{"id":"https://openalex.org/W4415141663","doi":"https://doi.org/10.1142/s1793984425750017","title":"Hypoxia and Parkinson\u2019s Disease: A Dangerous Oversimplification Based on a Subpar Mouse Model","display_name":"Hypoxia and Parkinson\u2019s Disease: A Dangerous Oversimplification Based on a Subpar Mouse Model","publication_year":2025,"publication_date":"2025-10-14","ids":{"openalex":"https://openalex.org/W4415141663","doi":"https://doi.org/10.1142/s1793984425750017","pmid":"https://pubmed.ncbi.nlm.nih.gov/41257284"},"language":"en","primary_location":{"id":"doi:10.1142/s1793984425750017","doi":"https://doi.org/10.1142/s1793984425750017","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s1793984425750017","pdf_url":null,"source":{"id":"https://openalex.org/S4210174734","display_name":"Nano LIFE","issn_l":"1793-9844","issn":["1793-9844","1793-9852"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310319815","host_organization_name":"World Scientific","host_organization_lineage":["https://openalex.org/P4310319815"],"host_organization_lineage_names":["World Scientific"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nano LIFE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055658784","display_name":"Martin L. Yarmush","orcid":"https://orcid.org/0000-0003-4986-8444","observed_orcids":["https://orcid.org/0000-0003-4986-8444"]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Martin Yarmush","raw_affiliation_strings":["Department of Biomedical Engineering, Rutgers University, Piscataway, New Jersey, USA"],"raw_orcid":"https://orcid.org/0000-0003-4986-8444","affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Rutgers University, Piscataway, New Jersey, USA","institution_ids":["https://openalex.org/I102322142"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5055658784"],"corresponding_institution_ids":["https://openalex.org/I102322142"],"apc_list":null,"apc_paid":null,"fwci":0.548,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.68882464,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"16","issue":"06","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13991","display_name":"Nuclear Receptors and Signaling","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10919","display_name":"Neurological disorders and treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.9449999928474426},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.8529999852180481},{"id":"https://openalex.org/keywords/mouse-model","display_name":"mouse model","score":0.46799999475479126},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.8980000019073486},{"id":"https://openalex.org/keywords/translational-validity","display_name":"translational validity","score":0.5989999771118164},{"id":"https://openalex.org/keywords/methodological-errors","display_name":"methodological errors","score":0.6520000100135803},{"id":"https://openalex.org/keywords/stress-adaptation","display_name":"stress adaptation","score":0.5870000123977661},{"id":"https://openalex.org/keywords/disease-progression","display_name":"disease progression","score":0.3140000104904175}],"concepts":[{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.6309000253677368},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.6291999816894531},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4918999969959259},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.43799999356269836},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.41510000824928284},{"id":"https://openalex.org/C2780665704","wikidata":"https://www.wikidata.org/wiki/Q959298","display_name":"Intervention (counseling)","level":2,"score":0.41029998660087585},{"id":"https://openalex.org/C76509639","wikidata":"https://www.wikidata.org/wiki/Q918036","display_name":"Race (biology)","level":2,"score":0.36039999127388},{"id":"https://openalex.org/C160450060","wikidata":"https://www.wikidata.org/wiki/Q104598479","display_name":"Hypoxia-inducible factors","level":3,"score":0.3560999929904938},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.33090001344680786},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3294999897480011},{"id":"https://openalex.org/C33507282","wikidata":"https://www.wikidata.org/wiki/Q4680759","display_name":"Adaptive response","level":2,"score":0.3222000002861023},{"id":"https://openalex.org/C2781354396","wikidata":"https://www.wikidata.org/wiki/Q840407","display_name":"Enthusiasm","level":2,"score":0.3190000057220459},{"id":"https://openalex.org/C2988867146","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Human