{"id":"https://openalex.org/W4415319683","doi":"https://doi.org/10.1016/j.ecoenv.2025.119243","title":"Pseudohypoxia induced by chemical pollutants: Biochemical evidence of environmental vulnerability","display_name":"Pseudohypoxia induced by chemical pollutants: Biochemical evidence of environmental vulnerability","publication_year":2025,"publication_date":"2025-10-01","ids":{"openalex":"https://openalex.org/W4415319683","doi":"https://doi.org/10.1016/j.ecoenv.2025.119243","pmid":"https://pubmed.ncbi.nlm.nih.gov/41110303"},"language":"en","primary_location":{"id":"doi:10.1016/j.ecoenv.2025.119243","doi":"https://doi.org/10.1016/j.ecoenv.2025.119243","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ecoenv.2025.119243","pdf_url":null,"source":{"id":"https://openalex.org/S13733787","display_name":"Ecotoxicology and Environmental Safety","issn_l":"0147-6513","issn":["0147-6513","1090-2414"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ecotoxicology and Environmental Safety","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.ecoenv.2025.119243","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017581594","display_name":"Chenxu Hu","orcid":"https://orcid.org/0009-0003-7292-4712","observed_orcids":["https://orcid.org/0009-0003-7292-4712"]},"institutions":[{"id":"https://openalex.org/I115592961","display_name":"Jiangsu University","ror":"https://ror.org/03jc41j30","country_code":"CN","type":"education","lineage":["https://openalex.org/I115592961"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chenxu Hu","raw_affiliation_strings":["Department of Preventive Medicine and Public Health Laboratory Sciences, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu 212013, China"],"raw_orcid":"https://orcid.org/0009-0003-7292-4712","affiliations":[{"raw_affiliation_string":"Department of Preventive Medicine and Public Health Laboratory Sciences, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu 212013, China","institution_ids":["https://openalex.org/I115592961"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012522503","display_name":"Zehua Tao","orcid":"https://orcid.org/0000-0001-9016-0590","observed_orcids":["https://orcid.org/0000-0001-9016-0590"]},"institutions":[{"id":"https://openalex.org/I115592961","display_name":"Jiangsu University","ror":"https://ror.org/03jc41j30","country_code":"CN","type":"education","lineage":["https://openalex.org/I115592961"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zehua Tao","raw_affiliation_strings":["Department of Preventive Medicine and Public Health Laboratory Sciences, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu 212013, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Preventive Medicine and Public Health Laboratory Sciences, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu 212013, China","institution_ids":["https://openalex.org/I115592961"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016184208","display_name":"Yanli Lin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I115592961","display_name":"Jiangsu University","ror":"https://ror.org/03jc41j30","country_code":"CN","type":"education","lineage":["https://openalex.org/I115592961"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanli Lin","raw_affiliation_strings":["Department of Preventive Medicine and Public Health Laboratory Sciences, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu 212013, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Preventive Medicine and Public Health Laboratory Sciences, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu 212013, China","institution_ids":["https://openalex.org/I115592961"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100660780","display_name":"Jian Chen","orcid":"https://orcid.org/0000-0002-0261-3578","observed_orcids":["https://orcid.org/0000-0002-0261-3578","https://orcid.org/0000-0001-5982-044X"]},"institutions":[{"id":"https://openalex.org/I115592961","display_name":"Jiangsu University","ror":"https://ror.org/03jc41j30","country_code":"CN","type":"education","lineage":["https://openalex.org/I115592961"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jian