{"id":"https://openalex.org/W4415312901","doi":"https://doi.org/10.1002/inmd.70070","title":"Single\u2010cell RNA sequencing reveals the niche transitions in the non\u2010small cell lung cancer microenvironment mediated by piR\u2010hsa\u2010164586 during the invasive and metastatic processes","display_name":"Single\u2010cell RNA sequencing reveals the niche transitions in the non\u2010small cell lung cancer microenvironment mediated by piR\u2010hsa\u2010164586 during the invasive and metastatic processes","publication_year":2025,"publication_date":"2025-10-18","ids":{"openalex":"https://openalex.org/W4415312901","doi":"https://doi.org/10.1002/inmd.70070"},"language":"en","primary_location":{"id":"doi:10.1002/inmd.70070","doi":"https://doi.org/10.1002/inmd.70070","is_oa":true,"landing_page_url":"https://doi.org/10.1002/inmd.70070","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/inmd.70070","source":{"id":"https://openalex.org/S4393919730","display_name":"Interdisciplinary medicine","issn_l":"2832-6237","issn":["2832-6237","2832-6245"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","dongbi-d"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Interdisciplinary Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/inmd.70070","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101479842","display_name":"Yan Tang","orcid":"https://orcid.org/0000-0003-4156-047X","observed_orcids":["https://orcid.org/0000-0003-4156-047X"]},"institutions":[{"id":"https://openalex.org/I108688024","display_name":"Qingdao University","ror":"https://ror.org/021cj6z65","country_code":"CN","type":"education","lineage":["https://openalex.org/I108688024"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan Tang","raw_affiliation_strings":["Institute of Regenerative Medicine and Laboratory Technology Innovation Qingdao University  Qingdao Shandong China","Institute of Regenerative Medicine and Laboratory Technology Innovation, Qingdao University, Qingdao, Shandong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Regenerative Medicine and Laboratory Technology Innovation Qingdao University  Qingdao Shandong China","institution_ids":["https://openalex.org/I108688024"]},{"raw_affiliation_string":"Institute of Regenerative Medicine and Laboratory Technology Innovation, Qingdao University, Qingdao, Shandong, China","institution_ids":["https://openalex.org/I108688024"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100413295","display_name":"Xiaomin Wang","orcid":"https://orcid.org/0000-0002-3627-6936","observed_orcids":["https://orcid.org/0000-0002-3627-6936"]},"institutions":[{"id":"https://openalex.org/I108688024","display_name":"Qingdao University","ror":"https://ror.org/021cj6z65","country_code":"CN","type":"education","lineage":["https://openalex.org/I108688024"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaomin Wang","raw_affiliation_strings":["Institute of Regenerative Medicine and Laboratory Technology Innovation Qingdao University  Qingdao Shandong China","Institute of Regenerative Medicine and Laboratory Technology Innovation, Qingdao University, Qingdao, Shandong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Regenerative Medicine and Laboratory Technology Innovation Qingdao University  Qingdao Shandong China","institution_ids":["https://openalex.org/I108688024"]},{"raw_affiliation_string":"Institute of Regenerative Medicine and Laboratory Technology Innovation, Qingdao University, Qingdao, Shandong, China","institution_ids":["https://openalex.org/I108688024"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114500338","display_name":"Yanli Li","orcid":"https://orcid.org/0000-0003-3109-7581","observed_orcids":["https://orcid.org/0000-0003-3109-7581"]},"institutions":[{"id":"https://openalex.org/I4210121984","display_name":"Shengli Oilfield Central Hospital","ror":"https://ror.org/035wt7p80","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121984"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanli Li","raw_affiliation_strings":["Department of Pathology Shengli Oilfield Central Hospital  Dongying Shandong China","Department of Pathology, Shengli Oilfield Central Hospital, Dongying, Shandong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology Shengli Oilfield Central Hospital  Dongying Shandong China","institution_ids":["https://openalex.org/I4210121984"]},{"raw_affiliation_string":"Department of Pathology, Shengli Oilfield Central Hospital, Dongying, Shandong, China","institution_ids":["https://openalex.org/I4210121984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029781040","display_name":"Kaibin Liu","orcid":"https://orcid.org/0000-0002-8658-8495","observed_orcids":["https://orcid.org/0000-0002-8658-8495"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210144482","display_name":"Shanghai Sixth People's Hospital","ror":"https://ror.org/049zrh188","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210144482"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kaibin