{"id":"https://openalex.org/W4415172575","doi":"https://doi.org/10.3389/fnhum.2025.1570555","title":"Emerging neuromodulation treatments for opioid and stimulant use disorders","display_name":"Emerging neuromodulation treatments for opioid and stimulant use disorders","publication_year":2025,"publication_date":"2025-10-14","ids":{"openalex":"https://openalex.org/W4415172575","doi":"https://doi.org/10.3389/fnhum.2025.1570555","pmid":"https://pubmed.ncbi.nlm.nih.gov/41164146","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12558984"},"language":"en","primary_location":{"id":"doi:10.3389/fnhum.2025.1570555","doi":"https://doi.org/10.3389/fnhum.2025.1570555","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnhum.2025.1570555","pdf_url":"https://www.frontiersin.org/journals/human-neuroscience/articles/10.3389/fnhum.2025.1570555/pdf","source":{"id":"https://openalex.org/S146364893","display_name":"Frontiers in Human Neuroscience","issn_l":"1662-5161","issn":["1662-5161"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Human Neuroscience","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/human-neuroscience/articles/10.3389/fnhum.2025.1570555/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008898069","display_name":"Susanna Howard","orcid":"https://orcid.org/0000-0003-3639-8877","observed_orcids":["https://orcid.org/0000-0003-3639-8877"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Susanna D. Howard","raw_affiliation_strings":["Department of Neurosurgery, University of Pennsylvania, Philadelphia, PA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, University of Pennsylvania, Philadelphia, PA, United States","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039095680","display_name":"Liming Qiu","orcid":"https://orcid.org/0000-0002-5246-2077","observed_orcids":["https://orcid.org/0000-0002-5246-2077"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Liming Qiu","raw_affiliation_strings":["Department of Neurosurgery, University of Pennsylvania, Philadelphia, PA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, University of Pennsylvania, Philadelphia, PA, United States","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000656343","display_name":"Nathan Hager","orcid":"https://orcid.org/0000-0003-2083-7337","observed_orcids":["https://orcid.org/0000-0003-2083-7337"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nathan Hager","raw_affiliation_strings":["Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, United States","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111329583","display_name":"Anna Rose Childress","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anna Rose Childress","raw_affiliation_strings":["Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, United States","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083415417","display_name":"Casey H. Halpern","orcid":"https://orcid.org/0000-0003-3907-216X","observed_orcids":["https://orcid.org/0000-0003-3907-216X"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Casey H. Halpern","raw_affiliation_strings":["Department of Neurosurgery, University of Pennsylvania, Philadelphia, PA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, University of Pennsylvania, Philadelphia, PA, United States","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010623271","display_name":"Katherine Wilson Scangos","orcid":"https://orcid.org/0000-0001-7983-7767","observed_orcids":["https://orcid.org/0000-0001-7983-7767"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katherine W. Scangos","raw_affiliation_strings":["Department of Neurosurgery, University of Pennsylvania, Philadelphia, PA, United States","Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, University of Pennsylvania, Philadelphia, PA, United States","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, United States","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5008898069"],"corresponding_institution_ids":["https://openalex.org/I79576946"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.1619,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.27666376,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":92,"max":95},"biblio":{"volume":"19","issue":null,"first_page":"1570555","last_page":"1570555"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10919","display_name":"Deep Brain Stimulation and Movement Disorders","score":0.6685000061988831,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10919","display_name":"Deep Brain Stimulation and Movement Disorders","score":0.6685000061988831,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10576","display_name":"Opioid Use Disorder