{"id":"https://openalex.org/W4415286014","doi":"https://doi.org/10.48550/arxiv.2510.24751","title":"How can methods for classifying and clustering trajectories be used for prevention trials? An example in Alzheimer's disease area","display_name":"How can methods for classifying and clustering trajectories be used for prevention trials? An example in Alzheimer's disease area","publication_year":2025,"publication_date":"2025-10-17","ids":{"openalex":"https://openalex.org/W4415286014","doi":"https://doi.org/10.48550/arxiv.2510.24751"},"language":"en","primary_location":{"id":"pmh:oai:arXiv.org:2510.24751","doi":null,"is_oa":true,"landing_page_url":"http://arxiv.org/abs/2510.24751","pdf_url":"https://arxiv.org/pdf/2510.24751","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":"2331-8422","issn":["2331-8422"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["arxiv","datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://arxiv.org/pdf/2510.24751","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014616046","display_name":"C\u00e9line Bougel","orcid":"https://orcid.org/0000-0002-1598-7827","observed_orcids":["https://orcid.org/0000-0002-1598-7827"]},"institutions":[{"id":"https://openalex.org/I4405265615","display_name":"Centre d'Epid\u00e9miologie et de Recherche en sant\u00e9 des POPulations de Toulouse","ror":"https://ror.org/059jved31","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I4405258862","https://openalex.org/I4405265615"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Bougel, C\u00e9line","raw_affiliation_strings":["CERPOP","CERPOP - Centre d'Epid\u00e9miologie et de Recherche en sant\u00e9 des POPulations (37 all\u00e9es J. Guesde \r\n31000 Toulouse - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CERPOP","institution_ids":["https://openalex.org/I4405265615"]},{"raw_affiliation_string":"CERPOP - Centre d'Epid\u00e9miologie et de Recherche en sant\u00e9 des POPulations (37 all\u00e9es J. Guesde \r\n31000 Toulouse - France)","institution_ids":["https://openalex.org/I4405265615"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054957441","display_name":"S\u00e9bastien Dejean","orcid":"https://orcid.org/0000-0001-9610-5306","observed_orcids":["https://orcid.org/0000-0001-9610-5306"]},"institutions":[{"id":"https://openalex.org/I134560555","display_name":"Universit\u00e9 Toulouse III - Paul Sabatier","ror":"https://ror.org/02v6kpv12","country_code":"FR","type":"education","lineage":["https://openalex.org/I134560555","https://openalex.org/I4405258862"]},{"id":"https://openalex.org/I196454796","display_name":"Institut National des Sciences Appliqu\u00e9es de Toulouse","ror":"https://ror.org/01h8pf755","country_code":"FR","type":"education","lineage":["https://openalex.org/I196454796"]},{"id":"https://openalex.org/I84500057","display_name":"Institut de Math\u00e9matiques de Toulouse","ror":"https://ror.org/014vp6c30","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I196454796","https://openalex.org/I4210092408","https://openalex.org/I4210126056","https://openalex.org/I4210141950","https://openalex.org/I4210152422","https://openalex.org/I4405258862","https://openalex.org/I84500057"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"D\u00e9jean, S\u00e9bastien","raw_affiliation_strings":["IMT, UT3","IMT - Institut de Math\u00e9matiques de Toulouse UMR5219 (UPS IMT, F-31062 Toulouse Cedex 9, \r\nINSA Toulouse, F-31077 Toulouse,\r\nFrance UT1, F-31042 Toulouse, \r\nFrance UT2, F-31058 Toulouse,\r\n\r\nT\u00e9l\u00e9phone : 05.61.55.67.90 - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IMT, UT3","institution_ids":[]},{"raw_affiliation_string":"IMT - Institut de Math\u00e9matiques de Toulouse UMR5219 (UPS IMT, F-31062 Toulouse Cedex 9, \r\nINSA Toulouse, F-31077 Toulouse,\r\nFrance UT1, F-31042 Toulouse, \r\nFrance UT2, F-31058 Toulouse,\r\n\r\nT\u00e9l\u00e9phone : 05.61.55.67.90 - France)","institution_ids":["https://openalex.org/I134560555","https://openalex.org/I196454796","https://openalex.org/I84500057"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086251863","display_name":"Caroline