{"id":"https://openalex.org/W4415170010","doi":"https://doi.org/10.1039/d5ra04219d","title":"Properties of human centrin 2 and cooperative effects between the N- and C-terminal domains","display_name":"Properties of human centrin 2 and cooperative effects between the N- and C-terminal domains","publication_year":2025,"publication_date":"2025-01-01","ids":{"openalex":"https://openalex.org/W4415170010","doi":"https://doi.org/10.1039/d5ra04219d","pmid":"https://pubmed.ncbi.nlm.nih.gov/41098958","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12519114"},"language":"en","primary_location":{"id":"doi:10.1039/d5ra04219d","doi":"https://doi.org/10.1039/d5ra04219d","is_oa":true,"landing_page_url":"https://doi.org/10.1039/d5ra04219d","pdf_url":"https://pubs.rsc.org/en/content/articlepdf/2025/ra/d5ra04219d","source":{"id":"https://openalex.org/S2481244646","display_name":"RSC Advances","issn_l":"2046-2069","issn":["2046-2069"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RSC Advances","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://pubs.rsc.org/en/content/articlepdf/2025/ra/d5ra04219d","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103148320","display_name":"Jing Ying Yang","orcid":"https://orcid.org/0000-0002-7639-4275","observed_orcids":["https://orcid.org/0000-0002-7639-4275"]},"institutions":[{"id":"https://openalex.org/I4405280265","display_name":"Taiyuan University","ror":"https://ror.org/02p6kn570","country_code":"CN","type":"education","lineage":["https://openalex.org/I4405280265"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Yang","raw_affiliation_strings":["Department of Materials and Chemical Engineering, Taiyuan University, Taiyuan, 030032, China"],"raw_orcid":"https://orcid.org/0000-0002-7639-4275","affiliations":[{"raw_affiliation_string":"Department of Materials and Chemical Engineering, Taiyuan University, Taiyuan, 030032, China","institution_ids":["https://openalex.org/I4405280265"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102881406","display_name":"Yaqin Zhao","orcid":"https://orcid.org/0000-0003-2464-9990","observed_orcids":["https://orcid.org/0000-0003-2464-9990"]},"institutions":[{"id":"https://openalex.org/I181877577","display_name":"Shanxi University","ror":"https://ror.org/03y3e3s17","country_code":"CN","type":"education","lineage":["https://openalex.org/I181877577"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yaqin Zhao","raw_affiliation_strings":["Institute of Molecular Science, Key Laboratory of Chemical Biology of Molecular, Shanxi University, Taiyuan 030006, China"],"raw_orcid":"https://orcid.org/0000-0003-2464-9990","affiliations":[{"raw_affiliation_string":"Institute of Molecular Science, Key Laboratory of Chemical Biology of Molecular, Shanxi University, Taiyuan 030006, China","institution_ids":["https://openalex.org/I181877577"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030230367","display_name":"Binsheng Yang","orcid":"https://orcid.org/0000-0002-6043-0534","observed_orcids":["https://orcid.org/0000-0002-6043-0534"]},"institutions":[{"id":"https://openalex.org/I181877577","display_name":"Shanxi University","ror":"https://ror.org/03y3e3s17","country_code":"CN","type":"education","lineage":["https://openalex.org/I181877577"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Binsheng Yang","raw_affiliation_strings":["Institute of Molecular Science, Key Laboratory of Chemical Biology of Molecular, Shanxi University, Taiyuan 030006, China"],"raw_orcid":"https://orcid.org/0000-0002-6043-0534","affiliations":[{"raw_affiliation_string":"Institute of Molecular Science, Key Laboratory of Chemical Biology of Molecular, Shanxi University, Taiyuan 030006, China","institution_ids":["https://openalex.org/I181877577"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5030230367"],"corresponding_institution_ids":["https://openalex.org/I181877577"],"apc_list":{"value":850,"currency":"GBP","value_usd":1042},"apc_paid":{"value":850,"currency":"GBP","value_usd":1042},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"15","issue":"45","first_page":"38201","last_page":"38210"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.5390999913215637,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.5390999913215637,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.2151000052690506,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.03269999846816063,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/n-terminal-domain","display_name":"N-terminal domain","score":0.8569999933242798},{"id":"https://openalex.org/keywords/c-terminal-domain","display_name":"C-terminal domain","score":1.0},{"id":"https://openalex.org/keywords/protein-aggregation","display_name":"protein