{"id":"https://openalex.org/W4415325276","doi":"https://doi.org/10.1186/s43042-025-00798-1","title":"Association between complement system, pulmonary fibrosis, and ABO system gene variants and COVID-19 severity and susceptibility: a Moroccan case\u2013control study","display_name":"Association between complement system, pulmonary fibrosis, and ABO system gene variants and COVID-19 severity and susceptibility: a Moroccan case\u2013control study","publication_year":2025,"publication_date":"2025-10-18","ids":{"openalex":"https://openalex.org/W4415325276","doi":"https://doi.org/10.1186/s43042-025-00798-1"},"language":"en","primary_location":{"id":"doi:10.1186/s43042-025-00798-1","doi":"https://doi.org/10.1186/s43042-025-00798-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s43042-025-00798-1","pdf_url":"https://jmhg.springeropen.com/counter/pdf/10.1186/s43042-025-00798-1","source":{"id":"https://openalex.org/S3034796422","display_name":"Egyptian Journal of Medical Human Genetics","issn_l":"1110-8630","issn":["1110-8630","2090-2441"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jpps-1","jufo-1","poland-40","russia-white-list-4","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Egyptian Journal of Medical Human Genetics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://jmhg.springeropen.com/counter/pdf/10.1186/s43042-025-00798-1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5093710378","display_name":"Fatima-Zahra El Yousfi","orcid":"https://orcid.org/0000-0001-8217-2612","observed_orcids":["https://orcid.org/0000-0001-8217-2612"]},"institutions":[{"id":"https://openalex.org/I126477371","display_name":"Mohammed V University","ror":"https://ror.org/00r8w8f84","country_code":"MA","type":"education","lineage":["https://openalex.org/I126477371"]}],"countries":["MA"],"is_corresponding":true,"raw_author_name":"Fatima-Zahra El Yousfi","raw_affiliation_strings":["Laboratory of Human Genetics, Medical School and Pharmacy, University Mohammed V, Rabat, Morocco"],"raw_orcid":"https://orcid.org/0000-0001-8217-2612","affiliations":[{"raw_affiliation_string":"Laboratory of Human Genetics, Medical School and Pharmacy, University Mohammed V, Rabat, Morocco","institution_ids":["https://openalex.org/I126477371"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092808682","display_name":"Chaimae Nebhani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126477371","display_name":"Mohammed V University","ror":"https://ror.org/00r8w8f84","country_code":"MA","type":"education","lineage":["https://openalex.org/I126477371"]}],"countries":["MA"],"is_corresponding":false,"raw_author_name":"Chaimae Nebhani","raw_affiliation_strings":["Laboratory of Human Genetics, Medical School and Pharmacy, University Mohammed V, Rabat, Morocco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Human Genetics, Medical School and Pharmacy, University Mohammed V, Rabat, Morocco","institution_ids":["https://openalex.org/I126477371"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007823667","display_name":"Hamza Ghammaz","orcid":"https://orcid.org/0009-0003-4559-2572","observed_orcids":["https://orcid.org/0009-0003-4559-2572"]},"institutions":[{"id":"https://openalex.org/I4210089144","display_name":"Centre National pour la Recherche Scientifique et Technique (CNRST)","ror":"https://ror.org/00675rp98","country_code":"MA","type":"government","lineage":["https://openalex.org/I4210089144"]}],"countries":["MA"],"is_corresponding":false,"raw_author_name":"Hamza Ghammaz","raw_affiliation_strings":["Molecular Biology and Functional Genomics Platform, National Center for Scientific and Technical Research (CNRST), Rabat, Morocco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Biology and Functional Genomics Platform, National Center for Scientific and Technical Research (CNRST), Rabat, Morocco","institution_ids":["https://openalex.org/I4210089144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088092087","display_name":"Reda Benmansour","orcid":"https://orcid.org/0009-0002-7062-9536","observed_orcids":["https://orcid.org/0009-0002-7062-9536"]},"institutions":[{"id":"https://openalex.org/I126477371","display_name":"Mohammed V University","ror":"https://ror.org/00r8w8f84","country_code":"MA","type":"education","lineage":["https://openalex.org/I126477371"]}],"countries":["MA"],"is_corresponding":false,"raw_author_name":"Reda Benmansour","raw_affiliation_strings":["Center of Virology, Infectious and Tropical Diseases, Mohamed V Military Teaching Hospital, University Mohammed V, Rabat, Morocco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Virology, Infectious and Tropical Diseases, Mohamed V Military