{"id":"https://openalex.org/W4415323519","doi":"https://doi.org/10.64062/jpgmb.vol1.issue5.4","title":"Advances In Stem Cell Therapy for Cardiovascular Diseases","display_name":"Advances In Stem Cell Therapy for Cardiovascular Diseases","publication_year":2025,"publication_date":"2025-10-18","ids":{"openalex":"https://openalex.org/W4415323519","doi":"https://doi.org/10.64062/jpgmb.vol1.issue5.4"},"language":"en","primary_location":{"id":"doi:10.64062/jpgmb.vol1.issue5.4","doi":"https://doi.org/10.64062/jpgmb.vol1.issue5.4","is_oa":true,"landing_page_url":"https://doi.org/10.64062/jpgmb.vol1.issue5.4","pdf_url":"https://jpgmb.com/1/article/download/53/40","source":{"id":"https://openalex.org/S5407047266","display_name":"Journal of Pharmacology Genetics and Molecular Biology","issn_l":"3049-3757","issn":["3049-3757"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pharmacology, Genetics and Molecular Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://jpgmb.com/1/article/download/53/40","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028331818","display_name":"Srikumar Chakravarthi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I902764099","display_name":"SEGi University","ror":"https://ror.org/05crr5s63","country_code":"MY","type":"education","lineage":["https://openalex.org/I902764099"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Srikumar Chakravarthi","raw_affiliation_strings":["Faculty of Medicine, Nursing and Health Sciences, SEGi University, Selangor, Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine, Nursing and Health Sciences, SEGi University, Selangor, Malaysia","institution_ids":["https://openalex.org/I902764099"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108623530","display_name":"John Paul Judson","orcid":"https://orcid.org/0000-0002-8521-4854","observed_orcids":["https://orcid.org/0000-0002-8521-4854"]},"institutions":[{"id":"https://openalex.org/I931681460","display_name":"Universiti Tunku Abdul Rahman","ror":"https://ror.org/050pq4m56","country_code":"MY","type":"education","lineage":["https://openalex.org/I931681460"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"John Paul Judson","raw_affiliation_strings":["Faculty of Medicine and Health Sciences, Universiti Tunku Abdul Rahman, Selangor, Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine and Health Sciences, Universiti Tunku Abdul Rahman, Selangor, Malaysia","institution_ids":["https://openalex.org/I931681460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048592966","display_name":"Barani Karikalan","orcid":"https://orcid.org/0000-0002-5751-346X","observed_orcids":["https://orcid.org/0000-0002-5751-346X"]},"institutions":[{"id":"https://openalex.org/I4210102358","display_name":"Mahsa University","ror":"https://ror.org/00p43ne90","country_code":"MY","type":"education","lineage":["https://openalex.org/I4210102358"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Barani Karikalan","raw_affiliation_strings":["Faculty of Medicine, MAHSA University, Selangor, Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine, MAHSA University, Selangor, Malaysia","institution_ids":["https://openalex.org/I4210102358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093411157","display_name":"Prarthana Kalerammana Gopalakrishna","orcid":"https://orcid.org/0000-0002-1428-5305","observed_orcids":["https://orcid.org/0000-0002-1428-5305"]},"institutions":[{"id":"https://openalex.org/I62370553","display_name":"IMU University","ror":"https://ror.org/04d4wjw61","country_code":"MY","type":"education","lineage":["https://openalex.org/I62370553"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Prarthana  Kalerammana Gopalakrishna","raw_affiliation_strings":["Department of Human Biology, IMU University, Bukit Jalil, Kuala Lumpur, Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Biology, IMU University, Bukit Jalil, Kuala Lumpur, Malaysia","institution_ids":["https://openalex.org/I62370553"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108271809","display_name":"Mohammad Nazmul Hasan Maziz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210096221","display_name":"Perdana University","ror":"https://ror.org/00wfd0g93","country_code":"MY","type":"education","lineage":["https://openalex.org/I4210096221"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Mohammad Nazmul Hasan Maziz","raw_affiliation_strings":["Graduate School of Medicine, Perdana University, Kuala Lumpur, Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Medicine, Perdana University, Kuala