Liu","raw_affiliation_strings":["Department of Thoracic Surgery Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai China","Department of Thoracic Surgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic Surgery Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210144482"]},{"raw_affiliation_string":"Department of Thoracic Surgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210144482"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Anjing Gong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116869","display_name":"Affiliated Hospital of Qingdao University","ror":"https://ror.org/026e9yy16","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210116869"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Anjing Gong","raw_affiliation_strings":["Department of Neurosurgery Affiliated Hospital of Qingdao University  Qingdao Shandong China","Department of Neurosurgery, Affiliated Hospital of Qingdao University, Qingdao, Shandong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery Affiliated Hospital of Qingdao University  Qingdao Shandong China","institution_ids":["https://openalex.org/I4210116869"]},{"raw_affiliation_string":"Department of Neurosurgery, Affiliated Hospital of Qingdao University, Qingdao, Shandong, China","institution_ids":["https://openalex.org/I4210116869"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100667078","display_name":"Xin Ma","orcid":"https://orcid.org/0000-0002-6706-723X","observed_orcids":["https://orcid.org/0000-0002-6706-723X"]},"institutions":[{"id":"https://openalex.org/I108688024","display_name":"Qingdao University","ror":"https://ror.org/021cj6z65","country_code":"CN","type":"education","lineage":["https://openalex.org/I108688024"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xin Ma","raw_affiliation_strings":["Institute of Regenerative Medicine and Laboratory Technology Innovation Qingdao University  Qingdao Shandong China","Institute of Regenerative Medicine and Laboratory Technology Innovation, Qingdao University, Qingdao, Shandong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Regenerative Medicine and Laboratory Technology Innovation Qingdao University  Qingdao Shandong China","institution_ids":["https://openalex.org/I108688024"]},{"raw_affiliation_string":"Institute of Regenerative Medicine and Laboratory Technology Innovation, Qingdao University, Qingdao, Shandong, China","institution_ids":["https://openalex.org/I108688024"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jian Yuan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jian Yuan","raw_affiliation_strings":["Department of Biochemistry and Structural Biology School of Medicine University of Texas Health Science Center at San Antonio  San Antonio Texas USA","Department of Biochemistry and Structural Biology, School of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Structural Biology School of Medicine University of Texas Health Science Center at San Antonio  San Antonio Texas USA","institution_ids":["https://openalex.org/I165951966"]},{"raw_affiliation_string":"Department of Biochemistry and Structural Biology, School of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074928707","display_name":"Yanhan Dong","orcid":"https://orcid.org/0009-0001-5111-3123","observed_orcids":["https://orcid.org/0009-0001-5111-3123","https://orcid.org/0000-0001-9940-1303"]},"institutions":[{"id":"https://openalex.org/I108688024","display_name":"Qingdao University","ror":"https://ror.org/021cj6z65","country_code":"CN","type":"education","lineage":["https://openalex.org/I108688024"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanhan Dong","raw_affiliation_strings":["Institute of Regenerative Medicine and Laboratory Technology Innovation Qingdao University  Qingdao Shandong China","Institute of Regenerative Medicine and Laboratory Technology Innovation, Qingdao University, Qingdao, Shandong, China"],"raw_orcid":"https://orcid.org/0000-0001-9940-1303","affiliations":[{"raw_affiliation_string":"Institute of Regenerative Medicine and Laboratory Technology Innovation Qingdao University  Qingdao Shandong China","institution_ids":["https://openalex.org/I108688024"]},{"raw_affiliation_string":"Institute of Regenerative Medicine and Laboratory Technology Innovation, Qingdao University, Qingdao, Shandong, China","institution_ids":["https://openalex.org/I108688024"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100319790","display_name":"Xiao Li Xu","orcid":"https://orcid.org/0000-0001-9783-6776","observed_orcids":["https://orcid.org/0000-0001-9783-6776"]},"institutions":[{"id":"https://openalex.org/I108688024","display_name":"Qingdao University","ror":"https://ror.org/021cj6z65","country_code":"CN","type":"education","lineage":["https://openalex.org/I108688024"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiao Xu","raw_affiliation_strings":["Institute of Regenerative Medicine and Laboratory Technology Innovation Qingdao University  Qingdao Shandong China","Institute of Regenerative Medicine and