{"id":"https://openalex.org/W4415203271","doi":"https://doi.org/10.1101/2025.10.14.682312","title":"IRG1/itaconate/NRF2/GSH axis in tumor-associated macrophages drives therapy resistance and immune evasion in BRCA1-deficient breast cancer","display_name":"IRG1/itaconate/NRF2/GSH axis in tumor-associated macrophages drives therapy resistance and immune evasion in BRCA1-deficient breast cancer","publication_year":2025,"publication_date":"2025-10-15","ids":{"openalex":"https://openalex.org/W4415203271","doi":"https://doi.org/10.1101/2025.10.14.682312","pmid":"https://pubmed.ncbi.nlm.nih.gov/41279612","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12633074"},"language":"en","primary_location":{"id":"doi:10.1101/2025.10.14.682312","doi":"https://doi.org/10.1101/2025.10.14.682312","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.10.14.682312","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2025/10/15/2025.10.14.682312.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2025/10/15/2025.10.14.682312.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002676333","display_name":"Yabing Nan","orcid":"https://orcid.org/0000-0001-8744-9617","observed_orcids":["https://orcid.org/0000-0001-8744-9617"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yabing Nan","raw_affiliation_strings":["Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA","Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA","Dana-Farber Cancer Institute"],"raw_orcid":"https://orcid.org/0000-0001-8744-9617","affiliations":[{"raw_affiliation_string":"Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Dana-Farber Cancer Institute","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104183139","display_name":"Sophie O'Keefe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4390039272","display_name":"University of Virginia Cancer Center","ror":"https://ror.org/04w75nz84","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039272"]},{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sophie O\u2019keefe","raw_affiliation_strings":["Department of Microbiology, Immunology & Cancer Biology, University of Virginia School of Medicine, Charlottesville, VA, USA","University of Virginia Comprehensive Cancer Center, Charlottesville, VA, USA","University of Virginia School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Immunology & Cancer Biology, University of Virginia School of Medicine, Charlottesville, VA, USA","institution_ids":["https://openalex.org/I51556381"]},{"raw_affiliation_string":"University of Virginia Comprehensive Cancer Center, Charlottesville, VA, USA","institution_ids":["https://openalex.org/I4390039272"]},{"raw_affiliation_string":"University of Virginia School of Medicine","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101317438","display_name":"Xiadi He","orcid":"https://orcid.org/0009-0001-8171-9505","observed_orcids":["https://orcid.org/0009-0001-8171-9505"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2801556517","display_name":"Ruijin Hospital","ror":"https://ror.org/01hv94n30","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801556517"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiadi He","raw_affiliation_strings":["Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, National Clinical Research Center for Metabolic Diseases (Shanghai), Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Lifecycle Health Management Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China","Shanghai Jiao Tong University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, National Clinical Research Center for Metabolic Diseases (Shanghai), Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Lifecycle Health Management Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2801556517"]},{"raw_affiliation_string":"Shanghai Jiao Tong University School of Medicine","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102935494","display_name":"Qingyu Luo","orcid":"https://orcid.org/0000-0003-4164-637X","observed_orcids":["https://orcid.org/0000-0003-4164-637X"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qingyu Luo","raw_affiliation_strings":["Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA","One Patient One Cure, Boston, MA, USA","Dana-Farber Cancer Institute"],"raw_orcid":"https://orcid.org/0000-0003-4164-637X","affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453"]},{"raw_affiliation_string":"One Patient One Cure, Boston, MA, USA","institution_ids":[]},{"raw_affiliation_string":"Dana-Farber Cancer Institute","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100617567","display_name":"Xiaowei Wu","orcid":"https://orcid.org/0000-0003-4176-7198","observed_orcids":["https://orcid.org/0000-0003-4176-7198"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaowei Wu","raw_affiliation_strings":["Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA","Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA","Dana-Farber Cancer Institute"],"raw_orcid":"https://orcid.org/0000-0003-4176-7198","affiliations":[{"raw_affiliation_string":"Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Dana-Farber Cancer