{"id":"https://openalex.org/W4415312325","doi":"https://doi.org/10.1007/s00210-025-04672-0","title":"MUC1 promotes NSCLC progression by regulating ICAM-1-mediated mitochondria transfer from tCAFs to cancer cells","display_name":"MUC1 promotes NSCLC progression by regulating ICAM-1-mediated mitochondria transfer from tCAFs to cancer cells","publication_year":2025,"publication_date":"2025-10-17","ids":{"openalex":"https://openalex.org/W4415312325","doi":"https://doi.org/10.1007/s00210-025-04672-0","pmid":"https://pubmed.ncbi.nlm.nih.gov/41105252"},"language":"en","primary_location":{"id":"doi:10.1007/s00210-025-04672-0","doi":"https://doi.org/10.1007/s00210-025-04672-0","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00210-025-04672-0","pdf_url":null,"source":{"id":"https://openalex.org/S159534381","display_name":"Naunyn-Schmiedeberg s Archives of Pharmacology","issn_l":"0028-1298","issn":["0028-1298","0340-5249","1432-1912"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Naunyn-Schmiedeberg's Archives of Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Feifan Ji","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210138078","display_name":"Second Affiliated Hospital of Nanjing Medical University","ror":"https://ror.org/04pge2a40","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210138078"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Feifan Ji","raw_affiliation_strings":["Department of Thoracic Surgery, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, 210000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic Surgery, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, 210000, China","institution_ids":["https://openalex.org/I4210138078"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003375535","display_name":"Donglian Wang","orcid":"https://orcid.org/0000-0002-7075-6888","observed_orcids":["https://orcid.org/0000-0002-7075-6888"]},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]},{"id":"https://openalex.org/I4210158774","display_name":"Zhejiang Taizhou Hospital","ror":"https://ror.org/05m0wv206","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158774","https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Donglian Wang","raw_affiliation_strings":["Department of Clinical Laboratory, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Linhai, Zhejiang Province, 317000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Laboratory, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Linhai, Zhejiang Province, 317000, China","institution_ids":["https://openalex.org/I27781120","https://openalex.org/I4210158774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018072091","display_name":"Jingguang Jin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104616","display_name":"Taizhou Municipal Hospital","ror":"https://ror.org/027gw7s27","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210104616"]},{"id":"https://openalex.org/I4405281598","display_name":"Taizhou University","ror":"https://ror.org/04m19xd94","country_code":"CN","type":"education","lineage":["https://openalex.org/I4405281598"]},{"id":"https://openalex.org/I82760581","display_name":"Taizhou University","ror":"https://ror.org/04fzhyx73","country_code":"CN","type":"education","lineage":["https://openalex.org/I82760581"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jingguang Jin","raw_affiliation_strings":["Department of Laboratory Medicine, Taizhou Municipal Hospital (Taizhou University Affiliated Municipal Hospital), School of Medicine, Taizhou University, Taizhou, Zhejiang Province, 318000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, Taizhou Municipal Hospital (Taizhou University Affiliated Municipal Hospital), School of Medicine, Taizhou University, Taizhou, Zhejiang Province, 318000, China","institution_ids":["https://openalex.org/I4210104616","https://openalex.org/I4405281598","https://openalex.org/I82760581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050008040","display_name":"Jin Zhang","orcid":"https://orcid.org/0000-0002-9117-2793","observed_orcids":["https://orcid.org/0000-0002-9117-2793"]},"institutions":[{"id":"https://openalex.org/I4210104616","display_name":"Taizhou Municipal Hospital","ror":"https://ror.org/027gw7s27","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210104616"]},{"id":"https://openalex.org/I4405281598","display_name":"Taizhou University","ror":"https://ror.org/04m19xd94","country_code":"CN","type":"education","lineage":["https://openalex.org/I4405281598"]},{"id":"https://openalex.org/I82760581","display_name":"Taizhou University","ror":"https://ror.org/04fzhyx73","country_code":"CN","type":"education","lineage":["https://openalex.org/I82760581"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jin Zhang","raw_affiliation_strings":["Department of Laboratory Medicine, Taizhou Municipal Hospital (Taizhou University Affiliated Municipal Hospital), School of Medicine, Taizhou University, Taizhou, Zhejiang Province, 318000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, Taizhou Municipal Hospital (Taizhou University Affiliated Municipal Hospital), School of Medicine, Taizhou University, Taizhou, Zhejiang Province, 318000, China","institution_ids":["https://openalex.org/I4210104616","https://openalex.org/I4405281598","https://openalex.org/I82760581"]}]},{"author_position":"last","author":{"id":null,"display_name":"Lingyu Guan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104616","display_name":"Taizhou Municipal Hospital","ror":"https://ror.org/027gw7s27","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210104616"]},{"id":"https://openalex.org/I4405281598","display_name":"Taizhou University","ror":"https://ror.org/04m19xd94","country_code":"CN","type":"education","lineage":["https://openalex.org/I4405281598"]},{"id":"https://openalex.org/I82760581","display_name":"Taizhou University","ror":"https://ror.org/04fzhyx73","country_code":"CN","type":"education","lineage":["https://openalex.org/I82760581"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Lingyu Guan","raw_affiliation_strings":["Department of Laboratory Medicine, Taizhou Municipal Hospital (Taizhou University Affiliated Municipal Hospital), School of Medicine, Taizhou University, Taizhou, Zhejiang Province, 318000, China. Andy20170625@163.