Laboratory Technology Innovation, Qingdao University, Qingdao, Shandong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Regenerative Medicine and Laboratory Technology Innovation Qingdao University  Qingdao Shandong China","institution_ids":["https://openalex.org/I108688024"]},{"raw_affiliation_string":"Institute of Regenerative Medicine and Laboratory Technology Innovation, Qingdao University, Qingdao, Shandong, China","institution_ids":["https://openalex.org/I108688024"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101966691","display_name":"Dan Han","orcid":"https://orcid.org/0000-0002-0736-4718","observed_orcids":["https://orcid.org/0000-0002-0736-4718"]},"institutions":[{"id":"https://openalex.org/I108688024","display_name":"Qingdao University","ror":"https://ror.org/021cj6z65","country_code":"CN","type":"education","lineage":["https://openalex.org/I108688024"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dan Han","raw_affiliation_strings":["Institute of Regenerative Medicine and Laboratory Technology Innovation Qingdao University  Qingdao Shandong China","Institute of Regenerative Medicine and Laboratory Technology Innovation, Qingdao University, Qingdao, Shandong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Regenerative Medicine and Laboratory Technology Innovation Qingdao University  Qingdao Shandong China","institution_ids":["https://openalex.org/I108688024"]},{"raw_affiliation_string":"Institute of Regenerative Medicine and Laboratory Technology Innovation, Qingdao University, Qingdao, Shandong, China","institution_ids":["https://openalex.org/I108688024"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012078329","display_name":"Liang Zhang","orcid":"https://orcid.org/0000-0002-0454-8001","observed_orcids":["https://orcid.org/0000-0002-0454-8001"]},"institutions":[{"id":"https://openalex.org/I108688024","display_name":"Qingdao University","ror":"https://ror.org/021cj6z65","country_code":"CN","type":"education","lineage":["https://openalex.org/I108688024"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liang Zhang","raw_affiliation_strings":["Institute of Regenerative Medicine and Laboratory Technology Innovation Qingdao University  Qingdao Shandong China","Institute of Regenerative Medicine and Laboratory Technology Innovation, Qingdao University, Qingdao, Shandong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Regenerative Medicine and Laboratory Technology Innovation Qingdao University  Qingdao Shandong China","institution_ids":["https://openalex.org/I108688024"]},{"raw_affiliation_string":"Institute of Regenerative Medicine and Laboratory Technology Innovation, Qingdao University, Qingdao, Shandong, China","institution_ids":["https://openalex.org/I108688024"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Junlin Lv","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I108688024","display_name":"Qingdao University","ror":"https://ror.org/021cj6z65","country_code":"CN","type":"education","lineage":["https://openalex.org/I108688024"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Junlin Lv","raw_affiliation_strings":["Institute of Regenerative Medicine and Laboratory Technology Innovation Qingdao University  Qingdao Shandong China","Institute of Regenerative Medicine and Laboratory Technology Innovation, Qingdao University, Qingdao, Shandong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Regenerative Medicine and Laboratory Technology Innovation Qingdao University  Qingdao Shandong China","institution_ids":["https://openalex.org/I108688024"]},{"raw_affiliation_string":"Institute of Regenerative Medicine and Laboratory Technology Innovation, Qingdao University, Qingdao, Shandong, China","institution_ids":["https://openalex.org/I108688024"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102203828","display_name":"Yi-Wei Xu","orcid":"https://orcid.org/0009-0002-8816-6971","observed_orcids":["https://orcid.org/0009-0002-8816-6971"]},"institutions":[{"id":"https://openalex.org/I108688024","display_name":"Qingdao University","ror":"https://ror.org/021cj6z65","country_code":"CN","type":"education","lineage":["https://openalex.org/I108688024"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yiwei Xu","raw_affiliation_strings":["Institute of Regenerative Medicine and Laboratory Technology Innovation Qingdao University  Qingdao Shandong China","Institute of Regenerative Medicine and Laboratory Technology Innovation, Qingdao University, Qingdao, Shandong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Regenerative Medicine and Laboratory Technology Innovation Qingdao University  Qingdao Shandong China","institution_ids":["https://openalex.org/I108688024"]},{"raw_affiliation_string":"Institute of Regenerative Medicine and Laboratory Technology Innovation, Qingdao University, Qingdao, Shandong, China","institution_ids":["https://openalex.org/I108688024"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Zhen Shang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I108688024","display_name":"Qingdao