Chen","raw_affiliation_strings":["Department of Preventive Medicine and Public Health Laboratory Sciences, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu 212013, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Preventive Medicine and Public Health Laboratory Sciences, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu 212013, China","institution_ids":["https://openalex.org/I115592961"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5098801378","display_name":"Ngwa Adeline Ngeng","orcid":"https://orcid.org/0009-0006-1514-3137","observed_orcids":["https://orcid.org/0009-0006-1514-3137"]},"institutions":[{"id":"https://openalex.org/I115592961","display_name":"Jiangsu University","ror":"https://ror.org/03jc41j30","country_code":"CN","type":"education","lineage":["https://openalex.org/I115592961"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ngwa Adeline Ngeng","raw_affiliation_strings":["Department of Preventive Medicine and Public Health Laboratory Sciences, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu 212013, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Preventive Medicine and Public Health Laboratory Sciences, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu 212013, China","institution_ids":["https://openalex.org/I115592961"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035503566","display_name":"Michael Aschner","orcid":"https://orcid.org/0000-0002-2619-1656","observed_orcids":["https://orcid.org/0000-0002-2619-1656"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Aschner","raw_affiliation_strings":["Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USA","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091107637","display_name":"Alexey A. Tinkov","orcid":"https://orcid.org/0000-0003-0348-6192","observed_orcids":["https://orcid.org/0000-0003-0348-6192"]},"institutions":[{"id":"https://openalex.org/I196486018","display_name":"Orenburg State University","ror":"https://ror.org/05b0f8e85","country_code":"RU","type":"education","lineage":["https://openalex.org/I196486018"]},{"id":"https://openalex.org/I198371094","display_name":"Yaroslavl State University","ror":"https://ror.org/044s2fj67","country_code":"RU","type":"education","lineage":["https://openalex.org/I198371094"]}],"countries":["RU"],"is_corresponding":true,"raw_author_name":"Alexey A. Tinkov","raw_affiliation_strings":["Institute of Bioelementology, Orenburg State University, Orenburg 460001, Russia; Laboratory of Ecobiomonitoring and Quality Control, Yaroslavl State University, Yaroslavl 150003, Russia. Electronic address: a.tinkov@uniyar.ac.ru"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Bioelementology, Orenburg State University, Orenburg 460001, Russia; Laboratory of Ecobiomonitoring and Quality Control, Yaroslavl State University, Yaroslavl 150003, Russia. Electronic address: a.tinkov@uniyar.ac.ru","institution_ids":["https://openalex.org/I196486018","https://openalex.org/I198371094"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070189896","display_name":"Rongzhu Lu","orcid":"https://orcid.org/0000-0002-8633-8453","observed_orcids":["https://orcid.org/0000-0002-8633-8453"]},"institutions":[{"id":"https://openalex.org/I115592961","display_name":"Jiangsu University","ror":"https://ror.org/03jc41j30","country_code":"CN","type":"education","lineage":["https://openalex.org/I115592961"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Rongzhu Lu","raw_affiliation_strings":["Department of Preventive Medicine and Public Health Laboratory Sciences, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu 212013, China; Clinical Experimental Research Center, Kunshan Hospital Affiliated to Jiangsu University, Kunshan, Suzhou, Jiangsu 215300, China. Electronic address: lurz@ujs.edu.cn"],"raw_orcid":"https://orcid.org/0000-0002-8633-8453","affiliations":[{"raw_affiliation_string":"Department of Preventive Medicine and Public Health Laboratory Sciences, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu 212013, China; Clinical Experimental Research Center, Kunshan Hospital Affiliated to