{"id":"https://openalex.org/W4415106963","doi":"https://doi.org/10.7554/elife.108825","title":"Dietary sulfur amino acid restriction elicits a cold-like transcriptional response in inguinal but not epididymal white adipose tissue of male mice","display_name":"Dietary sulfur amino acid restriction elicits a cold-like transcriptional response in inguinal but not epididymal white adipose tissue of male mice","publication_year":2025,"publication_date":"2025-10-13","ids":{"openalex":"https://openalex.org/W4415106963","doi":"https://doi.org/10.7554/elife.108825","pmid":"https://pubmed.ncbi.nlm.nih.gov/41842927"},"language":"en","primary_location":{"id":"doi:10.7554/elife.108825","doi":"https://doi.org/10.7554/elife.108825","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.108825","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"journal-article"},"volume":null,"type":"preprint","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.7554/elife.108825","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112603909","display_name":"Philip M. M. Ruppert","orcid":"https://orcid.org/0000-0002-4028-8200","observed_orcids":["https://orcid.org/0000-0002-4028-8200"]},"institutions":[{"id":"https://openalex.org/I177969490","display_name":"University of Southern Denmark","ror":"https://ror.org/03yrrjy16","country_code":"DK","type":"education","lineage":["https://openalex.org/I177969490"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Philip MM Ruppert","raw_affiliation_strings":["Functional Genomics and Metabolism Unit, Department for Biochemistry and Molecular Biology, University of Southern Denmark"],"raw_orcid":"https://orcid.org/0000-0002-4028-8200","affiliations":[{"raw_affiliation_string":"Functional Genomics and Metabolism Unit, Department for Biochemistry and Molecular Biology, University of Southern Denmark","institution_ids":["https://openalex.org/I177969490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104290410","display_name":"Aylin Seren G\u00fcller","orcid":"https://orcid.org/0009-0000-3636-2773","observed_orcids":["https://orcid.org/0009-0000-3636-2773"]},"institutions":[{"id":"https://openalex.org/I177969490","display_name":"University of Southern Denmark","ror":"https://ror.org/03yrrjy16","country_code":"DK","type":"education","lineage":["https://openalex.org/I177969490"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Aylin S Gueller","raw_affiliation_strings":["Functional Genomics and Metabolism Unit, Department for Biochemistry and Molecular Biology, University of Southern Denmark"],"raw_orcid":"https://orcid.org/0009-0000-3636-2773","affiliations":[{"raw_affiliation_string":"Functional Genomics and Metabolism Unit, Department for Biochemistry and Molecular Biology, University of Southern Denmark","institution_ids":["https://openalex.org/I177969490"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Marcus Skj\u00e6veland","orcid":"https://orcid.org/0009-0009-7393-4721","observed_orcids":["https://orcid.org/0009-0009-7393-4721"]},"institutions":[{"id":"https://openalex.org/I177969490","display_name":"University of Southern Denmark","ror":"https://ror.org/03yrrjy16","country_code":"DK","type":"education","lineage":["https://openalex.org/I177969490"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Marcus Skj\u00e6veland","raw_affiliation_strings":["Functional Genomics and Metabolism Unit, Department for Biochemistry and Molecular Biology, University of Southern Denmark"],"raw_orcid":"https://orcid.org/0009-0009-7393-4721","affiliations":[{"raw_affiliation_string":"Functional Genomics and Metabolism Unit, Department for Biochemistry and Molecular Biology, University of Southern Denmark","institution_ids":["https://openalex.org/I177969490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028384405","display_name":"Nata\u0161a Stani\u0107","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177969490","display_name":"University of Southern Denmark","ror":"https://ror.org/03yrrjy16","country_code":"DK","type":"education","lineage":["https://openalex.org/I177969490"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Natasa Stanic","raw_affiliation_strings":["Functional Genomics and Metabolism Unit, Department for Biochemistry and Molecular Biology, University of Southern Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Functional Genomics and Metabolism Unit, Department for Biochemistry