Treatment","score":0.20389999449253082,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10043","display_name":"Substance Abuse Treatment and Outcomes","score":0.05660000070929527,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neuromodulation","display_name":"neuromodulation","score":0.8830000162124634},{"id":"https://openalex.org/keywords/opioid-use-disorder","display_name":"opioid use disorder","score":0.9039999842643738},{"id":"https://openalex.org/keywords/stimulant-dependence","display_name":"stimulant use disorder","score":0.9990000128746033},{"id":"https://openalex.org/keywords/deep-brain-stimulation","display_name":"deep brain stimulation","score":0.9929999709129333},{"id":"https://openalex.org/keywords/addiction-treatment","display_name":"addiction treatment","score":0.7419999837875366},{"id":"https://openalex.org/keywords/relapse","display_name":"relapse","score":0.753000020980835},{"id":"https://openalex.org/keywords/opioid-overdose","display_name":"opioid overdose","score":0.8299999833106995},{"id":"https://openalex.org/keywords/fentanyl","display_name":"fentanyl","score":0.9430000185966492},{"id":"https://openalex.org/keywords/medication-assisted-treatment","display_name":"medication-assisted treatment","score":0.7630000114440918}],"concepts":[{"id":"https://openalex.org/C2780557958","wikidata":"https://www.wikidata.org/wiki/Q211036","display_name":"Stimulant","level":2,"score":0.8952999711036682},{"id":"https://openalex.org/C2780375056","wikidata":"https://www.wikidata.org/wiki/Q905905","display_name":"Neuromodulation","level":3,"score":0.8093000054359436},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7910000085830688},{"id":"https://openalex.org/C2779418921","wikidata":"https://www.wikidata.org/wiki/Q1639178","display_name":"Opioid use disorder","level":4,"score":0.6736999750137329},{"id":"https://openalex.org/C2781063702","wikidata":"https://www.wikidata.org/wiki/Q427523","display_name":"Opioid","level":3,"score":0.6700999736785889},{"id":"https://openalex.org/C2781072394","wikidata":"https://www.wikidata.org/wiki/Q407541","display_name":"Fentanyl","level":2,"score":0.6183000206947327},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.42649999260902405},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.4154999852180481},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.38659998774528503},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.35359999537467957},{"id":"https://openalex.org/C3018890749","wikidata":"https://www.wikidata.org/wiki/Q204711","display_name":"Food and drug administration","level":2,"score":0.34220001101493835},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3314000070095062},{"id":"https://openalex.org/C3017551082","wikidata":"https://www.wikidata.org/wiki/Q1863718","display_name":"Sacral nerve stimulation","level":2,"score":0.31279999017715454},{"id":"https://openalex.org/C2777972943","wikidata":"https://www.wikidata.org/wiki/Q409587","display_name":"Naltrexone","level":4,"score":0.2761000096797943}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fnhum.2025.1570555","doi":"https://doi.org/10.3389/fnhum.2025.1570555","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnhum.2025.1570555","pdf_url":"https://www.frontiersin.org/journals/human-neuroscience/articles/10.3389/fnhum.2025.1570555/pdf","source":{"id":"https://openalex.org/S146364893","display_name":"Frontiers in Human Neuroscience","issn_l":"1662-5161","issn":["1662-5161"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Human Neuroscience","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:11368277","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12558984","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:41164146","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41164146","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in human neuroscience","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:cd02962c54d649a4a2dcc1411ed78acd","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/cd02962c54d649a4a2dcc1411ed78acd","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Human Neuroscience, Vol 19 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fnhum.2025.1570555","doi":"https://doi.org/10.3389/fnhum.2025.1570555","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnhum.2025.1570555","pdf_url":"https://www.frontiersin.org/journals/human-neuroscience/articles/10.3389/fnhum.2025.1570555/pdf","source":{"id":"https://openalex.org/S146364893","display_name":"Frontiers in Human