Jiangsu University, Kunshan, Suzhou, Jiangsu 215300, China. Electronic address: lurz@ujs.edu.cn","institution_ids":["https://openalex.org/I115592961"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5070189896","https://openalex.org/A5091107637"],"corresponding_institution_ids":["https://openalex.org/I115592961","https://openalex.org/I196486018","https://openalex.org/I198371094"],"apc_list":{"value":3650,"currency":"USD","value_usd":3650},"apc_paid":{"value":3650,"currency":"USD","value_usd":3650},"fwci":0.6572,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.69299583,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":97},"biblio":{"volume":"305","issue":null,"first_page":"119243","last_page":"119243"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.7846999764442444,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.7846999764442444,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10447","display_name":"Environmental Toxicology and Ecotoxicology","score":0.029999999329447746,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":0.022099999710917473,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pseudohypoxia","display_name":"pseudohypoxia","score":0.9990000128746033},{"id":"https://openalex.org/keywords/chemical-contaminants","display_name":"chemical contaminants","score":0.7670000195503235},{"id":"https://openalex.org/keywords/hypoxia-inducible-factor-1alpha","display_name":"hypoxia-inducible factor-1\u03b1","score":0.9769999980926514},{"id":"https://openalex.org/keywords/hif-1alpha-stabilization","display_name":"HIF-1\u03b1 stabilization","score":0.8999999761581421},{"id":"https://openalex.org/keywords/environmental-exposure","display_name":"environmental exposure","score":0.550000011920929},{"id":"https://openalex.org/keywords/metals-and-metalloids","display_name":"metals and metalloids","score":0.8209999799728394},{"id":"https://openalex.org/keywords/cadmium","display_name":"cadmium","score":0.9559999704360962},{"id":"https://openalex.org/keywords/arsenic","display_name":"arsenic","score":0.8740000128746033},{"id":"https://openalex.org/keywords/cobalt","display_name":"cobalt","score":0.8140000104904175},{"id":"https://openalex.org/keywords/bisphenol-a","display_name":"bisphenol A","score":0.8569999933242798},{"id":"https://openalex.org/keywords/dioxins","display_name":"dioxins","score":0.972000002861023},{"id":"https://openalex.org/keywords/polychlorinated-biphenyls","display_name":"polychlorinated biphenyls","score":0.9909999966621399},{"id":"https://openalex.org/keywords/pm2-5","display_name":"PM2.5","score":0.8240000009536743},{"id":"https://openalex.org/keywords/diesel-exhaust-particles","display_name":"diesel exhaust particles","score":0.9950000047683716},{"id":"https://openalex.org/keywords/persistent-organic-pollutants","display_name":"persistent organic pollutants","score":0.7760000228881836},{"id":"https://openalex.org/keywords/cellular-energy-metabolism","display_name":"cellular energy metabolism","score":0.7799999713897705},{"id":"https://openalex.org/keywords/disease-susceptibility","display_name":"disease susceptibility","score":0.7179999947547913},{"id":"https://openalex.org/keywords/cancer-risk","display_name":"cancer risk","score":0.5509999990463257},{"id":"https://openalex.org/keywords/cardiovascular-disease","display_name":"cardiovascular disease","score":0.7829999923706055},{"id":"https://openalex.org/keywords/chronic-respiratory-disease","display_name":"chronic respiratory disease","score":0.9610000252723694}],"concepts":[{"id":"https://openalex.org/C82685317","wikidata":"https://www.wikidata.org/wiki/Q19829510","display_name":"Pollutant","level":2,"score":0.7809000015258789},{"id":"https://openalex.org/C107872376","wikidata":"https://www.wikidata.org/wiki/Q321355","display_name":"Environmental chemistry","level":1,"score":0.4377000033855438},{"id":"https://openalex.org/C39432304","wikidata":"https://www.wikidata.org/wiki/Q188847","display_name":"Environmental science","level":0,"score":0.4244999885559082},{"id":"https://openalex.org/C2909468537","wikidata":"https://www.wikidata.org/wiki/Q58734","display_name":"Environmental