Giulioli","orcid":"https://orcid.org/0000-0002-5472-1298","observed_orcids":["https://orcid.org/0000-0002-5472-1298"]},"institutions":[{"id":"https://openalex.org/I4405265615","display_name":"Centre d'Epid\u00e9miologie et de Recherche en sant\u00e9 des POPulations de Toulouse","ror":"https://ror.org/059jved31","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I4405258862","https://openalex.org/I4405265615"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Giulioli, Caroline","raw_affiliation_strings":["CERPOP","CERPOP - Centre d'Epid\u00e9miologie et de Recherche en sant\u00e9 des POPulations (37 all\u00e9es J. Guesde \r\n31000 Toulouse - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CERPOP","institution_ids":["https://openalex.org/I4405265615"]},{"raw_affiliation_string":"CERPOP - Centre d'Epid\u00e9miologie et de Recherche en sant\u00e9 des POPulations (37 all\u00e9es J. Guesde \r\n31000 Toulouse - France)","institution_ids":["https://openalex.org/I4405265615"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5129330748","display_name":"Philippe Saint-Pierre","orcid":"https://orcid.org/0000-0002-7367-3770","observed_orcids":["https://orcid.org/0000-0002-7367-3770"]},"institutions":[{"id":"https://openalex.org/I134560555","display_name":"Universit\u00e9 Toulouse III - Paul Sabatier","ror":"https://ror.org/02v6kpv12","country_code":"FR","type":"education","lineage":["https://openalex.org/I134560555","https://openalex.org/I4405258862"]},{"id":"https://openalex.org/I196454796","display_name":"Institut National des Sciences Appliqu\u00e9es de Toulouse","ror":"https://ror.org/01h8pf755","country_code":"FR","type":"education","lineage":["https://openalex.org/I196454796"]},{"id":"https://openalex.org/I84500057","display_name":"Institut de Math\u00e9matiques de Toulouse","ror":"https://ror.org/014vp6c30","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I196454796","https://openalex.org/I4210092408","https://openalex.org/I4210126056","https://openalex.org/I4210141950","https://openalex.org/I4210152422","https://openalex.org/I4405258862","https://openalex.org/I84500057"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Saint-Pierre, Philippe","raw_affiliation_strings":["IMT, UT3","IMT - Institut de Math\u00e9matiques de Toulouse UMR5219 (UPS IMT, F-31062 Toulouse Cedex 9, \r\nINSA Toulouse, F-31077 Toulouse,\r\nFrance UT1, F-31042 Toulouse, \r\nFrance UT2, F-31058 Toulouse,\r\n\r\nT\u00e9l\u00e9phone : 05.61.55.67.90 - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IMT, UT3","institution_ids":[]},{"raw_affiliation_string":"IMT - Institut de Math\u00e9matiques de Toulouse UMR5219 (UPS IMT, F-31062 Toulouse Cedex 9, \r\nINSA Toulouse, F-31077 Toulouse,\r\nFrance UT1, F-31042 Toulouse, \r\nFrance UT2, F-31058 Toulouse,\r\n\r\nT\u00e9l\u00e9phone : 05.61.55.67.90 - France)","institution_ids":["https://openalex.org/I134560555","https://openalex.org/I196454796","https://openalex.org/I84500057"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015893514","display_name":"Nicolas Savy","orcid":"https://orcid.org/0000-0001-9839-9598","observed_orcids":["https://orcid.org/0000-0001-9839-9598"]},"institutions":[{"id":"https://openalex.org/I134560555","display_name":"Universit\u00e9 Toulouse III - Paul Sabatier","ror":"https://ror.org/02v6kpv12","country_code":"FR","type":"education","lineage":["https://openalex.org/I134560555","https://openalex.org/I4405258862"]},{"id":"https://openalex.org/I196454796","display_name":"Institut National des Sciences Appliqu\u00e9es de Toulouse","ror":"https://ror.org/01h8pf755","country_code":"FR","type":"education","lineage":["https://openalex.org/I196454796"]},{"id":"https://openalex.org/I84500057","display_name":"Institut de Math\u00e9matiques de Toulouse","ror":"https://ror.org/014vp6c30","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I196454796","https://openalex.org/I4210092408","https://openalex.org/I4210126056","https://openalex.org/I4210141950","https://openalex.org/I4210152422","https://openalex.org/I4405258862","https://openalex.org/I84500057"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Savy, Nicolas","raw_affiliation_strings":["IMT, UT3","IMT - Institut de Math\u00e9matiques de Toulouse UMR5219 (UPS IMT, F-31062 Toulouse Cedex 9, \r\nINSA Toulouse, F-31077 Toulouse,\r\nFrance UT1, F-31042 Toulouse, \r\nFrance UT2, F-31058 Toulouse,\r\n\r\nT\u00e9l\u00e9phone : 05.61.55.67.90 - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IMT, UT3","institution_ids":[]},{"raw_affiliation_string":"IMT - Institut de Math\u00e9matiques de Toulouse UMR5219 (UPS IMT, F-31062 Toulouse Cedex 9, \r\nINSA Toulouse, F-31077 Toulouse,\r\nFrance UT1, F-31042 Toulouse, \r\nFrance UT2, F-31058 Toulouse,\r\n\r\nT\u00e9l\u00e9phone : 05.61.55.67.90 - France)","institution_ids":["https://openalex.org/I134560555","https://openalex.org/I196454796","https://openalex.org/I84500057"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5107408072","display_name":"Sandrine Andrieu","orcid":"https://orcid.org/0000-0002-1142-770X","observed_orcids":["https://orcid.org/0000-0002-1142-770X"]},"institutions":[{"id":"https://openalex.org/I3019448017","display_name":"Centre Hospitalier Universitaire de Toulouse","ror":"https://ror.org/017h5q109","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019448017"]},{"id":"https://openalex.org/I4210138343","display_name":"H\u00f4pital Purpan","ror":"https://ror.org/03vcx3f97","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019448017","https://openalex.org/I4210138343"]},{"id":"https://openalex.org/I4405265615","display_name":"Centre d'Epid\u00e9miologie et de Recherche en sant\u00e9 des POPulations de Toulouse","ror":"https://ror.org/059jved31","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I4405258862","https://openalex.org/I4405265615"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Andrieu, Sandrine","raw_affiliation_strings":["CERPOP","CERPOP - Centre d'Epid\u00e9miologie et de Recherche en sant\u00e9 des POPulations (37 all\u00e9es J. Guesde \r\n31000 Toulouse - France)","Service Epid\u00e9miologie clinique et sant\u00e9 publique [CHU Toulouse] (Facult\u00e9 de m\u00e9decine de Purpan, \r\n37, all\u00e9es Jules Guesde, 31000 Toulouse - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CERPOP","institution_ids":["https://openalex.org/I4405265615"]},{"raw_affiliation_string":"CERPOP - Centre d'Epid\u00e9miologie et de Recherche en sant\u00e9 des POPulations (37 all\u00e9es J. Guesde \r\n31000 Toulouse - France)","institution_ids":["https://openalex.org/I4405265615"]},{"raw_affiliation_string":"Service Epid\u00e9miologie clinique et sant\u00e9 publique [CHU Toulouse] (Facult\u00e9 de m\u00e9decine de Purpan, \r\n37, all\u00e9es Jules Guesde, 31000 Toulouse - France)","institution_ids":["https://openalex.org/I3019448017","https://openalex.org/I4210138343"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.5889000296592712,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.5889000296592712,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10243","display_name":"Statistical Methods and Bayesian Inference","score":0.23549999296665192,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.04390000179409981,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trajectory-classification","display_name":"trajectory classification","score":0.921999990940094},{"id":"https://openalex.org/keywords/trajectory-clustering","display_name":"trajectory clustering","score":0.9789999723434448},{"id":"https://openalex.org/keywords/prevention-trials","display_name":"prevention trials","score":0.906000018119812},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9829999804496765},{"id":"https://openalex.org/keywords/cognitive-decline","display_name":"cognitive decline","score":0.7480000257492065},{"id":"https://openalex.org/keywords/subgroup-heterogeneity","display_name":"subgroup heterogeneity","score":0.7390000224113464},{"id":"https://openalex.org/keywords/hierarchical-clustering","display_name":"hierarchical clustering","score":0.9419999718666077},{"id":"https://openalex.org/keywords/amyloid-beta","display_name":"amyloid-beta","score":0.6430000066757202},{"id":"https://openalex.org/keywords/exploratory-data-analysis","display_name":"exploratory data analysis","score":0.6019999980926514},{"id":"https://openalex.org/keywords/treatment-heterogeneity","display_name":"treatment