{"id":"https://openalex.org/W4415230596","doi":"https://doi.org/10.1186/s12967-025-07217-4","title":"Genomic data-driven framework for drug target discovery in atrial fibrillation","display_name":"Genomic data-driven framework for drug target discovery in atrial fibrillation","publication_year":2025,"publication_date":"2025-10-15","ids":{"openalex":"https://openalex.org/W4415230596","doi":"https://doi.org/10.1186/s12967-025-07217-4","pmid":"https://pubmed.ncbi.nlm.nih.gov/41094627","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12529848"},"language":"en","primary_location":{"id":"doi:10.1186/s12967-025-07217-4","doi":"https://doi.org/10.1186/s12967-025-07217-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12967-025-07217-4","pdf_url":"https://translational-medicine.biomedcentral.com/counter/pdf/10.1186/s12967-025-07217-4","source":{"id":"https://openalex.org/S142026636","display_name":"Journal of Translational Medicine","issn_l":"1479-5876","issn":["1479-5876"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Translational Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://translational-medicine.biomedcentral.com/counter/pdf/10.1186/s12967-025-07217-4","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101375319","display_name":"Yuhang Tao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802390878","display_name":"Sir Run Run Shaw Hospital","ror":"https://ror.org/00ka6rp58","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802390878"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuhang Tao","raw_affiliation_strings":["Department of Cardiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310016, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310016, P.R. China","institution_ids":["https://openalex.org/I2802390878","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100453185","display_name":"Qi Liu","orcid":"https://orcid.org/0000-0002-2103-0781","observed_orcids":["https://orcid.org/0000-0002-2103-0781"]},"institutions":[{"id":"https://openalex.org/I2802390878","display_name":"Sir Run Run Shaw Hospital","ror":"https://ror.org/00ka6rp58","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802390878"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qi Liu","raw_affiliation_strings":["Department of Cardiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310016, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310016, P.R. China","institution_ids":["https://openalex.org/I2802390878","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108050989","display_name":"Yuxing Wang","orcid":"https://orcid.org/0000-0002-1580-9262","observed_orcids":["https://orcid.org/0000-0002-1580-9262","https://orcid.org/0009-0001-3987-6750","https://orcid.org/0009-0003-9190-8734","https://orcid.org/0009-0005-9649-4459","https://orcid.org/0009-0007-6593-0523","https://orcid.org/0009-0008-1085-8330","https://orcid.org/0009-0008-4862-9613","https://orcid.org/0000-0001-6085-5615","https://orcid.org/0000-0001-7151-2706","https://orcid.org/0000-0001-8302-5518","https://orcid.org/0000-0001-8328-7569","https://orcid.org/0000-0001-9156-0377","https://orcid.org/0000-0001-9613-6372","https://orcid.org/0000-0002-0012-4455","https://orcid.org/0000-0002-0394-140X","https://orcid.org/0000-0002-0763-1513","https://orcid.org/0000-0002-1131-238X","https://orcid.org/0000-0002-1743-6383","https://orcid.org/0000-0002-1842-339X","https://orcid.org/0000-0002-5620-2328","https://orcid.org/0000-0002-6216-791X","https://orcid.org/0000-0002-7546-2096","https://orcid.org/0000-0002-8141-0858","https://orcid.org/0000-0002-8970-6856","https://orcid.org/0000-0003-0066-6454","https://orcid.org/0000-0003-0695-8861","https://orcid.org/0000-0003-0800-8990","https://orcid.org/0000-0003-1157-2234","https://orcid.org/0000-0003-1521-8232","https://orcid.org/0000-0003-2622-8989","https://orcid.org/0000-0003-2749-7793","https://orcid.org/0009-0000-0458-5120","https://orcid.org/0009-0000-1339-8458","https://orcid.org/0009-0001-0348-0666","https://orcid.org/0009-0001-3428-0763","https://orcid.org/0009-0001-4636-5916","https://orcid.org/0009-0001-5987-383X","https://orcid.org/0009-0001-9894-7141","https://orcid.org/0009-0002-8960-8225","https://orcid.org/0009-0002-9941-8054","https://orcid.org/0009-0003-3811-7044","https://orcid.org/0009-0003-4201-4830","https://orcid.org/0009-0003-5386-7273","https://orcid.org/0009-0003-8483-5733","https://orcid.org/0009-0003-9808-4715","https://orcid.org/0009-0004-9066-2258","https://orcid.org/0009-0005-1069-045X","https://orcid.org/0009-0005-3481-5165","https://orcid.org/0009-0005-9041-3646","https://orcid.org/0009-0006-0079-0470","https://orcid.org/0009-0006-2445-819X","https://orcid.org/0009-0006-4724-950X","https://orcid.org/0009-0006-6200-4279","https://orcid.org/0009-0007-0640-6238","https://orcid.org/0009-0008-2822-2488","https://orcid.org/0009-0008-7110-6722","https://orcid.org/0009-0008-8173-6349","https://orcid.org/0009-0009-3338-1309","https://orcid.org/0009-0009-3939-3458","https://orcid.org/0009-0009-9717-8481","https://orcid.org/0009-0007-8833-2497"]},"institutions":[{"id":"https://openalex.org/I2802390878","display_name":"Sir