{"id":"https://openalex.org/W4415264285","doi":"https://doi.org/10.21203/rs.3.rs-7693100/v1","title":"Bioactive potential of Macrocybe titans extracts: antioxidant activity, antimicrobial effects, and phenolic composition","display_name":"Bioactive potential of Macrocybe titans extracts: antioxidant activity, antimicrobial effects, and phenolic composition","publication_year":2025,"publication_date":"2025-10-16","ids":{"openalex":"https://openalex.org/W4415264285","doi":"https://doi.org/10.21203/rs.3.rs-7693100/v1"},"language":"en","primary_location":{"id":"doi:10.21203/rs.3.rs-7693100/v1","doi":"https://doi.org/10.21203/rs.3.rs-7693100/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-7693100/v1","pdf_url":"https://www.researchsquare.com/article/rs-7693100/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.researchsquare.com/article/rs-7693100/latest.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026259876","display_name":"Gabrielle Caroline Peiter","orcid":"https://orcid.org/0000-0001-7965-4434","observed_orcids":["https://orcid.org/0000-0001-7965-4434"]},"institutions":[{"id":"https://openalex.org/I52418104","display_name":"Universidade Federal do Paran\u00e1","ror":"https://ror.org/05syd6y78","country_code":"BR","type":"education","lineage":["https://openalex.org/I52418104"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Gabrielle Caroline Peiter","raw_affiliation_strings":["Federal University of Paran\u00e1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Federal University of Paran\u00e1","institution_ids":["https://openalex.org/I52418104"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023986100","display_name":"Keiti Lopes Maestre","orcid":"https://orcid.org/0000-0002-5759-4597","observed_orcids":["https://orcid.org/0000-0002-5759-4597"]},"institutions":[{"id":"https://openalex.org/I193876067","display_name":"Universidade Estadual do Oeste do Paran\u00e1","ror":"https://ror.org/05ne20t07","country_code":"BR","type":"education","lineage":["https://openalex.org/I193876067"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Keiti Lopes Maestre","raw_affiliation_strings":["State University of West Paran\u00e1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State University of West Paran\u00e1","institution_ids":["https://openalex.org/I193876067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049681291","display_name":"Thiago Cintra Maniglia","orcid":"https://orcid.org/0000-0002-8741-3777","observed_orcids":["https://orcid.org/0000-0002-8741-3777"]},"institutions":[{"id":"https://openalex.org/I1283613182","display_name":"Universidade Tecnol\u00f3gica Federal do Paran\u00e1","ror":"https://ror.org/002v2kq79","country_code":"BR","type":"education","lineage":["https://openalex.org/I1283613182"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Thiago Cintra Maniglia","raw_affiliation_strings":["Federal Technological University of Paran\u00e1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Federal Technological University of Paran\u00e1","institution_ids":["https://openalex.org/I1283613182"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047091061","display_name":"Ricardo Fiori Zara","orcid":"https://orcid.org/0000-0003-1558-8567","observed_orcids":["https://orcid.org/0000-0003-1558-8567"]},"institutions":[{"id":"https://openalex.org/I1283613182","display_name":"Universidade Tecnol\u00f3gica Federal do Paran\u00e1","ror":"https://ror.org/002v2kq79","country_code":"BR","type":"education","lineage":["https://openalex.org/I1283613182"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Ricardo Fiori Zara","raw_affiliation_strings":["Federal University of Technology - Paran\u00e1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Federal University of Technology - Paran\u00e1","institution_ids":["https://openalex.org/I1283613182"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016505477","display_name":"Gabrieli Maria Huff","orcid":"https://orcid.org/0000-0001-9943-1860","observed_orcids":["https://orcid.org/0000-0001-9943-1860"]},"institutions":[{"id":"https://openalex.org/I4405286366","display_name":"Instituto Carlos Chagas","ror":"https://ror.org/01y8gmz47","country_code":"BR","type":"government","lineage":["https://openalex.org/I4405286366","https://openalex.org/I52325"]},{"id":"https://openalex.org/I52325","display_name":"Funda\u00e7\u00e3o Oswaldo