{"id":"https://openalex.org/W4415315746","doi":"https://doi.org/10.1016/j.jddst.2025.107673","title":"Bilosomes-mediated trans-ocular delivery of azelastine hydrochloride for the treatment of allergic conjunctivitis: In vitro, ex vivo and in vivo investigations","display_name":"Bilosomes-mediated trans-ocular delivery of azelastine hydrochloride for the treatment of allergic conjunctivitis: In vitro, ex vivo and in vivo investigations","publication_year":2025,"publication_date":"2025-10-18","ids":{"openalex":"https://openalex.org/W4415315746","doi":"https://doi.org/10.1016/j.jddst.2025.107673"},"language":"en","primary_location":{"id":"doi:10.1016/j.jddst.2025.107673","doi":"https://doi.org/10.1016/j.jddst.2025.107673","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jddst.2025.107673","pdf_url":null,"source":{"id":"https://openalex.org/S97205441","display_name":"Journal of Drug Delivery Science and Technology","issn_l":"1773-2247","issn":["1773-2247","2588-8943"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Drug Delivery Science and Technology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5120049505","display_name":"Kholoud Mohy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145487455","display_name":"Cairo University","ror":"https://ror.org/03q21mh05","country_code":"EG","type":"education","lineage":["https://openalex.org/I145487455"]},{"id":"https://openalex.org/I61869032","display_name":"Ahram Canadian University","ror":"https://ror.org/02t055680","country_code":"EG","type":"education","lineage":["https://openalex.org/I61869032"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Kholoud Mohy","raw_affiliation_strings":[", Faculty of Pharmacy, Cairo University","Department of Pharmaceutics, Faculty of Pharmacy, Ahram Canadian University, 6th of October City, Cairo, 12451, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":", Faculty of Pharmacy, Cairo University","institution_ids":["https://openalex.org/I145487455"]},{"raw_affiliation_string":"Department of Pharmaceutics, Faculty of Pharmacy, Ahram Canadian University, 6th of October City, Cairo, 12451, Egypt","institution_ids":["https://openalex.org/I61869032"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026740462","display_name":"Mona Ahmed Elhabak","orcid":"https://orcid.org/0000-0003-0902-5362","observed_orcids":["https://orcid.org/0000-0003-0902-5362"]},"institutions":[{"id":"https://openalex.org/I61869032","display_name":"Ahram Canadian University","ror":"https://ror.org/02t055680","country_code":"EG","type":"education","lineage":["https://openalex.org/I61869032"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Mona Elhabak","raw_affiliation_strings":["Department of Pharmaceutics, Faculty of Pharmacy, Ahram Canadian University, 6th of October City, Cairo, 12451, Egypt"],"raw_orcid":"https://orcid.org/0000-0003-0902-5362","affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, Faculty of Pharmacy, Ahram Canadian University, 6th of October City, Cairo, 12451, Egypt","institution_ids":["https://openalex.org/I61869032"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063397258","display_name":"Nermeen Adel ElKasabgy","orcid":"https://orcid.org/0000-0003-1953-7353","observed_orcids":["https://orcid.org/0000-0003-1953-7353"]},"institutions":[{"id":"https://openalex.org/I145487455","display_name":"Cairo University","ror":"https://ror.org/03q21mh05","country_code":"EG","type":"education","lineage":["https://openalex.org/I145487455"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Nermeen A. Elkasabgy","raw_affiliation_strings":["Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Cairo, 11562, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Cairo, 11562, Egypt","institution_ids":["https://openalex.org/I145487455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034930631","display_name":"Rania Hassan Fahmy","orcid":"https://orcid.org/0000-0002-8762-3272","observed_orcids":["https://orcid.org/0000-0002-8762-3272"]},"institutions":[{"id":"https://openalex.org/I145487455","display_name":"Cairo University","ror":"https://ror.org/03q21mh05","country_code":"EG","type":"education","lineage":["https://openalex.org/I145487455"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Rania Hassan Fahmy","raw_affiliation_strings":["Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Cairo, 11562, Egypt"],"raw_orcid":"https://orcid.org/0000-0002-8762-3272","affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Cairo, 11562, Egypt","institution_ids":["https://openalex.org/I145487455"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071286700","display_name":"Nihal Farid Younes","orcid":"https://orcid.org/0000-0002-5105-3669","observed_orcids":["https://orcid.org/0000-0002-5105-3669"]},"institutions":[{"id":"https://openalex.org/I145487455","display_name":"Cairo University","ror":"https://ror.org/03q21mh05","country_code":"EG","type":"education","lineage":["https://openalex.org/I145487455"]}],"countries":["EG"],"is_corresponding":true,"raw_author_name":"Nihal