Run Run Shaw Hospital","ror":"https://ror.org/00ka6rp58","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802390878"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuxing Wang","raw_affiliation_strings":["Department of Emergency Medicine, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310016, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency Medicine, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310016, P.R. China","institution_ids":["https://openalex.org/I2802390878","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012301152","display_name":"Ruhong Jiang","orcid":"https://orcid.org/0000-0002-1698-2286","observed_orcids":["https://orcid.org/0000-0002-1698-2286"]},"institutions":[{"id":"https://openalex.org/I2802390878","display_name":"Sir Run Run Shaw Hospital","ror":"https://ror.org/00ka6rp58","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802390878"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ruhong Jiang","raw_affiliation_strings":["Department of Cardiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310016, P.R. China. jrh@zju.edu.cn","Department of Cardiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310016, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310016, P.R. China. jrh@zju.edu.cn","institution_ids":["https://openalex.org/I2802390878","https://openalex.org/I76130692"]},{"raw_affiliation_string":"Department of Cardiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310016, P.R. China","institution_ids":["https://openalex.org/I2802390878","https://openalex.org/I76130692"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100323947","display_name":"Kai Zhang","orcid":"https://orcid.org/0000-0002-2747-3962","observed_orcids":["https://orcid.org/0000-0002-2747-3962","https://orcid.org/0000-0002-6562-870X"]},"institutions":[{"id":"https://openalex.org/I2802390878","display_name":"Sir Run Run Shaw Hospital","ror":"https://ror.org/00ka6rp58","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802390878"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Kai Zhang","raw_affiliation_strings":["Department of Cardiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310016, P.R. China. 3321038@zju.edu.cn","Department of Cardiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310016, P.R. China"],"raw_orcid":"https://orcid.org/0000-0002-2747-3962","affiliations":[{"raw_affiliation_string":"Department of Cardiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310016, P.R. China. 3321038@zju.edu.cn","institution_ids":["https://openalex.org/I2802390878","https://openalex.org/I76130692"]},{"raw_affiliation_string":"Department of Cardiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310016, P.R. China","institution_ids":["https://openalex.org/I2802390878","https://openalex.org/I76130692"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5012301152","https://openalex.org/A5100323947"],"corresponding_institution_ids":["https://openalex.org/I2802390878","https://openalex.org/I76130692"],"apc_list":{"value":3890,"currency":"USD","value_usd":3890},"apc_paid":{"value":3890,"currency":"USD","value_usd":3890},"fwci":2.8936,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.918496,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"23","issue":"1","first_page":"1110","last_page":"1110"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.6567000150680542,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.6567000150680542,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10065","display_name":"Atrial Fibrillation Management and Outcomes","score":0.19760000705718994,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.12870000302791595,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/atrial-fibrillation","display_name":"atrial fibrillation","score":1.0},{"id":"https://openalex.org/keywords/drug-target-identification","display_name":"drug target identification","score":0.8560000061988831},{"id":"https://openalex.org/keywords/genetic-risk-variants","display_name":"genetic risk variants","score":0.8650000095367432},{"id":"https://openalex.org/keywords/novel-genetic-loci","display_name":"novel genetic loci","score":0.6209999918937683},{"id":"https://openalex.org/keywords/expression-quantitative-trait-loci","display_name":"expression quantitative trait loci","score":0.8119999766349792},{"id":"https://openalex.org/keywords/transcriptome-wide-association-study","display_name":"transcriptome-wide