Institute","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056760841","display_name":"Jing Ni","orcid":"https://orcid.org/0000-0002-4229-775X","observed_orcids":["https://orcid.org/0000-0002-4229-775X"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jing Ni","raw_affiliation_strings":["Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA","Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA","Dana Farber Cancer Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Dana Farber Cancer Institute","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048093999","display_name":"Yutian Zou","orcid":"https://orcid.org/0000-0002-5205-9923","observed_orcids":["https://orcid.org/0000-0002-5205-9923"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yutian Zou","raw_affiliation_strings":["Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA","Dana-Farber Cancer Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Dana-Farber Cancer Institute","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jerryd Marcus Meade","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4390039272","display_name":"University of Virginia Cancer Center","ror":"https://ror.org/04w75nz84","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039272"]},{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jerryd Marcus Meade","raw_affiliation_strings":["Department of Microbiology, Immunology & Cancer Biology, University of Virginia School of Medicine, Charlottesville, VA, USA","University of Virginia Comprehensive Cancer Center, Charlottesville, VA, USA","University of Virginia School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Immunology & Cancer Biology, University of Virginia School of Medicine, Charlottesville, VA, USA","institution_ids":["https://openalex.org/I51556381"]},{"raw_affiliation_string":"University of Virginia Comprehensive Cancer Center, Charlottesville, VA, USA","institution_ids":["https://openalex.org/I4390039272"]},{"raw_affiliation_string":"University of Virginia School of Medicine","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000959850","display_name":"Yutong Li","orcid":"https://orcid.org/0009-0002-1468-4151","observed_orcids":["https://orcid.org/0009-0002-1468-4151"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yutong Li","raw_affiliation_strings":["Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA","Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA","Dana-Farber Cancer Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Dana-Farber Cancer Institute","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053994269","display_name":"Renlei Ji","orcid":"https://orcid.org/0000-0001-6258-1777","observed_orcids":["https://orcid.org/0000-0001-6258-1777"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Renlei Ji","raw_affiliation_strings":["Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA","Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA","Dana-Farber Cancer Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Dana-Farber Cancer Institute","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084992574","display_name":"Anwaruddin Mohammad","orcid":"https://orcid.org/0009-0000-3783-1906","observed_orcids":["https://orcid.org/0009-0000-3783-1906"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anwaruddin Mohammad","raw_affiliation_strings":["Bioinformatics Core, University of Virginia School of Medicine, Charlottesville, VA, USA","University of Virginia School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics Core, University of Virginia School of Medicine, Charlottesville, VA, USA","institution_ids":["https://openalex.org/I51556381"]},{"raw_affiliation_string":"University of Virginia School of Medicine","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068687737","display_name":"Pankaj Kumar","orcid":"https://orcid.org/0000-0002-8702-8879","observed_orcids":["https://orcid.org/0000-0002-8702-8879"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pankaj Kumar","raw_affiliation_strings":["Bioinformatics Core, University of Virginia School of Medicine, Charlottesville, VA, USA","Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA, USA","University of Virginia School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics Core, University of Virginia School of Medicine, Charlottesville, VA, USA","institution_ids":["https://openalex.org/I51556381"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA, USA","institution_ids":["https://openalex.org/I51556381"]},{"raw_affiliation_string":"University of Virginia School of Medicine","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100617670","display_name":"Qiwei Wang","orcid":"https://orcid.org/0000-0001-9197-3163","observed_orcids":["https://orcid.org/0000-0001-9197-3163"]},"institutions":[{"id":"https://openalex.org/I4390039272","display_name":"University of Virginia Cancer Center","ror":"https://ror.org/04w75nz84","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039272"]},{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qiwei Wang","raw_affiliation_strings":["Beirne B. Carter Center for Immunology Research, University of Virginia School of Medicine, Charlottesville, VA, USA","Department of