Farid Younes","raw_affiliation_strings":["Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Cairo, 11562, Egypt"],"raw_orcid":"https://orcid.org/0000-0002-5105-3669","affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Cairo, 11562, Egypt","institution_ids":["https://openalex.org/I145487455"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5071286700"],"corresponding_institution_ids":["https://openalex.org/I145487455"],"apc_list":{"value":3810,"currency":"USD","value_usd":3810},"apc_paid":null,"fwci":1.0995,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.7005204,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":97},"biblio":{"volume":"115","issue":null,"first_page":"107673","last_page":"107673"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bilosomes","display_name":"bilosomes","score":0.9070000052452087},{"id":"https://openalex.org/keywords/azelastine-hydrochloride","display_name":"azelastine hydrochloride","score":0.9959999918937683},{"id":"https://openalex.org/keywords/allergic-conjunctivitis","display_name":"allergic conjunctivitis","score":0.9779999852180481},{"id":"https://openalex.org/keywords/corneal-permeation","display_name":"corneal permeation","score":0.8140000104904175},{"id":"https://openalex.org/keywords/sustained-release","display_name":"sustained drug release","score":0.7990000247955322},{"id":"https://openalex.org/keywords/antihistamines","display_name":"antihistamines","score":0.7239999771118164},{"id":"https://openalex.org/keywords/ocular-bioavailability","display_name":"ocular bioavailability","score":0.7699999809265137},{"id":"https://openalex.org/keywords/thin-film-hydration","display_name":"thin-film hydration","score":0.6489999890327454},{"id":"https://openalex.org/keywords/formulation-optimization","display_name":"formulation optimization","score":0.5070000290870667}],"concepts":[{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.7978000044822693},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.7264999747276306},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6545000076293945},{"id":"https://openalex.org/C2780113039","wikidata":"https://www.wikidata.org/wiki/Q419820","display_name":"Azelastine","level":2,"score":0.6205000281333923},{"id":"https://openalex.org/C18150654","wikidata":"https://www.wikidata.org/wiki/Q17153796","display_name":"Nanocarriers","level":3,"score":0.5992000102996826},{"id":"https://openalex.org/C50670333","wikidata":"https://www.wikidata.org/wiki/Q907651","display_name":"Permeation","level":3,"score":0.5084999799728394},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.38499999046325684},{"id":"https://openalex.org/C2780870513","wikidata":"https://www.wikidata.org/wiki/Q471521","display_name":"Allergic conjunctivitis","level":3,"score":0.3725999891757965},{"id":"https://openalex.org/C19831878","wikidata":"https://www.wikidata.org/wiki/Q659446","display_name":"Therapeutic index","level":3,"score":0.36340001225471497},{"id":"https://openalex.org/C111113717","wikidata":"https://www.wikidata.org/wiki/Q725307","display_name":"Pharmacodynamics","level":3,"score":0.359499990940094},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34459999203681946},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.34220001101493835},{"id":"https://openalex.org/C85663871","wikidata":"https://www.wikidata.org/wiki/Q6966562","display_name":"Nasal administration","level":2,"score":0.3343000113964081},{"id":"https://openalex.org/C86181022","wikidata":"https://www.wikidata.org/wiki/Q196823","display_name":"Zeta potential","level":3,"score":0.33009999990463257},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.329800009727478},{"id":"https://openalex.org/C2776880894","wikidata":"https://www.wikidata.org/wiki/Q324089","display_name":"Antihistamine","level":2,"score":0.32420000433921814},{"id":"https://openalex.org/C10335311","wikidata":"https://www.wikidata.org/wiki/Q309513","display_name":"Histamine H1 receptor","level":4,"score":0.31769999861717224},{"id":"https://openalex.org/C13245373","wikidata":"https://www.wikidata.org/wiki/Q3715494","display_name":"Drug carrier","level":3,"score":0.27000001072883606},{"id":"https://openalex.org/C102652120","wikidata":"https://www.wikidata.org/wiki/Q2419430","display_name":"Therapeutic effect","level":2,"score":0.2651999890804291}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.jddst.2025.107673","doi":"https://doi.org/10.1016/j.jddst.2025.107673","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jddst.2025.107673","pdf_url":null,"source":{"id":"https://openalex.org/S97205441","display_name":"Journal of Drug Delivery Science and Technology","issn_l":"1773-2247","issn":["1773-2247","2588-8943"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Drug Delivery Science and