{"id":"https://openalex.org/W4415249649","doi":"https://doi.org/10.3389/fcell.2025.1687816","title":"Enhanced tenogenic potential of tendon-derived mesenchymal stem cells: transcriptomic profiling and in vivo validation","display_name":"Enhanced tenogenic potential of tendon-derived mesenchymal stem cells: transcriptomic profiling and in vivo validation","publication_year":2025,"publication_date":"2025-10-16","ids":{"openalex":"https://openalex.org/W4415249649","doi":"https://doi.org/10.3389/fcell.2025.1687816","pmid":"https://pubmed.ncbi.nlm.nih.gov/41181702","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12574453"},"language":"en","primary_location":{"id":"doi:10.3389/fcell.2025.1687816","doi":"https://doi.org/10.3389/fcell.2025.1687816","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcell.2025.1687816","pdf_url":null,"source":{"id":"https://openalex.org/S2596924766","display_name":"Frontiers in Cell and Developmental Biology","issn_l":"2296-634X","issn":["2296-634X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cell and Developmental Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3389/fcell.2025.1687816","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050068379","display_name":"H Almabruk Khaled","orcid":"https://orcid.org/0000-0003-4138-3688","observed_orcids":["https://orcid.org/0000-0003-4138-3688","https://orcid.org/0009-0005-8391-9235"]},"institutions":[{"id":"https://openalex.org/I80611190","display_name":"Jeonbuk National University","ror":"https://ror.org/05q92br09","country_code":"KR","type":"education","lineage":["https://openalex.org/I80611190"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hadeer Khaled","raw_affiliation_strings":["Laboratory of Veterinary Pathology and Biosafety Research Institute, College of Veterinary Medicine, Jeonbuk National University, Iksan, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Veterinary Pathology and Biosafety Research Institute, College of Veterinary Medicine, Jeonbuk National University, Iksan, Republic of Korea","institution_ids":["https://openalex.org/I80611190"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057884963","display_name":"Mohammed Zayed","orcid":"https://orcid.org/0000-0002-3361-0943","observed_orcids":["https://orcid.org/0000-0002-3361-0943"]},"institutions":[{"id":"https://openalex.org/I189575948","display_name":"South Valley University","ror":"https://ror.org/00jxshx33","country_code":"EG","type":"education","lineage":["https://openalex.org/I189575948"]},{"id":"https://openalex.org/I80611190","display_name":"Jeonbuk National University","ror":"https://ror.org/05q92br09","country_code":"KR","type":"education","lineage":["https://openalex.org/I80611190"]}],"countries":["EG","KR"],"is_corresponding":false,"raw_author_name":"Mohammed Zayed","raw_affiliation_strings":["Department of Bioactive Material Sciences, Jeonbuk National University, Jeonju, Republic of Korea","Department of Surgery, College of Veterinary Medicine, South Valley University, Qena, Egypt","Korea Zoonosis Research Institute, Jeonbuk National University, Iksan, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioactive Material Sciences, Jeonbuk National University, Jeonju, Republic of Korea","institution_ids":["https://openalex.org/I80611190"]},{"raw_affiliation_string":"Department of Surgery, College of Veterinary Medicine, South Valley University, Qena, Egypt","institution_ids":["https://openalex.org/I189575948"]},{"raw_affiliation_string":"Korea Zoonosis Research Institute, Jeonbuk National University, Iksan, Republic of Korea","institution_ids":["https://openalex.org/I80611190"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034673378","display_name":"Bumseok Kim","orcid":"https://orcid.org/0000-0003-0392-2513","observed_orcids":["https://orcid.org/0000-0003-0392-2513"]},"institutions":[{"id":"https://openalex.org/I80611190","display_name":"Jeonbuk National University","ror":"https://ror.org/05q92br09","country_code":"KR","type":"education","lineage":["https://openalex.org/I80611190"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Bumseok Kim","raw_affiliation_strings":["Laboratory of Veterinary Pathology and Biosafety Research Institute, College of Veterinary Medicine, Jeonbuk National University, Iksan, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Veterinary Pathology and Biosafety Research Institute, College of Veterinary Medicine, Jeonbuk National University, Iksan, Republic of Korea","institution_ids":["https://openalex.org/I80611190"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090580336","display_name":"Byung\u2010Hoon