{"id":"https://openalex.org/W4415211359","doi":"https://doi.org/10.1101/2025.10.14.682334","title":"Distinct neurophysiological features and memory representations along the long axis of the developing medial temporal lobe","display_name":"Distinct neurophysiological features and memory representations along the long axis of the developing medial temporal lobe","publication_year":2025,"publication_date":"2025-10-14","ids":{"openalex":"https://openalex.org/W4415211359","doi":"https://doi.org/10.1101/2025.10.14.682334","pmid":"https://pubmed.ncbi.nlm.nih.gov/41279595","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12632991"},"language":"en","primary_location":{"id":"doi:10.1101/2025.10.14.682334","doi":"https://doi.org/10.1101/2025.10.14.682334","is_oa":false,"landing_page_url":"https://doi.org/10.1101/2025.10.14.682334","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12632991/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103026173","display_name":"Qin Yin","orcid":"https://orcid.org/0000-0003-1345-9905","observed_orcids":["https://orcid.org/0000-0003-1345-9905"]},"institutions":[{"id":"https://openalex.org/I162577319","display_name":"The University of Texas at Dallas","ror":"https://ror.org/049emcs32","country_code":"US","type":"education","lineage":["https://openalex.org/I162577319"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Qin Yin","raw_affiliation_strings":["University of Texas at Dallas"],"raw_orcid":"https://orcid.org/0000-0003-1345-9905","affiliations":[{"raw_affiliation_string":"University of Texas at Dallas","institution_ids":["https://openalex.org/I162577319"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012617444","display_name":"Adam J. O. Dede","orcid":"https://orcid.org/0000-0002-3619-4631","observed_orcids":["https://orcid.org/0000-0002-3619-4631"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]},{"id":"https://openalex.org/I4210100400","display_name":"Northwestern University","ror":"https://ror.org/00m6w7z96","country_code":"PH","type":"education","lineage":["https://openalex.org/I4210100400"]}],"countries":["PH","US"],"is_corresponding":false,"raw_author_name":"Adam J.O. Dede","raw_affiliation_strings":["Departments of Medical Social Science and Neurology, Northwestern University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medical Social Science and Neurology, Northwestern University","institution_ids":["https://openalex.org/I111979921","https://openalex.org/I4210100400"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039414463","display_name":"Robert Thomas Knight","orcid":"https://orcid.org/0000-0001-8686-1685","observed_orcids":["https://orcid.org/0000-0001-8686-1685"]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert T. Knight","raw_affiliation_strings":["Departments of Psychology and Neuroscience and the Helen Wills Neuroscience Institute, University of California, Berkeley"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Psychology and Neuroscience and the Helen Wills Neuroscience Institute, University of California, Berkeley","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001566787","display_name":"Eishi Asano","orcid":"https://orcid.org/0000-0001-8391-4067","observed_orcids":["https://orcid.org/0000-0001-8391-4067"]},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]},{"id":"https://openalex.org/I4210130818","display_name":"Children's Hospital of Michigan","ror":"https://ror.org/0429x9p85","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800326109","https://openalex.org/I4210130818"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eishi Asano","raw_affiliation_strings":["Children's Hospital of Michigan, Wayne State University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Hospital of Michigan, Wayne State University","institution_ids":["https://openalex.org/I185443292","https://openalex.org/I4210130818"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075223867","display_name":"Elizabeth L. Johnson","orcid":"https://orcid.org/0000-0001-5297-5019","observed_orcids":["https://orcid.org/0000-0001-5297-5019"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]},{"id":"https://openalex.org/I4210100400","display_name":"Northwestern University","ror":"https://ror.org/00m6w7z96","country_code":"PH","type":"education","lineage":["https://openalex.org/I4210100400"]}],"countries":["PH","US"],"is_corresponding":false,"raw_author_name":"Elizabeth L. Johnson","raw_affiliation_strings":["Departments of Medical Social Science, Pediatrics, and Psychology, Northwestern University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medical Social Science, Pediatrics, and Psychology, Northwestern University","institution_ids":["https://openalex.org/I111979921","https://openalex.org/I4210100400"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045847024","display_name":"Noa