{"id":"https://openalex.org/W4415261069","doi":"https://doi.org/10.71221/ajp.09308","title":"Evaluation of hypolipidemic and hypoglycemic effects of Dillenia indica L. on alloxan-induced diabetic rats","display_name":"Evaluation of hypolipidemic and hypoglycemic effects of Dillenia indica L. on alloxan-induced diabetic rats","publication_year":2025,"publication_date":"2025-09-30","ids":{"openalex":"https://openalex.org/W4415261069","doi":"https://doi.org/10.71221/ajp.09308"},"language":"en","primary_location":{"id":"doi:10.71221/ajp.09308","doi":"https://doi.org/10.71221/ajp.09308","is_oa":true,"landing_page_url":"https://doi.org/10.71221/ajp.09308","pdf_url":"https://doi.org/10.71221/ajp.09308","source":{"id":"https://openalex.org/S5406929631","display_name":"Asian Journal of Pharmacognosy","issn_l":"0128-1119","issn":["0128-1119"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Asian Journal of Pharmacognosy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://doi.org/10.71221/ajp.09308","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113408183","display_name":"Md Mahfuj Alam Siddiq","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Md Mahfuj Alam Siddiq","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113425589","display_name":"Jeasmin Akter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200606013","display_name":"Daffodil International University","ror":"https://ror.org/052t4a858","country_code":"BD","type":"education","lineage":["https://openalex.org/I200606013"]}],"countries":["BD"],"is_corresponding":false,"raw_author_name":"Jeasmin Akter","raw_affiliation_strings":["Department of Pharmacy , Faculty of Health and Life Sciences , Daffodil International University , Bangladesh ;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy , Faculty of Health and Life Sciences , Daffodil International University , Bangladesh ;","institution_ids":["https://openalex.org/I200606013"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112635837","display_name":"Zakia Sultana Sathi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4392738091","display_name":"Emory National Primate Research Center","ror":"https://ror.org/038kr2d80","country_code":null,"type":"facility","lineage":["https://openalex.org/I150468666","https://openalex.org/I4392738091"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zakia Sultana Sathi","raw_affiliation_strings":["Department of Neuropharmacology & Neurologic Diseases , Emory Primate Research Centre , Emory University , United States;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuropharmacology & Neurologic Diseases , Emory Primate Research Centre , Emory University , United States;","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I4392738091"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102883393","display_name":"Md Ruhul Kuddus","orcid":"https://orcid.org/0000-0002-7038-3399","observed_orcids":["https://orcid.org/0000-0002-7038-3399"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Md. Ruhul Kuddus","raw_affiliation_strings":["Phytochemical Research Laboratory , Department of Pharmaceutical Chemistry ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Phytochemical Research Laboratory , Department of Pharmaceutical Chemistry ,","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085255814","display_name":"Mohammad A Rashid","orcid":"https://orcid.org/0000-0003-1464-7115","observed_orcids":["https://orcid.org/0000-0003-1464-7115"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mohammad A. Rashid","raw_affiliation_strings":["Phytochemical Research Laboratory , Department of Pharmaceutical Chemistry ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Phytochemical Research Laboratory , Department of Pharmaceutical Chemistry ,","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.31441245,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"9","issue":"3","first_page":"1","last_page":"11"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11140","display_name":"Natural Antidiabetic Agents Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11140","display_name":"Natural Antidiabetic Agents Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dillenia-indica","display_name":"Dillenia indica","score":1.0},{"id":"https://openalex.org/keywords/antidiabetic-activity","display_name":"antidiabetic