Teaching Hospital, University Mohammed V, Rabat, Morocco","institution_ids":["https://openalex.org/I126477371"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018831142","display_name":"Hanaa Skhoun","orcid":"https://orcid.org/0000-0002-4081-1604","observed_orcids":["https://orcid.org/0000-0002-4081-1604"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hanaa Skhoun","raw_affiliation_strings":["Genetics Unit, Military Hospital Mohammed V, Rabat, Morocco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetics Unit, Military Hospital Mohammed V, Rabat, Morocco","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011811290","display_name":"Khalid Ennibi","orcid":"https://orcid.org/0000-0001-6480-0507","observed_orcids":["https://orcid.org/0000-0001-6480-0507"]},"institutions":[{"id":"https://openalex.org/I126477371","display_name":"Mohammed V University","ror":"https://ror.org/00r8w8f84","country_code":"MA","type":"education","lineage":["https://openalex.org/I126477371"]}],"countries":["MA"],"is_corresponding":false,"raw_author_name":"Khalid Ennibi","raw_affiliation_strings":["Center of Virology, Infectious and Tropical Diseases, Mohamed V Military Teaching Hospital, University Mohammed V, Rabat, Morocco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Virology, Infectious and Tropical Diseases, Mohamed V Military Teaching Hospital, University Mohammed V, Rabat, Morocco","institution_ids":["https://openalex.org/I126477371"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047691762","display_name":"Jihane Belayachi","orcid":"https://orcid.org/0000-0001-5617-5860","observed_orcids":["https://orcid.org/0000-0001-5617-5860"]},"institutions":[{"id":"https://openalex.org/I126477371","display_name":"Mohammed V University","ror":"https://ror.org/00r8w8f84","country_code":"MA","type":"education","lineage":["https://openalex.org/I126477371"]},{"id":"https://openalex.org/I4210130352","display_name":"Centre Hospitalier Ibn Sina","ror":"https://ror.org/038zpvz53","country_code":"MA","type":"healthcare","lineage":["https://openalex.org/I4210130352"]}],"countries":["MA"],"is_corresponding":false,"raw_author_name":"Jihane Belayachi","raw_affiliation_strings":["Acute Medical Unit, Ibn Sina University Hospital, Rabat, Morocco","Laboratory of Biostatistics, Clinical and Epidemiological Research, Department of Public Health, Medical School and Pharmacy, University Mohammed V, Rabat, Morocco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Acute Medical Unit, Ibn Sina University Hospital, Rabat, Morocco","institution_ids":["https://openalex.org/I4210130352"]},{"raw_affiliation_string":"Laboratory of Biostatistics, Clinical and Epidemiological Research, Department of Public Health, Medical School and Pharmacy, University Mohammed V, Rabat, Morocco","institution_ids":["https://openalex.org/I126477371"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082488041","display_name":"R\u00e9douane Abouqal","orcid":"https://orcid.org/0000-0002-6117-4341","observed_orcids":["https://orcid.org/0000-0002-6117-4341"]},"institutions":[{"id":"https://openalex.org/I126477371","display_name":"Mohammed V University","ror":"https://ror.org/00r8w8f84","country_code":"MA","type":"education","lineage":["https://openalex.org/I126477371"]},{"id":"https://openalex.org/I4210130352","display_name":"Centre Hospitalier Ibn Sina","ror":"https://ror.org/038zpvz53","country_code":"MA","type":"healthcare","lineage":["https://openalex.org/I4210130352"]}],"countries":["MA"],"is_corresponding":false,"raw_author_name":"Redouane Abouqal","raw_affiliation_strings":["Acute Medical Unit, Ibn Sina University Hospital, Rabat, Morocco","Laboratory of Biostatistics, Clinical and Epidemiological Research, Department of Public Health, Medical School and Pharmacy, University Mohammed V, Rabat, Morocco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Acute Medical Unit, Ibn Sina University Hospital, Rabat, Morocco","institution_ids":["https://openalex.org/I4210130352"]},{"raw_affiliation_string":"Laboratory of Biostatistics, Clinical and Epidemiological Research, Department of Public Health, Medical School and Pharmacy, University Mohammed V, Rabat, Morocco","institution_ids":["https://openalex.org/I126477371"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069720425","display_name":"Jamila El Baghdadi","orcid":"https://orcid.org/0000-0002-1920-2310","observed_orcids":["https://orcid.org/0000-0002-1920-2310"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jamila El Baghdadi","raw_affiliation_strings":["Genetics Unit, Military Hospital Mohammed V, Rabat, Morocco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetics Unit, Military Hospital Mohammed V, Rabat, Morocco","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086162355","display_name":"Ahmed Bouhouche","orcid":"https://orcid.org/0000-0001-5279-8649","observed_orcids":["https://orcid.org/0000-0001-5279-8649"]},"institutions":[{"id":"https://openalex.org/I126477371","display_name":"Mohammed V University","ror":"https://ror.org/00r8w8f84","country_code":"MA","type":"education","lineage":["https://openalex.org/I126477371"]},{"id":"https://openalex.org/I4388891835","display_name":"Universit\u00e9 Internationale Abulcasis des Sciences de la Sant\u00e9","ror":"https://ror.org/059qgcz87","country_code":"MA","type":"education","lineage":["https://openalex.org/I4388891835"]}],"countries":["MA"],"is_corresponding":false,"raw_author_name":"Ahmed Bouhouche","raw_affiliation_strings":["Genomic Center of the Cheikh Zaid Foundation, Abulcasis International University of Health Sciences, Rabat, Morocco","Laboratory of Human Genetics, Medical School and Pharmacy, University Mohammed V, Rabat, Morocco","Neuroscience and Neurogenetics Research Team, Faculty of Medicine and Pharmacy, University Mohammed V, Rabat, Morocco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genomic Center of the Cheikh Zaid Foundation, Abulcasis International University of Health Sciences, Rabat, Morocco","institution_ids":["https://openalex.org/I4388891835"]},{"raw_affiliation_string":"Laboratory of Human Genetics, Medical School and Pharmacy, University Mohammed V, Rabat, Morocco","institution_ids":["https://openalex.org/I126477371"]},{"raw_affiliation_string":"Neuroscience and Neurogenetics Research Team, Faculty of Medicine and Pharmacy, University Mohammed V, Rabat, Morocco","institution_ids":["https://openalex.org/I126477371"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5093710378"],"corresponding_institution_ids":["https://openalex.org/I126477371"],"apc_list":{"value":0,"currency":"USD","value_usd":0},"apc_paid":null,"fwci":0.6384,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.69776411,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"26","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.6577000021934509,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.6577000021934509,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.14880000054836273,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.13089999556541443,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/covid-19-severity","display_name":"COVID-19 severity","score":0.9259999990463257},{"id":"https://openalex.org/keywords/sars-cov-2","display_name":"SARS-CoV-2","score":0.8679999709129333},{"id":"https://openalex.org/keywords/complement-system","display_name":"complement system","score":0.7950000166893005},{"id":"https://openalex.org/keywords/mbl2","display_name":"MBL2","score":0.7379999756813049},{"id":"https://openalex.org/keywords/masp-2","display_name":"MASP-2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/mcp-1","display_name":"MCP-1","score":0.9729999899864197},{"id":"https://openalex.org/keywords/muc5b","display_name":"MUC5B","score":0.8889999985694885},{"id":"https://openalex.org/keywords/tert","display_name":"telomerase reverse transcriptase","score":0.9860000014305115},{"id":"https://openalex.org/keywords/abo-blood-group","display_name":"ABO blood group system","score":0.8410000205039978},{"id":"https://openalex.org/keywords/fut2","display_name":"FUT2","score":0.9779999852180481},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.6470000147819519},{"id":"https://openalex.org/keywords/pulmonary-fibrosis","display_name":"pulmonary fibrosis","score":0.8889999985694885},{"id":"https://openalex.org/keywords/moroccan-population","display_name":"Moroccan population","score":0.5509999990463257}],"concepts":[{"id":"https://openalex.org/C2777910003","wikidata":"https://www.wikidata.org/wiki/Q1707292","display_name":"Asymptomatic","level":2,"score":0.7099000215530396},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.6693999767303467},{"id":"https://openalex.org/C176080213","wikidata":"https://www.wikidata.org/wiki/Q188010","display_name":"ABO blood group system","level":2,"score":0.6462000012397766},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.6432999968528748},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.6075999736785889},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5142999887466431},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.45660001039505005},{"id":"https://openalex.org/C157410074","wikidata":"https://www.wikidata.org/wiki/Q6869145","display_name":"Minor allele