{"id":"https://openalex.org/W4415106953","doi":"https://doi.org/10.7554/elife.108892","title":"Overexpression of Ssd1 and calorie restriction extend yeast replicative lifespan by preventing deleterious age-dependent iron uptake","display_name":"Overexpression of Ssd1 and calorie restriction extend yeast replicative lifespan by preventing deleterious age-dependent iron uptake","publication_year":2025,"publication_date":"2025-10-13","ids":{"openalex":"https://openalex.org/W4415106953","doi":"https://doi.org/10.7554/elife.108892","pmid":"https://pubmed.ncbi.nlm.nih.gov/41524536","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12795504"},"language":"en","primary_location":{"id":"doi:10.7554/elife.108892","doi":"https://doi.org/10.7554/elife.108892","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.108892","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"journal-article"},"volume":null,"type":"preprint","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.7554/elife.108892","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101820403","display_name":"J Ignacio Gutierrez","orcid":"https://orcid.org/0000-0002-9017-8384","observed_orcids":["https://orcid.org/0000-0002-9017-8384"]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"J Ignacio Gutierrez","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, Weill Cornell Medicine"],"raw_orcid":"https://orcid.org/0000-0002-9017-8384","affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, Weill Cornell Medicine","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Claudia Edgar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Claudia Edgar","raw_affiliation_strings":["BCMB Graduate Program, Weill Cornell Graduate School of Biomedical Sciences","Department of Pathology and Laboratory Medicine, Weill Cornell Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BCMB Graduate Program, Weill Cornell Graduate School of Biomedical Sciences","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]},{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, Weill Cornell Medicine","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042369850","display_name":"Jessica K. Tyler","orcid":"https://orcid.org/0000-0001-9765-1659","observed_orcids":["https://orcid.org/0000-0001-9765-1659"]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jessica K Tyler","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, Weill Cornell Medicine"],"raw_orcid":"https://orcid.org/0000-0001-9765-1659","affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, Weill Cornell Medicine","institution_ids":["https://openalex.org/I4387153466"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5042369850","https://openalex.org/A5101820403"],"corresponding_institution_ids":["https://openalex.org/I4387153466"],"apc_list":{"value":3000,"currency":"USD","value_usd":2500},"apc_paid":{"value":3000,"currency":"USD","value_usd":2500},"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"14","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ssd1","display_name":"Ssd1","score":0.9760000109672546},{"id":"https://openalex.org/keywords/mrna-binding-proteins","display_name":"mRNA-binding proteins","score":0.7179999947547913},{"id":"https://openalex.org/keywords/replicative-lifespan","display_name":"replicative lifespan","score":0.8370000123977661},{"id":"https://openalex.org/keywords/caloric-restriction","display_name":"caloric restriction","score":0.9649999737739563},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.6380000114440918},{"id":"https://openalex.org/keywords/iron-absorption","display_name":"iron absorption","score":0.8100000023841858},{"id":"https://openalex.org/keywords/iron-regulon","display_name":"iron regulon","score":0.9679999947547913},{"id":"https://openalex.org/keywords/aft1","display_name":"Aft1","score":0.8939999938011169},{"id":"https://openalex.org/keywords/cytoplasmic-foci","display_name":"cytoplasmic foci","score":0.8370000123977661},{"id":"https://openalex.org/keywords/liquid-liquid-phase-separation","display_name":"liquid-liquid phase separation","score":0.6859999895095825},{"id":"https://openalex.org/keywords/mitosis","display_name":"mitosis","score":0.6859999895095825},{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.8169999718666077},{"id":"https://openalex.org/keywords/epistasis","display_name":"epistasis","score":0.7229999899864197},{"id":"https://openalex.org/keywords/intracellular-iron-accumulation","display_name":"intracellular iron accumulation","score":0.6729999780654907},{"id":"https://openalex.org/keywords/nuclear-translocation","display_name":"nuclear translocation","score":0.7310000061988831}],"concepts":[{"id":"https://openalex.org/C62361671","wikidata":"https://www.wikidata.org/wiki/Q1754612","display_name":"Regulon","level":4,"score":0.6955000162124634},{"id":"https://openalex.org/C2778707264","wikidata":"https://www.wikidata.org/wiki/Q1332886","display_name":"Calorie