effect heterogeneity","score":0.5820000171661377}],"concepts":[{"id":"https://openalex.org/C73555534","wikidata":"https://www.wikidata.org/wiki/Q622825","display_name":"Cluster analysis","level":2,"score":0.6193000078201294},{"id":"https://openalex.org/C13662910","wikidata":"https://www.wikidata.org/wiki/Q193139","display_name":"Trajectory","level":2,"score":0.47110000252723694},{"id":"https://openalex.org/C12713177","wikidata":"https://www.wikidata.org/wiki/Q1900281","display_name":"Perspective (graphical)","level":2,"score":0.4253999888896942},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.4228000044822693},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.4219000041484833},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.40369999408721924},{"id":"https://openalex.org/C92835128","wikidata":"https://www.wikidata.org/wiki/Q1277447","display_name":"Hierarchical clustering","level":3,"score":0.3971000015735626},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.39469999074935913},{"id":"https://openalex.org/C87007009","wikidata":"https://www.wikidata.org/wiki/Q210832","display_name":"Statistical hypothesis testing","level":2,"score":0.38850000500679016},{"id":"https://openalex.org/C120894424","wikidata":"https://www.wikidata.org/wiki/Q1322871","display_name":"Exploratory data analysis","level":2,"score":0.38499999046325684},{"id":"https://openalex.org/C117251300","wikidata":"https://www.wikidata.org/wiki/Q1849855","display_name":"Parametric statistics","level":2,"score":0.3677000105381012},{"id":"https://openalex.org/C2779466056","wikidata":"https://www.wikidata.org/wiki/Q107630651","display_name":"Time point","level":2,"score":0.3513000011444092},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.3481999933719635},{"id":"https://openalex.org/C9357733","wikidata":"https://www.wikidata.org/wiki/Q6878417","display_name":"Missing data","level":2,"score":0.3269999921321869},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.321399986743927},{"id":"https://openalex.org/C164866538","wikidata":"https://www.wikidata.org/wiki/Q367351","display_name":"Cluster (spacecraft)","level":2,"score":0.31369999051094055},{"id":"https://openalex.org/C183763347","wikidata":"https://www.wikidata.org/wiki/Q120976","display_name":"Factorial","level":2,"score":0.31049999594688416},{"id":"https://openalex.org/C28719098","wikidata":"https://www.wikidata.org/wiki/Q44946","display_name":"Point (geometry)","level":2,"score":0.3093999922275543},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.30630001425743103},{"id":"https://openalex.org/C61224824","wikidata":"https://www.wikidata.org/wiki/Q2260434","display_name":"Mixture model","level":2,"score":0.2989000082015991},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.2944999933242798},{"id":"https://openalex.org/C2777267654","wikidata":"https://www.wikidata.org/wiki/Q3519023","display_name":"Test (biology)","level":2,"score":0.29100000858306885},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.2906000018119812},{"id":"https://openalex.org/C75553542","wikidata":"https://www.wikidata.org/wiki/Q178161","display_name":"A priori and a posteriori","level":2,"score":0.2856000065803528},{"id":"https://openalex.org/C129844170","wikidata":"https://www.wikidata.org/wiki/Q41299","display_name":"Quadratic equation","level":2,"score":0.2745000123977661},{"id":"https://openalex.org/C168743327","wikidata":"https://www.wikidata.org/wiki/Q1826427","display_name":"Random effects model","level":3,"score":0.27149999141693115},{"id":"https://openalex.org/C105611402","wikidata":"https://www.wikidata.org/wiki/Q2976589","display_name":"Spectral clustering","level":3,"score":0.26919999718666077},{"id":"https://openalex.org/C102959455","wikidata":"https://www.wikidata.org/wiki/Q7313954","display_name":"Repeated measures design","level":2,"score":0.26809999346733093},{"id":"https://openalex.org/C53059260","wikidata":"https://www.wikidata.org/wiki/Q374758","display_name":"Multilevel model","level":2,"score":0.26570001244544983},{"id":"https://openalex.org/C5274069","wikidata":"https://www.wikidata.org/wiki/Q2285707","display_name":"Categorical