{"id":"https://openalex.org/W4415316009","doi":"https://doi.org/10.1007/s10439-026-04273-9","title":"A Geometric Feature Tracking Approach for Noninvasive Patient-Specific Estimation of Leaflet Strain from 3D Images of Heart Valves","display_name":"A Geometric Feature Tracking Approach for Noninvasive Patient-Specific Estimation of Leaflet Strain from 3D Images of Heart Valves","publication_year":2026,"publication_date":"2026-07-11","ids":{"openalex":"https://openalex.org/W4415316009","doi":"https://doi.org/10.1007/s10439-026-04273-9","pmid":"https://pubmed.ncbi.nlm.nih.gov/42435266","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13472144"},"language":"en","primary_location":{"id":"doi:10.1007/s10439-026-04273-9","doi":"https://doi.org/10.1007/s10439-026-04273-9","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s10439-026-04273-9","pdf_url":"https://link.springer.com/content/pdf/10.1007/s10439-026-04273-9.pdf","source":{"id":"https://openalex.org/S141152059","display_name":"Annals of Biomedical Engineering","issn_l":"0090-6964","issn":["0090-6964","0191-5649","1573-9686"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Biomedical Engineering","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["arxiv","crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s10439-026-04273-9.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035592893","display_name":"Weitong Wu","orcid":"https://orcid.org/0000-0001-8644-534X","observed_orcids":["https://orcid.org/0000-0001-8644-534X","https://orcid.org/0000-0001-5380-7746","https://orcid.org/0000-0001-8729-3982"]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Wensi Wu","raw_affiliation_strings":["Cardiovascular Institute, Children's Hospital of Philadelphia, Philadelphia, PA, USA. wensiwu@engineering.upenn.edu","Department of Mechanical Engineering and Applied Mechanics, University of Pennsylvania, Philadelphia, PA, USA. wensiwu@engineering.upenn.edu"],"raw_orcid":"https://orcid.org/0000-0001-5380-7746","affiliations":[{"raw_affiliation_string":"Cardiovascular Institute, Children's Hospital of Philadelphia, Philadelphia, PA, USA. wensiwu@engineering.upenn.edu","institution_ids":["https://openalex.org/I1335321130","https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Mechanical Engineering and Applied Mechanics, University of Pennsylvania, Philadelphia, PA, USA. wensiwu@engineering.upenn.edu","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093591143","display_name":"Matthew Daemer","orcid":"https://orcid.org/0009-0008-6059-8469","observed_orcids":["https://orcid.org/0009-0008-6059-8469"]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew Daemer","raw_affiliation_strings":["Department of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I1335321130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054820125","display_name":"Jeffrey A. Weiss","orcid":"https://orcid.org/0000-0002-7264-2454","observed_orcids":["https://orcid.org/0000-0002-7264-2454"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey A. Weiss","raw_affiliation_strings":["Department of Biomedical Engineering, University of Utah, Salt Lake City, UT, USA","Scientific Computing Institute, University of Utah, Salt Lake City, UT, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, University of Utah, Salt Lake City, UT, USA","institution_ids":["https://openalex.org/I223532165"]},{"raw_affiliation_string":"Scientific Computing Institute, University of Utah, Salt Lake City, UT, USA","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073734860","display_name":"Alison M. Pouch","orcid":"https://orcid.org/0000-0001-8854-5301","observed_orcids":["https://orcid.org/0000-0001-8854-5301"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alison M. Pouch","raw_affiliation_strings":["Department of Radiology and Bioengineering, University of Pennsylvania, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology and Bioengineering, University of Pennsylvania, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018251647","display_name":"Matthew A. Jolley","orcid":"https://orcid.org/0000-0002-5626-0130","observed_orcids":["https://orcid.org/0000-0002-5626-0130"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew A. Jolley","raw_affiliation_strings":["Department of Mechanical Engineering and Applied Mechanics, University of Pennsylvania, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mechanical Engineering and Applied Mechanics, University of