{"id":"https://openalex.org/W4415300033","doi":"https://doi.org/10.1016/j.saa.2025.127050","title":"Spectroscopic investigation of the competitive-allosteric-synergistic mechanism in the binding of benazepril/apigenin to bovine serum albumin","display_name":"Spectroscopic investigation of the competitive-allosteric-synergistic mechanism in the binding of benazepril/apigenin to bovine serum albumin","publication_year":2025,"publication_date":"2025-10-17","ids":{"openalex":"https://openalex.org/W4415300033","doi":"https://doi.org/10.1016/j.saa.2025.127050","pmid":"https://pubmed.ncbi.nlm.nih.gov/41108928"},"language":"en","primary_location":{"id":"doi:10.1016/j.saa.2025.127050","doi":"https://doi.org/10.1016/j.saa.2025.127050","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.saa.2025.127050","pdf_url":null,"source":{"id":"https://openalex.org/S96873385","display_name":"Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy","issn_l":"1386-1425","issn":["1386-1425","1873-3557"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102765508","display_name":"Xue Li","orcid":"https://orcid.org/0009-0006-0837-368X","observed_orcids":["https://orcid.org/0009-0006-0837-368X"]},"institutions":[{"id":"https://openalex.org/I97009856","display_name":"Bohai University","ror":"https://ror.org/01kdzej58","country_code":"CN","type":"education","lineage":["https://openalex.org/I97009856"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xue Li","raw_affiliation_strings":["College of Chemistry and Chemical Engineering, Bohai University, Jinzhou 121013, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Chemistry and Chemical Engineering, Bohai University, Jinzhou 121013, PR China","institution_ids":["https://openalex.org/I97009856"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087379534","display_name":"Xinying Yuan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I97009856","display_name":"Bohai University","ror":"https://ror.org/01kdzej58","country_code":"CN","type":"education","lineage":["https://openalex.org/I97009856"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinying Yuan","raw_affiliation_strings":["College of Chemistry and Chemical Engineering, Bohai University, Jinzhou 121013, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Chemistry and Chemical Engineering, Bohai University, Jinzhou 121013, PR China","institution_ids":["https://openalex.org/I97009856"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101805623","display_name":"Shijun Yu","orcid":"https://orcid.org/0009-0003-1196-0525","observed_orcids":["https://orcid.org/0009-0003-1196-0525"]},"institutions":[{"id":"https://openalex.org/I97009856","display_name":"Bohai University","ror":"https://ror.org/01kdzej58","country_code":"CN","type":"education","lineage":["https://openalex.org/I97009856"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shijun Yu","raw_affiliation_strings":["College of Chemistry and Chemical Engineering, Bohai University, Jinzhou 121013, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Chemistry and Chemical Engineering, Bohai University, Jinzhou 121013, PR China","institution_ids":["https://openalex.org/I97009856"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100953695","display_name":"Jiali Gu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I97009856","display_name":"Bohai University","ror":"https://ror.org/01kdzej58","country_code":"CN","type":"education","lineage":["https://openalex.org/I97009856"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jiali Gu","raw_affiliation_strings":["College of Chemistry and Chemical Engineering, Bohai University, Jinzhou 121013, PR China. Electronic address: gubohaibhu@163.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Chemistry and Chemical Engineering, Bohai University, Jinzhou 121013, PR China. Electronic address: gubohaibhu@163.com","institution_ids":["https://openalex.org/I97009856"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5100953695"],"corresponding_institution_ids":["https://openalex.org/I97009856"],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"347","issue":null,"first_page":"127050","last_page":"127050"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11908","display_name":"Protein Interaction Studies and Fluorescence Analysis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11908","display_name":"Protein Interaction