pollution","level":2,"score":0.41110000014305115},{"id":"https://openalex.org/C2987853052","wikidata":"https://www.wikidata.org/wiki/Q131123","display_name":"Air pollutants","level":3,"score":0.3955000042915344},{"id":"https://openalex.org/C2776053758","wikidata":"https://www.wikidata.org/wiki/Q105789","display_name":"Heavy metals","level":2,"score":0.35499998927116394},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.34150001406669617},{"id":"https://openalex.org/C521259446","wikidata":"https://www.wikidata.org/wiki/Q58734","display_name":"Pollution","level":2,"score":0.33500000834465027},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33410000801086426},{"id":"https://openalex.org/C201052633","wikidata":"https://www.wikidata.org/wiki/Q5381223","display_name":"Environmental epidemiology","level":2,"score":0.33340001106262207},{"id":"https://openalex.org/C2987857752","wikidata":"https://www.wikidata.org/wiki/Q12147","display_name":"Human health","level":2,"score":0.3075000047683716},{"id":"https://openalex.org/C559116025","wikidata":"https://www.wikidata.org/wiki/Q131123","display_name":"Air pollution","level":2,"score":0.30559998750686646},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.2870999872684479},{"id":"https://openalex.org/C24245907","wikidata":"https://www.wikidata.org/wiki/Q498957","display_name":"Particulates","level":2,"score":0.28529998660087585},{"id":"https://openalex.org/C41157215","wikidata":"https://www.wikidata.org/wiki/Q3995923","display_name":"Environmental toxicology","level":3,"score":0.2770000100135803},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.26100000739097595},{"id":"https://openalex.org/C77288539","wikidata":"https://www.wikidata.org/wiki/Q19596","display_name":"Metalloid","level":3,"score":0.2563999891281128},{"id":"https://openalex.org/C539469273","wikidata":"https://www.wikidata.org/wiki/Q1749732","display_name":"Environmental monitoring","level":2,"score":0.25220000743865967},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.2513999938964844}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D004781","descriptor_name":"Environmental Exposure","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D004781","descriptor_name":"Environmental Exposure","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D004781","descriptor_name":"Environmental Exposure","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D004785","descriptor_name":"Environmental Pollutants","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D004785","descriptor_name":"Environmental Pollutants","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D004785","descriptor_name":"Environmental Pollutants","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051795","descriptor_name":"Hypoxia-Inducible Factor 1, alpha Subunit","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051795","descriptor_name":"Hypoxia-Inducible Factor 1, alpha Subunit","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051795","descriptor_name":"Hypoxia-Inducible Factor 1, alpha Subunit","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.ecoenv.2025.119243","doi":"https://doi.org/10.1016/j.ecoenv.2025.119243","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ecoenv.2025.119243","pdf_url":null,"source":{"id":"https://openalex.org/S13733787","display_name":"Ecotoxicology and Environmental Safety","issn_l":"0147-6513","issn":["0147-6513","1090-2414"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ecotoxicology and Environmental Safety","raw_type":"journal-article"},{"id":"pmid:41110303","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41110303","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ecotoxicology and environmental safety","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.ecoenv.2025.119243","doi":"https://doi.org/10.1016/j.ecoenv.2025.119243","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ecoenv.2025.119243","pdf_url":null,"source":{"id":"https://openalex.org/S13733787","display_name":"Ecotoxicology and Environmental