Microbiology, Immunology & Cancer Biology, University of Virginia School of Medicine, Charlottesville, VA, USA","University of Virginia Comprehensive Cancer Center, Charlottesville, VA, USA","University of Virginia School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beirne B. Carter Center for Immunology Research, University of Virginia School of Medicine, Charlottesville, VA, USA","institution_ids":["https://openalex.org/I51556381"]},{"raw_affiliation_string":"Department of Microbiology, Immunology & Cancer Biology, University of Virginia School of Medicine, Charlottesville, VA, USA","institution_ids":["https://openalex.org/I51556381"]},{"raw_affiliation_string":"University of Virginia Comprehensive Cancer Center, Charlottesville, VA, USA","institution_ids":["https://openalex.org/I4390039272"]},{"raw_affiliation_string":"University of Virginia School of Medicine","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043714628","display_name":"Jean J. Zhao","orcid":"https://orcid.org/0000-0002-4561-5688","observed_orcids":["https://orcid.org/0000-0002-4561-5688"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jean J. Zhao","raw_affiliation_strings":["Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA","Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA","Laboratory of Systems Pharmacology, Harvard Medical School, Boston, MA, USA","Dana-Farber Cancer Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Laboratory of Systems Pharmacology, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Dana-Farber Cancer Institute","institution_ids":["https://openalex.org/I4210117453"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5043714628"],"corresponding_institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.00570000009611249,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tumor-associated-macrophages","display_name":"tumor-associated macrophages","score":0.9670000076293945},{"id":"https://openalex.org/keywords/parp-inhibitor-resistance","display_name":"PARP inhibitor resistance","score":0.9430000185966492},{"id":"https://openalex.org/keywords/nrf2","display_name":"Nrf2","score":0.9610000252723694},{"id":"https://openalex.org/keywords/glutathione","display_name":"glutathione","score":0.9259999990463257},{"id":"https://openalex.org/keywords/ferroptosis","display_name":"ferroptosis","score":0.8460000157356262},{"id":"https://openalex.org/keywords/sting-signaling","display_name":"STING signaling","score":0.7699999809265137},{"id":"https://openalex.org/keywords/immune-evasion","display_name":"immune evasion","score":0.6439999938011169},{"id":"https://openalex.org/keywords/stat5","display_name":"STAT5","score":0.7329999804496765},{"id":"https://openalex.org/keywords/mitochondrial-metabolism","display_name":"mitochondrial metabolism","score":0.9279999732971191},{"id":"https://openalex.org/keywords/immunometabolism","display_name":"immunometabolism","score":0.9350000023841858},{"id":"https://openalex.org/keywords/antitumor-immunity","display_name":"antitumor immunity","score":0.7120000123977661}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.7228000164031982},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6154999732971191},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5979999899864197},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.5927000045776367},{"id":"https://openalex.org/C2780252810","wikidata":"https://www.wikidata.org/wiki/Q1455316","display_name":"Immunosuppression","level":2,"score":0.5802000164985657},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5408999919891357},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.4853000044822693},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.46970000863075256},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.43700000643730164},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.4009999930858612},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.3959999978542328},{"id":"https://openalex.org/C2781251061","wikidata":"https://www.wikidata.org/wiki/Q5416089","display_name":"Evasion (ethics)","level":3,"score":0.3898000121116638},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3499000072479248},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.32910001277923584},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.32600000500679016},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.31679999828338623},{"id":"https://openalex.org/C2910239545","wikidata":"https://www.wikidata.org/wiki/Q3843811","display_name":"Immune Dysfunction","level":3,"score":0.31290000677108765},{"id":"https://openalex.org/C182979987","wikidata":"https://www.wikidata.org/wiki/Q3907241","display_name":"Poly ADP ribose polymerase","level":4,"score":0.31209999322891235},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.30329999327659607},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.298799991607666},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.2818000018596649},{"id":"https://openalex.org/C2994294914","wikidata":"https://www.wikidata.org/wiki/Q1645075","display_name":"Acquired resistance","level":3,"score":0.27630001306533813},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.2651999890804291},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.26100000739097595},{"id":"https://openalex.org/C2777702733","wikidata":"https://www.wikidata.org/wiki/Q1356761","display_name":"Immune tolerance","level":3,"score":0.2531000077724457},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25200000405311584}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1101/2025.10.14.682312","doi":"https://doi.org/10.1101/2025.10.14.682312","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.10.14.682312","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2025/10/15/2025.10.14.682312.