association study","score":0.9350000023841858},{"id":"https://openalex.org/keywords/protein-quantitative-trait-loci","display_name":"protein quantitative trait loci","score":0.9229999780654907},{"id":"https://openalex.org/keywords/genetic-correlation","display_name":"genetic correlation","score":0.7129999995231628},{"id":"https://openalex.org/keywords/mendelian-randomization","display_name":"Mendelian randomization","score":0.800000011920929},{"id":"https://openalex.org/keywords/protein-colocalization","display_name":"protein colocalization","score":0.7720000147819519},{"id":"https://openalex.org/keywords/druggability","display_name":"druggability","score":0.7200000286102295},{"id":"https://openalex.org/keywords/cardiomyocytes","display_name":"cardiomyocytes","score":0.8420000076293945},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.984000027179718},{"id":"https://openalex.org/keywords/myocardial-fibrosis","display_name":"myocardial fibrosis","score":0.8859999775886536},{"id":"https://openalex.org/keywords/cardiac-hypertrophy","display_name":"cardiac hypertrophy","score":0.8560000061988831},{"id":"https://openalex.org/keywords/heart-development","display_name":"heart development","score":0.777999997138977}],"concepts":[{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.6736000180244446},{"id":"https://openalex.org/C168393362","wikidata":"https://www.wikidata.org/wiki/Q5421706","display_name":"Expression quantitative trait loci","level":5,"score":0.6029999852180481},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5666999816894531},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5512999892234802},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.5108000040054321},{"id":"https://openalex.org/C2779901538","wikidata":"https://www.wikidata.org/wiki/Q6816584","display_name":"Mendelian randomization","level":5,"score":0.5037999749183655},{"id":"https://openalex.org/C81941488","wikidata":"https://www.wikidata.org/wiki/Q853421","display_name":"Quantitative trait locus","level":3,"score":0.4880000054836273},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.46540001034736633},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.44339999556541443},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.41589999198913574},{"id":"https://openalex.org/C69991583","wikidata":"https://www.wikidata.org/wiki/Q1423575","display_name":"Candidate gene","level":3,"score":0.40950000286102295},{"id":"https://openalex.org/C10679952","wikidata":"https://www.wikidata.org/wiki/Q5308937","display_name":"Druggability","level":3,"score":0.39660000801086426},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.36410000920295715},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.3375999927520752},{"id":"https://openalex.org/C68873052","wikidata":"https://www.wikidata.org/wiki/Q349856","display_name":"Genetic variation","level":3,"score":0.32359999418258667},{"id":"https://openalex.org/C170734499","wikidata":"https://www.wikidata.org/wiki/Q1152227","display_name":"Pharmacogenomics","level":2,"score":0.3149000108242035},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.30720001459121704},{"id":"https://openalex.org/C55775858","wikidata":"https://www.wikidata.org/wiki/Q1152227","display_name":"Pharmacogenetics","level":4,"score":0.30660000443458557},{"id":"https://openalex.org/C64869954","wikidata":"https://www.wikidata.org/wiki/Q1859747","display_name":"False positive paradox","level":2,"score":0.3050000071525574},{"id":"https://openalex.org/C104397665","wikidata":"https://www.wikidata.org/wiki/Q860947","display_name":"Proteome","level":2,"score":0.3021000027656555},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.2994999885559082},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.2840999960899353},{"id":"https://openalex.org/C2779161974","wikidata":"https://www.wikidata.org/wiki/Q815819","display_name":"Atrial fibrillation","level":2,"score":0.2761000096797943},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.2662000060081482},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.2590999901294708},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.2540000081062317},{"id":"https://openalex.org/C9927688","wikidata":"https://www.wikidata.org/wiki/Q4915012","display_name":"Biological pathway","level":4,"score":0.2522999942302704},{"id":"https://openalex.org/C2989108626","wikidata":"https://www.wikidata.org/wiki/Q904407","display_name":"Drug target","level":2,"score":0.251800000667572},{"id":"https://openalex.org/C16671776","wikidata":"https://www.wikidata.org/wiki/Q5420592","display_name":"Exome sequencing","level":4,"score":0.2508000135421753}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001281","descriptor_name":"Atrial