{"id":"https://openalex.org/W4415212987","doi":"https://doi.org/10.1158/0008-5472.can-25-3623","title":"Editor\u2019s Note: MDR1 Synonymous Polymorphisms Alter Transporter Specificity and Protein Stability in a Stable Epithelial Monolayer","display_name":"Editor\u2019s Note: MDR1 Synonymous Polymorphisms Alter Transporter Specificity and Protein Stability in a Stable Epithelial Monolayer","publication_year":2025,"publication_date":"2025-10-15","ids":{"openalex":"https://openalex.org/W4415212987","doi":"https://doi.org/10.1158/0008-5472.can-25-3623","pmid":"https://pubmed.ncbi.nlm.nih.gov/41088880"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.can-25-3623","doi":"https://doi.org/10.1158/0008-5472.can-25-3623","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-25-3623","pdf_url":"https://aacrjournals.org/cancerres/article-pdf/85/20/4037/3658481/can-25-3623.pdf","source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://aacrjournals.org/cancerres/article-pdf/85/20/4037/3658481/can-25-3623.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005110089","display_name":"King Leung Fung","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"King Leung Fung","raw_affiliation_strings":["Cancer Res 2025;85:4037","85:4037"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Res 2025;85:4037","institution_ids":[]},{"raw_affiliation_string":"85:4037","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079730813","display_name":"James Pan","orcid":"https://orcid.org/0000-0002-2789-8629","observed_orcids":["https://orcid.org/0000-0002-2789-8629"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"James Pan","raw_affiliation_strings":["Cancer Res 2025;85:4037","85:4037"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Res 2025;85:4037","institution_ids":[]},{"raw_affiliation_string":"85:4037","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053003549","display_name":"Shinobu Ohnuma","orcid":"https://orcid.org/0000-0002-0205-8957","observed_orcids":["https://orcid.org/0000-0002-0205-8957"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shinobu Ohnuma","raw_affiliation_strings":["Cancer Res 2025;85:4037","85:4037"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Res 2025;85:4037","institution_ids":[]},{"raw_affiliation_string":"85:4037","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010714060","display_name":"Paul E. Lund","orcid":"https://orcid.org/0000-0003-0496-1434","observed_orcids":["https://orcid.org/0000-0003-0496-1434"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paul E. Lund","raw_affiliation_strings":["Cancer Res 2025;85:4037","85:4037"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Res 2025;85:4037","institution_ids":[]},{"raw_affiliation_string":"85:4037","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052729241","display_name":"Jessica N. Pixley","orcid":"https://orcid.org/0000-0001-9049-1808","observed_orcids":["https://orcid.org/0000-0001-9049-1808"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jessica N. Pixley","raw_affiliation_strings":["Cancer Res 2025;85:4037","85:4037"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Res 2025;85:4037","institution_ids":[]},{"raw_affiliation_string":"85:4037","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035292060","display_name":"Chava Kimchi\u2010Sarfaty","orcid":"https://orcid.org/0000-0002-9355-8585","observed_orcids":["https://orcid.org/0000-0002-9355-8585"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chava Kimchi-Sarfaty","raw_affiliation_strings":["Cancer Res 2025;85:4037","85:4037"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Res 2025;85:4037","institution_ids":[]},{"raw_affiliation_string":"85:4037","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081938413","display_name":"Suresh V. Ambudkar","orcid":"https://orcid.org/0000-0002-2639-4955","observed_orcids":["https://orcid.org/0000-0002-2639-4955"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Suresh V. Ambudkar","raw_affiliation_strings":["Cancer Res 2025;85:4037","85:4037"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Res 2025;85:4037","institution_ids":[]},{"raw_affiliation_string":"85:4037","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030334751","display_name":"Michael M. Gottesman","orcid":"https://orcid.org/0000-0001-8908-2097","observed_orcids":["https://orcid.org/0000-0001-8908-2097"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael M. Gottesman","raw_affiliation_strings":["Cancer Res 2025;85:4037","85:4037"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Res 2025;85:4037","institution_ids":[]},{"raw_affiliation_string":"85:4037","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.28409581,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"85","issue":"20","first_page":"4037","last_page":"4037"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mdr1","display_name":"MDR1","score":0.9750000238418579},{"id":"https://openalex.org/keywords/p-glycoprotein","display_name":"P-glycoprotein","score":0.8769999742507935},{"id":"https://openalex.org/keywords/synonymous-polymorphism","display_name":"synonymous polymorphism","score":0.8610000014305115},{"id":"https://openalex.org/keywords/transporter-specificity","display_name":"transporter specificity","score":0.8669999837875366},{"id":"https://openalex.org/keywords/protein-stability","display_name":"protein stability","score":0.996999979019165},{"id":"https://openalex.org/keywords/epithelial-monolayers","display_name":"epithelial monolayers","score":0.9110000133514404},{"id":"https://openalex.org/keywords/multidrug-resistance","display_name":"multidrug resistance","score":0.8349999785423279}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6104000210762024},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4307999908924103},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.426800012588501},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.42669999599456787},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3569999933242798},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3546999990940094},{"id":"https://openalex.org/C529295009","wikidata":"https://www.wikidata.org/wiki/Q41301","display_name":"Epithelium","level":2,"score":0.34060001373291016},{"id":"https://openalex.org/C149011108","wikidata":"https://www.wikidata.org/wiki/Q652985","display_name":"Transporter","level":3,"score":0.3253999948501587},{"id":"https://openalex.org/C2988375501","wikidata":"https://www.wikidata.org/wiki/Q847556","display_name":"Protein stability","level":2,"score":0.31049999594688416},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3073999881744385},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.29919999837875366},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.29809999465942383},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.29100000858306885},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.27160000801086426},{"id":"https://openalex.org/C7070889","wikidata":"https://www.wikidata.org/wiki/Q902488","display_name":"Monolayer","level":2,"score":0.2685999870300293},{"id":"https://openalex.org/C144647389","wikidata":"https://www.wikidata.org/wiki/Q423042","display_name":"Membrane protein","level":3,"score":0.266400009393692},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2578999996185303}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1158/0008-5472.can-25-3623","doi":"https://doi.org/10.1158/0008-5472.can-25-3623","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-25-3623","pdf_url":"https://aacrjournals.org/cancerres/article-pdf/85/20/4037/3658481/can-25-3623.pdf","source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},{"id":"pmid:41088880","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41088880","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Published Erratum"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.can-25-3623","doi":"https://doi.org/10.1158/0008-5472.can-25-3623","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-25-3623","pdf_url":"https://aacrjournals.org/cancerres/article-pdf/85/20/4037/3658481/can-25-3623.pdf","source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.504800021648407}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4415212987.pdf","grobid_xml":"https://content.openalex.org/works/W4415212987.grobid-xml"},"referenced_works_count":1,"referenced_works":["https://openalex.org/W2149454816"],"related_works":[],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-16T00:00:00"}