restriction","level":2,"score":0.661300003528595},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6080999970436096},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.569100022315979},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5327000021934509},{"id":"https://openalex.org/C2779222958","wikidata":"https://www.wikidata.org/wiki/Q45422","display_name":"Yeast","level":2,"score":0.478300005197525},{"id":"https://openalex.org/C61727976","wikidata":"https://www.wikidata.org/wiki/Q751748","display_name":"Epistasis","level":3,"score":0.420199990272522},{"id":"https://openalex.org/C158448853","wikidata":"https://www.wikidata.org/wiki/Q425218","display_name":"Repressor","level":4,"score":0.3862999975681305},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.36480000615119934},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.34599998593330383},{"id":"https://openalex.org/C22814914","wikidata":"https://www.wikidata.org/wiki/Q410473","display_name":"Transferrin","level":2,"score":0.33809998631477356},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3377000093460083},{"id":"https://openalex.org/C522857546","wikidata":"https://www.wikidata.org/wiki/Q2070979","display_name":"Senescence","level":2,"score":0.33570000529289246},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3343999981880188},{"id":"https://openalex.org/C2776200302","wikidata":"https://www.wikidata.org/wiki/Q827450","display_name":"Hepatocyte","level":3,"score":0.3253999948501587},{"id":"https://openalex.org/C93304396","wikidata":"https://www.wikidata.org/wiki/Q14763008","display_name":"Mitosis","level":2,"score":0.3118000030517578},{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.3109999895095825},{"id":"https://openalex.org/C138626823","wikidata":"https://www.wikidata.org/wiki/Q916504","display_name":"Chromosomal translocation","level":3,"score":0.30720001459121704},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.3000999987125397},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.29739999771118164},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.2955000102519989},{"id":"https://openalex.org/C2777576037","wikidata":"https://www.wikidata.org/wiki/Q719725","display_name":"Saccharomyces cerevisiae","level":3,"score":0.29159998893737793},{"id":"https://openalex.org/C179185449","wikidata":"https://www.wikidata.org/wiki/Q219699","display_name":"Suppressor","level":3,"score":0.2858999967575073},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.28459998965263367},{"id":"https://openalex.org/C191141034","wikidata":"https://www.wikidata.org/wiki/Q3087369","display_name":"Cell physiology","level":3,"score":0.27619999647140503},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.27489998936653137},{"id":"https://openalex.org/C20719415","wikidata":"https://www.wikidata.org/wiki/Q416896","display_name":"Metallothionein","level":3,"score":0.2734000086784363},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.27149999141693115},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.2671999931335449},{"id":"https://openalex.org/C186256576","wikidata":"https://www.wikidata.org/wiki/Q1058294","display_name":"Hormesis","level":3,"score":0.2639999985694885}],"mesh":[{"descriptor_ui":"D007501","descriptor_name":"Iron","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015966","descriptor_name":"Gene Expression Regulation, Fungal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018085","descriptor_name":"Regulon","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D031204","descriptor_name":"Caloric Restriction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.7554/elife.108892","doi":"https://doi.org/10.7554/elife.108892","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.108892","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12795504","doi":null,"is_oa":true,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41524536/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12795504/pdf/elife-108892.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"Text"},{"id":"pmid:41524536","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41524536","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:d2481542afc54caea67865694820aafe","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/d2481542afc54caea67865694820aafe","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"eLife, Vol 14 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.7554/elife.108892","doi":"https://doi.org/10.7554/elife.108892","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.108892","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.7246000170707703,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1040831581","display_name":null,"funder_award_id":"RO1 AG079883","funder_id":"https://openalex.org/F4320337349","funder_display_name":"NIH Office of the Director"},{"id":"https://openalex.org/G8277340995","display_name":null,"funder_award_id":"GM139816","funder_id":"https://openalex.org/F4320337349","funder_display_name":"NIH Office of the Director"},{"id":"https://openalex.org/G9000915517","display_name":"Discovering how autophagy is sufficient to extend yeast replicative lifespan","funder_award_id":"R01AG079883","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000919613","display_name":"Novel pathways that regulate DNA double-strand break repair events in mammalian cells","funder_award_id":"R35GM139816","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332513","display_name":"Weill Cornell Medical College","ror":"https://ror.org/02r109517"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337349","display_name":"NIH Office of the