Studies and Fluorescence Analysis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/benazepril","display_name":"benazepril","score":0.9980000257492065},{"id":"https://openalex.org/keywords/apigenin","display_name":"apigenin","score":1.0},{"id":"https://openalex.org/keywords/bovine-serum-albumin","display_name":"bovine serum albumin","score":1.0},{"id":"https://openalex.org/keywords/competitive-binding","display_name":"competitive binding","score":0.6079999804496765},{"id":"https://openalex.org/keywords/allosteric-effects","display_name":"allosteric effects","score":0.8019999861717224},{"id":"https://openalex.org/keywords/drug-synergy","display_name":"drug synergy","score":0.8169999718666077},{"id":"https://openalex.org/keywords/protein-ligand-binding","display_name":"protein-ligand binding","score":0.718999981880188},{"id":"https://openalex.org/keywords/binding-site-i","display_name":"binding site I","score":0.5809999704360962},{"id":"https://openalex.org/keywords/protein-secondary-structure","display_name":"protein secondary structure","score":0.753000020980835},{"id":"https://openalex.org/keywords/fluorescence-quenching","display_name":"fluorescence quenching","score":0.593999981880188},{"id":"https://openalex.org/keywords/energy-transfer","display_name":"energy transfer","score":0.8040000200271606},{"id":"https://openalex.org/keywords/sulfhydryl-groups","display_name":"sulfhydryl groups","score":0.8930000066757202},{"id":"https://openalex.org/keywords/esterase-inhibition","display_name":"esterase inhibition","score":0.7979999780654907},{"id":"https://openalex.org/keywords/drug-protein-interactions","display_name":"drug-protein interactions","score":0.3610000014305115}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9789999723434448},{"id":"https://openalex.org/C86807702","wikidata":"https://www.wikidata.org/wiki/Q2620381","display_name":"Bovine serum albumin","level":2,"score":0.8454999923706055},{"id":"https://openalex.org/C133571119","wikidata":"https://www.wikidata.org/wiki/Q899102","display_name":"Circular dichroism","level":2,"score":0.6965000033378601},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5227000117301941},{"id":"https://openalex.org/C166342909","wikidata":"https://www.wikidata.org/wiki/Q845326","display_name":"Allosteric regulation","level":3,"score":0.5116999745368958},{"id":"https://openalex.org/C165616093","wikidata":"https://www.wikidata.org/wiki/Q424232","display_name":"Serum albumin","level":2,"score":0.4291999936103821},{"id":"https://openalex.org/C62614982","wikidata":"https://www.wikidata.org/wiki/Q904984","display_name":"Protein secondary structure","level":2,"score":0.40400001406669617},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3944999873638153},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.37040001153945923},{"id":"https://openalex.org/C51639874","wikidata":"https://www.wikidata.org/wiki/Q167149","display_name":"Plasma protein binding","level":2,"score":0.3650999963283539},{"id":"https://openalex.org/C2777339483","wikidata":"https://www.wikidata.org/wiki/Q647203","display_name":"Conformational change","level":2,"score":0.3578000068664551},{"id":"https://openalex.org/C2776120743","wikidata":"https://www.wikidata.org/wiki/Q3271540","display_name":"Mechanism of action","level":3,"score":0.3264000117778778},{"id":"https://openalex.org/C2776966407","wikidata":"https://www.wikidata.org/wiki/Q24779410","display_name":"Lysozyme","level":2,"score":0.30799999833106995},{"id":"https://openalex.org/C96305047","wikidata":"https://www.wikidata.org/wiki/Q367473","display_name":"F\u00f6rster resonance energy transfer","level":3,"score":0.3075999915599823},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3025999963283539},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.2935999929904938},{"id":"https://openalex.org/C2778896982","wikidata":"https://www.wikidata.org/wiki/Q2033625","display_name":"Thioflavin","level":4,"score":0.28040000796318054},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.2784999907016754},{"id":"https://openalex.org/C2777261171","wikidata":"https://www.wikidata.org/wiki/Q418750","display_name":"Esterase","level":3,"score":0.2766999900341034},{"id":"https://openalex.org/C2777516457","wikidata":"https://www.wikidata.org/wiki/Q2413613","display_name":"Singlet