Jeong","orcid":"https://orcid.org/0000-0002-4525-9994","observed_orcids":["https://orcid.org/0000-0002-4525-9994"]},"institutions":[{"id":"https://openalex.org/I80611190","display_name":"Jeonbuk National University","ror":"https://ror.org/05q92br09","country_code":"KR","type":"education","lineage":["https://openalex.org/I80611190"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Byung-Hoon Jeong","raw_affiliation_strings":["Department of Bioactive Material Sciences, Jeonbuk National University, Jeonju, Republic of Korea","Korea Zoonosis Research Institute, Jeonbuk National University, Iksan, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioactive Material Sciences, Jeonbuk National University, Jeonju, Republic of Korea","institution_ids":["https://openalex.org/I80611190"]},{"raw_affiliation_string":"Korea Zoonosis Research Institute, Jeonbuk National University, Iksan, Republic of Korea","institution_ids":["https://openalex.org/I80611190"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040367880","display_name":"Sang\u2010Ik Oh","orcid":"https://orcid.org/0000-0003-0877-9170","observed_orcids":["https://orcid.org/0000-0003-0877-9170"]},"institutions":[{"id":"https://openalex.org/I80611190","display_name":"Jeonbuk National University","ror":"https://ror.org/05q92br09","country_code":"KR","type":"education","lineage":["https://openalex.org/I80611190"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Sang-Ik Oh","raw_affiliation_strings":["Laboratory of Veterinary Pathology and Biosafety Research Institute, College of Veterinary Medicine, Jeonbuk National University, Iksan, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Veterinary Pathology and Biosafety Research Institute, College of Veterinary Medicine, Jeonbuk National University, Iksan, Republic of Korea","institution_ids":["https://openalex.org/I80611190"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5040367880","https://openalex.org/A5090580336"],"corresponding_institution_ids":["https://openalex.org/I80611190"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":4.2221,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.93132712,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"13","issue":null,"first_page":"1687816","last_page":"1687816"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11068","display_name":"Tendon Structure and Treatment","score":0.7973999977111816,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11068","display_name":"Tendon Structure and Treatment","score":0.7973999977111816,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.19789999723434448,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11570","display_name":"Periodontal Regeneration and Treatments","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tenogenic-differentiation","display_name":"tenogenic differentiation","score":0.824999988079071},{"id":"https://openalex.org/keywords/tendon-regeneration","display_name":"tendon regeneration","score":0.8980000019073486},{"id":"https://openalex.org/keywords/achilles-tendon-injury","display_name":"Achilles tendon injury","score":0.9160000085830688},{"id":"https://openalex.org/keywords/bone-marrow-derived-mesenchymal-stem-cells","display_name":"bone marrow-derived mesenchymal stem cells","score":0.9800000190734863},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.9409999847412109},{"id":"https://openalex.org/keywords/type-i-collagen","display_name":"type I collagen","score":0.7210000157356262},{"id":"https://openalex.org/keywords/chondrogenic-differentiation","display_name":"chondrogenic differentiation","score":0.6899999976158142},{"id":"https://openalex.org/keywords/stem-cell-therapy","display_name":"stem cell therapy","score":0.5519999861717224}],"concepts":[{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.801800012588501},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.7275000214576721},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6341999769210815},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5641999840736389},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.5218999981880188},{"id":"https://openalex.org/C10854531","wikidata":"https://www.wikidata.org/wiki/Q1061415","display_name":"Regenerative