Pennsylvania, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5035592893"],"corresponding_institution_ids":["https://openalex.org/I1335321130","https://openalex.org/I79576946"],"apc_list":{"value":4390,"currency":"USD","value_usd":4390},"apc_paid":{"value":4390,"currency":"USD","value_usd":4390},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00326224,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10172","display_name":"Cardiac Valve Diseases and Treatments","score":0.7886000275611877,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10172","display_name":"Cardiac Valve Diseases and Treatments","score":0.7886000275611877,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10052","display_name":"Medical Image Segmentation Techniques","score":0.13510000705718994,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.045099999755620956,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/heart-valves","display_name":"heart valves","score":0.7279999852180481},{"id":"https://openalex.org/keywords/atrioventricular-valves","display_name":"atrioventricular valves","score":0.8569999933242798},{"id":"https://openalex.org/keywords/three-dimensional-echocardiography","display_name":"three-dimensional echocardiography","score":0.8180000185966492},{"id":"https://openalex.org/keywords/non-rigid-registration","display_name":"non-rigid registration","score":0.8799999952316284},{"id":"https://openalex.org/keywords/coherent-point-drift","display_name":"coherent point drift","score":0.9359999895095825},{"id":"https://openalex.org/keywords/gaussian-mixture-model","display_name":"Gaussian mixture model","score":0.9179999828338623},{"id":"https://openalex.org/keywords/valvular-heart-disease","display_name":"valvular heart disease","score":0.8790000081062317},{"id":"https://openalex.org/keywords/leaflet-prolapse","display_name":"leaflet prolapse","score":0.7820000052452087},{"id":"https://openalex.org/keywords/principal-strain","display_name":"principal strain","score":0.5619999766349792},{"id":"https://openalex.org/keywords/pediatric-patients","display_name":"pediatric patients","score":0.6050000190734863}],"concepts":[{"id":"https://openalex.org/C2987395694","wikidata":"https://www.wikidata.org/wiki/Q557891","display_name":"Feature tracking","level":3,"score":0.5425999760627747},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5105000138282776},{"id":"https://openalex.org/C135628077","wikidata":"https://www.wikidata.org/wiki/Q220184","display_name":"Finite element method","level":2,"score":0.5059999823570251},{"id":"https://openalex.org/C2776229121","wikidata":"https://www.wikidata.org/wiki/Q215620","display_name":"Heart valve","level":2,"score":0.4943000078201294},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.48570001125335693},{"id":"https://openalex.org/C2776401178","wikidata":"https://www.wikidata.org/wiki/Q12050496","display_name":"Feature (linguistics)","level":2,"score":0.4562999904155731},{"id":"https://openalex.org/C2779736815","wikidata":"https://www.wikidata.org/wiki/Q1130519","display_name":"valvular heart disease","level":2,"score":0.4408999979496002},{"id":"https://openalex.org/C2778022156","wikidata":"https://www.wikidata.org/wiki/Q576145","display_name":"Strain (injury)","level":2,"score":0.41749998927116394},{"id":"https://openalex.org/C185798385","wikidata":"https://www.wikidata.org/wiki/Q1161707","display_name":"Benchmark (surveying)","level":2,"score":0.41029998660087585},{"id":"https://openalex.org/C91158637","wikidata":"https://www.wikidata.org/wiki/Q223818","display_name":"Biplane","level":2,"score":0.4032999873161316},{"id":"https://openalex.org/C2776659728","wikidata":"https://www.wikidata.org/wiki/Q887004","display_name":"Leaflet (botany)","level":2,"score":0.4009000062942505},{"id":"https://openalex.org/C2775936607","wikidata":"https://www.wikidata.org/wiki/Q466845","display_name":"Tracking (education)","level":2,"score":0.3971000015735626},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.392300009727478},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.3537999987602234},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.34850001335144043},{"id":"https://openalex.org/C2993958809","wikidata":"https://www.wikidata.org/wiki/Q215620","display_name":"Atrioventricular valve","level":3,"score":0.3481000065803528},{"id":"https://openalex.org/C176217482","wikidata":"https://www.wikidata.org/wiki/Q860554","display_name":"Metric (unit)","level":2,"score":0.3434999883174896},{"id":"https://openalex.org/C2780074459","wikidata":"https://www.wikidata.org/wiki/Q389735","display_name":"Heart disease","level":2,"score":0.33559998869895935},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33469998836517334},{"id":"https://openalex.org/C27438332","wikidata":"https://www.wikidata.org/wiki/Q2873","display_name":"Principal