Technology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":129,"referenced_works":["https://openalex.org/W1579419386","https://openalex.org/W1977072597","https://openalex.org/W1977371539","https://openalex.org/W1979634506","https://openalex.org/W1983109347","https://openalex.org/W1996853317","https://openalex.org/W1999408043","https://openalex.org/W2006210373","https://openalex.org/W2016559101","https://openalex.org/W2026068184","https://openalex.org/W2026214918","https://openalex.org/W2028138888","https://openalex.org/W2029184658","https://openalex.org/W2039583937","https://openalex.org/W2047399850","https://openalex.org/W2050656614","https://openalex.org/W2056425243","https://openalex.org/W2069516100","https://openalex.org/W2074822022","https://openalex.org/W2076068691","https://openalex.org/W2084303570","https://openalex.org/W2086889742","https://openalex.org/W2089123352","https://openalex.org/W2092215721","https://openalex.org/W2097562776","https://openalex.org/W2115439624","https://openalex.org/W2160738246","https://openalex.org/W2175081477","https://openalex.org/W2315280595","https://openalex.org/W2334086700","https://openalex.org/W2583098273","https://openalex.org/W2741771838","https://openalex.org/W2773976603","https://openalex.org/W2790092507","https://openalex.org/W2794079980","https://openalex.org/W2794135364","https://openalex.org/W2805779846","https://openalex.org/W2884636034","https://openalex.org/W2888664093","https://openalex.org/W2898133507","https://openalex.org/W2901476092","https://openalex.org/W2914275571","https://openalex.org/W2920977270","https://openalex.org/W2922408224","https://openalex.org/W2939864385","https://openalex.org/W2942033525","https://openalex.org/W2953613995","https://openalex.org/W2956479787","https://openalex.org/W2966617570","https://openalex.org/W2967089531","https://openalex.org/W2986506409","https://openalex.org/W3010224452","https://openalex.org/W3027413586","https://openalex.org/W3028708380","https://openalex.org/W3035986373","https://openalex.org/W3043418978","https://openalex.org/W3047967484","https://openalex.org/W3048712258","https://openalex.org/W3087933272","https://openalex.org/W3089124556","https://openalex.org/W3093063904","https://openalex.org/W3097402068","https://openalex.org/W3105065878","https://openalex.org/W3112180281","https://openalex.org/W3126070213","https://openalex.org/W3161413659","https://openalex.org/W3176385631","https://openalex.org/W3194130326","https://openalex.org/W3196830795","https://openalex.org/W3202315811","https://openalex.org/W3208531235","https://openalex.org/W4200208794","https://openalex.org/W4214606379","https://openalex.org/W4214892256","https://openalex.org/W4220740875","https://openalex.org/W4220790366","https://openalex.org/W4225529271","https://openalex.org/W4281568466","https://openalex.org/W4282026571","https://openalex.org/W4283761915","https://openalex.org/W4283789447","https://openalex.org/W4294992677","https://openalex.org/W4295086782","https://openalex.org/W4304013976","https://openalex.org/W4306709139","https://openalex.org/W4311301039","https://openalex.org/W4313442278","https://openalex.org/W4315487161","https://openalex.org/W4320857476","https://openalex.org/W4321597995","https://openalex.org/W4323350844","https://openalex.org/W4323977320","https://openalex.org/W4379010947","https://openalex.org/W4381548207","https://openalex.org/W4384818928","https://openalex.org/W4387780155","https://openalex.org/W4390401389","https://openalex.org/W4390704525","https://openalex.org/W4391965643","https://openalex.org/W4392549681","https://openalex.org/W4394879663","https://openalex.org/W4395052164","https://openalex.org/W4396521207","https://openalex.org/W4398235934","https://openalex.org/W4399101571","https://openalex.org/W4399500514","https://openalex.org/W4399547767","https://openalex.org/W4400059203","https://openalex.org/W4401315250","https://openalex.org/W4401393153","https://openalex.org/W4401479966","https://openalex.org/W4401499514","https://openalex.org/W4401920332","https://openalex.org/W4402650798","https://openalex.org/W4403187621","https://openalex.org/W4403402972","https://openalex.org/W4404008741","https://openalex.org/W4404278752","https://openalex.org/W4404991632","https://openalex.org/W4407142345","https://openalex.org/W4407957739","https://openalex.org/W4408150281","https://openalex.org/W4408197727","https://openalex.org/W4408958557","https://openalex.org/W4409834124","https://openalex.org/W4410050384","https://openalex.org/W4410436689","https://openalex.org/W4412437832","https://openalex.org/W4412521889"],"related_works":["https://openalex.org/W3043418978","https://openalex.org/W2966617570","https://openalex.org/W4408958557","https://openalex.org/W3022331947","https://openalex.org/W2529643657","https://openalex.org/W4408237257","https://openalex.org/W7202167311","https://openalex.org/W7154391837","https://openalex.org/W4214815822","https://openalex.org/W4416412641"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2025-10-18T00:00:00"}