Fibrillation","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001281","descriptor_name":"Atrial Fibrillation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D040641","descriptor_name":"Quantitative Trait Loci","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D058990","descriptor_name":"Molecular Targeted Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12967-025-07217-4","doi":"https://doi.org/10.1186/s12967-025-07217-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12967-025-07217-4","pdf_url":"https://translational-medicine.biomedcentral.com/counter/pdf/10.1186/s12967-025-07217-4","source":{"id":"https://openalex.org/S142026636","display_name":"Journal of Translational Medicine","issn_l":"1479-5876","issn":["1479-5876"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Translational Medicine","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:11337963","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12529848","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:41094627","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41094627","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of translational medicine","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:44baeb6f133e4baebf2d91500f095bc2","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/44baeb6f133e4baebf2d91500f095bc2","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Translational Medicine, Vol 23, Iss 1, Pp 1-16 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12967-025-07217-4","doi":"https://doi.org/10.1186/s12967-025-07217-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12967-025-07217-4","pdf_url":"https://translational-medicine.biomedcentral.com/counter/pdf/10.1186/s12967-025-07217-4","source":{"id":"https://openalex.org/S142026636","display_name":"Journal of Translational Medicine","issn_l":"1479-5876","issn":["1479-5876"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Translational Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G3880359340","display_name":null,"funder_award_id":"82200343","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4635042470","display_name":null,"funder_award_id":"82200434","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320327235","display_name":"Servier","ror":"https://ror.org/034e7c066"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4415230596.pdf","grobid_xml":"https://content.openalex.org/works/W4415230596.grobid-xml"},"referenced_works_count":86,"referenced_works":["https://openalex.org/W181831398","https://openalex.org/W1533942137","https://openalex.org/W1597890814","https://openalex.org/W1977897249","https://openalex.org/W1983977742","https://openalex.org/W1988231248","https://openalex.org/W2003508302","https://openalex.org/W2012896813","https://openalex.org/W2030842103","https://openalex.org/W2047592374","https://openalex.org/W2051314902","https://openalex.org/W2070515279","https://openalex.org/W2073836327","https://openalex.org/W2076073579","https://openalex.org/W2118822739","https://openalex.org/W2133520037","https://openalex.org/W2153860431","https://openalex.org/W2172100956","https://openalex.org/W2264585211","https://openalex.org/W2277397529","https://openalex.org/W2317267184","https://openalex.org/W2617679519","https://openalex.org/W2729948611","https://openalex.org/W2743198652","https://openalex.org/W2751767740","https://openalex.org/W2770092353","https://openalex.org/W2799530220","https://openalex.org/W2884743521","https://openalex.org/W2930987887","https://openalex.org/W2943309532","https://openalex.org/W2951249671","https://openalex.org/W2954095901","https://openalex.org/W2956538253","https://openalex.org/W3005071382","https://openalex.org/W3005544936","https://openalex.org/W3023891555","https://openalex.org/W3036755425","https://openalex.org/W3049272392","https://openalex.org/W3093632264","https://openalex.org/W3096435635","https://openalex.org/W3097798638","https://openalex.org/W3098263601","https://openalex.org/W3106143834","https://openalex.org/W3162254480","https://openalex.org/W3164663864","https://openalex.org/W3181803629","https://openalex.org/W3196241093","https://openalex.org/W3210958990","https://openalex.org/W4200495872","https://openalex.org/W4200624717","https://openalex.org/W4223534056","https://openalex.org/W4225689602","https://openalex.org/W4225764473","https://openalex.org/W4229031518","https://openalex.org/W4232277679","https://openalex.org/W4282829878","https://openalex.org/W4284976235","https://openalex.org/W4296588716","https://openalex.org/W4312051959","https://openalex.org/W4313423887","https://openalex.org/W4317366348","https://openalex.org/W4317390883","https://openalex.org/W4321612502","https://openalex.org/W4377195976","https://openalex.org/W4383720502","https://openalex.org/W4384