activity","score":0.8600000143051147},{"id":"https://openalex.org/keywords/hypoglycemic-effect","display_name":"hypoglycemic effect","score":0.9039999842643738},{"id":"https://openalex.org/keywords/lipid-lowering-effect","display_name":"hypolipidemic effect","score":0.972000002861023},{"id":"https://openalex.org/keywords/alloxan-induced-diabetes","display_name":"alloxan-induced diabetes","score":0.9120000004768372},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9959999918937683},{"id":"https://openalex.org/keywords/chloroform-fraction","display_name":"chloroform fraction","score":0.8769999742507935},{"id":"https://openalex.org/keywords/fruit-extract","display_name":"fruit extract","score":0.902999997138977},{"id":"https://openalex.org/keywords/bark-extract","display_name":"bark extract","score":0.9990000128746033},{"id":"https://openalex.org/keywords/fasting-blood-glucose","display_name":"fasting blood glucose","score":0.8209999799728394},{"id":"https://openalex.org/keywords/total-cholesterol","display_name":"total cholesterol","score":0.7689999938011169},{"id":"https://openalex.org/keywords/triglycerides","display_name":"triglycerides","score":0.9950000047683716},{"id":"https://openalex.org/keywords/dyslipidemia","display_name":"dyslipidemia","score":0.8119999766349792},{"id":"https://openalex.org/keywords/metformin-comparison","display_name":"metformin comparison","score":0.6610000133514404},{"id":"https://openalex.org/keywords/natural-medicine","display_name":"natural medicine","score":0.4490000009536743}],"concepts":[{"id":"https://openalex.org/C195475562","wikidata":"https://www.wikidata.org/wiki/Q1639139","display_name":"Phytochemical","level":2,"score":0.6610000133514404},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.6208999752998352},{"id":"https://openalex.org/C133446333","wikidata":"https://www.wikidata.org/wiki/Q38681","display_name":"Bark (sound)","level":2,"score":0.5789999961853027},{"id":"https://openalex.org/C2778913445","wikidata":"https://www.wikidata.org/wiki/Q186319","display_name":"Triglyceride","level":3,"score":0.5454999804496765},{"id":"https://openalex.org/C2778096610","wikidata":"https://www.wikidata.org/wiki/Q1476525","display_name":"Dyslipidemia","level":3,"score":0.5139999985694885},{"id":"https://openalex.org/C2781144210","wikidata":"https://www.wikidata.org/wiki/Q172275","display_name":"Chloroform","level":2,"score":0.4851999878883362},{"id":"https://openalex.org/C2780323712","wikidata":"https://www.wikidata.org/wiki/Q19484","display_name":"Metformin","level":3,"score":0.40720000863075256},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3919000029563904},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.35749998688697815},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.350600004196167},{"id":"https://openalex.org/C2780159080","wikidata":"https://www.wikidata.org/wiki/Q1400536","display_name":"Intraperitoneal injection","level":2,"score":0.3449999988079071},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.33079999685287476},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.31130000948905945},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30219998955726624},{"id":"https://openalex.org/C206103511","wikidata":"https://www.wikidata.org/wiki/Q426694","display_name":"Terpenoid","level":2,"score":0.29670000076293945},{"id":"https://openalex.org/C160492267","wikidata":"https://www.wikidata.org/wiki/Q319616","display_name":"Pharmacognosy","level":4,"score":0.2888999879360199},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.2831000089645386},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2809999883174896},{"id":"https://openalex.org/C2779969877","wikidata":"https://www.wikidata.org/wiki/Q861699","display_name":"Phytotherapy","level":3,"score":0.2799000144004822},{"id":"https://openalex.org/C104488531","wikidata":"https://www.wikidata.org/wiki/Q864212","display_name":"Bioassay","level":2,"score":0.26820001006126404},{"id":"https://openalex.org/C2779280383","wikidata":"https://www.wikidata.org/wiki/Q257331","display_name":"Streptozotocin","level":3,"score":0.2624000012874603},{"id":"https://openalex.org/C2779158651","wikidata":"https://www.wikidata.org/wiki/Q188840","display_name":"Medicinal