and Molecular Biology, University of Southern Denmark","institution_ids":["https://openalex.org/I177969490"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022998819","display_name":"Jan\u2010Wilhelm Kornfeld","orcid":"https://orcid.org/0000-0002-6802-4442","observed_orcids":["https://orcid.org/0000-0002-6802-4442"]},"institutions":[{"id":"https://openalex.org/I177969490","display_name":"University of Southern Denmark","ror":"https://ror.org/03yrrjy16","country_code":"DK","type":"education","lineage":["https://openalex.org/I177969490"]},{"id":"https://openalex.org/I2801134892","display_name":"Novo Nordisk Foundation","ror":"https://ror.org/04txyc737","country_code":"DK","type":"facility","lineage":["https://openalex.org/I2801134892"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Jan-Wilhelm Kornfeld","raw_affiliation_strings":["Functional Genomics and Metabolism Unit, Department for Biochemistry and Molecular Biology, University of Southern Denmark","Novo Nordisk Foundation Center for Adipocyte Signaling, University of Southern Denmark"],"raw_orcid":"https://orcid.org/0000-0002-6802-4442","affiliations":[{"raw_affiliation_string":"Functional Genomics and Metabolism Unit, Department for Biochemistry and Molecular Biology, University of Southern Denmark","institution_ids":["https://openalex.org/I177969490"]},{"raw_affiliation_string":"Novo Nordisk Foundation Center for Adipocyte Signaling, University of Southern Denmark","institution_ids":["https://openalex.org/I177969490","https://openalex.org/I2801134892"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3000,"currency":"USD","value_usd":2500},"apc_paid":{"value":3000,"currency":"USD","value_usd":2500},"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"14","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12745","display_name":"Dietary Effects on Health","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/methionine-restriction","display_name":"methionine restriction","score":0.9570000171661377},{"id":"https://openalex.org/keywords/cold-exposure","display_name":"cold exposure","score":0.8029999732971191},{"id":"https://openalex.org/keywords/diet-induced-thermogenesis","display_name":"diet-induced thermogenesis","score":0.9660000205039978},{"id":"https://openalex.org/keywords/energy-expenditure","display_name":"energy expenditure","score":0.7699999809265137},{"id":"https://openalex.org/keywords/brown-adipose-tissue","display_name":"brown adipose tissue","score":0.8690000176429749},{"id":"https://openalex.org/keywords/white-adipose-tissue","display_name":"white adipose tissue","score":0.9649999737739563},{"id":"https://openalex.org/keywords/inguinal-white-adipose-tissue","display_name":"inguinal adipose tissue","score":0.8379999995231628},{"id":"https://openalex.org/keywords/epididymal-white-adipose-tissue","display_name":"epididymal adipose tissue","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tissue-specific-expression","display_name":"tissue-specific gene expression","score":0.6570000052452087},{"id":"https://openalex.org/keywords/lipid-oxidation","display_name":"lipid oxidation","score":0.7540000081062317},{"id":"https://openalex.org/keywords/ppar-signaling-pathway","display_name":"PPAR signaling","score":0.7940000295639038},{"id":"https://openalex.org/keywords/ampk","display_name":"AMPK","score":0.7360000014305115},{"id":"https://openalex.org/keywords/glucagon-signaling","display_name":"glucagon signaling","score":0.8339999914169312},{"id":"https://openalex.org/keywords/tricarboxylic-acid-cycle","display_name":"TCA cycle","score":0.7749999761581421},{"id":"https://openalex.org/keywords/fatty-acid-degradation","display_name":"fatty acid degradation","score":0.7749999761581421},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.6129999756813049}],"concepts":[{"id":"https://openalex.org/C151955695","wikidata":"https://www.wikidata.org/wiki/Q654528","display_name":"White adipose tissue","level":3,"score":0.7409999966621399},{"id":"https://openalex.org/C151279926","wikidata":"https://www.wikidata.org/wiki/Q965695","display_name":"Thermogenesis","level":3,"score":0.7218000292778015},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7074999809265137},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7027000188827515},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.6335999965667725},{"id":"https://openalex.org/C2780642333","wikidata":"https://www.wikidata.org/wiki/Q901269","display_name":"Brown