variable","level":2,"score":0.26260000467300415},{"id":"https://openalex.org/C5297727","wikidata":"https://www.wikidata.org/wiki/Q786970","display_name":"Autocorrelation","level":2,"score":0.25609999895095825},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.2556000053882599},{"id":"https://openalex.org/C148220186","wikidata":"https://www.wikidata.org/wiki/Q7111912","display_name":"Outcome (game theory)","level":2,"score":0.25459998846054077}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:arXiv.org:2510.24751","doi":null,"is_oa":true,"landing_page_url":"http://arxiv.org/abs/2510.24751","pdf_url":"https://arxiv.org/pdf/2510.24751","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":"2331-8422","issn":["2331-8422"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},{"id":"doi:10.48550/arxiv.2510.24751","doi":"https://doi.org/10.48550/arxiv.2510.24751","is_oa":true,"landing_page_url":"https://doi.org/10.48550/arxiv.2510.24751","pdf_url":null,"source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":"2331-8422","issn":["2331-8422"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Preprint"}],"best_oa_location":{"id":"pmh:oai:arXiv.org:2510.24751","doi":null,"is_oa":true,"landing_page_url":"http://arxiv.org/abs/2510.24751","pdf_url":"https://arxiv.org/pdf/2510.24751","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":"2331-8422","issn":["2331-8422"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320309738","display_name":"Fondation de l'Avenir pour la Recherche M\u00e9dicale Appliqu\u00e9e","ror":"https://ror.org/02dddmh90"},{"id":"https://openalex.org/F4320335322","display_name":"European Regional Development Fund","ror":"https://ror.org/00k4n6c32"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4415286014.pdf","grobid_xml":"https://content.openalex.org/works/W4415286014.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W1491512019","https://openalex.org/W1982652636","https://openalex.org/W1989430616","https://openalex.org/W1998871699","https://openalex.org/W1998937446","https://openalex.org/W2000555003","https://openalex.org/W2002571399","https://openalex.org/W2008992496","https://openalex.org/W2013188809","https://openalex.org/W2013358874","https://openalex.org/W2021964708","https://openalex.org/W2032594557","https://openalex.org/W2041750354","https://openalex.org/W2068751176","https://openalex.org/W2069203452","https://openalex.org/W2079507529","https://openalex.org/W2085487226","https://openalex.org/W2085630472","https://openalex.org/W2097450481","https://openalex.org/W2116633293","https://openalex.org/W2133120537","https://openalex.org/W2134458253","https://openalex.org/W2137944397","https://openalex.org/W2140718540","https://openalex.org/W2142409409","https://openalex.org/W2155537822","https://openalex.org/W2164059021","https://openalex.org/W2164186760","https://openalex.org/W2165279131","https://openalex.org/W2298887234","https://openalex.org/W2417877795","https://openalex.org/W2471090910","https://openalex.org/W2510836191","https://openalex.org/W2515067055","https://openalex.org/W2601075442","https://openalex.org/W2891381594","https://openalex.org/W2915080368","https://openalex.org/W2975761185","https://openalex.org/W4233622592","https://openalex.org/W4387874035"],"related_works":["https://openalex.org/W4389275054","https://openalex.org/W4407949160","https://openalex.org/W4391988162","https://openalex.org/W4389280318","https://openalex.org/W7202128621","https://openalex.org/W2736615279","https://openalex.org/W3195485315","https://openalex.org/W7155186346","https://openalex.org/W1687656967","https://openalex.org/W4405369081"],"abstract_inverted_index":{"Background:":[0],"Clinical":[1],"trials":[2],"are":[3],"designed":[4],"to":[5,54,58,66,74,136,195,227,260,281,290,299,337,359,364,396,429],"prove":[6],"the":[7,29,42,56,71,89,94,103,108,118,138,197,249,261,264,273,301,309,326,351,354,365,368,417,425,430],"efficacy":[8],"of":[9,14,79,91,99,105,113,120,132,140,199,242,252,294,303,321,367,383,408,411,420,424],"an":[10,33,83,292,392],"intervention":[11],"by":[12,181],"means":[13],"model-based":[15],"approaches":[16],"involving":[17],"parametric":[18],"hypothesis":[19],"testing.":[20],"Issues":