component analysis","level":2,"score":0.3068999946117401},{"id":"https://openalex.org/C2777543888","wikidata":"https://www.wikidata.org/wiki/Q369939","display_name":"Mitral valve","level":2,"score":0.30309998989105225},{"id":"https://openalex.org/C31601959","wikidata":"https://www.wikidata.org/wiki/Q931309","display_name":"Medical imaging","level":2,"score":0.2980000078678131},{"id":"https://openalex.org/C170700871","wikidata":"https://www.wikidata.org/wiki/Q193378","display_name":"Biomechanics","level":2,"score":0.29010000824928284},{"id":"https://openalex.org/C204366326","wikidata":"https://www.wikidata.org/wiki/Q3027650","display_name":"Deformation (meteorology)","level":2,"score":0.2768000066280365},{"id":"https://openalex.org/C56435381","wikidata":"https://www.wikidata.org/wiki/Q1196371","display_name":"Geometric transformation","level":3,"score":0.26820001006126404},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.2680000066757202},{"id":"https://openalex.org/C99398487","wikidata":"https://www.wikidata.org/wiki/Q257319","display_name":"Cardiac cycle","level":2,"score":0.26489999890327454},{"id":"https://openalex.org/C112604564","wikidata":"https://www.wikidata.org/wiki/Q7489226","display_name":"Shape analysis (program analysis)","level":3,"score":0.2540999948978424},{"id":"https://openalex.org/C148483581","wikidata":"https://www.wikidata.org/wiki/Q446488","display_name":"Feature selection","level":2,"score":0.2502000033855438}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1007/s10439-026-04273-9","doi":"https://doi.org/10.1007/s10439-026-04273-9","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s10439-026-04273-9","pdf_url":"https://link.springer.com/content/pdf/10.1007/s10439-026-04273-9.pdf","source":{"id":"https://openalex.org/S141152059","display_name":"Annals of Biomedical Engineering","issn_l":"0090-6964","issn":["0090-6964","0191-5649","1573-9686"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Biomedical Engineering","raw_type":"journal-article"},{"id":"pmid:42435266","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42435266","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of biomedical engineering","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13472144","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13472144/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ann Biomed Eng","raw_type":"Text"},{"id":"pmh:oai:arXiv.org:2510.06578","doi":null,"is_oa":true,"landing_page_url":"http://arxiv.org/abs/2510.06578","pdf_url":"https://arxiv.org/pdf/2510.06578","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":"2331-8422","issn":["2331-8422"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},{"id":"doi:10.48550/arxiv.2510.06578","doi":"https://doi.org/10.48550/arxiv.2510.06578","is_oa":true,"landing_page_url":"https://doi.org/10.48550/arxiv.2510.06578","pdf_url":null,"source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":"2331-8422","issn":["2331-8422"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Preprint"}],"best_oa_location":{"id":"doi:10.1007/s10439-026-04273-9","doi":"https://doi.org/10.1007/s10439-026-04273-9","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s10439-026-04273-9","pdf_url":"https://link.springer.com/content/pdf/10.1007/s10439-026-04273-9.pdf","source":{"id":"https://openalex.org/S141152059","display_name":"Annals of Biomedical Engineering","issn_l":"0090-6964","issn":["0090-6964","0191-5649","1573-9686"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Biomedical Engineering","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6240000128746033,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1565823954","display_name":null,"funder_award_id":"HL153166","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G267383535","display_name":null,"funder_award_id":"NHLBI K25 HL168235","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2979467845","display_name":null,"funder_award_id":"GM083925","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G3042147918","display_name":null,"funder_award_id":"NHLBI R01 HL163202","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3083901529","display_name":null,"funder_award_id":"NHLBI R01 HL153166","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3200417801","display_name":null,"funder_award_id":"NIGMS-R01GM083925","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G6430920535","display_name":"Computer Modeling of the Tricuspid Valve in Hypoplastic Left Heart Syndrome","funder_award_id":"R01HL153166","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000893485","display_name":"Finite