Cruz","ror":"https://ror.org/04jhswv08","country_code":"BR","type":"facility","lineage":["https://openalex.org/I52325"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Gabrieli Maria Huff","raw_affiliation_strings":["FIOCRUZ - Paran\u00e1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"FIOCRUZ - Paran\u00e1","institution_ids":["https://openalex.org/I4405286366","https://openalex.org/I52325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032624873","display_name":"Adriana Fiorini","orcid":"https://orcid.org/0000-0001-8610-5062","observed_orcids":["https://orcid.org/0000-0001-8610-5062"]},"institutions":[{"id":"https://openalex.org/I52418104","display_name":"Universidade Federal do Paran\u00e1","ror":"https://ror.org/05syd6y78","country_code":"BR","type":"education","lineage":["https://openalex.org/I52418104"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Adriana Fiorini Rosado","raw_affiliation_strings":["Federal University of Paran\u00e1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Federal University of Paran\u00e1","institution_ids":["https://openalex.org/I52418104"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035280662","display_name":"F\u00e1bio Rog\u00e9rio Rosado","orcid":"https://orcid.org/0000-0003-3056-3202","observed_orcids":["https://orcid.org/0000-0003-3056-3202"]},"institutions":[{"id":"https://openalex.org/I52418104","display_name":"Universidade Federal do Paran\u00e1","ror":"https://ror.org/05syd6y78","country_code":"BR","type":"education","lineage":["https://openalex.org/I52418104"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"F\u00e1bio Rog\u00e9rio Rosado","raw_affiliation_strings":["Federal University of Paran\u00e1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Federal University of Paran\u00e1","institution_ids":["https://openalex.org/I52418104"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022038578","display_name":"Joana A. Loureiro","orcid":"https://orcid.org/0000-0002-9841-3967","observed_orcids":["https://orcid.org/0000-0002-9841-3967"]},"institutions":[{"id":"https://openalex.org/I182534213","display_name":"Universidade do Porto","ror":"https://ror.org/043pwc612","country_code":"PT","type":"education","lineage":["https://openalex.org/I182534213"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Joana Ang\u00e9lica Loureiro","raw_affiliation_strings":["University of Porto"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Porto","institution_ids":["https://openalex.org/I182534213"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11085","display_name":"Fungal Biology and Applications","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11085","display_name":"Fungal Biology and Applications","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11613","display_name":"Phytochemistry and Biological Activities","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fungal-extracts","display_name":"fungal extracts","score":0.734000027179718},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.9649999737739563},{"id":"https://openalex.org/keywords/antimicrobial-activity","display_name":"antimicrobial activity","score":0.9940000176429749},{"id":"https://openalex.org/keywords/phenolic-compounds","display_name":"phenolic compounds","score":0.9599999785423279},{"id":"https://openalex.org/keywords/flavonoids","display_name":"flavonoids","score":0.9990000128746033},{"id":"https://openalex.org/keywords/gallic-acid","display_name":"gallic acid","score":0.8880000114440918},{"id":"https://openalex.org/keywords/chlorogenic-acid","display_name":"chlorogenic acid","score":0.9990000128746033},{"id":"https://openalex.org/keywords/catechins","display_name":"catechins","score":0.9390000104904175},{"id":"https://openalex.org/keywords/caffeic-acid","display_name":"caffeic acid","score":0.9980000257492065},{"id":"https://openalex.org/keywords/extraction-methods","display_name":"extraction methods","score":0.5709999799728394},{"id":"https://openalex.org/keywords/fungal-identification","display_name":"fungal identification","score":0.515999972820282},{"id":"https://openalex.org/keywords/its-sequences","display_name":"ITS sequences","score":0.6899999976158142},{"id":"https://openalex.org/keywords/natural-products","display_name":"natural products","score":0.5440000295639038},{"id":"https://openalex.org/keywords/functional-foods","display_name":"functional