[21],"arise":[22],"when":[23],"no":[24,334],"effect":[25,34,84,376],"is":[26,96,110,192],"observed":[27],"in":[28,38,296,379],"study":[30,187],"population.":[31],"Indeed,":[32],"may":[35,371],"be":[36,86,257,360],"present":[37],"a":[39,59,97,111,156,170,374,380,421],"subgroup":[40,382],"and":[41,73,145,220,240,298,319,414],"statistical":[43],"test":[44],"cannot":[45],"detect":[46],"it.":[47],"To":[48],"investigate":[49,196],"this":[50,133],"possibility,":[51],"we":[52,278,341,389],"proposed":[53],"change":[55,295,304,322],"paradigm":[57],"data-driven":[60,200],"approach.":[61],"We":[62,403],"selected":[63],"exploratory":[64],"methods":[65,121,142,201,206],"provide":[67],"another":[68],"perspective":[69],"on":[70,346,400],"data":[72,125,178,284],"identify":[75,406],"particular":[76],"homogeneous":[77],"subgroups":[78],"subjects":[80],"within":[81],"which":[82,116,370],"might":[85],"detected.":[87],"In":[88,102,350],"setting":[90],"prevention":[92,106,355],"trials,":[93,107],"endpoint":[95,109,432],"trajectory":[98,112,203],"repeated":[100,114,268],"measures.":[101],"settings":[104],"measures,":[115],"requires":[117],"use":[119,198],"that":[122],"can":[123],"take":[124],"autocorrelation":[126],"into":[127],"account.":[128],"The":[129,149,166,177,205,316],"primary":[130,167,262],"aim":[131],"work":[134],"was":[135,155,169,188,287,314,357],"explore":[137],"applicability":[139],"different":[141],"for":[143,202,211,233,325],"clustering":[144],"classifying":[146],"trajectories.":[147,402],"Methods:":[148],"Multidomain":[150],"Alzheimer":[151],"Preventive":[152],"Trial":[153],"(MAPT)":[154],"three-year":[157],"randomized":[158],"controlled":[159],"trial":[160,356],"with":[161,223,267],"four":[162,174],"parallel":[163],"arms":[164],"(NCT00672685).":[165],"outcome":[168],"composite":[171,265],"Z-score":[172,266],"combining":[173],"cognitive":[175,246,412],"tests.":[176],"were":[179,208,238,279,323,333],"analyzed":[180],"quadratic":[182],"mixed":[183],"effects":[184],"model.":[185],"This":[186,254],"inconclusive.":[189],"Exploratory":[190],"analysis":[191,222],"therefore":[193,288],"relevant":[194],"classification.":[204],"used":[207],"unsupervised:":[209],"k-means":[210,232],"longitudinal":[212,234,283],"data,":[213,235],"Hierarchical":[214],"Cluster":[215],"Analysis":[216],"(HCA),":[217],"graphic":[218,327],"semiology,":[219],"supervised":[221],"dichotomous":[224],"classification":[225],"according":[226],"responder":[228,339],"status.":[229],"Results:":[230],"Using":[231],"three":[236,250],"groups":[237,244],"obtained":[239],"one":[241],"these":[243],"showed":[245],"decline":[247,413],"over":[248,270],"years":[251],"follow-up.":[253],"method":[255],"could":[256,404],"applied":[258,324],"directly":[259],"outcome,":[263],"observations":[269],"time.":[271],"With":[272],"two":[274,306],"others":[275],"unsupervised":[276,394],"methods,":[277],"unable":[280],"process":[282],"directly.":[285],"It":[286],"necessary":[289],"choose":[291],"indicator":[293],"trajectories":[297,410],"consider":[300],"rate":[302],"between":[305],"measurements.":[307],"For":[308],"HCA":[310],"method,":[311],"Ward's":[312],"aggregation":[313],"performed.":[315],"Euclidean":[317],"distance":[318],"rates":[320],"semiology":[328],"method.":[329],"Lastly,":[330],"as":[331],"there":[332],"objective":[335],"criteria":[336],"define":[338],"status,":[340],"defined":[342],"our":[343],"responders":[344],"based":[345,399],"clinical":[347],"criteria.":[348],"Discussion:":[349],"princeps":[352],"study,":[353],"found":[358],"inconclusive,":[361],"likely":[362],"due":[363,428],"heterogeneity":[366,423],"population,":[369],"have":[372,390],"masked":[373],"treatment":[375],"later":[377],"identified":[378],"refined":[381],"high":[384],"Beta":[385],"Amyloid":[386],"subjects.":[387],"So,":[388],"adopted":[391],"alternative":[393],"approach":[395],"subject":[397],"stratification":[398],"their":[401],"then":[405],"patterns":[407],"similar":[409],"also":[415],"highlight":[416],"potential":[418],"problem":[419],"large":[422],"profiles,":[426],"maybe":[427],"final":[431],"considered.":[433]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2025-10-17T00:00:00"}