University","ror":"https://ror.org/021cj6z65","country_code":"CN","type":"education","lineage":["https://openalex.org/I108688024"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhen Shang","raw_affiliation_strings":["Institute of Regenerative Medicine and Laboratory Technology Innovation Qingdao University  Qingdao Shandong China","Institute of Regenerative Medicine and Laboratory Technology Innovation, Qingdao University, Qingdao, Shandong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Regenerative Medicine and Laboratory Technology Innovation Qingdao University  Qingdao Shandong China","institution_ids":["https://openalex.org/I108688024"]},{"raw_affiliation_string":"Institute of Regenerative Medicine and Laboratory Technology Innovation, Qingdao University, Qingdao, Shandong, China","institution_ids":["https://openalex.org/I108688024"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104318996","display_name":"Nailong Pan","orcid":"https://orcid.org/0009-0002-4856-0763","observed_orcids":["https://orcid.org/0009-0002-4856-0763"]},"institutions":[{"id":"https://openalex.org/I108688024","display_name":"Qingdao University","ror":"https://ror.org/021cj6z65","country_code":"CN","type":"education","lineage":["https://openalex.org/I108688024"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Nailong Pan","raw_affiliation_strings":["Institute of Regenerative Medicine and Laboratory Technology Innovation Qingdao University  Qingdao Shandong China","Institute of Regenerative Medicine and Laboratory Technology Innovation, Qingdao University, Qingdao, Shandong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Regenerative Medicine and Laboratory Technology Innovation Qingdao University  Qingdao Shandong China","institution_ids":["https://openalex.org/I108688024"]},{"raw_affiliation_string":"Institute of Regenerative Medicine and Laboratory Technology Innovation, Qingdao University, Qingdao, Shandong, China","institution_ids":["https://openalex.org/I108688024"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082013187","display_name":"Xiaoying Kong","orcid":"https://orcid.org/0000-0001-9326-6171","observed_orcids":["https://orcid.org/0000-0001-9326-6171"]},"institutions":[{"id":"https://openalex.org/I108688024","display_name":"Qingdao University","ror":"https://ror.org/021cj6z65","country_code":"CN","type":"education","lineage":["https://openalex.org/I108688024"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiaoying Kong","raw_affiliation_strings":["Institute of Regenerative Medicine and Laboratory Technology Innovation Qingdao University  Qingdao Shandong China","Institute of Regenerative Medicine and Laboratory Technology Innovation, Qingdao University, Qingdao, Shandong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Regenerative Medicine and Laboratory Technology Innovation Qingdao University  Qingdao Shandong China","institution_ids":["https://openalex.org/I108688024"]},{"raw_affiliation_string":"Institute of Regenerative Medicine and Laboratory Technology Innovation, Qingdao University, Qingdao, Shandong, China","institution_ids":["https://openalex.org/I108688024"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100634724","display_name":"Wenhua Xu","orcid":"https://orcid.org/0000-0001-7426-6950","observed_orcids":["https://orcid.org/0000-0001-7426-6950"]},"institutions":[{"id":"https://openalex.org/I108688024","display_name":"Qingdao University","ror":"https://ror.org/021cj6z65","country_code":"CN","type":"education","lineage":["https://openalex.org/I108688024"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Wenhua Xu","raw_affiliation_strings":["Institute of Regenerative Medicine and Laboratory Technology Innovation Qingdao University  Qingdao Shandong China","Institute of Regenerative Medicine and Laboratory Technology Innovation, Qingdao University, Qingdao, Shandong, China"],"raw_orcid":"https://orcid.org/0000-0001-7426-6950","affiliations":[{"raw_affiliation_string":"Institute of Regenerative Medicine and Laboratory Technology Innovation Qingdao University  Qingdao Shandong China","institution_ids":["https://openalex.org/I108688024"]},{"raw_affiliation_string":"Institute of Regenerative Medicine and Laboratory Technology Innovation, Qingdao University, Qingdao, Shandong, China","institution_ids":["https://openalex.org/I108688024"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5082013187","https://openalex.org/A5100634724"],"corresponding_institution_ids":["https://openalex.org/I108688024"],"apc_list":{"value":0,"currency":"USD","value_usd":0},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.23187964,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"3","issue":"6","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9369999766349792,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9369999766349792,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.009800000116229057,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.00860000029206276,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/piwi-interacting-rnas","display_name":"piRNA","score":0.8370000123977661},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.996999979019165},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.9399999976158142},{"id":"https://openalex.org/keywords/tumor-niche","display_name":"tumor