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, Taizhou Municipal Hospital (Taizhou University Affiliated Municipal Hospital), School of Medicine, Taizhou University, Taizhou, Zhejiang Province, 318000, China. Andy20170625@163.com","institution_ids":["https://openalex.org/I4210104616","https://openalex.org/I4405281598","https://openalex.org/I82760581"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210104616","https://openalex.org/I4405281598","https://openalex.org/I82760581"],"apc_list":{"value":4790,"currency":"USD","value_usd":4790},"apc_paid":null,"fwci":1.4417,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.81435531,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"399","issue":"3","first_page":"4285","last_page":"4303"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.6029999852180481,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.6029999852180481,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.17329999804496765,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.06360000371932983,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/muc1","display_name":"MUC1","score":0.9900000095367432},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.9269999861717224},{"id":"https://openalex.org/keywords/cancer-associated-fibroblasts","display_name":"cancer-associated fibroblasts","score":0.9850000143051147},{"id":"https://openalex.org/keywords/mitochondrial-transfer","display_name":"mitochondrial transfer","score":0.8330000042915344},{"id":"https://openalex.org/keywords/icam-1","display_name":"ICAM-1","score":0.8889999985694885},{"id":"https://openalex.org/keywords/exosomes","display_name":"exosomes","score":0.9570000171661377},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.7770000100135803},{"id":"https://openalex.org/keywords/cancer-cell-proliferation-and-invasion","display_name":"cancer cell proliferation and invasion","score":0.7409999966621399},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8360000252723694},{"id":"https://openalex.org/keywords/tumor-growth","display_name":"tumor growth","score":0.6389999985694885}],"concepts":[{"id":"https://openalex.org/C81729549","wikidata":"https://www.wikidata.org/wiki/Q4649475","display_name":"A549 cell","level":3,"score":0.8730999827384949},{"id":"https://openalex.org/C2777421810","wikidata":"https://www.wikidata.org/wiki/Q21145188","display_name":"MUC1","level":3,"score":0.6894999742507935},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6122999787330627},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.6031000018119812},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.5400000214576721},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.5149999856948853},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5045999884605408},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5},{"id":"https://openalex.org/C20518536","wikidata":"https://www.wikidata.org/wiki/Q6840469","display_name":"Microvesicles","level":4,"score":0.4537000060081482},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.4474000036716461},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.44179999828338623},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.39239999651908875},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.34279999136924744},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3246000111103058},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.3239000141620636},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3228999972343445},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.3077999949455261},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.2957000136375427},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.2924000024795532},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.2750000059604645},{"id":"https://openalex.org/C166703698","wikidata":"https://www.wikidata.org/wiki/Q201993","display_name":"RNA interference","level":4,"score":0.2702000141143799},{"id":"https://openalex.org/C179264091","wikidata":"https://www.wikidata.org/wiki/Q410862","display_name":"Mucin","level":2,"score":0.2599000036716461}],"mesh":[{"descriptor_ui":"D000072283","descriptor_name":"A549 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072645","descriptor_name":"Cancer-Associated Fibroblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000072645","descriptor_name":"Cancer-Associated Fibroblasts","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018396","descriptor_name":"Mucin-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018396","descriptor_name":"Mucin-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018799","descriptor_name":"Intercellular Adhesion Molecule-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018920","descriptor_name":"Coculture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055354","descriptor_name":"Exosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/s00210-025-04672-0","doi":"https://doi.org/10.1007/s00210-025-04672-0","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00210-025-04672-0","pdf_url":null,"source":{"id":"https://openalex.org/S159534381","display_name":"Naunyn-Schmiedeberg s Archives of Pharmacology","issn_l":"0028-1298","issn":["0028-1298","0340-5249","1432-1912"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Naunyn-Schmiedeberg's Archives of Pharmacology","raw_type":"journal-article"},{"id":"pmid:41105252","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41105252","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Naunyn-Schmiedeberg's archives of pharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W2152189731","https://openalex.org/W2162538445","https://openalex.org/W2789018621","https://openalex.org/W3010838109","https://openalex.org/W4280616623","https://openalex.org/W4307731493","https://openalex.org/W4319593279","https://openalex.org/W4319964795","https://openalex.org/W4386248363","https://openalex.org/W4388294364","https://openalex.org/W4390972792","https://openalex.org/W4391823109","https://openalex.org/W4392459941","https://openalex.org/W4392698682","https://openalex.org/W4394738501","https://openalex.org/W4394915424","https://openalex.org/W4394981624","https://openalex.org/W4398140619","https://openalex.org/W4398176077","https://openalex.org/W4398183237","https://openalex.org/W4398783096","https://openalex.org/W4399296016","https://openalex.org/W4399679771","https://openalex.org/W4399742220","https://openalex.org/W4399955308","https://openalex.org/W4400459456","https://openalex.org/W4400978492","https://openalex.org/W4401032495","https://openalex.org/W4401406616","https://openalex.org/W4402040674","https://openalex.org/W4402171729","https://openalex.org/W4402324051","https://openalex.org/W4402639721","https://openalex.org/W4402732177","https://openalex.org/W4402886999","https://openalex.org/W4403335627","https://openalex.org/W4403538428","https://openalex.org/W4404831901","https://openalex.org/W4404882714","https://openalex.org/W4405760175","https://openalex.org/W4406330095","https://openalex.org/W4407364468","https://openalex.org/W4408070457","https://openalex.org/W4408659186","https://openalex.org/W4410219182"],"related_works":["https://openalex.org/W4402527449","https://openalex.org/W4297199251","https://openalex.org/W7214104526","https://openalex.org/W7167795715","https://openalex.org/W4394848502","https://openalex.org/W4403846686","https://openalex.org/W4327761263","https://openalex.org/W4211032048","https://openalex.org/W4405572193","https://openalex.org/W4286260500"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2025-10-18T00:00:00"}