Ofen","orcid":"https://orcid.org/0000-0003-3927-8408","observed_orcids":["https://orcid.org/0000-0003-3927-8408"]},"institutions":[{"id":"https://openalex.org/I162577319","display_name":"The University of Texas at Dallas","ror":"https://ror.org/049emcs32","country_code":"US","type":"education","lineage":["https://openalex.org/I162577319"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Noa Ofen","raw_affiliation_strings":["University of Texas at Dallas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas at Dallas","institution_ids":["https://openalex.org/I162577319"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5103026173"],"corresponding_institution_ids":["https://openalex.org/I162577319"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10918","display_name":"Memory Processes and Influences","score":0.010400000028312206,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.006000000052154064,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/medial-temporal-lobe","display_name":"medial temporal lobe","score":0.9490000009536743},{"id":"https://openalex.org/keywords/episodic-memory","display_name":"episodic memory","score":0.8709999918937683},{"id":"https://openalex.org/keywords/memory-formation","display_name":"memory formation","score":0.6129999756813049},{"id":"https://openalex.org/keywords/high-frequency-oscillations","display_name":"high-frequency oscillations","score":0.8019999861717224},{"id":"https://openalex.org/keywords/theta-oscillations","display_name":"theta oscillations","score":0.9729999899864197},{"id":"https://openalex.org/keywords/phase-amplitude-coupling","display_name":"phase-amplitude coupling","score":0.9679999947547913},{"id":"https://openalex.org/keywords/visual-scene-recognition","display_name":"visual scene recognition","score":0.7919999957084656},{"id":"https://openalex.org/keywords/scene-classification","display_name":"scene classification","score":0.7110000252723694},{"id":"https://openalex.org/keywords/memory-representation","display_name":"memory representation","score":0.36399999260902405},{"id":"https://openalex.org/keywords/pediatric-epilepsy","display_name":"pediatric epilepsy","score":0.6119999885559082},{"id":"https://openalex.org/keywords/electrocorticography","display_name":"electrocorticography","score":0.7950000166893005},{"id":"https://openalex.org/keywords/brain-development","display_name":"brain development","score":0.39800000190734863}],"concepts":[{"id":"https://openalex.org/C152478114","wikidata":"https://www.wikidata.org/wiki/Q660910","display_name":"Neurophysiology","level":2,"score":0.671999990940094},{"id":"https://openalex.org/C2781099131","wikidata":"https://www.wikidata.org/wiki/Q744385","display_name":"Temporal lobe","level":3,"score":0.6700000166893005},{"id":"https://openalex.org/C197914299","wikidata":"https://www.wikidata.org/wiki/Q18650","display_name":"Semantic memory","level":3,"score":0.6521999835968018},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.6233999729156494},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5896000266075134},{"id":"https://openalex.org/C88576662","wikidata":"https://www.wikidata.org/wiki/Q18646","display_name":"Episodic memory","level":3,"score":0.5149000287055969},{"id":"https://openalex.org/C90269970","wikidata":"https://www.wikidata.org/wiki/Q7302606","display_name":"Recognition memory","level":3,"score":0.5131999850273132},{"id":"https://openalex.org/C178278151","wikidata":"https://www.wikidata.org/wiki/Q7936607","display_name":"Visual memory","level":3,"score":0.45239999890327454},{"id":"https://openalex.org/C112049663","wikidata":"https://www.wikidata.org/wiki/Q18608","display_name":"Explicit memory","level":4,"score":0.40799999237060547},{"id":"https://openalex.org/C43729271","wikidata":"https://www.wikidata.org/wiki/Q3560550","display_name":"Spatial memory","level":4,"score":0.39809998869895935},{"id":"https://openalex.org/C26760741","wikidata":"https://www.wikidata.org/wiki/Q160402","display_name":"Perception","level":2,"score":0.3977000117301941},{"id":"https://openalex.org/C180747234","wikidata":"https://www.wikidata.org/wiki/Q23373","display_name":"Cognitive psychology","level":1,"score":0.38260000944137573},{"id":"https://openalex.org/C2776359362","wikidata":"https://www.wikidata.org/wiki/Q2145286","display_name":"Representation (politics)","level":3,"score":0.3686999976634979},{"id":"https://openalex.org/C2993858690","wikidata":"https://www.wikidata.org/wiki/Q744385","display_name":"Temporal cortex","level":2,"score":0.35370001196861267},{"id":"https://openalex.org/C148089829","wikidata":"https://www.wikidata.org/wiki/Q18608","display_name":"Declarative memory","level":3,"score":0.34610000252723694},{"id":"https://openalex.org/C2775858120","wikidata":"https://www.wikidata.org/wiki/Q3333604","display_name":"Memoria","level":3,"score":0.3278999924659729},{"id":"https://openalex.org/C522805319","wikidata":"https://www.wikidata.org/wiki/Q179965","display_name":"Electroencephalography","level":2,"score":0.3160000145435333},{"id":"https://openalex.org/C93424556","wikidata":"https://www.wikidata.org/wiki/Q1080996","display_name":"Sensory