disease","level":3,"score":0.3000999987125397},{"id":"https://openalex.org/C3018263421","wikidata":"https://www.wikidata.org/wiki/Q80083","display_name":"Human studies","level":2,"score":0.29249998927116394},{"id":"https://openalex.org/C139807058","wikidata":"https://www.wikidata.org/wiki/Q352374","display_name":"Adaptation (eye)","level":2,"score":0.28369998931884766},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27570000290870667},{"id":"https://openalex.org/C138496976","wikidata":"https://www.wikidata.org/wiki/Q175002","display_name":"Developmental psychology","level":1,"score":0.2655999958515167},{"id":"https://openalex.org/C78604142","wikidata":"https://www.wikidata.org/wiki/Q1640582","display_name":"Fight-or-flight response","level":3,"score":0.2574999928474426},{"id":"https://openalex.org/C2778360308","wikidata":"https://www.wikidata.org/wiki/Q1332954","display_name":"Nocebo","level":4,"score":0.25679999589920044},{"id":"https://openalex.org/C77255625","wikidata":"https://www.wikidata.org/wiki/Q402093","display_name":"Reprogramming","level":3,"score":0.25589999556541443}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1142/s1793984425750017","doi":"https://doi.org/10.1142/s1793984425750017","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s1793984425750017","pdf_url":null,"source":{"id":"https://openalex.org/S4210174734","display_name":"Nano LIFE","issn_l":"1793-9844","issn":["1793-9844","1793-9852"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310319815","host_organization_name":"World Scientific","host_organization_lineage":["https://openalex.org/P4310319815"],"host_organization_lineage_names":["World Scientific"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nano LIFE","raw_type":"journal-article"},{"id":"pmid:41257284","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41257284","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nano LIFE","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G6549768257","display_name":"Rutgers University Biotechnology Training Program","funder_award_id":"T32GM008339","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W2097427623","https://openalex.org/W2109516545","https://openalex.org/W2890691659","https://openalex.org/W3126822618","https://openalex.org/W3158822120","https://openalex.org/W4225162106","https://openalex.org/W4379987946","https://openalex.org/W4384627173","https://openalex.org/W4386409267","https://openalex.org/W4413025350"],"related_works":[],"abstract_inverted_index":{"A":[0],"recent":[1],"Nature":[2],"Neuroscience":[3],"paper":[4],"by":[5],"Marutani":[6],"and":[7,53,65,86,106,123,152],"colleagues":[8],"makes":[9],"the":[10,21,42,46,57,63,72,149],"striking":[11],"claim":[12],"that":[13,145],"chronic":[14],"hypoxia":[15],"can":[16],"reverse":[17],"or":[18],"even":[19],"halt":[20],"progression":[22],"of":[23,68,148],"Parkinson\u2019s":[24],"disease":[25,58],"(PD),":[26],"based":[27],"on":[28],"findings":[29,122],"in":[30,119,131,139],"an":[31],"[Formula:":[32],"see":[33],"text]-synuclein":[34],"pre-formed":[35],"fibril":[36],"(PFF)":[37],"mouse":[38],"model.":[39],"1":[40],"While":[41],"concept":[43],"is":[44,48,80],"provocative,":[45],"study":[47],"riddled":[49],"with":[50],"critical":[51],"methodological":[52],"interpretive":[54],"flaws.":[55],"First,":[56],"model":[59],"fails":[60],"to":[61,76,112],"reflect":[62],"multifactorial":[64],"progressive":[66],"reality":[67],"human":[69],"PD.":[70,132],"Second,":[71],"intervention\u2013":[73],"sustained":[74],"exposure":[75],"11%":[77],"oxygen":[78],"\u2014":[79],"neither":[81],"safe":[82],"nor":[83],"clinically":[84],"translatable,":[85],"its":[87],"reported":[88],"benefits":[89],"may":[90],"stem":[91],"from":[92],"non-specific":[93],"stress":[94],"adaptation":[95],"rather":[96],"than":[97],"targeted":[98],"neuroprotection.":[99],"Third,":[100],"mechanistic":[101],"assertions":[102],"lack":[103],"causal":[104],"validation,":[105],"behavioral":[107],"improvements":[108],"are":[109],"tenuously":[110],"linked":[111],"neuronal":[113],"function.":[114],"This":[115],"correspondence":[116],"urges":[117],"caution":[118],"interpreting":[120],"such":[121],"warns":[124],"against":[125],"premature":[126],"enthusiasm":[127],"for":[128],"hypoxia-based":[129],"therapies":[130],"The":[133],"work":[134],"exemplifies":[135],"a":[136],"growing":[137],"problem":[138],"biomedical":[140],"research:":[141],"eye-catching,":[142],"media-ready":[143],"conclusions":[144],"race":[146],"ahead":[147],"data\u2019s":[150],"rigor":[151],"clinical":[153],"relevance.":[154]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-10-15T10:00:46.086208","created_date":"2025-10-14T00:00:00"}