Elements For Biomechanics And Biophysics","funder_award_id":"R01GM083925","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000905851","display_name":"4D Multimodal Image-Based Modeling for Bicuspid Aortic Valve Repair Surgery","funder_award_id":"R01HL163202","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000918244","display_name":"Toward Patient-Specific Computational Modeling of Tricuspid Valve Repair in Hypoplastic Left Heart Syndrome","funder_award_id":"K25HL168235","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320309099","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48"},{"id":"https://openalex.org/F4320319761","display_name":"Additional Ventures","ror":"https://ror.org/01jmvv781"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4415316009.pdf","grobid_xml":"https://content.openalex.org/works/W4415316009.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7165649409","https://openalex.org/W2888594222","https://openalex.org/W7106597116","https://openalex.org/W4415790309","https://openalex.org/W2110768684","https://openalex.org/W2346121605","https://openalex.org/W2173042416","https://openalex.org/W1967095332","https://openalex.org/W7098633120","https://openalex.org/W1606099948"],"abstract_inverted_index":{"Abstract":[0],"Purpose:":[1],"Valvular":[2],"heart":[3,12,279,288,303],"disease":[4,290],"is":[5,17],"prevalent":[6],"and":[7,28,67,82,102,123,150,165,190,221,273,298],"a":[8,18,53,88,114,125,133,145,226,249],"major":[9],"contributor":[10],"to":[11,51,93,103,119,163,172,294],"failure.":[13],"Valve":[14],"leaflet":[15,73,97,191,240,258],"strain":[16,40,74,98,192,205,237,259,267],"promising":[19],"metric":[20],"for":[21,36,138,252],"evaluating":[22],"the":[23,26,108,152,199,231,284,292],"mechanics":[24],"underlying":[25],"initiation":[27],"progression":[29],"of":[30,69,213,230,255,265,277,283,287,301],"valvular":[31,39,278,302],"pathology.":[32],"However,":[33],"generalizable":[34,250],"methods":[35],"noninvasively":[37],"quantifying":[38,187],"from":[41,75,99,260],"clinically":[42],"acquired":[43],"patient":[44,167],"images":[45,79,101],"remain":[46],"limited.":[47],"This":[48,244],"study":[49],"aims":[50],"develop":[52],"robust":[54],"feature":[55,90,245],"tracking":[56,91,157,212,246],"framework":[57,92,137,160,208,247],"that":[58],"enables":[59],"accurate":[60],"shape":[61],"matching":[62],"across":[63,107,175,216],"variable":[64,176],"valve":[65,177,214,257,289],"morphologies":[66,218],"quantification":[68,254],"in":[70,80,95,186,219],"vivo":[71,96],"atrioventricular":[72,256],"three-dimensional":[76],"echocardiographic":[77],"(3DE)":[78],"pediatric":[81,164,220],"adult":[83,166,222],"patients.":[84,223],"Methods":[85],"We":[86,141],"developed":[87],"geometric":[89,116,121],"quantify":[94],"3DE":[100,262],"assess":[104,173],"anatomical":[105,188],"deformation":[106,215],"cardiac":[109],"cycle.":[110],"Our":[111],"approach":[112,153],"integrates":[113],"cohort-derived":[115],"reference":[117],"atlas":[118],"establish":[120],"correspondence":[122],"introduces":[124],"novel":[126],"distance-weighted":[127],"coherent":[128],"point":[129],"drift":[130],"algorithm":[131],"within":[132],"Gaussian":[134],"mixture":[135],"model":[136,149],"non-rigid":[139],"registration.":[140],"evaluated":[142],"performance":[143],"against":[144,198],"finite":[146,200],"element":[147,201],"benchmark":[148,202],"compared":[151],"with":[154,239],"conventional":[155,194],"point-based":[156,195],"methods.":[158],"The":[159,180,207],"was":[161],"applied":[162],"datasets":[168],"(N":[169],"=":[170],"31)":[171],"robustness":[174],"morphologies.":[178],"Results":[179],"proposed":[181],"method":[182,251],"demonstrated":[183],"greater":[184],"accuracy":[185],"alignment":[189],"than":[193],"approaches.":[196],"Validation":[197],"confirmed":[203],"improved":[204],"estimation.":[206],"achieved":[209],"reliable":[210],"inter-phase":[211],"diverse":[217],"Analysis":[224],"identified":[225],"consistent":[227],"distribution":[228],"pattern":[229],"$$1^{\\text":[232],"{st}}$$":[233],"1":[234],"st":[235],"principal":[236],"associated":[238],"billow":[241],"(prolapse).":[242],"Conclusion":[243],"provides":[248],"noninvasive":[253],"clinical":[261],"images.":[263],"Characterization":[264],"biomechanical":[266,285],"patterns":[268],"may":[269],"improve":[270],"prognostic":[271,296],"assessment":[272,297],"support":[274],"longitudinal":[275,299],"evaluation":[276,300],"disease.":[280,304],"Further":[281],"investigation":[282],"signatures":[286],"has":[291],"potential":[293],"enhance":[295]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2025-10-18T00:00:00"}