Safety","issn_l":"0147-6513","issn":["0147-6513","1090-2414"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ecotoxicology and Environmental Safety","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6240000128746033,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1648296056","display_name":null,"funder_award_id":"R01 ES10563","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G172142613","display_name":null,"funder_award_id":"R01-ES07331","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G2731555932","display_name":null,"funder_award_id":"FENZ-2023\u20130004","funder_id":"https://openalex.org/F4320327494","funder_display_name":"Ministry of Science and Higher Education of the Russian Federation"},{"id":"https://openalex.org/G3263691978","display_name":null,"funder_award_id":"81273124","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7177056774","display_name":null,"funder_award_id":"075-15-2024-550","funder_id":"https://openalex.org/F4320327494","funder_display_name":"Ministry of Science and Higher Education of the Russian Federation"},{"id":"https://openalex.org/G7901214698","display_name":null,"funder_award_id":"30872139","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320327494","display_name":"Ministry of Science and Higher Education of the Russian Federation","ror":null},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":250,"referenced_works":["https://openalex.org/W628038580","https://openalex.org/W1486970902","https://openalex.org/W1507967795","https://openalex.org/W1736968472","https://openalex.org/W1749022239","https://openalex.org/W1899746275","https://openalex.org/W1963545628","https://openalex.org/W1967127565","https://openalex.org/W1970358298","https://openalex.org/W1972605901","https://openalex.org/W1973352921","https://openalex.org/W1979377219","https://openalex.org/W1980556134","https://openalex.org/W1980809421","https://openalex.org/W1981706852","https://openalex.org/W1982203453","https://openalex.org/W1983211715","https://openalex.org/W1986702410","https://openalex.org/W1988089343","https://openalex.org/W1992019157","https://openalex.org/W1994464169","https://openalex.org/W1997934335","https://openalex.org/W1998916860","https://openalex.org/W2004714156","https://openalex.org/W2004917142","https://openalex.org/W2011560554","https://openalex.org/W2011856993","https://openalex.org/W2012698286","https://openalex.org/W2014049184","https://openalex.org/W2015644147","https://openalex.org/W2017200866","https://openalex.org/W2018393684","https://openalex.org/W2023851008","https://openalex.org/W2026171313","https://openalex.org/W2029213094","https://openalex.org/W2032039586","https://openalex.org/W2040678852","https://openalex.org/W2046006673","https://openalex.org/W2049818378","https://openalex.org/W2050213142","https://openalex.org/W2051215275","https://openalex.org/W2053251778","https://openalex.org/W2053258939","https://openalex.org/W2057199368","https://openalex.org/W2058990908","https://openalex.org/W2060727180","https://openalex.org/W2061488891","https://openalex.org/W2062538630","https://openalex.org/W2064271041","https://openalex.org/W2065239727","https://openalex.org/W2069601083","https://openalex.org/W2070152906","https://openalex.org/W2075608184","https://openalex.org/W2080451545","https://openalex.org/W2080458437","https://openalex.org/W2082493554","https://openalex.org/W2083511611","https://openalex.org/W2087214757","https://openalex.org/W2090975426","https://openalex.org/W2097601801","https://openalex.org/W2101952777","https://openalex.org/W2102884195","https://openalex.org/W2109673760","https://openalex.org/W2113902100","https://openalex.org/W2117524910","https://openalex.org/W2119065814","https://openalex.org/W2120090919","https://openalex.org/W2121744013","https://openalex.org/W2123945461","https://openalex.org/W2127865289","https://openalex.org/W2129691517","https://openalex.org/W2131473358","https://openalex.org/W2141528928","https://openalex.org/W2144099275","https://openalex.org/W2151309632","https://openalex.org/W2152288875","https://openalex.org/W2159013209","https://openalex.org/W2160338349","https://openalex.org/W