{"id":"https://openalex.org/W4415096832","doi":"https://doi.org/10.3389/fvets.2025.1639055","title":"Age-related obesity and inflammaging in cats","display_name":"Age-related obesity and inflammaging in cats","publication_year":2025,"publication_date":"2025-10-13","ids":{"openalex":"https://openalex.org/W4415096832","doi":"https://doi.org/10.3389/fvets.2025.1639055","pmid":"https://pubmed.ncbi.nlm.nih.gov/41158939","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12554617"},"language":"en","primary_location":{"id":"doi:10.3389/fvets.2025.1639055","doi":"https://doi.org/10.3389/fvets.2025.1639055","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fvets.2025.1639055","pdf_url":"https://www.frontiersin.org/journals/veterinary-science/articles/10.3389/fvets.2025.1639055/pdf","source":{"id":"https://openalex.org/S2594976040","display_name":"Frontiers in Veterinary Science","issn_l":"2297-1769","issn":["2297-1769"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Veterinary Science","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/veterinary-science/articles/10.3389/fvets.2025.1639055/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083051082","display_name":"Miki Kobayashi","orcid":"https://orcid.org/0000-0001-8116-0505","observed_orcids":["https://orcid.org/0000-0001-8116-0505","https://orcid.org/0009-0000-0102-1346"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Miki Kobayashi","raw_affiliation_strings":["Seijo Kobayashi Veterinary Clinic, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Seijo Kobayashi Veterinary Clinic, Tokyo, Japan","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111759440","display_name":"Motoo Kobayashi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Motoo Kobayashi","raw_affiliation_strings":["Seijo Kobayashi Veterinary Clinic, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Seijo Kobayashi Veterinary Clinic, Tokyo, Japan","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5111759440"],"corresponding_institution_ids":[],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.3308,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.36857143,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":97},"biblio":{"volume":"12","issue":null,"first_page":"1639055","last_page":"1639055"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11580","display_name":"Veterinary Medicine and Surgery","score":0.5673999786376953,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11580","display_name":"Veterinary Medicine and Surgery","score":0.5673999786376953,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.34689998626708984,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.020800000056624413,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/age-related-obesity","display_name":"age-related obesity","score":0.843999981880188},{"id":"https://openalex.org/keywords/inflammaging","display_name":"inflammaging","score":0.9480000138282776},{"id":"https://openalex.org/keywords/cats","display_name":"cats","score":0.8579999804496765},{"id":"https://openalex.org/keywords/cellular-senescence","display_name":"cellular senescence","score":0.8759999871253967},{"id":"https://openalex.org/keywords/senescence-associated-secretory-phenotype","display_name":"senescence-associated secretory phenotype","score":0.9810000061988831},{"id":"https://openalex.org/keywords/immunosenescence","display_name":"immunosenescence","score":0.9049999713897705},{"id":"https://openalex.org/keywords/adiponectin","display_name":"adiponectin","score":0.871999979019165},{"id":"https://openalex.org/keywords/adipokines","display_name":"adipokines","score":0.8740000128746033},{"id":"https://openalex.org/keywords/visceral-fat","display_name":"visceral fat","score":0.7670000195503235},{"id":"https://openalex.org/keywords/hepatic-steatosis","display_name":"hepatic steatosis","score":0.7760000228881836},{"id":"https://openalex.org/keywords/macrophage-infiltration","display_name":"macrophage infiltration","score":0.8379999995231628},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.7990000247955322},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.8360000252723694},{"id":"https://openalex.org/keywords/chronic-low-grade-inflammation","display_name":"low-grade inflammation","score":0.7229999899864197},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.42399999499320984},{"id":"https://openalex.org/keywords/lifestyle-intervention","display_name":"lifestyle