niche","score":0.8230000138282776},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.777999997138977},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.949999988079071},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.9779999852180481},{"id":"https://openalex.org/keywords/pi3k-akt-signaling","display_name":"PI3K/Akt signaling","score":0.8949999809265137},{"id":"https://openalex.org/keywords/myh9","display_name":"MYH9","score":0.9589999914169312},{"id":"https://openalex.org/keywords/mesenchymal-subtype","display_name":"mesenchymal subtype","score":0.7009999752044678},{"id":"https://openalex.org/keywords/extracellular-vesicles","display_name":"extracellular vesicles","score":0.949999988079071},{"id":"https://openalex.org/keywords/tumor-markers","display_name":"tumor markers","score":0.5630000233650208},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.7409999966621399}],"concepts":[{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.7250000238418579},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6743000149726868},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.6642000079154968},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.657800018787384},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.6409000158309937},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.4788999855518341},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.44760000705718994},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.44040000438690186},{"id":"https://openalex.org/C2781230642","wikidata":"https://www.wikidata.org/wiki/Q492646","display_name":"Targeted therapy","level":3,"score":0.4253000020980835},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.42419999837875366},{"id":"https://openalex.org/C76419328","wikidata":"https://www.wikidata.org/wiki/Q74419","display_name":"Epithelial\u2013mesenchymal transition","level":4,"score":0.4050000011920929},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.3456999957561493},{"id":"https://openalex.org/C22615655","wikidata":"https://www.wikidata.org/wiki/Q203221","display_name":"Small interfering RNA","level":4,"score":0.3409999907016754},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.33959999680519104},{"id":"https://openalex.org/C153991713","wikidata":"https://www.wikidata.org/wiki/Q17142856","display_name":"Niche","level":2,"score":0.3391999900341034},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.31850001215934753},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.3034999966621399},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.3012999892234802},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.29170000553131104},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.28439998626708984},{"id":"https://openalex.org/C2777362581","wikidata":"https://www.wikidata.org/wiki/Q10881532","display_name":"Molecular oncology","level":4,"score":0.267300009727478},{"id":"https://openalex.org/C61238886","wikidata":"https://www.wikidata.org/wiki/Q5121689","display_name":"Circulating tumor cell","level":4,"score":0.2644999921321869},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2632000148296356},{"id":"https://openalex.org/C41282012","wikidata":"https://www.wikidata.org/wiki/Q3928341","display_name":"RNA-binding protein","level":4,"score":0.25920000672340393},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.2578999996185303},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.25690001249313354},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.2549000084400177}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1002/inmd.70070","doi":"https://doi.org/10.1002/inmd.70070","is_oa":true,"landing_page_url":"https://doi.org/10.1002/inmd.70070","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/inmd.70070","source":{"id":"https://openalex.org/S4393919730","display_name":"Interdisciplinary medicine","issn_l":"2832-6237","issn":["2832-6237","2832-6245"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","dongbi-d"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Interdisciplinary Medicine","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:33ba9e4cb7844423955ee07d5f9c172c","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/33ba9e4cb7844423955ee07d5f9c172c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Interdisciplinary Medicine, Vol 3, Iss 6, Pp n/a-n/a (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1002/inmd.70070","doi":"https://doi.org/10.1002/inmd.70070","is_oa":true,"landing_page_url":"https://doi.org/10.1002/inmd.70070","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/inmd.70070","source":{"id":"https://openalex.org/S4393919730","display_name":"Interdisciplinary