foods","score":0.8180000185966492}],"concepts":[{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.8330000042915344},{"id":"https://openalex.org/C2780117898","wikidata":"https://www.wikidata.org/wiki/Q421964","display_name":"Chlorogenic acid","level":2,"score":0.7789000272750854},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.7735000252723694},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7556999921798706},{"id":"https://openalex.org/C2778362808","wikidata":"https://www.wikidata.org/wiki/Q375837","display_name":"Gallic acid","level":3,"score":0.6851999759674072},{"id":"https://openalex.org/C2778224086","wikidata":"https://www.wikidata.org/wiki/Q414116","display_name":"Caffeic acid","level":3,"score":0.6517000198364258},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.6043000221252441},{"id":"https://openalex.org/C4725764","wikidata":"https://www.wikidata.org/wiki/Q844704","display_name":"Extraction (chemistry)","level":2,"score":0.5332000255584717},{"id":"https://openalex.org/C67031304","wikidata":"https://www.wikidata.org/wiki/Q274579","display_name":"Preservative","level":2,"score":0.4514000117778778},{"id":"https://openalex.org/C40231798","wikidata":"https://www.wikidata.org/wiki/Q1333743","display_name":"Composition (language)","level":2,"score":0.4122999906539917},{"id":"https://openalex.org/C176947019","wikidata":"https://www.wikidata.org/wiki/Q597889","display_name":"Minimum inhibitory concentration","level":3,"score":0.39969998598098755},{"id":"https://openalex.org/C2993907526","wikidata":"https://www.wikidata.org/wiki/Q1259977","display_name":"Aqueous extract","level":2,"score":0.3765999972820282},{"id":"https://openalex.org/C184651966","wikidata":"https://www.wikidata.org/wiki/Q906356","display_name":"Aqueous solution","level":2,"score":0.3734999895095825},{"id":"https://openalex.org/C149849071","wikidata":"https://www.wikidata.org/wiki/Q1263816","display_name":"Chemical composition","level":2,"score":0.33570000529289246},{"id":"https://openalex.org/C70899900","wikidata":"https://www.wikidata.org/wiki/Q290439","display_name":"Polyphenol","level":3,"score":0.3319999873638153},{"id":"https://openalex.org/C2776474821","wikidata":"https://www.wikidata.org/wiki/Q83093","display_name":"Mushroom","level":2,"score":0.3028999865055084},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.2994999885559082},{"id":"https://openalex.org/C116073593","wikidata":"https://www.wikidata.org/wiki/Q864491","display_name":"Biological activity","level":3,"score":0.26420000195503235},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.25760000944137573}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21203/rs.3.rs-7693100/v1","doi":"https://doi.org/10.21203/rs.3.rs-7693100/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-7693100/v1","pdf_url":"https://www.researchsquare.com/article/rs-7693100/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-7693100/v1","doi":"https://doi.org/10.21203/rs.3.rs-7693100/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-7693100/v1","pdf_url":"https://www.researchsquare.com/article/rs-7693100/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1279857300","display_name":null,"funder_award_id":"10.54499/LA/P/0045/2020","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G2680426100","display_name":"ALICE - Laborat\u00f3rio Associado em Engenharia Qu\u00edmica","funder_award_id":"LA/P/0045/2020","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G3537227798","display_name":null,"funder_award_id":"LA/P/0045","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G4737455006","display_name":"Laborat\u00f3rio de Engenharia de Processos, Ambiente, Biotecnologia e Energia","funder_award_id":"UIDB/00511/2020","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G5088119131","display_name":null,"funder_award_id":"UIDB/0 0511/2020","funder_id":"https://openalex.org/F4320323642","funder_display_name":"Minist\u00e9rio da Ci\u00eancia, Tecnologia e Ensino Superior"},{"id":"https://openalex.org/G5538107981","display_name":null,"funder_award_id":"UIDP/00511/2020","funder_id":"https://openalex.org/F4320323642","funder_display_name":"Minist\u00e9rio da Ci\u00eancia, Tecnologia e Ensino Superior"},{"id":"https://openalex.org/G5606619412","display_name":"Laborat\u00f3rio de Engenharia de Processos, Ambiente, Biotecnologia e