intervention","score":0.5410000085830688}],"concepts":[{"id":"https://openalex.org/C194832188","wikidata":"https://www.wikidata.org/wiki/Q2638593","display_name":"Adipokine","level":4,"score":0.8278999924659729},{"id":"https://openalex.org/C2779904517","wikidata":"https://www.wikidata.org/wiki/Q5008900","display_name":"CATS","level":2,"score":0.7537000179290771},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7390999794006348},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.720300018787384},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.6255999803543091},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.5939000248908997},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5597000122070312},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5360000133514404},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5094000101089478},{"id":"https://openalex.org/C2776252253","wikidata":"https://www.wikidata.org/wiki/Q7663815","display_name":"Systemic inflammation","level":3,"score":0.48840001225471497},{"id":"https://openalex.org/C2778772119","wikidata":"https://www.wikidata.org/wiki/Q6058862","display_name":"Fatty liver","level":3,"score":0.4535999894142151},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4205000102519989},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.4106999933719635},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.4036000072956085},{"id":"https://openalex.org/C500499127","wikidata":"https://www.wikidata.org/wiki/Q332154","display_name":"Ageing","level":2,"score":0.30000001192092896},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.2879999876022339},{"id":"https://openalex.org/C2780578515","wikidata":"https://www.wikidata.org/wiki/Q657193","display_name":"Metabolic syndrome","level":3,"score":0.26969999074935913}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fvets.2025.1639055","doi":"https://doi.org/10.3389/fvets.2025.1639055","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fvets.2025.1639055","pdf_url":"https://www.frontiersin.org/journals/veterinary-science/articles/10.3389/fvets.2025.1639055/pdf","source":{"id":"https://openalex.org/S2594976040","display_name":"Frontiers in Veterinary Science","issn_l":"2297-1769","issn":["2297-1769"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Veterinary Science","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:11362008","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12554617","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:41158939","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41158939","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in veterinary science","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:31155b6f604c424381e146091bae27a7","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/31155b6f604c424381e146091bae27a7","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Veterinary Science, Vol 12 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fvets.2025.1639055","doi":"https://doi.org/10.3389/fvets.2025.1639055","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fvets.2025.1639055","pdf_url":"https://www.frontiersin.org/journals/veterinary-science/articles/10.3389/fvets.2025.1639055/pdf","source":{"id":"https://openalex.org/S2594976040","display_name":"Frontiers in Veterinary Science","issn_l":"2297-1769","issn":["2297-1769"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Veterinary Science","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4415096832.pdf","grobid_xml":"https://content.openalex.org/works/W4415096832.grobid-xml"},"referenced_works_count":86,"referenced_works":["https://openalex.org/W1500247249","https://openalex.org/W1524549603","https://openalex.org/W1594796751","https://openalex.org/W1622777525","https://openalex.org/W1682935539","https://openalex.org/W1966706887","https://openalex.org/W1973140848","https://openalex.org/W2001720505","https://openalex.org/W2019486401","https://openalex.org/W2025906171","https://openalex.org/W2043608242","https://openalex.org/W2046534092","https://openalex.org/W2069946908","https://openalex.org/W2071383165","https://openalex.org/W2072541352","https://openalex.org/W2076135478","https://openalex.org/W2078575160","https://openalex.org/W2082402714","https://openalex.org/W2084807681","https://openalex.org/W2088263905","https://openalex.org/W2090464564","https://openalex.org/W2092333751","https://openalex.org/W2092415044","https://openalex.org/W2098432330","https://openalex.org/W2109600107","https://openalex.org/W2110463517","https://openalex.org/W2112186984","https://openalex.org/W2112299930","https://openalex.org/W2126525177","https://openalex.org/W2128214241","https://openalex.org/W2136024338","https://openalex.org/W2136392296","https://openalex.org/W2140204893","https://openalex.org/W2140592417","https://openalex.org/W2141956031","https://openalex.org/W2146774191","https://openalex.org/W2150748567","https://openalex.org/W2162808674","https://openalex.org/W2167759667","https://openalex