frequency","level":5,"score":0.4309999942779541},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.38670000433921814},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.3790999948978424},{"id":"https://openalex.org/C111684460","wikidata":"https://www.wikidata.org/wiki/Q334848","display_name":"Complement system","level":3,"score":0.367900013923645},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.35690000653266907},{"id":"https://openalex.org/C68873052","wikidata":"https://www.wikidata.org/wiki/Q349856","display_name":"Genetic variation","level":3,"score":0.3476000130176544},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3411000072956085},{"id":"https://openalex.org/C534529494","wikidata":"https://www.wikidata.org/wiki/Q7891","display_name":"Respiratory system","level":2,"score":0.3386000096797943},{"id":"https://openalex.org/C37463918","wikidata":"https://www.wikidata.org/wiki/Q387981","display_name":"Allele frequency","level":4,"score":0.3375999927520752},{"id":"https://openalex.org/C146304588","wikidata":"https://www.wikidata.org/wiki/Q961652","display_name":"Case-control study","level":2,"score":0.32019999623298645},{"id":"https://openalex.org/C69991583","wikidata":"https://www.wikidata.org/wiki/Q1423575","display_name":"Candidate gene","level":3,"score":0.28360000252723694},{"id":"https://openalex.org/C2993183539","wikidata":"https://www.wikidata.org/wiki/Q754447","display_name":"Respiratory infection","level":3,"score":0.27810001373291016},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.275299996137619},{"id":"https://openalex.org/C112313634","wikidata":"https://www.wikidata.org/wiki/Q7886648","display_name":"Complement (music)","level":5,"score":0.262800008058548},{"id":"https://openalex.org/C2993967602","wikidata":"https://www.wikidata.org/wiki/Q5532932","display_name":"Genetic variants","level":4,"score":0.26010000705718994},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2597000002861023}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1186/s43042-025-00798-1","doi":"https://doi.org/10.1186/s43042-025-00798-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s43042-025-00798-1","pdf_url":"https://jmhg.springeropen.com/counter/pdf/10.1186/s43042-025-00798-1","source":{"id":"https://openalex.org/S3034796422","display_name":"Egyptian Journal of Medical Human Genetics","issn_l":"1110-8630","issn":["1110-8630","2090-2441"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jpps-1","jufo-1","poland-40","russia-white-list-4","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Egyptian Journal of Medical Human Genetics","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:29d0350934f8464dba0896e592260e80","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/29d0350934f8464dba0896e592260e80","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Egyptian Journal of Medical Human Genetics, Vol 26, Iss 1, Pp 1-11 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s43042-025-00798-1","doi":"https://doi.org/10.1186/s43042-025-00798-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s43042-025-00798-1","pdf_url":"https://jmhg.springeropen.com/counter/pdf/10.1186/s43042-025-00798-1","source":{"id":"https://openalex.org/S3034796422","display_name":"Egyptian Journal of Medical Human Genetics","issn_l":"1110-8630","issn":["1110-8630","2090-2441"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jpps-1","jufo-1","poland-40","russia-white-list-4","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Egyptian Journal of Medical Human Genetics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4415325276.pdf","grobid_xml":"https://content.openalex.org/works/W4415325276.grobid-xml"},"referenced_works_count":45,"referenced_works":["https://openalex.org/W1865473340","https://openalex.org/W2044179985","https://openalex.org/W2591928747","https://openalex.org/W2943293482","https://openalex.org/W2967893991","https://openalex.org/W3033582955","https://openalex.org/W3036779511","https://openalex.org/W3091417714","https://openalex.org/W3123792432","https://openalex.org/W3134621903","https://openalex.org/W3137582917","https://openalex.org/W3176164237","https://openalex.org/W3182807823","https://openalex.org/W3186668527","https://openalex.org/W3216223664","https://openalex.org/W4205117962","https://openalex.org/W4206946171","https://openalex.org/W4206950334","https://openalex.org/W4213110221","https://openalex.org/W4221018844","https://openalex.org/W4280616097","https://openalex.org/W4281250436","https://openalex.org/W4281734829","https://openalex.org/W4283752403","https://openalex.org/W4288886081","https://openalex.org/W4292553225","https://openalex.org/W4309561268","https://openalex.org/W4310798821","https://openalex.org/W4313544423","