medicine","level":3,"score":0.5113999843597412},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.5095999836921692},{"id":"https://openalex.org/C35496256","wikidata":"https://www.wikidata.org/wiki/Q5104524","display_name":"Chondrogenesis","level":3,"score":0.46950000524520874},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.39660000801086426},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.36160001158714294},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3458000123500824},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.32199999690055847},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.30140000581741333},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.27970001101493835},{"id":"https://openalex.org/C2780105995","wikidata":"https://www.wikidata.org/wiki/Q232358","display_name":"Tendon","level":2,"score":0.2793999910354614},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2712000012397766}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3389/fcell.2025.1687816","doi":"https://doi.org/10.3389/fcell.2025.1687816","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcell.2025.1687816","pdf_url":null,"source":{"id":"https://openalex.org/S2596924766","display_name":"Frontiers in Cell and Developmental Biology","issn_l":"2296-634X","issn":["2296-634X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cell and Developmental Biology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12574453","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12574453/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12574453/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Cell Dev Biol","raw_type":"Text"},{"id":"pmh:oai:europepmc.org:11383974","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12574453","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:41181702","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41181702","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in cell and developmental biology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:b2103e2df9b34257a0f48d0d0c63ffe3","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/b2103e2df9b34257a0f48d0d0c63ffe3","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Cell and Developmental Biology, Vol 13 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fcell.2025.1687816","doi":"https://doi.org/10.3389/fcell.2025.1687816","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcell.2025.1687816","pdf_url":null,"source":{"id":"https://openalex.org/S2596924766","display_name":"Frontiers in Cell and Developmental Biology","issn_l":"2296-634X","issn":["2296-634X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cell and Developmental Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9789000153541565,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320328992","display_name":"Jeonbuk National University","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4415249649.pdf","grobid_xml":"https://content.openalex.org/works/W4415249649.grobid-xml"},"referenced_works_count":67,"referenced_works":["https://openalex.org/W1531684976","https://openalex.org/W1578064330","https://openalex.org/W1689855489","https://openalex.org/W1965016339","https://openalex.org/W1981509058","https://openalex.org/W1988562672","https://openalex.org/W1999851686","https://openalex.org/W2045181137","https://openalex.org/W2053173504","https://openalex.org/W2054582866","https://openalex.org/W2072790398","https://openalex.org/W2073174423","https://openalex.org/W2080646120","https://openalex.org/W2089273131","https://openalex.org/W2106268159","https://openalex.org/W2113661263","https://openalex.org/W2144081238","https://openalex.org/W2145290347","https://openalex.org/W2149982662","https://openalex.org/W2153949260","https://openalex.org/W2158837806","https://openalex.org/W2318541567","https://openalex.org/W2410448085","https://openalex.org/W2513950615","https://openalex.org/W2556167135","https://openalex.org/W2747000493","https://openalex.org/W2759281102","https://openalex.org/W2767835733","https://openalex.org/W2767933641","https://openalex.org/W2804737098","https://openalex.org/W2805329598","https://openalex.org/W2911376101","https://openalex.org/W2913366331","https://openalex.org/W2917942679","https://openalex.org/W2952194887","https://openalex.org/W2973744859","https://openalex.org/W2977785400","https://openalex.org/W2991416247","https://openalex.org/W3022093655","https://openalex.org/W3023053517","https://openalex.org/W3026136707","https://openalex.org/W3036974645","https://openalex.org/W3087737038","https://openalex.org/W3155755943","https://openalex.org/W3165009965","https://openalex.org/W3166221402","https://openalex.org/W3200106449","https://openalex.org/W3217542384","https://openalex.org/W4281706245","https://openalex.org/W4282934252","https://openalex.org/W4288084885","https://openalex.org/W4297924131","https://openalex.org/W4310055680","https://openalex.org/W4321376923","https://openalex.org/W4323364304","https://openalex.org/W4376881035","https://openalex.org/W4387422172