aggregation","score":0.6169999837875366},{"id":"https://openalex.org/keywords/dna-binding","display_name":"DNA binding","score":0.9110000133514404},{"id":"https://openalex.org/keywords/dna-strand-breaks","display_name":"DNA strand breaks","score":0.7900000214576721},{"id":"https://openalex.org/keywords/centrin","display_name":"centrin","score":0.4169999957084656}],"concepts":[{"id":"https://openalex.org/C156911925","wikidata":"https://www.wikidata.org/wiki/Q643384","display_name":"Isothermal titration calorimetry","level":2,"score":0.9365000128746033},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6707000136375427},{"id":"https://openalex.org/C2778271344","wikidata":"https://www.wikidata.org/wiki/Q903395","display_name":"Agarose gel electrophoresis","level":3,"score":0.6606000065803528},{"id":"https://openalex.org/C29688787","wikidata":"https://www.wikidata.org/wiki/Q409145","display_name":"Calmodulin","level":3,"score":0.6496999859809875},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.6040999889373779},{"id":"https://openalex.org/C2778476535","wikidata":"https://www.wikidata.org/wiki/Q390697","display_name":"Agarose","level":2,"score":0.552299976348877},{"id":"https://openalex.org/C184866935","wikidata":"https://www.wikidata.org/wiki/Q191010","display_name":"Titration","level":2,"score":0.5026999711990356},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.48240000009536743},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4749000072479248},{"id":"https://openalex.org/C141315368","wikidata":"https://www.wikidata.org/wiki/Q4654881","display_name":"ATP hydrolysis","level":4,"score":0.44830000400543213},{"id":"https://openalex.org/C116084860","wikidata":"https://www.wikidata.org/wiki/Q48255","display_name":"Gel electrophoresis","level":2,"score":0.40860000252723694},{"id":"https://openalex.org/C40250595","wikidata":"https://www.wikidata.org/wiki/Q185098","display_name":"Electrophoresis","level":2,"score":0.3813999891281128},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3684999942779541},{"id":"https://openalex.org/C51639874","wikidata":"https://www.wikidata.org/wiki/Q167149","display_name":"Plasma protein binding","level":2,"score":0.36820000410079956},{"id":"https://openalex.org/C11804247","wikidata":"https://www.wikidata.org/wiki/Q896177","display_name":"Protein\u2013protein interaction","level":2,"score":0.3424000144004822},{"id":"https://openalex.org/C25166345","wikidata":"https://www.wikidata.org/wiki/Q4914012","display_name":"Binding domain","level":3,"score":0.34209999442100525},{"id":"https://openalex.org/C144292202","wikidata":"https://www.wikidata.org/wiki/Q898273","display_name":"Protein domain","level":3,"score":0.33230000734329224},{"id":"https://openalex.org/C187250156","wikidata":"https://www.wikidata.org/wiki/Q2902610","display_name":"Cooperative binding","level":3,"score":0.3287000060081482},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.32280001044273376},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.3084000051021576},{"id":"https://openalex.org/C36503486","wikidata":"https://www.wikidata.org/wiki/Q11235244","display_name":"Domain (mathematical analysis)","level":2,"score":0.3075000047683716},{"id":"https://openalex.org/C94412978","wikidata":"https://www.wikidata.org/wiki/Q103135","display_name":"Hydrolysis","level":2,"score":0.28349998593330383},{"id":"https://openalex.org/C93073132","wikidata":"https://www.wikidata.org/wiki/Q24726581","display_name":"DOCK","level":2,"score":0.274399995803833},{"id":"https://openalex.org/C122229402","wikidata":"https://www.wikidata.org/wiki/Q5018802","display_name":"Calcium-binding protein","level":3,"score":0.2711000144481659},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.2628999948501587},{"id":"https://openalex.org/C33987129","wikidata":"https://www.wikidata.org/wiki/Q13479514","display_name":"DNA-binding domain","level":4,"score":0.2540999948978424},{"id":"https://openalex.org/C101660505","wikidata":"https://www.wikidata.org/wiki/Q898301","display_name":"Polyacrylamide gel electrophoresis","level":3,"score":0.25189998745918274},{"id":"https://openalex.org/C191961535","wikidata":"https://www.wikidata.org/wiki/Q2360205","display_name":"A-DNA","level":3,"score":0.2508000135421753}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1039/d5ra04219d","doi":"https://doi.org/10.1039/d5ra04219d","is_oa":true,"landing_page_url":"https://doi.org/10.1039/d5ra04219d","pdf_url":"https://pubs.rsc.org/en/content/articlepdf/2025/ra/d5ra04219d","source":{"id":"https://openalex.org/S2481244646","display_name":"RSC Advances","issn_l":"2046-2069","issn":["2046-2069"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RSC Advances","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12519114","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12519114","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12519114/pdf/RA-015-D5RA04219D.