plants","level":2,"score":0.25859999656677246},{"id":"https://openalex.org/C2781005915","wikidata":"https://www.wikidata.org/wiki/Q417701","display_name":"Alloxan","level":3,"score":0.25200000405311584}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.71221/ajp.09308","doi":"https://doi.org/10.71221/ajp.09308","is_oa":true,"landing_page_url":"https://doi.org/10.71221/ajp.09308","pdf_url":"https://doi.org/10.71221/ajp.09308","source":{"id":"https://openalex.org/S5406929631","display_name":"Asian Journal of Pharmacognosy","issn_l":"0128-1119","issn":["0128-1119"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Asian Journal of Pharmacognosy","raw_type":"journal-article"},{"id":"pmh:oai:commons.case.edu:studentworks-1680","doi":null,"is_oa":false,"landing_page_url":"https://commons.case.edu/studentworks/678","pdf_url":null,"source":{"id":"https://openalex.org/S7407064353","display_name":"Scholarly Commons @ Case Western Reserve University","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Student Scholarship","raw_type":"text"}],"best_oa_location":{"id":"doi:10.71221/ajp.09308","doi":"https://doi.org/10.71221/ajp.09308","is_oa":true,"landing_page_url":"https://doi.org/10.71221/ajp.09308","pdf_url":"https://doi.org/10.71221/ajp.09308","source":{"id":"https://openalex.org/S5406929631","display_name":"Asian Journal of Pharmacognosy","issn_l":"0128-1119","issn":["0128-1119"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Asian Journal of Pharmacognosy","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4415261069.pdf","grobid_xml":"https://content.openalex.org/works/W4415261069.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Context:":[0],"Dillenia":[1],"indica":[2,53,91,149,216],"L.":[3],"a":[4,59,83,190,228],"tropical":[5],"fruit-bearing":[6],"plant":[7],"native":[8],"to":[9,19,43,199],"South":[10],"and":[11,24,33,48,55,93,120,139,172,177,197,202,207,221,235],"Southeast":[12],"Asia,":[13],"has":[14],"attracted":[15],"scientific":[16],"interest":[17],"due":[18],"its":[20,225],"rich":[21],"phytochemical":[22],"composition":[23],"potential":[25,46],"therapeutic":[26,230],"benefits":[27],"in":[28,58,71,237],"managing":[29,233],"diabetes,":[30],"lipid":[31],"disorders,":[32],"oxidative":[34],"stress.":[35],"Objective:":[36],"The":[37,86,144,211,241],"objective":[38],"of":[39,51,62,77,89,125,135,147,164,214,244],"this":[40],"study":[41],"was":[42,69],"investigate":[44],"the":[45,106,126,133,162,169,182,245],"antidiabetic":[47,220],"lipid-lowering":[49,222],"properties":[50],"D.":[52,90,148,215],"fruit":[54,92,150,217],"bark":[56,94,183,246],"extracts":[57],"rat":[60],"model":[61],"alloxan-induced":[63],"type":[64,238],"2":[65,239],"diabetes.":[66,240],"Methods:":[67],"Diabetes":[68],"induced":[70],"rats":[72],"using":[73],"an":[74],"intraperitoneal":[75],"injection":[76],"alloxan":[78],"monohydrate":[79],"(160":[80],"mg/kg)":[81,96,103],"after":[82,157],"12-hour":[84],"fast.":[85],"chloroform":[87,145,212],"fractions":[88],"(200":[95],"were":[97,114,130],"administered":[98],"intraperitoneally,":[99],"with":[100],"metformin":[101],"(150":[102],"serving":[104],"as":[105,227],"standard":[107],"drug.":[108],"Fasting":[109],"blood":[110,128],"glucose":[111],"(FBG)":[112],"levels":[113,154,174,204],"measured":[115],"at":[116,194],"0,":[117],"24,":[118],"40,":[119],"50":[121,158,195],"hours.":[122],"Upon":[123],"completion":[124],"experiment,":[127],"samples":[129],"collected":[131],"for":[132,232],"evaluation":[134],"total":[136],"cholesterol":[137],"(TC)":[138],"triglyceride":[140],"(TG)":[141],"levels.":[142],"Results:":[143],"fraction":[146,213],"significantly":[151],"reduced":[152],"FBG":[153,187],"by":[155,175,205],"65%":[156],"hours,":[159],"closely":[160],"matching":[161],"effect":[163],"metformin.":[165],"It":[166],"also":[167],"decreased":[168],"elevated":[170],"TC":[171,201],"TG":[173,203],"60%":[176],"55%,":[178],"respectively.":[179,209],"In":[180],"contrast,":[181],"extract":[184,247],"initially":[185],"lowered":[186],"but":[188],"caused":[189],"30%":[191],"rebound":[192],"increase":[193],"hours":[196],"led":[198],"increased":[200],"28%":[206],"54%,":[208],"Conclusion:":[210],"demonstrates":[218],"potent":[219],"activity,":[223],"indicating":[224],"promise":[226],"natural":[229],"agent":[231],"hyperglycemia":[234],"dyslipidemia":[236],"inconsistent":[242],"effects":[243],"warrant":[248],"further":[249],"investigation.":[250]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2025-10-17T00:00:00"}