198172","https://openalex.org/W4385680719","https://openalex.org/W4386630416","https://openalex.org/W4387190728","https://openalex.org/W4387344289","https://openalex.org/W4389742478","https://openalex.org/W4390562012","https://openalex.org/W4391566278","https://openalex.org/W4392292548","https://openalex.org/W4396721167","https://openalex.org/W4399790764","https://openalex.org/W4401327490","https://openalex.org/W4403280564","https://openalex.org/W4403454552","https://openalex.org/W4403680192","https://openalex.org/W4403836779","https://openalex.org/W4404501626","https://openalex.org/W4405693525","https://openalex.org/W4407107176","https://openalex.org/W4407567612","https://openalex.org/W4412399293"],"related_works":["https://openalex.org/W2807295499","https://openalex.org/W4410699067","https://openalex.org/W4400568785","https://openalex.org/W4403145802","https://openalex.org/W4412201767","https://openalex.org/W7025290383","https://openalex.org/W4401327490","https://openalex.org/W7127677975","https://openalex.org/W7071899108","https://openalex.org/W3134662101"],"abstract_inverted_index":{"BACKGROUND:":[0],"Atrial":[1],"fibrillation":[2],"(AF)":[3],"is":[4,12],"the":[5,28,39,60,100,112,140,145,209,216,259,265,270,299],"most":[6,262],"common":[7],"type":[8],"of":[9,18,30,41,50,70,170,261,283,304],"arrhythmia":[10],"and":[11,21,62,115,121,132,156,204,218,231,246,301,314],"linked":[13,286],"to":[14,65,126,287,317],"an":[15],"increased":[16],"risk":[17,167],"death,":[19],"stroke,":[20],"other":[22],"complications.":[23],"Although":[24],"studies":[25,64],"have":[26],"explored":[27],"pathophysiology":[29],"AF,":[31,192],"its":[32],"genetic":[33,68,90,200,300],"mechanisms":[34],"remain":[35],"poorly":[36],"understood,":[37],"limiting":[38],"development":[40,320],"effective":[42],"treatments.":[43],"METHODS:":[44],"We":[45,134,306],"conducted":[46,94,136],"a":[47,84,181],"large-scale":[48],"meta-analysis":[49,161],"genome-wide":[51,164],"association":[52,86,183],"study":[53,294],"(GWAS)":[54],"data":[55,110],"from":[56,111],"1,347,178":[57],"participants":[58],"in":[59,215,244,258,264],"FinnGen":[61],"Nielsen":[63],"identify":[66],"novel":[67,73],"variants":[69],"AF.":[71,133,305,323],"The":[72,88,248],"genes":[74,177,211,240,263],"were":[75,93,103,124,172,178,188,212],"validated":[76],"by":[77,180],"expression":[78,154,203,260],"quantitative":[79,107,249],"trait":[80,108],"loci":[81,109],"(eQTLs)":[82],"using":[83],"transcriptome-wide":[85,182],"study.":[87,184],"cross-phenotype":[89],"correlation":[91],"analyses":[92,123,206],"for":[95,139,322],"our":[96,308],"new":[97,296],"GWAS.":[98],"Afterward,":[99],"GWAS":[101],"results":[102,236,254],"integrated":[104],"with":[105,118,191,193,198,221,269],"protein":[106],"UK":[113],"Biobank,":[114],"Mendelian":[116],"randomization":[117],"postselection":[119],"inference":[120],"colocalization":[122,197],"used":[125],"infer":[127],"causal":[128],"relationships":[129],"between":[130],"proteins":[131,187],"also":[135],"downstream":[137],"analysis":[138],"identified":[141,179,210,277],"genes,":[142],"including":[143],"querying":[144],"Mouse":[146],"Genome":[147],"Informatics":[148],"database,":[149],"gene":[150,153],"enrichment":[151,205],"analysis,":[152,155,275],"druggability":[157,274],"assessment.":[158],"RESULTS:":[159],"Our":[160],"revealed":[162,207,237,255],"244":[163],"significant":[165,256],"AF":[166,199,266,279],"variants,":[168],"77":[169],"which":[171,284],"novel.":[173],"In":[174],"total,":[175],"372":[176],"Additionally,":[185],"155":[186],"significantly":[189],"associated":[190],"28":[194],"showing":[195],"strong":[196],"signals.":[201],"Gene":[202],"that":[208,238],"predominantly":[213],"expressed":[214,242],"heart":[217],"blood":[219],"vessels,":[220],"related":[222],"biological":[223],"pathways":[224],"such":[225],"as":[226],"cardiac":[227],"development,":[228],"myocardial":[229],"hypertrophy":[230],"fibrosis.":[232],"Single-nucleus":[233],"RNA":[234],"sequencing":[235],"these":[239],"are":[241,285],"mainly":[243],"cardiomyocytes":[245],"macrophages.":[247],"real-time":[250],"polymerase":[251],"chain":[252],"reaction":[253],"changes":[257],"group":[267],"compared":[268],"control":[271],"group.":[272],"Through":[273],"we":[276],"potential":[278],"drug":[280,319],"targets,":[281],"some":[282],"approved":[288],"or":[289],"clinical-stage":[290],"drugs.":[291],"CONCLUSION:":[292],"This":[293],"provides":[295],"insights":[297],"into":[298],"proteomic":[302],"basis":[303],"hope":[307],"findings":[309],"will":[310],"inspire":[311],"further":[312],"research":[313],"preclinical":[315],"work":[316],"advance":[318],"programs":[321]},"counts_by_year":[{"year":2026,"cited_by_count":5}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2025-10-16T00:00:00"}