medicine","issn_l":"2832-6237","issn":["2832-6237","2832-6245"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","dongbi-d"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Interdisciplinary Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2838352199","display_name":null,"funder_award_id":"32101137","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4333308713","display_name":null,"funder_award_id":"81770900","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6332822815","display_name":null,"funder_award_id":"82302653","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4415312901.pdf","grobid_xml":"https://content.openalex.org/works/W4415312901.grobid-xml"},"referenced_works_count":54,"referenced_works":["https://openalex.org/W1977733607","https://openalex.org/W2063640156","https://openalex.org/W2260331015","https://openalex.org/W2470749254","https://openalex.org/W2779501288","https://openalex.org/W2798231099","https://openalex.org/W2802101579","https://openalex.org/W2886387652","https://openalex.org/W2910471371","https://openalex.org/W2911161333","https://openalex.org/W2911233690","https://openalex.org/W2950996070","https://openalex.org/W2968344903","https://openalex.org/W2980985311","https://openalex.org/W3003522755","https://openalex.org/W3003595552","https://openalex.org/W3004781275","https://openalex.org/W3015438624","https://openalex.org/W3038194751","https://openalex.org/W3046277317","https://openalex.org/W3062735152","https://openalex.org/W3119660031","https://openalex.org/W3159177617","https://openalex.org/W3171485191","https://openalex.org/W3176200145","https://openalex.org/W3178825920","https://openalex.org/W3202373700","https://openalex.org/W3204494587","https://openalex.org/W3210595677","https://openalex.org/W3215052327","https://openalex.org/W4200204100","https://openalex.org/W4200307603","https://openalex.org/W4200347894","https://openalex.org/W4206439247","https://openalex.org/W4210600265","https://openalex.org/W4220769525","https://openalex.org/W4220925293","https://openalex.org/W4220959314","https://openalex.org/W4252851641","https://openalex.org/W4283258591","https://openalex.org/W4285253641","https://openalex.org/W4297965027","https://openalex.org/W4298006197","https://openalex.org/W4309000351","https://openalex.org/W4319656244","https://openalex.org/W4323364088","https://openalex.org/W4380792447","https://openalex.org/W4385267760","https://openalex.org/W4390600611","https://openalex.org/W4392509525","https://openalex.org/W4400412215","https://openalex.org/W4401858203","https://openalex.org/W4401908792","https://openalex.org/W4403450891"],"related_works":[],"abstract_inverted_index":{"Abstract":[0],"Screening":[1],"of":[2,25,38,50,58,101,107,113,134,148,168,174],"tumor\u2010specific":[3],"markers":[4],"and":[5,36,56,76,84,125,132,145],"targeted":[6,183],"therapy":[7],"has":[8],"achieved":[9],"significant":[10,31],"clinical":[11],"efficacy":[12],"in":[13,22,52,73,82,85,121],"recent":[14],"years.":[15],"PIWI\u2010interacting":[16],"RNAs":[17],"(piRNAs),":[18],"which":[19],"are":[20,27],"crucial":[21],"the":[23,34,48,54,99,104,130,146,164],"progression":[24],"tumors,":[26],"anticipated":[28],"to":[29,143,153],"be":[30],"targets":[32],"for":[33,180,185],"research":[35],"development":[37],"tumor":[39,105,114,172],"molecular":[40,95,182],"drugs":[41],"aimed":[42],"at":[43],"tumors.":[44],"This":[45],"study":[46],"corroborated":[47],"role":[49],"piR\u2010hsa\u2010164586":[51,102,118,144,149,169],"enhancing":[53],"invasion":[55,131],"metastasis":[57,133],"non\u2010small":[59],"cell":[60],"lung":[61],"cancer":[62],"(NSCLC)":[63],"cells,":[64],"as":[65,170],"previously":[66],"observed":[67],"with":[68,93],"its":[69],"unusually":[70],"high":[71],"expression":[72],"NSCLC":[74,108,135,155],"tissue":[75],"serum":[77],"extracellular":[78],"vesicles,":[79],"through":[80],"both":[81],"vitro":[83],"vivo":[86],"experiments.":[87],"Single\u2010cell":[88],"RNA":[89],"sequencing":[90],"(scRNA\u2010seq)":[91],"combined":[92],"other":[94],"techniques":[96],"revealed":[97,163],"that":[98],"overexpression":[100],"regulates":[103],"niche":[106],"by":[109],"upregulating":[110],"mesenchymal":[111],"subtypes":[112],"epithelial":[115],"cells.":[116,136],"Furthermore,":[117],"is":[119],"involved":[120],"regulating":[122],"PI3K\u2010AKT":[123],"pathway":[124],"epithelial\u2013mesenchymal":[126],"transition,":[127],"thereby":[128],"accelerating":[129],"MYH9":[137,151],"(a":[138],"non\u2010PIWI":[139],"protein)":[140],"could":[141],"bind":[142],"knockdown":[147],"or":[150],"links":[152],"better":[154],"prognoses.":[156],"In":[157],"conclusion,":[158],"this":[159],"work":[160],"not":[161],"only":[162],"specific":[165],"regulatory":[166],"mechanism":[167],"a":[171],"marker":[173],"NSCLC,":[175],"but":[176],"also":[177],"provided":[178],"support":[179],"developing":[181],"therapies":[184],"NSCLC.":[186]},"counts_by_year":[],"updated_date":"2026-10-13T10:08:12.033832","created_date":"2025-10-18T00:00:00"}