Neuroscience","issn_l":"1662-5161","issn":["1662-5161"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Human Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4415172575.pdf","grobid_xml":"https://content.openalex.org/works/W4415172575.grobid-xml"},"referenced_works_count":84,"referenced_works":["https://openalex.org/W1829183563","https://openalex.org/W1948497419","https://openalex.org/W1964703685","https://openalex.org/W1974524186","https://openalex.org/W1985892642","https://openalex.org/W1987627060","https://openalex.org/W1993361626","https://openalex.org/W2015499597","https://openalex.org/W2017366566","https://openalex.org/W2020327987","https://openalex.org/W2031548929","https://openalex.org/W2035240167","https://openalex.org/W2052074911","https://openalex.org/W2060707485","https://openalex.org/W2066848874","https://openalex.org/W2112830076","https://openalex.org/W2114329358","https://openalex.org/W2118798234","https://openalex.org/W2140078950","https://openalex.org/W2154268783","https://openalex.org/W2163887368","https://openalex.org/W2172107654","https://openalex.org/W2213369915","https://openalex.org/W2260524443","https://openalex.org/W2318209965","https://openalex.org/W2398419684","https://openalex.org/W2491181876","https://openalex.org/W2491859250","https://openalex.org/W2509375263","https://openalex.org/W2596698762","https://openalex.org/W2602926336","https://openalex.org/W2759584216","https://openalex.org/W2777973172","https://openalex.org/W2783130581","https://openalex.org/W2891889239","https://openalex.org/W2898004423","https://openalex.org/W2901666216","https://openalex.org/W2905973048","https://openalex.org/W2919998328","https://openalex.org/W2991474708","https://openalex.org/W2992020759","https://openalex.org/W2998473209","https://openalex.org/W3011608424","https://openalex.org/W3025607283","https://openalex.org/W3032896995","https://openalex.org/W3033548177","https://openalex.org/W3036656645","https://openalex.org/W3080093241","https://openalex.org/W3100808032","https://openalex.org/W3116241571","https://openalex.org/W3130273336","https://openalex.org/W3157239742","https://openalex.org/W3185964987","https://openalex.org/W3193963933","https://openalex.org/W3197696608","https://openalex.org/W3199107930","https://openalex.org/W3204807443","https://openalex.org/W3208689015","https://openalex.org/W3215816319","https://openalex.org/W4206963875","https://openalex.org/W4213300278","https://openalex.org/W4220738347","https://openalex.org/W4224992650","https://openalex.org/W4283830383","https://openalex.org/W4285741542","https://openalex.org/W4306392257","https://openalex.org/W4310220368","https://openalex.org/W4310249546","https://openalex.org/W4380151073","https://openalex.org/W4386774091","https://openalex.org/W4386885189","https://openalex.org/W4387808123","https://openalex.org/W4389614685","https://openalex.org/W4392032200","https://openalex.org/W4399662763","https://openalex.org/W4400536682","https://openalex.org/W4401587023","https://openalex.org/W4401694862","https://openalex.org/W4402325028","https://openalex.org/W4403483680","https://openalex.org/W4404486441","https://openalex.org/W4404506029","https://openalex.org/W4406213772","https://openalex.org/W7126025496"],"related_works":["https://openalex.org/W4413283270","https://openalex.org/W4400574574","https://openalex.org/W4401259926","https://openalex.org/W4200185252","https://openalex.org/W3091232918","https://openalex.org/W7118019305","https://openalex.org/W4322619608","https://openalex.org/W4386052250","https://openalex.org/W4283693518","https://openalex.org/W4391228258"],"abstract_inverted_index":{"Over":[0],"the":[1,15,41,49,57,86],"past":[2],"decade,":[3],"deaths":[4],"attributable":[5],"to":[6],"opioid":[7,27,46,92],"and":[8,18,53,95,100],"stimulant":[9,37,96],"use":[10,28,38,47,93,97],"have":[11],"risen":[12],"dramatically.":[13],"While":[14],"U.S.":[16],"Food":[17],"Drug":[19],"Administration":[20],"(FDA)":[21],"has":[22],"approved":[23],"three":[24],"medications":[25,44],"for":[26,36,45,71,76,91],"disorder,":[29,48],"there":[30],"is":[31,67],"currently":[32],"no":[33],"FDA-approved":[34],"treatment":[35,74],"disorder.":[39,98],"Despite":[40],"availability":[42],"of":[43,51,59,85,89],"rates":[50],"relapse":[52],"overdose,":[54],"particularly":[55],"in":[56],"time":[58],"widespread":[60],"fentanyl":[61],"use,":[62],"remain":[63],"distressingly":[64],"high.":[65],"There":[66],"an":[68,83],"urgent":[69],"need":[70],"more":[72],"effective":[73],"options":[75],"these":[77],"debilitating":[78],"disorders.":[79],"This":[80],"article":[81],"provides":[82],"overview":[84],"current":[87],"standard":[88],"care":[90],"disorder":[94],"New":[99],"emerging":[101],"neuromodulation":[102],"approaches":[103],"with":[104],"a":[105],"particular":[106],"focus":[107],"on":[108],"deep":[109],"brain":[110],"stimulation":[111],"are":[112],"then":[113],"discussed.":[114]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-10-15T00:00:00"}