.org/W2222894597","https://openalex.org/W2462347288","https://openalex.org/W2470302757","https://openalex.org/W2518202212","https://openalex.org/W2538366370","https://openalex.org/W2560805164","https://openalex.org/W2583634043","https://openalex.org/W2588407182","https://openalex.org/W2608937663","https://openalex.org/W2609511098","https://openalex.org/W2623159596","https://openalex.org/W2743010525","https://openalex.org/W2768111757","https://openalex.org/W2775167938","https://openalex.org/W2777892103","https://openalex.org/W2779444716","https://openalex.org/W2802410718","https://openalex.org/W2908118585","https://openalex.org/W2909899734","https://openalex.org/W2946036755","https://openalex.org/W2959728234","https://openalex.org/W2964964456","https://openalex.org/W2967080190","https://openalex.org/W2967094898","https://openalex.org/W3011024942","https://openalex.org/W3022066296","https://openalex.org/W3092293735","https://openalex.org/W3096366497","https://openalex.org/W3107344158","https://openalex.org/W3117392781","https://openalex.org/W3133638730","https://openalex.org/W3180104497","https://openalex.org/W3205240380","https://openalex.org/W4206639971","https://openalex.org/W4220815276","https://openalex.org/W4226084107","https://openalex.org/W4289028880","https://openalex.org/W4294647575","https://openalex.org/W4306822659","https://openalex.org/W4309655180","https://openalex.org/W4312201518","https://openalex.org/W4313397724","https://openalex.org/W4379966446","https://openalex.org/W4380995142","https://openalex.org/W4401308779","https://openalex.org/W4409505067","https://openalex.org/W4411947792"],"related_works":["https://openalex.org/W7168965700","https://openalex.org/W1671379733","https://openalex.org/W4401308779","https://openalex.org/W2967094898","https://openalex.org/W2775167938","https://openalex.org/W3109404272","https://openalex.org/W4298152502","https://openalex.org/W4413290362","https://openalex.org/W4313397724","https://openalex.org/W2046534092"],"abstract_inverted_index":{"Aging":[0,173],"is":[1,160,174,195],"characterized":[2],"by":[3,8,46],"chronic":[4,18,49,71],"systemic":[5],"inflammation":[6],"accompanied":[7],"cellular":[9],"senescence,":[10],"immunosenescence,":[11],"organ":[12],"dysfunction,":[13],"and":[14,34,59,66,111,128,135,151,170,201],"age-related":[15,26,42,75,183,209],"diseases.":[16,57,76],"A":[17,157],"low-grade":[19,70],"pro-inflammatory":[20,133],"state":[21,205],"known":[22],"as":[23,29,87,132,162],"\"inflammaging\"":[24],"accelerates":[25],"diseases":[27],"such":[28,86],"obesity,":[30],"diabetes,":[31],"vascular":[32],"diseases,":[33],"certain":[35],"types":[36],"of":[37,90,108,182,192],"cancer.":[38],"Senescent":[39],"cells":[40],"drive":[41],"tissue":[43],"dysfunction":[44],"partially":[45],"inducing":[47],"a":[48,136,202],"senescence-associated":[50],"secretory":[51],"phenotype":[52],"(SASP)":[53],"associated":[54],"with":[55,63,144,154],"various":[56],"Obesity":[58,77],"insulin":[60],"resistance":[61],"change":[62],"advancing":[64],"age":[65],"are":[67,96],"linked":[68],"to":[69,74,99,104,167],"inflammation,":[72],"leading":[73],"results":[78],"in":[79,82,139,176,211],"significant":[80,137],"changes":[81],"the":[83,105,163,180,189],"adipokine":[84],"profile,":[85],"reduced":[88],"levels":[89],"anti-inflammatory":[91],"adipokines,":[92],"e.g.,":[93],"adiponectin.":[94,140],"Cats":[95],"more":[97],"prone":[98],"obesity":[100,210],"than":[101],"dogs":[102],"owing":[103],"unique":[106],"characteristics":[107],"their":[109],"glucose":[110],"lipid":[112],"metabolism.":[113],"Severely":[114],"obese":[115,142],"cats":[116,143],"show":[117],"excessive":[118,145],"visceral":[119,146],"fat":[120,147],"accumulation,":[121],"significantly":[122],"increased":[123],"triglyceride,":[124],"free":[125],"fatty":[126,149],"acids,":[127],"TNF-\u03b1":[129],"plasma":[130],"concentrations":[131],"markers,":[134],"decrease":[138],"Aged":[141],"exhibit":[148],"liver":[150],"enlarged":[152],"adipocytes":[153],"macrophage":[155],"infiltration.":[156],"healthy":[158],"lifestyle":[159],"recognized":[161],"most":[164],"effective":[165],"way":[166],"maintain":[168],"health":[169],"fight":[171],"aging.":[172],"inevitable":[175],"animals;":[177],"however,":[178],"delaying":[179],"onset":[181],"disease":[184],"through":[185],"adequate":[186],"interventions":[187],"at":[188],"early":[190],"stages":[191],"SASP":[193],"induction":[194],"possible.":[196],"Adequate":[197],"nutrition,":[198],"moderate":[199],"exercise,":[200],"good":[203],"mental":[204],"can":[206],"effectively":[207],"prevent":[208],"cats.":[212]},"counts_by_year":[{"year":2026,"cited_by_count":2}],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2025-10-13T00:00:00"}