adipose tissue","level":3,"score":0.5784000158309937},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.5371999740600586},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.529699981212616},{"id":"https://openalex.org/C106646824","wikidata":"https://www.wikidata.org/wiki/Q5425475","display_name":"FGF21","level":4,"score":0.4661000072956085},{"id":"https://openalex.org/C2780912031","wikidata":"https://www.wikidata.org/wiki/Q180341","display_name":"Methionine","level":3,"score":0.4544999897480011},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.335999995470047},{"id":"https://openalex.org/C187345961","wikidata":"https://www.wikidata.org/wiki/Q419629","display_name":"Peroxisome proliferator-activated receptor","level":3,"score":0.32330000400543213},{"id":"https://openalex.org/C141359234","wikidata":"https://www.wikidata.org/wiki/Q2734301","display_name":"Lipogenesis","level":3,"score":0.3206000030040741},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3138999938964844},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3001999855041504},{"id":"https://openalex.org/C2779918689","wikidata":"https://www.wikidata.org/wiki/Q3771842","display_name":"Stimulus (psychology)","level":2,"score":0.298799991607666},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.2971000075340271},{"id":"https://openalex.org/C2988147884","wikidata":"https://www.wikidata.org/wiki/Q5377024","display_name":"Energy expenditure","level":2,"score":0.29649999737739563},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2964000105857849},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2939000129699707},{"id":"https://openalex.org/C82714985","wikidata":"https://www.wikidata.org/wiki/Q306213","display_name":"Beta oxidation","level":3,"score":0.29019999504089355},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.28780001401901245},{"id":"https://openalex.org/C3019921246","wikidata":"https://www.wikidata.org/wiki/Q104853310","display_name":"Differential effects","level":2,"score":0.28200000524520874},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.27469998598098755},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.26460000872612},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.26170000433921814},{"id":"https://openalex.org/C4733338","wikidata":"https://www.wikidata.org/wiki/Q2792936","display_name":"Lipid metabolism","level":2,"score":0.25589999556541443},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.25380000472068787},{"id":"https://openalex.org/C140985366","wikidata":"https://www.wikidata.org/wiki/Q898489","display_name":"Lipolysis","level":3,"score":0.2515999972820282},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.2513999938964844}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002001","descriptor_name":"Adipose Tissue, Brown","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002001","descriptor_name":"Adipose Tissue, Brown","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003080","descriptor_name":"Cold Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003080","descriptor_name":"Cold Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003080","descriptor_name":"Cold Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003080","descriptor_name":"Cold Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003080","descriptor_name":"Cold Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004032","descriptor_name":"Diet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004032","descriptor_name":"Diet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004032","descriptor_name":"Diet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004032","descriptor_name":"Diet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004032","descriptor_name":"Diet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004822","descriptor_name":"Epididymis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004822","descriptor_name":"Epididymis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004822","descriptor_name":"Epididymis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004822","descriptor_name":"Epididymis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004822","descriptor_name":"Epididymis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008715","descriptor_name":"Methionine","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