memory","level":4,"score":0.31189998984336853},{"id":"https://openalex.org/C24590219","wikidata":"https://www.wikidata.org/wiki/Q18601","display_name":"Long-term memory","level":3,"score":0.31060001254081726},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.3066999912261963},{"id":"https://openalex.org/C178253425","wikidata":"https://www.wikidata.org/wiki/Q162668","display_name":"Visual perception","level":3,"score":0.2985000014305115},{"id":"https://openalex.org/C50231774","wikidata":"https://www.wikidata.org/wiki/Q639842","display_name":"Brain mapping","level":2,"score":0.2833000123500824},{"id":"https://openalex.org/C21963081","wikidata":"https://www.wikidata.org/wiki/Q11337567","display_name":"Working memory","level":3,"score":0.2750000059604645},{"id":"https://openalex.org/C129692064","wikidata":"https://www.wikidata.org/wiki/Q1771886","display_name":"Clinical neurophysiology","level":3,"score":0.27140000462532043},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.2662000060081482},{"id":"https://openalex.org/C15686315","wikidata":"https://www.wikidata.org/wiki/Q18614","display_name":"Implicit memory","level":3,"score":0.2637999951839447},{"id":"https://openalex.org/C103539492","wikidata":"https://www.wikidata.org/wiki/Q18648","display_name":"Neuroanatomy of memory","level":5,"score":0.2599000036716461}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1101/2025.10.14.682334","doi":"https://doi.org/10.1101/2025.10.14.682334","is_oa":false,"landing_page_url":"https://doi.org/10.1101/2025.10.14.682334","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:41279595","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41279595","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12632991","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12632991/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:12632991","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12632991/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.504800021648407,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G9000880723","display_name":"Development of Memory Networks in Children","funder_award_id":"R01MH107512","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4213210874","https://openalex.org/W39106841","https://openalex.org/W2490873048","https://openalex.org/W162909833","https://openalex.org/W4403375807","https://openalex.org/W2141086446","https://openalex.org/W2491596617","https://openalex.org/W3209134663","https://openalex.org/W3046652432","https://openalex.org/W2790486804"],"abstract_inverted_index":{"The":[0,30,77],"medial":[1],"temporal":[2],"lobe":[3],"(MTL)":[4],"is":[5,20],"crucial":[6],"for":[7],"episodic":[8],"memory,":[9],"whereby":[10],"posterior":[11,88,98,115,134],"MTL":[12,19,39,74,99,135,147,172,191],"preferentially":[13],"represents":[14],"visuospatial":[15],"information,":[16],"and":[17,89,100,124,153,199],"anterior":[18,90,110,146,171],"involved":[21],"in":[22,36,96,108,113,144],"the":[23,37,66,73,87,97,109,114,131,145,168,185,189,195],"representation":[24,196],"of":[25,33,69,79,120,133,163,170,188,197],"semantic":[26],"or":[27],"conceptual":[28,200],"information.":[29],"neurophysiological":[31,67,182],"underpinnings":[32,68],"content-preferential":[34],"organization":[35],"developing":[38,190],"are":[40],"largely":[41],"unknown.":[42],"Here":[43],"we":[44],"utilized":[45],"rare":[46],"electrocorticography":[47],"(ECoG)":[48],"recordings":[49],"from":[50],"23":[51],"pediatric":[52],"epilepsy":[53],"patients":[54],"who":[55],"completed":[56],"a":[57],"visual":[58],"scene":[59,94,102,106,158],"recognition":[60],"memory":[61,70,122,128,138,151,165,176,203],"task":[62],"to":[63,127,137,150,175],"systematically":[64],"examine":[65],"formation":[71,123],"along":[72,184],"long":[75],"axis.":[76],"timing":[78],"high-frequency":[80],"activity":[81],"(HFA,":[82],"~70-150":[83],"Hz)":[84],"differed":[85],"between":[86],"MTL,":[91,116],"peaking":[92],"after":[93],"onset":[95],"around":[101],"category":[103,159],"response":[104],"(indoor/outdoor":[105],"categorization)":[107],"MTL.":[111],"Further,":[112],"HFA":[117,136],"was":[118,148,161],"predictive":[119,162],"successful":[121,164],"positively":[125],"linked":[126,149],"performance,":[129,152],"highlighting":[130,167],"importance":[132,169],"formation.":[139,177,204],"In":[140],"contrast,":[141],"theta":[142,173],"frequency":[143],"theta-HFA":[154],"phase-amplitude":[155],"coupling":[156],"before":[157],"responses":[160],"formation,":[166],"oscillations":[174],"Our":[178],"findings":[179],"establish":[180],"distinct":[181],"features":[183],"posterior-to-anterior":[186],"axis":[187],"that":[192],"differentially":[193],"support":[194],"perceptual":[198],"information":[201],"during":[202]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2025-10-16T00:00:00"}