","https://openalex.org/W4389991843","https://openalex.org/W4397289930","https://openalex.org/W4400099744","https://openalex.org/W4401433648","https://openalex.org/W4401865890","https://openalex.org/W4402207412","https://openalex.org/W4404040700","https://openalex.org/W4404599793","https://openalex.org/W4409751909","https://openalex.org/W4410380368"],"related_works":["https://openalex.org/W7152502709","https://openalex.org/W2889834342","https://openalex.org/W2287782574","https://openalex.org/W4292693590","https://openalex.org/W2935129979","https://openalex.org/W2415564049","https://openalex.org/W2952194887","https://openalex.org/W2331247169","https://openalex.org/W1934940546","https://openalex.org/W2046434476"],"abstract_inverted_index":{"Tendon":[0],"injuries":[1],"represent":[2],"a":[3,33,86,185,211],"significant":[4],"clinical":[5],"challenge":[6],"in":[7,138,182,230,265,300,303,327],"the":[8,56,76,80,130,142,308],"treatment":[9,178,253],"of":[10,38,79,83,134,144,166,176,188,220,243,248,311],"musculoskeletal":[11],"disorders":[12],"due":[13],"to":[14,41,74,227,270,293],"their":[15,39,60,97,123],"restricted":[16],"intrinsic":[17,279],"regenerative":[18,102,328],"capacity":[19,100],"and":[20,47,62,95,101,106,109,117,121,154,169,194,210,224,246,263,295,302,316],"propensity":[21],"for":[22,198,282,313,325],"scar":[23],"tissue":[24],"formation.":[25],"Tendon-derived":[26],"mesenchymal":[27],"stem":[28],"cells":[29],"(TD-MSCs)":[30],"are":[31],"considered":[32],"promising":[34],"therapeutic":[35,63,81,174,309],"approach":[36],"because":[37],"ability":[40],"differentiate":[42],"into":[43],"tenocytes,":[44],"modulate":[45],"inflammation,":[46],"secrete":[48],"trophic":[49],"factors":[50],"that":[51,205,276],"facilitate":[52],"tendon":[53,190,283,314],"regeneration.":[54],"However,":[55],"molecular":[57,77,280],"mechanisms":[58],"underlying":[59],"effects":[61],"advantages":[64,281],"over":[65],"other":[66],"MSC":[67,322],"sources":[68],"remain":[69],"unclear.":[70],"This":[71,305],"study":[72,306],"aimed":[73],"elucidate":[75],"basis":[78],"potential":[82,133,298,310],"TD-MSCs":[84,108,135,206,235,255,277,312],"through":[85],"comprehensive":[87],"transcriptomic":[88,124,213],"comparison":[89],"with":[90,163,192,215,240,254],"bone":[91],"marrow-derived":[92],"MSCs":[93],"(BM-MSCs)":[94],"evaluate":[96],"tenogenic":[98,131,221,233,244,288],"differentiation":[99,115,132,238],"efficacy.":[103],"We":[104],"isolated":[105],"characterized":[107,285],"BM-MSCs":[110,294],"using":[111,156,184],"flow":[112],"cytometry,":[113],"tri-lineage":[114],"assays,":[116],"proliferation":[118,209],"assays":[119],"(CCK-8)":[120],"examined":[122],"profiles":[125,291],"via":[126,171],"RNA":[127],"sequencing.":[128],"Subsequently,":[129],"was":[136,179],"evaluated":[137],"vitro":[139,301],"by":[140,286],"analyzing":[141],"expression":[143,218,242,290],"key":[145],"markers":[146,245],"(SCX,":[147],"COL1,":[148,168],"COL3,":[149],"TN-C,":[150],"TNMD,":[151],"DCN,":[152],"THBS-4,":[153],"SOX9)":[155],"quantitative":[157],"reverse":[158],"transcription-polymerase":[159],"chain":[160],"reaction,":[161],"along":[162],"protein":[164],"levels":[165,219],"SCX,":[167],"COL3":[170],"immunofluorescence.":[172],"The":[173,202],"efficacy":[175],"TD-MSC":[177],"further":[180],"tested":[181],"vivo":[183,252],"rat":[186],"model":[187],"Achilles":[189],"injury,":[191],"histological":[193],"immunohistochemical":[195],"analyses":[196],"performed":[197],"6":[199],"weeks":[200],"post-injection.":[201],"results":[203],"showed":[204,236],"exhibited":[207],"superior":[208,266,296],"distinct":[212],"profile,":[214],"significantly":[216],"elevated":[217],"genes":[222],"(COL1":[223],"TN-C)":[225],"compared":[226,269],"those":[228],"observed":[229],"BM-MSCs.":[231],"Following":[232],"induction,":[234],"enhanced":[237,260,287],"capacity,":[239],"increased":[241],"downregulation":[247],"chondrogenic":[249],"markers.":[250],"In":[251],"improved":[256],"collagen":[257],"fiber":[258],"organization,":[259],"structural":[261],"integrity,":[262],"resulted":[264],"healing":[267],"outcomes":[268],"untreated":[271],"controls.":[272],"These":[273],"findings":[274],"suggest":[275],"possess":[278],"repair,":[284],"gene":[289],"relative":[292],"reparative":[297],"both":[299],"vivo.":[304],"highlights":[307],"regeneration":[315],"provides":[317],"scientific":[318],"evidence":[319],"supporting":[320],"tissue-specific":[321],"selection":[323],"strategies":[324],"application":[326],"medicine.":[329]},"counts_by_year":[{"year":2026,"cited_by_count":6}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2025-10-16T00:00:00"}