D008715","descriptor_name":"Methionine","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D008715","descriptor_name":"Methionine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008715","descriptor_name":"Methionine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008715","descriptor_name":"Methionine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008715","descriptor_name":"Methionine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008715","descriptor_name":"Methionine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D022722","descriptor_name":"Thermogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D022722","descriptor_name":"Thermogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D022722","descriptor_name":"Thermogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D022722","descriptor_name":"Thermogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D022722","descriptor_name":"Thermogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052436","descriptor_name":"Adipose Tissue, White","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D052436","descriptor_name":"Adipose Tissue, White","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D052436","descriptor_name":"Adipose Tissue, White","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D052436","descriptor_name":"Adipose Tissue, White","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D052436","descriptor_name":"Adipose Tissue, White","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D052436","descriptor_name":"Adipose Tissue, White","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D052436","descriptor_name":"Adipose Tissue, White","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D052436","descriptor_name":"Adipose Tissue, White","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D052436","descriptor_name":"Adipose Tissue, White","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D052436","descriptor_name":"Adipose Tissue, White","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.7554/elife.108825","doi":"https://doi.org/10.7554/elife.108825","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.108825","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"journal-article"},{"id":"pmid:41842927","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41842927","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:8e5d150d47a74e68a13c826b4b34875d","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/8e5d150d47a74e68a13c826b4b34875d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"eLife, Vol 14 (2026)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12995289","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12995289/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"eLife","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.7554/elife.108825","doi":"https://doi.org/10.7554/elife.108825","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.108825","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G4222832493","display_name":null,"funder_award_id":"NNF21OC0070263","funder_id":"https://openalex.org/F4320325957","funder_display_name":"Novo Nordisk Fonden"},{"id":"https://openalex.org/G601566102","display_name":null,"funder_award_id":"ALTF 676-2021","funder_id":"https://openalex.org/F4320307844","funder_display_name":"European Molecular Biology Organization"}],"funders":[{"id":"https://openalex.org/F4320307844","display_name":"European Molecular Biology Organization","ror":"https://ror.org/04wfr2810"},{"id":"https://openalex.org/F4320325957","display_name":"Novo Nordisk Fonden","ror":"https://ror.org/04txyc737"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W2035618305","https://openalex.org/W2040087293","https://openalex.org/W2051993213","https://openalex.org/W2121051938","https://openalex.org/W2130410032","https://openalex.org/W2138207763","https://openalex.org/W2149851259","https://openalex.org/W2150590213","https://openalex.org/W2162023168","https://openalex.org/W2169456326","https://openalex.org/W2170065584","https://openalex.org/W2179438025","https://openalex.org/W2197124664","https://openalex.org/W2508199148","https://openalex.org/W2574042705","https://openalex.org/W2592811885","https://openalex.org/W2615736974","https://openalex.org/W2746874841","https://openalex.org/W2753963188","https://openalex.org/W2768810688","https://openalex.org/W2799499403","https://