2161877652","https://openalex.org/W2162271763","https://openalex.org/W2167761137","https://openalex.org/W2169061609","https://openalex.org/W2171464417","https://openalex.org/W2171748049","https://openalex.org/W2172266351","https://openalex.org/W2205685406","https://openalex.org/W2230074349","https://openalex.org/W2235989189","https://openalex.org/W2254871225","https://openalex.org/W2271442879","https://openalex.org/W2322134651","https://openalex.org/W2325267338","https://openalex.org/W2330594329","https://openalex.org/W2343656714","https://openalex.org/W2345672003","https://openalex.org/W2401661980","https://openalex.org/W2412403360","https://openalex.org/W2415589882","https://openalex.org/W2466683250","https://openalex.org/W2500425528","https://openalex.org/W2509187156","https://openalex.org/W2513560160","https://openalex.org/W2554066088","https://openalex.org/W2576495906","https://openalex.org/W2592535610","https://openalex.org/W2617805895","https://openalex.org/W2735138265","https://openalex.org/W2738758192","https://openalex.org/W2773055127","https://openalex.org/W2789063912","https://openalex.org/W2790528704","https://openalex.org/W2792761620","https://openalex.org/W2797779096","https://openalex.org/W2802180781","https://openalex.org/W2883586346","https://openalex.org/W2885979349","https://openalex.org/W2886755062","https://openalex.org/W2889154432","https://openalex.org/W2901556472","https://openalex.org/W2902385652","https://openalex.org/W2903595671","https://openalex.org/W2921552993","https://openalex.org/W2930040264","https://openalex.org/W2930283374","https://openalex.org/W2936786334","https://openalex.org/W2941085962","https://openalex.org/W2947955160","https://openalex.org/W2951278033","https://openalex.org/W2957295726","https://openalex.org/W2977733682","https://openalex.org/W2981938452","https://openalex.org/W2991112079","https://openalex.org/W2991379561","https://openalex.org/W2992123506","https://openalex.org/W2993012387","https://openalex.org/W2999491023","https://openalex.org/W3003140379","https://openalex.org/W3010641114","https://openalex.org/W3012380876","https://openalex.org/W3012829893","https://openalex.org/W3033235740","https://openalex.org/W3044118640","https://openalex.org/W3046180206","https://openalex.org/W3047131132","https://openalex.org/W3047438853","https://openalex.org/W3048777645","https://openalex.org/W3089301898","https://openalex.org/W3093142271","https://openalex.org/W3093710724","https://openalex.org/W3100865382","https://openalex.org/W3109820548","https://openalex.org/W3110784232","https://openalex.org/W3116132272","https://openalex.org/W3128130740","https://openalex.org/W3134599547","https://openalex.org/W3135081303","https://openalex.org/W3135452407","https://openalex.org/W3146105830","https://openalex.org/W3152671368","https://openalex.org/W3156269357","https://openalex.org/W3156289478","https://openalex.org/W3158231901","https://openalex.org/W3163063086","https://openalex.org/W3164831205","https://openalex.org/W3168186382","https://openalex.org/W3184891994","https://openalex.org/W3185378999","https://openalex.org/W3195216273","https://openalex.org/W3202214532","https://openalex.org/W3203758520","https://openalex.org/W3207750761","https://openalex.org/W3213214654","https://openalex.org/W3215888906","https://openalex.org/W3216778992","https://openalex.org/W4210329547","https://openalex.org/W4210678296","https://openalex.org/W4210787142","https://openalex.org/W4220860300","https://openalex.org/W4220878110","https://openalex.org/W4221072988","https://openalex.org/W4224942219","https://openalex.org/W4224999651","https://openalex.org/W4225121117","https://openalex.org/W4280496153","https://openalex.org/W4281639787","https://openalex.org/W4283030689","https://openalex.org/W4283820794","https://openalex.org/W4294718043","https://openalex.org/W4296050196","https://openalex.org/W4303647036","https://openalex.org/W4308548733","https://openalex.org/W4311742654","https://openalex.org/W4311989400","https://openalex.org/W4312197459","https://openalex.org/W4315798214","https://openalex.org/W4318064998","https://openalex.org/W4318754719","https://openalex.org/W4323859311","https://openalex.org/W4327559999","https://openalex.org/W4366257126","https://openalex.org/W4366978143","https://openalex.org/W4367839144","https://openalex.org/W4376609807","https://openalex.org/W4378648441","https://openalex.org/W4381384500","https://openalex.org/W4384203808","https://openalex.org/W4385605045","https://openalex.org/W4386505169","https://openalex.org/W4386529659","https://openalex.org/W4387567644","https://openalex.org/W4388346874","https://openalex.org/W4389209495","https://openalex.org/W4390326412","https://openalex.org/W4390743827","https://openalex.org/W4391667587","https://openalex.org/W4391919704","https://openalex.org/W4392557253","https://openalex.org/W4393093376","https://openalex.org/W4393143542","https://openalex.org/W4393294814","https://openalex.org/W4393377549","https://openalex.org/W4394600799","https://openalex.org/W4394601776","https://openalex.org/W4396224412","https://openalex.org/W4396873908","https://openalex.org/W4396920496","https://openalex.org/W4397022796","https://openalex.org/W4398760312","https://openalex.org/W4399019290","https://openalex.org/W4399356876","https://openalex.org/W4399571832","https://openalex.org/W4399582164","https://openalex.org/W4399894882","https://openalex.org/W4399907547","https://openalex.org/W4400610917","https://openalex.org/W4400997675","https://openalex.org/W4401001950","https://openalex.org/W4401425246","https://openalex.org/W4401480851","https://openalex.org/W4401559258","https://openalex.org/W4402110484","https://openalex.org/W4402404956","https://openalex.org/W4402668749","https://openalex.org/W4403146470","https://openalex.org/W4403886560","https://openalex.org/W4404437057","https://openalex.org/W4406696398","https://openalex.org/W4406997998","https://openalex.org/W4408892108","https://openalex.org/W4409624277"],"related_works":[],"abstract_inverted_index":{"Chemical":[0],"pollutants":[1,76,90,108,116],"can":[2,34,77],"abnormally":[3],"elevate":[4],"hypoxia-inducible":[5],"factor":[6],"1-alpha":[7],"(HIF-1\u03b1)":[8],"levels":[9],"under":[10],"normoxic":[11],"conditions,":[12],"leading":[13],"to":[14,98,137],"pseudohypoxia.":[15],"This":[16,134],"condition":[17],"disrupts":[18],"normal":[19],"cellular":[20],"energy":[21],"metabolism,":[22],"gene":[23],"expression,":[24],"and":[25,46,55,64,80,100,113,122,131,155,161],"signal":[26],"transduction,":[27],"thereby":[28,148],"inducing":[29],"detrimental":[30],"physiological":[31],"effects.":[32],"Pseudohypoxia":[33],"also":[35,86],"increase":[36],"the":[37,59,124,153],"risk":[38],"of":[39,157],"various":[40,88,132],"diseases,":[41,45,49],"including":[42,94],"cancer,":[43],"cardiovascular":[44],"chronic":[47],"respiratory":[48],"while":[50],"adversely":[51],"affecting":[52],"disease":[53,160],"treatment":[54,156],"prognosis.":[56],"Focusing":[57],"on":[58],"intersection":[60],"between":[61,127],"environmental":[62,89,146,158],"pollution":[63],"hypoxia":[65],"signaling":[66],"pathways,":[67],"this":[68],"review":[69,135],"proposes":[70],"a":[71],"novel":[72,139],"concept":[73],"that":[74,91],"chemical":[75],"induce":[78,92],"pseudohypoxia":[79,143],"elucidates":[81],"its":[82],"underlying":[83],"mechanisms.":[84],"We":[85],"identify":[87],"pseudohypoxia,":[93,130],"but":[95],"not":[96],"limited":[97],"metals":[99],"metalloids":[101],"(e.g.,":[102,109,117],"cadmium,":[103],"cobalt,":[104],"arsenic),":[105],"persistent":[106],"organic":[107],"BPA,":[110],"dioxins,":[111],"PCBs),":[112],"atmospheric":[114],"particulate":[115],"PM2.5,":[118],"diesel":[119],"exhaust":[120],"particles),":[121],"examine":[123],"complex":[125],"interplay":[126],"these":[128],"pollutants,":[129],"diseases.":[133],"aims":[136],"offer":[138],"strategies":[140],"for":[141],"managing":[142],"caused":[144],"by":[145],"exposures,":[147],"offering":[149],"new":[150],"insights":[151],"into":[152],"prevention":[154],"exposure-related":[159],"susceptibility.":[162]},"counts_by_year":[{"year":2026,"cited_by_count":2}],"updated_date":"2026-10-13T10:08:12.033832","created_date":"2025-10-19T00:00:00"}