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:41279612","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41279612","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:11440531","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12633074","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1101/2025.10.14.682312","doi":"https://doi.org/10.1101/2025.10.14.682312","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.10.14.682312","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2025/10/15/2025.10.14.682312.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3261725791","display_name":null,"funder_award_id":"CA168504","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3873843905","display_name":"HARNESSING HOST INNATE IMMUNITY WITH INNOVATIVE THERAPEUTIC STRATEGIES IN TRIPLE-NEGATIVE BREAST CANCER","funder_award_id":"HT94252310026","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"},{"id":"https://openalex.org/G5884675678","display_name":null,"funder_award_id":"CA210057","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000890047","display_name":"Cancer Research Training Program: From Molecular Mechanisms to Therapeutic Strategies","funder_award_id":"T32CA009109","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000893326","display_name":"Dana Farber/Harvard Cancer Center Specialized Program of Research Excellence in Breast Cancer","funder_award_id":"P50CA168504","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000904306","display_name":"Targeting Replication Stress and DNA Damage Response in Uterine Cancer","funder_award_id":"P01CA269021","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000910562","display_name":"Integrating targeted therapy and immunotherapy to break through cancer","funder_award_id":"R35CA210057","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306078","display_name":"U.S. Department of Defense","ror":"https://ror.org/0447fe631"},{"id":"https://openalex.org/F4320306260","display_name":"Breast Cancer Research Foundation","ror":"https://ror.org/0348ff195"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4415203271.pdf","grobid_xml":"https://content.openalex.org/works/W4415203271.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3182066591","https://openalex.org/W4281673144","https://openalex.org/W3112241528","https://openalex.org/W4322773872","https://openalex.org/W4304196243","https://openalex.org/W4205964579","https://openalex.org/W3212566265","https://openalex.org/W4233287672","https://openalex.org/W4399046505","https://openalex.org/W3098985666"],"abstract_inverted_index":{"Tumor-associated":[0],"macrophages":[1],"(TAMs)":[2],"are":[3],"major":[4],"contributors":[5],"to":[6,13,138],"immunosuppression":[7],"and":[8,49,68,94,108,128],"therapeutic":[9,136],"resistance,":[10],"including":[11],"resistance":[12,27],"PARP":[14],"inhibitors":[15],"(PARPi)":[16],"in":[17,63,112,142],"BRCA1-deficient":[18,113],"breast":[19,144],"cancer.":[20,145],"However,":[21],"the":[22,38,60,78,130],"mechanisms":[23],"underlying":[24],"TAM-mediated":[25],"PARPi":[26,41,106,126],"remain":[28],"unclear.":[29],"Here,":[30],"we":[31],"demonstrate":[32],"that":[33,124],"TAM-derived":[34],"glutathione":[35],"(GSH)":[36],"impairs":[37],"efficacy":[39,127],"of":[40,59,100],"by":[42,86],"protecting":[43,89],"tumor":[44,79,87,114],"cells":[45],"from":[46,91],"DNA":[47],"damage":[48],"ferroptosis":[50],"while":[51],"suppressing":[52],"STING-mediated":[53],"immune":[54,96],"activation.":[55],"Mechanistically,":[56],"STAT5-driven":[57],"upregulation":[58],"IRG1/itaconate":[61],"axis":[62,132],"TAMs":[64],"rewires":[65],"mitochondrial":[66],"metabolism":[67],"activates":[69],"NRF2-dependent":[70],"GSH":[71,73],"biosynthesis.":[72],"is":[74,83],"subsequently":[75],"released":[76],"into":[77],"microenvironment,":[80],"where":[81],"it":[82],"taken":[84],"up":[85],"cells,":[88],"them":[90],"PARPi-induced":[92],"cytotoxicity":[93],"dampening":[95],"responses.":[97],"Pharmacological":[98],"inhibition":[99],"IRG1":[101],"reverses":[102],"these":[103,117],"effects,":[104],"restoring":[105],"sensitivity":[107],"enhancing":[109],"anti-tumor":[110],"immunity":[111],"models.":[115],"Collectively,":[116],"findings":[118],"uncover":[119],"a":[120,134],"TAM-specific":[121],"immunometabolic":[122],"program":[123],"limits":[125],"highlight":[129],"IRG1/NRF2/GSH":[131],"as":[133],"promising":[135],"target":[137],"improve":[139],"treatment":[140],"outcomes":[141],"BRCA1-associated":[143]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2025-10-16T00:00:00"}