Lumpur, Malaysia","institution_ids":["https://openalex.org/I4210096221"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.20081179,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"54","last_page":"68"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.9336000084877014,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.9336000084877014,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.03819999843835831,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.01590000092983246,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/stem-cell-therapy","display_name":"stem cell therapy","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cardiovascular-disease","display_name":"cardiovascular disease","score":0.9959999918937683},{"id":"https://openalex.org/keywords/cardiac-regeneration","display_name":"cardiac regeneration","score":0.8820000290870667},{"id":"https://openalex.org/keywords/mesenchymal-stem-cells","display_name":"mesenchymal stem cells","score":0.9710000157356262},{"id":"https://openalex.org/keywords/cardiac-stem-cells","display_name":"cardiac stem cells","score":0.9980000257492065},{"id":"https://openalex.org/keywords/induced-pluripotent-stem-cells","display_name":"induced pluripotent stem cells","score":1.0},{"id":"https://openalex.org/keywords/paracrine-signaling","display_name":"paracrine signaling","score":0.9890000224113464},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.9620000123977661},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.996999979019165},{"id":"https://openalex.org/keywords/biomaterial-scaffolds","display_name":"biomaterial scaffolds","score":0.8849999904632568},{"id":"https://openalex.org/keywords/cell-delivery","display_name":"cell delivery","score":0.921999990940094},{"id":"https://openalex.org/keywords/engraftment","display_name":"engraftment","score":0.8859999775886536},{"id":"https://openalex.org/keywords/tumorigenicity","display_name":"tumorigenicity","score":0.949999988079071},{"id":"https://openalex.org/keywords/immune-rejection","display_name":"immune rejection","score":0.75},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.8619999885559082},{"id":"https://openalex.org/keywords/personalized-medicine","display_name":"personalized medicine","score":0.8119999766349792}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7778000235557556},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.690500020980835},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.6861000061035156},{"id":"https://openalex.org/C107459253","wikidata":"https://www.wikidata.org/wiki/Q674925","display_name":"Induced pluripotent stem cell","level":4,"score":0.6577000021934509},{"id":"https://openalex.org/C10882517","wikidata":"https://www.wikidata.org/wiki/Q15268054","display_name":"Cell therapy","level":3,"score":0.5490000247955322},{"id":"https://openalex.org/C2779389132","wikidata":"https://www.wikidata.org/wiki/Q1533033","display_name":"Stem-cell therapy","level":3,"score":0.4984000027179718},{"id":"https://openalex.org/C10854531","wikidata":"https://www.wikidata.org/wiki/Q1061415","display_name":"Regenerative medicine","level":3,"score":0.4602999985218048},{"id":"https://openalex.org/C7876069","wikidata":"https://www.wikidata.org/wiki/Q14873666","display_name":"Paracrine signalling","level":3,"score":0.44110000133514404},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.39500001072883606},{"id":"https://openalex.org/C2910577704","wikidata":"https://www.wikidata.org/wiki/Q10334846","display_name":"Cardiac cell","level":2,"score":0.37400001287460327},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3125999867916107},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3059000074863434},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.29269999265670776},{"id":"https://openalex.org/C2991719091","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell biology","level":5,"score":0.29100000858306885},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.29089999198913574},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.28999999165534973},{"id":"https://openalex.org/C2781230642","wikidata":"https://www.wikidata.org/wiki/Q492646","display_name":"Targeted therapy","level":3,"score":0.27900001406669617},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.2775000035762787},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.274399995803833},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.27309998869895935},{"id":"https://openalex.org/C2994604686","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell function","level":3,"score":0.27140000462532043},{"id":"https://openalex.org/C111566952","wikidata":"https://www.wikidata.org/wiki/Q1303462","display_name":"Cardiac function