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RSC Adv","raw_type":"Text"},{"id":"pmh:oai:europepmc.org:11326848","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12519114","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:41098958","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41098958","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RSC advances","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1039/d5ra04219d","doi":"https://doi.org/10.1039/d5ra04219d","is_oa":true,"landing_page_url":"https://doi.org/10.1039/d5ra04219d","pdf_url":"https://pubs.rsc.org/en/content/articlepdf/2025/ra/d5ra04219d","source":{"id":"https://openalex.org/S2481244646","display_name":"RSC Advances","issn_l":"2046-2069","issn":["2046-2069"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RSC Advances","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1187454685","display_name":null,"funder_award_id":"21571117, 20901048","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G207870841","display_name":null,"funder_award_id":"201801D121198","funder_id":"https://openalex.org/F4320322666","funder_display_name":"Natural Science Foundation of Shanxi Province"},{"id":"https://openalex.org/G2327713391","display_name":"CopC\u94dc\u8c03\u63a7\u673a\u7406\u7684\u5316\u5b66\u7814\u7a76","funder_award_id":"20771068","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G2460678558","display_name":null,"funder_award_id":"202103021224021","funder_id":"https://openalex.org/F4320322666","funder_display_name":"Natural Science Foundation of Shanxi Province"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322666","display_name":"Natural Science Foundation of Shanxi Province","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4415170010.pdf","grobid_xml":"https://content.openalex.org/works/W4415170010.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W1918385449","https://openalex.org/W1966552622","https://openalex.org/W1969971056","https://openalex.org/W1979464734","https://openalex.org/W1991501067","https://openalex.org/W1993330845","https://openalex.org/W1995679594","https://openalex.org/W1995818888","https://openalex.org/W2000116209","https://openalex.org/W2003048000","https://openalex.org/W2007773837","https://openalex.org/W2020484714","https://openalex.org/W2022001968","https://openalex.org/W2031848332","https://openalex.org/W2034593148","https://openalex.org/W2045355819","https://openalex.org/W2059265317","https://openalex.org/W2064448884","https://openalex.org/W2071628857","https://openalex.org/W2089459741","https://openalex.org/W2099249575","https://openalex.org/W2106814970","https://openalex.org/W2116609429","https://openalex.org/W2120190800","https://openalex.org/W2168234700","https://openalex.org/W2184627161","https://openalex.org/W2587745945","https://openalex.org/W2768056794","https://openalex.org/W2874050616","https://openalex.org/W2905787390","https://openalex.org/W2907207510","https://openalex.org/W2914864787","https://openalex.org/W2953028197","https://openalex.org/W3214293681","https://openalex.org/W4293898914"],"related_works":["https://openalex.org/W346906124","https://openalex.org/W7095632914","https://openalex.org/W2042746313","https://openalex.org/W1971612235","https://openalex.org/W3104454249","https://openalex.org/W581028526","https://openalex.org/W2971772352","https://openalex.org/W2009132196","https://openalex.org/W2874050616","https://openalex.org/W2620410624"],"abstract_inverted_index":{"-induced":[0],"HsCen2":[1,8,27,80],"aggregation.":[2],"Interestingly,":[3],"DNA":[4,20,43],"can":[5],"bind":[6],"to":[7,19,28],"or":[9,11],"C-HsCen2":[10,17,61],"N-HsCen2,":[12],"and":[13,35,50,69,76],"the":[14,47,51,56,70,74],"affinity":[15],"of":[16,25,55,79],"binding":[18],"is":[21,81],"stronger":[22],"than":[23],"that":[24,41],"intact":[26],"DNA.":[29],"In":[30],"addition,":[31],"HsCen2,":[32],"isolated":[33,36],"C-HsCen2,":[34],"N-HsCen2":[37,59],"exhibited":[38],"endonuclease-like":[39,52],"activities":[40],"induced":[42],"strand":[44],"break":[45],"through":[46],"hydrolysis":[48],"pathway,":[49],"activity":[53],"was":[54],"following":[57],"order:":[58],">":[60,62],"HsCen2.":[63],"The":[64],"results":[65],"are":[66],"extensively":[67],"discussed,":[68],"cooperative":[71],"effect":[72],"between":[73],"N-":[75],"C-terminal":[77],"domains":[78],"explored.":[82]},"counts_by_year":[],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2025-10-15T00:00:00"}