https://openalex.org/W4313891539","https://openalex.org/W4317042593","https://openalex.org/W4318588145","https://openalex.org/W4321076741","https://openalex.org/W4361224213","https://openalex.org/W4365459981","https://openalex.org/W4366815714","https://openalex.org/W4382602076","https://openalex.org/W4387420868","https://openalex.org/W4387663211","https://openalex.org/W4391133115","https://openalex.org/W4394888181","https://openalex.org/W4396748378","https://openalex.org/W4400494300","https://openalex.org/W4401241331","https://openalex.org/W4403784356"],"related_works":["https://openalex.org/W7202255334","https://openalex.org/W4310984244","https://openalex.org/W6958207499","https://openalex.org/W4289972136","https://openalex.org/W3123792432","https://openalex.org/W7164324690","https://openalex.org/W7018937864","https://openalex.org/W4396748378","https://openalex.org/W6938976638","https://openalex.org/W3206629419"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"SARS-CoV-2":[2,136],"infection":[3,97],"manifests":[4],"in":[5,66,103,162,166,170,174,178,183,198,252,286],"a":[6,104,189,266,331],"wide":[7],"range":[8],"of":[9,22,29,53,101,117,155,246,260,281,302,313,317,323,334,342],"clinical":[10],"outcomes,":[11],"ranging":[12],"from":[13],"asymptomatic":[14,119],"or":[15,98,120],"mild":[16,122],"respiratory":[17],"symptoms":[18],"to":[19,58,96,127,264],"severe":[20,99,128,247,315,349],"forms":[21,316],"COVID-19.":[23,54,318],"This":[24,55],"variability":[25],"highlights":[26],"the":[27,49,60,67,86,199,203,208,237,244,253,257,277,282,287,303,320,324,339],"influence":[28],"various":[30],"factors,":[31],"such":[32],"as":[33],"age,":[34],"gender,":[35],"and":[36,51,75,82,85,91,94,108,130,181,230],"pre-existing":[37],"health":[38],"conditions.":[39],"Additionally,":[40,256],"exploring":[41],"genetic":[42,64],"factors":[43],"can":[44],"offer":[45],"valuable":[46],"insights":[47],"into":[48],"mechanisms":[50],"pathogenesis":[52],"study":[56,112,209],"aimed":[57],"investigate":[59],"possible":[61],"link":[62],"between":[63],"variants":[65,157,187],"complement":[68],"system":[69,88],"(":[70,80,89],"MBL2":[71,184,214],",":[72,74,164,168,172,176,180],"MASP2":[73,175,216,218,283,325],"CCL2":[76],"),":[77,84],"pulmonary":[78],"fibrosis":[79],"MUC5B":[81,163,220,222,238,261,304,343],"TERT":[83,179],"ABO":[87,90,167,224,226,228],"FUT2":[92,171,231],")":[93],"susceptibility":[95],"outcomes":[100],"COVID-19":[102,248,271,295],"Moroccan":[105,254],"cohort.":[106],"Patients":[107],"methods":[109],"Our":[110],"case\u2013control":[111],"involved":[113],"324":[114,139],"participants,":[115],"consisting":[116],"101":[118],"experienced":[121],"symptoms,":[123,129],"105":[124],"presented":[125],"moderate":[126],"118":[131],"healthy":[132],"controls":[133],"negative":[134],"for":[135],"infection.":[137],"The":[138],"samples":[140],"were":[141,158,308],"analyzed":[142],"using":[143],"gene-panel":[144],"next-generation":[145],"sequencing":[146],"(NGS)":[147],"that":[148,236],"included":[149,197],"eight":[150],"genes.":[151],"Results":[152],"A":[153],"total":[154],"139":[156],"identified,":[159],"including":[160],"99":[161],"12":[165],"9":[169,173],"7":[177],"3":[182],".":[185],"Only":[186],"with":[188,293,330],"minor":[190],"allele":[191,241,307],"frequency":[192],"(MAF)":[193],">":[194],"10%":[195],"are":[196],"association":[200],"analysis.":[201],"Following":[202],"common":[204],"disease/common":[205],"variant":[206,327],"hypothesis,":[207],"revealed":[210],"nine":[211],"candidate":[212],"variants:":[213],"rs1800450,":[215],"rs2273346,":[217],"rs12711521,":[219],"rs2943531,":[221],"rs2075853,":[223],"rs512770,":[225],"rs8176719,":[227],"rs8176740,":[229],"rs601338.":[232],"Statistical":[233],"analysis":[234],"indicates":[235],"rs2943531":[239,305],"G":[240,306],"may":[242,345],"increase":[243],"risk":[245,312,333],"(p":[249,273,297],"=":[250,274,298],"0.027)":[251],"population.":[255],"CT":[258,340],"genotype":[259,280,322,341],"rs2075853":[262,344],"seems":[263],"have":[265],"potential":[267],"protective":[268],"effect":[269],"against":[270,348],"severity":[272,296],"0.032).":[275],"Moreover,":[276],"CA":[278,321],"heterozygous":[279],"rs12711521":[284,326],"variant,":[285],"dominant/recessive":[288],"model,":[289],"was":[290,328],"significantly":[291],"associated":[292,329],"increased":[294,311],"0.023).":[299],"Conclusion":[300],"Carriers":[301],"at":[309],"an":[310],"developing":[314],"Similarly,":[319],"higher":[332],"disease":[335],"severity.":[336],"In":[337],"contrast,":[338],"confer":[346],"protection":[347],"outcomes.":[350]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2025-10-19T00:00:00"}