curve","level":3,"score":0.2712000012397766},{"id":"https://openalex.org/C20875687","wikidata":"https://www.wikidata.org/wiki/Q2642600","display_name":"Adult stem cell","level":4,"score":0.2655999958515167},{"id":"https://openalex.org/C49892992","wikidata":"https://www.wikidata.org/wiki/Q1540285","display_name":"Tissue engineering","level":2,"score":0.2621999979019165},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.25949999690055847},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.25769999623298645}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.64062/jpgmb.vol1.issue5.4","doi":"https://doi.org/10.64062/jpgmb.vol1.issue5.4","is_oa":true,"landing_page_url":"https://doi.org/10.64062/jpgmb.vol1.issue5.4","pdf_url":"https://jpgmb.com/1/article/download/53/40","source":{"id":"https://openalex.org/S5407047266","display_name":"Journal of Pharmacology Genetics and Molecular Biology","issn_l":"3049-3757","issn":["3049-3757"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pharmacology, Genetics and Molecular Biology","raw_type":"journal-article"},{"id":"pmh:oai:ojs2.jpgmb.com:article/53","doi":null,"is_oa":false,"landing_page_url":"https://jpgmb.com/index/article/view/53","pdf_url":null,"source":{"id":"https://openalex.org/S5407047266","display_name":"Journal of Pharmacology Genetics and Molecular Biology","issn_l":"3049-3757","issn":["3049-3757"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"3049-3757","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.64062/jpgmb.vol1.issue5.4","doi":"https://doi.org/10.64062/jpgmb.vol1.issue5.4","is_oa":true,"landing_page_url":"https://doi.org/10.64062/jpgmb.vol1.issue5.4","pdf_url":"https://jpgmb.com/1/article/download/53/40","source":{"id":"https://openalex.org/S5407047266","display_name":"Journal of Pharmacology Genetics and Molecular Biology","issn_l":"3049-3757","issn":["3049-3757"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pharmacology, Genetics and Molecular Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4415323519.pdf","grobid_xml":"https://content.openalex.org/works/W4415323519.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4414374507","https://openalex.org/W7109229436","https://openalex.org/W4412589072","https://openalex.org/W4404944229","https://openalex.org/W4390909491","https://openalex.org/W7217959310","https://openalex.org/W4395703956","https://openalex.org/W7147028924","https://openalex.org/W2404919006","https://openalex.org/W4393356691"],"abstract_inverted_index":{"Cardiovascular":[0],"diseases":[1],"(CVDs)":[2],"are":[3,89],"a":[4,34],"major":[5],"global":[6],"health":[7],"concern,":[8],"but":[9],"current":[10],"treatment":[11],"methods":[12,76],"mostly":[13],"aim":[14],"at":[15],"alleviating":[16],"symptoms":[17],"rather":[18],"than":[19],"repairing":[20],"damaged":[21],"heart":[22],"tissue.":[23],"It":[24],"has":[25],"been":[26],"suggested":[27],"that":[28,113],"stem":[29,51,55,61],"cell":[30,81,122],"therapy":[31],"might":[32],"be":[33],"viable":[35],"regenerative":[36],"option":[37],"for":[38],"restoring":[39],"cardiac":[40,54],"function":[41],"by":[42],"direct":[43],"differentiation,":[44],"paracrine":[45],"signaling,":[46],"immunomodulation,":[47],"and":[48,58,73,84,103,128,136],"angiogenesis.":[49],"Mesenchymal":[50],"cells":[52,56,62],"(MSCs),":[53],"(CSCs),":[57],"induced":[59],"pluripotent":[60],"(iPSCs)":[63],"have":[64,114],"therapeutic":[65],"potential,":[66],"according":[67],"to":[68,79,116,132,143,150],"preclinical":[69],"study.":[70],"Biomaterial":[71],"scaffolding":[72],"improved":[74,80,121],"delivery":[75],"also":[77],"lead":[78],"survival,":[82],"retention,":[83],"integration.":[85],"Although":[86],"the":[87,138,141],"outcomes":[88],"encouraging,":[90],"shortcomings":[91],"associated":[92],"with":[93,140],"this":[94],"approach":[95],"include":[96],"low":[97],"long-term":[98],"engraftment,":[99],"immune":[100],"rejection,":[101],"tumorigenicity,":[102],"inconsistency":[104],"in":[105],"outcomes,":[106],"which":[107],"discourage":[108],"clinical":[109],"translation.":[110],"Current":[111],"studies":[112],"aimed":[115],"address":[117],"these":[118,134],"limitations":[119],"through":[120],"selection,":[123],"combination":[124],"therapy,":[125],"biomaterials":[126],"engineering,":[127],"personalized":[129],"therapies,":[130],"promise":[131],"overcome":[133],"obstacles":[135],"provide":[137],"community":[139],"possibility":[142],"transform":[144],"cardiovascular":[145],"care":[146,149],"beyond":[147],"palliative":[148],"actual":[151],"myocardial":[152],"regeneration.":[153]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-10-19T00:00:00"}