Director","ror":"https://ror.org/00fj8a872"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":74,"referenced_works":["https://openalex.org/W1756179169","https://openalex.org/W1966072209","https://openalex.org/W1975959567","https://openalex.org/W1982007814","https://openalex.org/W1985868277","https://openalex.org/W2025674512","https://openalex.org/W2029473695","https://openalex.org/W2038846256","https://openalex.org/W2050014475","https://openalex.org/W2053893341","https://openalex.org/W2055184550","https://openalex.org/W2067395327","https://openalex.org/W2073461422","https://openalex.org/W2075377743","https://openalex.org/W2080094749","https://openalex.org/W2082152349","https://openalex.org/W2098343475","https://openalex.org/W2099547258","https://openalex.org/W2108584575","https://openalex.org/W2111997766","https://openalex.org/W2116951302","https://openalex.org/W2119678624","https://openalex.org/W2128329787","https://openalex.org/W2129721121","https://openalex.org/W2130652636","https://openalex.org/W2135020156","https://openalex.org/W2140446904","https://openalex.org/W2141876679","https://openalex.org/W2146503498","https://openalex.org/W2149480306","https://openalex.org/W2154164675","https://openalex.org/W2155135457","https://openalex.org/W2158059089","https://openalex.org/W2158345992","https://openalex.org/W2189788457","https://openalex.org/W2294812607","https://openalex.org/W2345124960","https://openalex.org/W2460960517","https://openalex.org/W2515386838","https://openalex.org/W2751404870","https://openalex.org/W2793498520","https://openalex.org/W2794179220","https://openalex.org/W2886122923","https://openalex.org/W2920373067","https://openalex.org/W2937046550","https://openalex.org/W2946704044","https://openalex.org/W2978258070","https://openalex.org/W2979629052","https://openalex.org/W2994160326","https://openalex.org/W2999000740","https://openalex.org/W3002736291","https://openalex.org/W3020028184","https://openalex.org/W3037859040","https://openalex.org/W3043302462","https://openalex.org/W3046002695","https://openalex.org/W3082688865","https://openalex.org/W3084241396","https://openalex.org/W3109596984","https://openalex.org/W3126029420","https://openalex.org/W3144561945","https://openalex.org/W3159312058","https://openalex.org/W3159801532","https://openalex.org/W3212959806","https://openalex.org/W4205682885","https://openalex.org/W4256202468","https://openalex.org/W4286250324","https://openalex.org/W4290065269","https://openalex.org/W4313531093","https://openalex.org/W4389049682","https://openalex.org/W4389130791","https://openalex.org/W4398160090","https://openalex.org/W4403852165","https://openalex.org/W4404695107","https://openalex.org/W4408153450"],"related_works":["https://openalex.org/W2238833893","https://openalex.org/W7097436189","https://openalex.org/W7095612687","https://openalex.org/W2006022142","https://openalex.org/W7097856953","https://openalex.org/W2900384194","https://openalex.org/W2067377711","https://openalex.org/W3148230608","https://openalex.org/W4256202468","https://openalex.org/W2055169604"],"abstract_inverted_index":{"Overexpression":[0],"of":[1,35,63,101,106,128,151,180],"the":[2,8,61,102,107,129,137,152,181,193,218],"mRNA":[3],"binding":[4],"protein":[5],"Ssd1":[6,29,37,41,65,79,145,166,172,190],"extends":[7],"yeast":[9,77,194],"replicative":[10,195],"lifespan.":[11,64],"Using":[12],"microfluidics":[13],"to":[14,55,85,178],"trap":[15],"and":[16,52,76,131,144,165,189,210,220],"image":[17],"single":[18],"cells":[19],"throughout":[20],"their":[21,53,91],"lifespans,":[22],"we":[23],"find":[24],"that":[25,45,116,187],"lifespan":[26,74,88,119,169,196,208,219],"extension":[27,170,209],"by":[28,33,95,123,142,163,171,197],"overexpression":[30,66,173,191],"is":[31],"accompanied":[32],"formation":[34],"cytoplasmic":[36],"foci.":[38],"The":[39,98],"age-dependent":[40,126,149,200],"foci":[42],"are":[43],"condensates":[44],"appear":[46],"dynamically":[47],"in":[48,113,222],"a":[49,114],"cell-cycle-dependent":[50],"manner,":[51],"failure":[54],"resolve":[56],"during":[57,111,158],"mitosis":[58],"coincided":[59],"with":[60,69,148],"end":[62],"was":[67,121,140,161,176],"epistatic":[68,177],"calorie":[70],"restriction":[71],"(CR)":[72],"for":[73,207],"extension,":[75],"overexpressing":[78],"or":[80,174],"undergoing":[81],"CR":[82,143,164,175,188,215],"were":[83,93],"resistant":[84],"iron":[86,96,108,134,138,153,156,182,201],"supplementation-induced":[87],"shortening,":[89],"while":[90],"lifespans":[92],"reduced":[94,141],"chelation.":[97],"nuclear":[99],"translocation":[100],"Aft1":[103],"transcriptional":[104],"regulator":[105],"regulon":[109,139],"occurred":[110],"aging":[112,159],"manner":[115],"predicted":[117],"remaining":[118],"but":[120,160],"prevented":[122,162],"CR.":[124],"Accordingly,":[125],"induction":[127],"Fit2":[130],"Arn1":[132],"high-affinity":[133],"transporters":[135],"within":[136],"overexpression.":[146,167],"Consistent":[147],"activation":[150],"regulon,":[154],"intracellular":[155],"accumulated":[157],"Moreover,":[168],"inactivation":[179],"regulon.":[183],"These":[184],"studies":[185],"reveal":[186],"extend":[192,217],"blocking":[198],"deleterious":[199],"uptake,":[202],"identifying":[203],"novel":[204],"therapeutic":[205],"targets":[206],"providing":[211],"insight":[212],"into":[213],"how":[214],"may":[216],"healthspan":[221],"humans.":[223]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2025-10-13T00:00:00"}