of Santa Maria","institution_ids":["https://openalex.org/I33501960"]},{"raw_affiliation_string":"Federal University of Santa Maria, Santa Maria, Brazil","institution_ids":["https://openalex.org/I33501960"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070746475","display_name":"Nicolly Esp\u00edndola Gelsleichter","orcid":"https://orcid.org/0000-0002-8342-3281","observed_orcids":["https://orcid.org/0000-0002-8342-3281"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nicolly Espindola Gelsleichter","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064076115","display_name":"Audrey Guilbaud","orcid":"https://orcid.org/0000-0002-4587-3900","observed_orcids":["https://orcid.org/0000-0002-4587-3900"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Audrey Guilbaud","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032996867","display_name":"Marine Sarlandie","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marine Sarlandie","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059152576","display_name":"Julie Pelletier","orcid":"https://orcid.org/0000-0003-0461-8126","observed_orcids":["https://orcid.org/0000-0003-0461-8126"]},"institutions":[{"id":"https://openalex.org/I43406934","display_name":"Universit\u00e9 Laval","ror":"https://ror.org/04sjchr03","country_code":"CA","type":"education","lineage":["https://openalex.org/I43406934"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Julie Pelletier","raw_affiliation_strings":["Universit\u00e9 Laval"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 Laval","institution_ids":["https://openalex.org/I43406934"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012615383","display_name":"Jean S\u00e9vigny","orcid":"https://orcid.org/0000-0003-2922-1600","observed_orcids":["https://orcid.org/0000-0003-2922-1600"]},"institutions":[{"id":"https://openalex.org/I43406934","display_name":"Universit\u00e9 Laval","ror":"https://ror.org/04sjchr03","country_code":"CA","type":"education","lineage":["https://openalex.org/I43406934"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Jean S\u00e9vigny","raw_affiliation_strings":["Universit\u00e9 Laval"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 Laval","institution_ids":["https://openalex.org/I43406934"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025337586","display_name":"Vittoria Colotta","orcid":"https://orcid.org/0000-0002-9296-6819","observed_orcids":["https://orcid.org/0000-0002-9296-6819"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vittoria Colotta","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5000990423"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11193","display_name":"Adenosine and Purinergic Signaling","score":0.9535999894142151,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11193","display_name":"Adenosine and Purinergic Signaling","score":0.9535999894142151,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14099","display_name":"Synthesis and Characterization of Heterocyclic Compounds","score":0.03229999914765358,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.004100000020116568,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cd73","display_name":"CD73","score":0.9110000133514404},{"id":"https://openalex.org/keywords/amp-hydrolysis","display_name":"AMP hydrolysis","score":0.7789999842643738},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.8600000143051147},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.8080000281333923},{"id":"https://openalex.org/keywords/small-molecule-inhibitors","display_name":"small molecule inhibitors","score":0.7739999890327454},{"id":"https://openalex.org/keywords/scaffold-modification","display_name":"scaffold modification","score":0.31200000643730164}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7134000062942505},{"id":"https://openalex.org/C139489369","wikidata":"https://www.wikidata.org/wiki/Q770846","display_name":"Structural similarity","level":2,"score":0.6301000118255615},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.6148999929428101},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.5458999872207642},{"id":"https://openalex.org/C2776991684","wikidata":"https://www.wikidata.org/wiki/Q190012","display_name":"Adenosine","level":2,"score":0.444599986076355},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.3783000111579895},{"id":"https://openalex.org/C193042331","wikidata":"https://www.wikidata.org/wiki/Q1772003","display_name":"Structure\u2013activity relationship","level":3,"score":0.37400001287460327},{"id":"https://openalex.org/C2909748322","wikidata":"https://www.wikidata.org/wiki/Q255933","display_name":"Inosine monophosphate","level":4,"score":0.34700000286102295},{"id":"https://openalex.org/C94412978","wikidata":"https://www.wikidata.org/wiki/Q103135","display_name":"Hydrolysis","level":2,"score":0.33649998903274536},{"id":"https://openalex.org/C2779876172","wikidata":"https://www.wikidata.org/wiki/Q318369","display_name":"Adenosine monophosphate","level":3,"score":0.31679999828338623},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3165999948978424},{"id":"https://openalex.org/C141315368","wikidata":"https://www.wikidata.org/wiki/Q4654881","display_name":"ATP hydrolysis","level":4,"score":0.2985000014305115},{"id":"https://openalex.org/C62826618","wikidata":"https://www.wikidata.org/wiki/Q424304","display_name":"Phosphodiesterase","level":3,"score":0.28519999980926514},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.27959999442100525},{"id":"https://openalex.org/C2776980637","wikidata":"https://www.wikidata.org/wiki/Q427492","display_name":"Enzyme inhibitor","level":3,"score":0.26249998807907104},{"id":"https://openalex.org/C2780120296","wikidata":"https://www.wikidata.org/wiki/Q96286","display_name":"Hydrolase","level":3,"score":0.26190000772476196},{"id":"https://openalex.org/C18880352","wikidata":"https://www.wikidata.org/wiki/Q421431","display_name":"Nucleotidase","level":3,"score":0.2556000053882599}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.2139/ssrn.5609132","doi":"https://doi.org/10.2139/ssrn.5609132","is_oa":true,"landing_page_url":"https://doi.org/10.2139/ssrn.5609132","pdf_url":null,"source":{"id":"https://openalex.org/S4210172589","display_name":"SSRN Electronic Journal","issn_l":"1556-5068","issn":["1556-5068"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1318003438","host_organization_name":"RELX Group (Netherlands)","host_organization_lineage":["https://openalex.org/I1318003438"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.2139/ssrn.5609132","doi":"https://doi.org/10.2139/ssrn.5609132","is_oa":true,"landing_page_url":"https://doi.org/10.2139/ssrn.5609132","pdf_url":null,"source":{"id":"https://openalex.org/S4210172589","display_name":"SSRN Electronic Journal","issn_l":"1556-5068","issn":["1556-5068"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1318003438","host_organization_name":"RELX Group (Netherlands)","host_organization_lineage":["https://openalex.org/I1318003438"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7218449272","https://openalex.org/W4386210550","https://openalex.org/W4402105935","https://openalex.org/W4409534103","https://openalex.org/W6929456190","https://openalex.org/W4413064610","https://openalex.org/W3216403971","https://openalex.org/W4318168209","https://openalex.org/W4403300658","https://openalex.org/W4405377202"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2025-10-19T00:00:00"}