openalex.org/W2942143569","https://openalex.org/W2950221693","https://openalex.org/W2964871068","https://openalex.org/W2972936715","https://openalex.org/W3047205014","https://openalex.org/W3087027712","https://openalex.org/W3120832178","https://openalex.org/W3131597949","https://openalex.org/W3155957136","https://openalex.org/W3161292401","https://openalex.org/W3164030515","https://openalex.org/W3175075811","https://openalex.org/W3217337816","https://openalex.org/W4205268484","https://openalex.org/W4225650434","https://openalex.org/W4280538712","https://openalex.org/W4280557943","https://openalex.org/W4280566776","https://openalex.org/W4378978906","https://openalex.org/W4392304105","https://openalex.org/W4400014658","https://openalex.org/W4402509701","https://openalex.org/W4404535307","https://openalex.org/W4410973905","https://openalex.org/W4411364375"],"related_works":[],"abstract_inverted_index":{"About":[0],"1":[1],"billion":[2],"people":[3],"are":[4,18],"living":[5],"with":[6,28,128,207,219,242],"obesity":[7],"worldwide.":[8],"GLP-1-based":[9],"drugs":[10],"have":[11,72],"massively":[12],"transformed":[13],"care,":[14],"but":[15,61],"long-term":[16],"consequences":[17],"unclear":[19],"in":[20,25,178,253],"part":[21],"due":[22],"to":[23,101,141],"reductions":[24],"energy":[26],"expenditure":[27],"ongoing":[29],"use.":[30],"Diet-induced":[31],"thermogenesis":[32,104,270],"(DIT)":[33],"and":[34,46,107,111,122,131,150,170,186,195,204,214,228,236,271,279],"cold":[35],"exposure":[36],"(CE)":[37],"raise":[38],"EE":[39,63,147,167],"via":[40],"brown":[41],"adipose":[42,50],"tissue":[43,51],"(BAT)":[44],"activation":[45],"beiging":[47],"of":[48],"white":[49],"(WAT).":[52],"Methionine":[53],"restriction":[54],"(MetR)":[55,267],"is":[56,245],"a":[57,79,132,160,246,254,260],"candidate":[58],"DIT":[59,163,248],"stimulus,":[60],"its":[62],"effect":[64],"has":[65],"not":[66],"been":[67,76],"benchmarked":[68],"against":[69,105,268],"CE,":[70],"nor":[71],"their":[73,273],"tissue-level":[74],"interactions":[75,274],"defined.":[77],"In":[78,199,211,232],"2\u00d72":[80],"design":[81],"(Control":[82],"vs.":[83,89],"MetR;":[84],"room":[85],"temperature,":[86],"RT:":[87],"22\u00b0C":[88],"CE:":[90],"4\u00b0C":[91],"for":[92],"24":[93],"hr),":[94],"we":[95],"used":[96,140],"male":[97],"C57BL/6":[98],"N":[99],"mice":[100],"benchmark":[102],"MetR-induced":[103],"CE":[106,165,180,187,201,215],"mapped":[108],"how":[109],"diet":[110,133,172],"temperature":[112,135],"interact":[113],"across":[114,168,275],"tissues.":[115],"Bulk":[116],"RNA-seq":[117],"profiled":[118],"liver,":[119,179,276],"iBAT,":[120,200,277],"iWAT,":[121,212,278],"eWAT.":[123,280],"Differential":[124],"expression":[125,239],"was":[126,139],"modeled":[127],"main":[129],"effects":[130],"\u00d7":[134],"interaction.":[136],"KEGG":[137],"GSEA":[138],"assess":[142],"pathway-level":[143],"enrichment.":[144],"MetR":[145,158,185,209,213,244],"increased":[146],"at":[148],"RT":[149],"shifted":[151],"fuel":[152],"use":[153],"towards":[154],"lipid":[155],"oxidation,":[156],"supporting":[157],"as":[159],"bona":[161],"fide":[162],"stimulus.":[164],"elevated":[166],"diets":[169],"blunted":[171],"differences.":[173],"Transcriptomic":[174],"responses":[175],"were":[176],"tissue-specific:":[177],"dominated":[181,202],"gene":[182],"induction":[183],"while":[184],"cooperatively":[188],"repressed":[189],"genes.":[190],"The":[191],"combination":[192],"enriched":[193],"glucagon/AMPK-linked":[194],"core":[196],"metabolic":[197],"pathways.":[198,231],"thermogenic":[203],"lipid-oxidation":[205],"programs":[206],"minimal":[208],"contribution.":[210],"acted":[216],"largely":[217],"additively":[218],"high":[220],"concordance,":[221],"enhancing":[222],"fatty-acid":[223],"degradation,":[224],"PPAR":[225],"signaling,":[226],"thermogenesis,":[227],"TCA":[229],"cycle":[230],"eWAT,":[233],"robust":[234],"co-dependent":[235],"synergistic":[237],"differential":[238],"emerged":[240],"only":[241],"MetR+CE.":[243],"genuine":[247],"stimulus":[249],"that":[250,264],"remodels":[251],"metabolism":[252],"tissue-specific":[255],"manner.":[256],"Our":[257],"study":[258],"provides":[259],"tissue-resolved":[261],"transcriptomic":[262],"resource":[263],"benchmarks":[265],"diet-induced":[266],"cold-induced":[269],"maps":[272]},"counts_by_year":[],"updated_date":"2026-10-17T09:40:24.721904","created_date":"2025-10-13T00:00:00"}