Energia","funder_award_id":"UIDP/00511/2020","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G6701175450","display_name":null,"funder_award_id":"LA/P/0045/2020","funder_id":"https://openalex.org/F4320323642","funder_display_name":"Minist\u00e9rio da Ci\u00eancia, Tecnologia e Ensino Superior"},{"id":"https://openalex.org/G6997658380","display_name":null,"funder_award_id":"10.54499","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"}],"funders":[{"id":"https://openalex.org/F4320323642","display_name":"Minist\u00e9rio da Ci\u00eancia, Tecnologia e Ensino Superior","ror":"https://ror.org/045b9pr88"},{"id":"https://openalex.org/F4320334779","display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","ror":"https://ror.org/00snfqn58"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4415264285.pdf","grobid_xml":"https://content.openalex.org/works/W4415264285.grobid-xml"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W1470932523","https://openalex.org/W1942494909","https://openalex.org/W1965606785","https://openalex.org/W2043516022","https://openalex.org/W2057401312","https://openalex.org/W2070662757","https://openalex.org/W2097706568","https://openalex.org/W2127039838","https://openalex.org/W2138720929","https://openalex.org/W2189235816","https://openalex.org/W2202819904","https://openalex.org/W2340372406","https://openalex.org/W2343177674","https://openalex.org/W2481711331","https://openalex.org/W2586534281","https://openalex.org/W2592338368","https://openalex.org/W2779019546","https://openalex.org/W2790991431","https://openalex.org/W2799524357","https://openalex.org/W2887907392","https://openalex.org/W2939676850","https://openalex.org/W2996794214","https://openalex.org/W4224939781","https://openalex.org/W4313494663","https://openalex.org/W4376132769","https://openalex.org/W4387033258","https://openalex.org/W4400451273"],"related_works":["https://openalex.org/W7204469307","https://openalex.org/W4376132769","https://openalex.org/W7163549927","https://openalex.org/W2794030564","https://openalex.org/W4205970987","https://openalex.org/W7120348154","https://openalex.org/W2887907392","https://openalex.org/W2189235816","https://openalex.org/W7137023754","https://openalex.org/W4367311326"],"abstract_inverted_index":{"Abstract":[0],"This":[1],"study":[2],"investigated":[3],"the":[4,13,52,57,88,98,145,153,161],"antioxidant":[5,166],"and":[6,25,38,44,62,76,103,111,137,151,165],"antimicrobial":[7,65,164],"properties":[8],"of":[9,100,128,147,155,163],"extracts":[10],"obtained":[11],"from":[12],"giant":[14],"mushroom":[15],"Macrocybe":[16],"titans":[17,123],".":[18],"Fungal":[19],"isolates":[20],"were":[21,34],"identified":[22,115],"through":[23,46],"molecular":[24],"phylogenetic":[26],"analyses":[27],"based":[28],"on":[29],"ITS":[30],"rDNA":[31],"sequencing.":[32],"Extracts":[33],"prepared":[35],"using":[36],"aqueous":[37,53],"organic":[39],"solvents":[40],"(acetone,":[41],"isopropanol,":[42],"ethanol,":[43],"methanol)":[45],"different":[47],"extraction":[48,59],"methods.":[49],"Among":[50],"these,":[51],"extract":[54],"(AgSk)":[55],"showed":[56],"highest":[58],"efficiency":[60],"(44.8%)":[61],"demonstrated":[63],"remarkable":[64],"potential,":[66],"as":[67,114,124,158],"evidenced":[68],"by":[69,116],"its":[70],"low":[71],"minimum":[72,77],"inhibitory":[73],"concentration":[74,79],"(MIC)":[75],"bactericidal":[78],"(MBC)":[80],"values.":[81],"Antioxidant":[82],"activity":[83],"was":[84],"also":[85],"detected":[86],"across":[87],"extracts,":[89],"further":[90],"supporting":[91],"their":[92],"bioactivity.":[93],"Chemical":[94],"composition":[95],"analysis":[96],"revealed":[97],"presence":[99],"phenolic":[101],"compounds":[102],"flavonoids,":[104],"including":[105],"gallic":[106],"acid,":[107,109,113],"chlorogenic":[108],"catechin,":[110],"caffeic":[112],"UHPLC-DAD.":[117],"Together,":[118],"these":[119],"findings":[120],"highlight":[121],"M.":[122],"a":[125],"promising":[126],"source":[127],"bioactive":[129],"molecules":[130],"with":[131],"potential":[132],"applications":[133],"in":[134],"pharmaceutical":[135],"formulations":[136],"functional":[138],"foods.":[139],"The":[140],"results":[141],"contribute":[142],"to":[143],"expanding":[144],"knowledge":[146],"unexplored":[148],"fungal":[149],"species":[150],"support":[152],"valorization":[154],"natural":[156],"products":[157],"alternatives":[159],"for":[160],"development":[162],"agents.":[167]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2025-10-17T00:00:00"}