oxygen","level":3,"score":0.2687000036239624},{"id":"https://openalex.org/C2776125364","wikidata":"https://www.wikidata.org/wiki/Q169219","display_name":"Albumin","level":2,"score":0.2639999985694885},{"id":"https://openalex.org/C553089730","wikidata":"https://www.wikidata.org/wiki/Q4914021","display_name":"Binding protein","level":3,"score":0.2572999894618988}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001552","descriptor_name":"Benzazepines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001552","descriptor_name":"Benzazepines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001667","descriptor_name":"Binding, Competitive","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002942","descriptor_name":"Circular Dichroism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012710","descriptor_name":"Serum Albumin, Bovine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012710","descriptor_name":"Serum Albumin, Bovine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013050","descriptor_name":"Spectrometry, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047310","descriptor_name":"Apigenin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D047310","descriptor_name":"Apigenin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.saa.2025.127050","doi":"https://doi.org/10.1016/j.saa.2025.127050","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.saa.2025.127050","pdf_url":null,"source":{"id":"https://openalex.org/S96873385","display_name":"Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy","issn_l":"1386-1425","issn":["1386-1425","1873-3557"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy","raw_type":"journal-article"},{"id":"pmid:41108928","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41108928","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6240000128746033,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5690511253","display_name":null,"funder_award_id":"2024-MSBA-88","funder_id":"https://openalex.org/F4320323086","funder_display_name":"Natural Science Foundation of Liaoning Province"}],"funders":[{"id":"https://openalex.org/F4320323086","display_name":"Natural Science Foundation of Liaoning Province","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W1981737320","https://openalex.org/W2007790334","https://openalex.org/W2043244508","https://openalex.org/W2050174866","https://openalex.org/W2057716684","https://openalex.org/W2071703141","https://openalex.org/W2086725966","https://openalex.org/W2092157292","https://openalex.org/W2132525235","https://openalex.org/W2140449653","https://openalex.org/W2147472203","https://openalex.org/W2491458126","https://openalex.org/W2602460649","https://openalex.org/W2789238333","https://openalex.org/W2809612276","https://openalex.org/W2810024217","https://openalex.org/W2810242058","https://openalex.org/W3027308092","https://openalex.org/W3089319309","https://openalex.org/W3134051698","https://openalex.org/W3140268994","https://openalex.org/W3156076408","https://openalex.org/W3164719796","https://openalex.org/W3199477388","https://openalex.org/W3204142120","https://openalex.org/W4205538970","https://openalex.org/W4362666564","https://openalex.org/W4376527229","https://openalex.org/W4387409890","https://openalex.org/W4388835398","https://openalex.org/W4389298805","https://openalex.org/W4390685605","https://openalex.org/W4391973226","https://openalex.org/W4396906372","https://openalex.org/W4399430607","https://openalex.org/W4399809648","https://openalex.org/W4399977631","https://openalex.org/W4402371755","https://openalex.org/W4403791192","https://openalex.org/W4404734500","https://openalex.org/W4405531472","https://openalex.org/W4405985978","https://openalex.org/W4406061736","https://openalex.org/W4406169517","https://openalex.org/W4406689970","https://openalex.org/W4407086857","https://openalex.org/W4407598269","https://openalex.org/W4409266461","https://openalex.org/W4409762053","https://openalex.org/W4410506277","https://openalex.org/W4413389101"],"related_works":["https://openalex.org/W2906230124","https://openalex.org/W2993487360","https://openalex.org/W2048727413","https://openalex.org/W2034809579","https://openalex.org/W2808396499","https://openalex.org/W2370836670","https://openalex.org/W2060210476","https://openalex.org/W2512763192","https://openalex.org/W4404409510","https://openalex.org/W337615078"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2025-10-18T00:00:00"}
