{"id":"https://openalex.org/W4415045191","doi":"https://doi.org/10.1016/j.cub.2025.09.041","title":"Decoding human olfaction by high heterologous expression of odorant receptors detecting signature odorants","display_name":"Decoding human olfaction by high heterologous expression of odorant receptors detecting signature odorants","publication_year":2025,"publication_date":"2025-10-10","ids":{"openalex":"https://openalex.org/W4415045191","doi":"https://doi.org/10.1016/j.cub.2025.09.041","pmid":"https://pubmed.ncbi.nlm.nih.gov/41075782"},"language":"en","primary_location":{"id":"doi:10.1016/j.cub.2025.09.041","doi":"https://doi.org/10.1016/j.cub.2025.09.041","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cub.2025.09.041","pdf_url":null,"source":{"id":"https://openalex.org/S128425624","display_name":"Current Biology","issn_l":"0960-9822","issn":["0960-9822","1879-0445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.cub.2025.09.041","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081028070","display_name":"Roger Emter","orcid":"https://orcid.org/0000-0002-3624-2429","observed_orcids":["https://orcid.org/0000-0002-3624-2429"]},"institutions":[{"id":"https://openalex.org/I2800326226","display_name":"Givaudan (Switzerland)","ror":"https://ror.org/012ddpd05","country_code":"CH","type":"company","lineage":["https://openalex.org/I2800326226"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Roger Emter","raw_affiliation_strings":["Fragrances S&T, Ingredients Research, Givaudan Schweiz AG, Kemptpark 50, 8310 Kemptthal, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fragrances S&T, Ingredients Research, Givaudan Schweiz AG, Kemptpark 50, 8310 Kemptthal, Switzerland","institution_ids":["https://openalex.org/I2800326226"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5095369395","display_name":"Christel M\u00e9rillat","orcid":"https://orcid.org/0009-0002-5567-3264","observed_orcids":["https://orcid.org/0009-0002-5567-3264"]},"institutions":[{"id":"https://openalex.org/I2800326226","display_name":"Givaudan (Switzerland)","ror":"https://ror.org/012ddpd05","country_code":"CH","type":"company","lineage":["https://openalex.org/I2800326226"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Christel Merillat","raw_affiliation_strings":["Fragrances S&T, Ingredients Research, Givaudan Schweiz AG, Kemptpark 50, 8310 Kemptthal, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fragrances S&T, Ingredients Research, Givaudan Schweiz AG, Kemptpark 50, 8310 Kemptthal, Switzerland","institution_ids":["https://openalex.org/I2800326226"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5119942129","display_name":"Fiona Buchli","orcid":"https://orcid.org/0009-0008-4349-0069","observed_orcids":["https://orcid.org/0009-0008-4349-0069"]},"institutions":[{"id":"https://openalex.org/I2800326226","display_name":"Givaudan (Switzerland)","ror":"https://ror.org/012ddpd05","country_code":"CH","type":"company","lineage":["https://openalex.org/I2800326226"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Fiona Buchli","raw_affiliation_strings":["Fragrances S&T, Ingredients Research, Givaudan Schweiz AG, Kemptpark 50, 8310 Kemptthal, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fragrances S&T, Ingredients Research, Givaudan Schweiz AG, Kemptpark 50, 8310 Kemptthal, Switzerland","institution_ids":["https://openalex.org/I2800326226"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068753530","display_name":"Felix Flachsmann","orcid":"https://orcid.org/0000-0002-8165-8714","observed_orcids":["https://orcid.org/0000-0002-8165-8714"]},"institutions":[{"id":"https://openalex.org/I2800326226","display_name":"Givaudan (Switzerland)","ror":"https://ror.org/012ddpd05","country_code":"CH","type":"company","lineage":["https://openalex.org/I2800326226"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Felix Flachsmann","raw_affiliation_strings":["Fragrances S&T, Ingredients Research, Givaudan Schweiz AG, Kemptpark 50, 8310 Kemptthal, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fragrances S&T, Ingredients Research, Givaudan Schweiz AG, Kemptpark 50, 8310 Kemptthal, Switzerland","institution_ids":["https://openalex.org/I2800326226"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023479712","display_name":"Andreas Natsch","orcid":"https://orcid.org/0000-0003-2231-2489","observed_orcids":["https://orcid.org/0000-0003-2231-2489"]},"institutions":[{"id":"https://openalex.org/I2800326226","display_name":"Givaudan (Switzerland)","ror":"https://ror.org/012ddpd05","country_code":"CH","type":"company","lineage":["https://openalex.org/I2800326226"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Andreas Natsch","raw_affiliation_strings":["Fragrances S&T, Ingredients Research, Givaudan Schweiz AG, Kemptpark 50, 8310 Kemptthal, Switzerland. Electronic address: andreas.natsch@givaudan.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fragrances S&T, Ingredients Research, Givaudan Schweiz AG, Kemptpark 50, 8310 Kemptthal, Switzerland. Electronic address: andreas.natsch@givaudan.com","institution_ids":["https://openalex.org/I2800326226"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5023479712"],"corresponding_institution_ids":["https://openalex.org/I2800326226"],"apc_list":{"value":7030,"currency":"USD","value_usd":7030},"apc_paid":{"value":7030,"currency":"USD","value_usd":7030},"fwci":5.1601,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.96038647,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"35","issue":"21","first_page":"5252","last_page":"5263.e4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10971","display_name":"Olfactory and Sensory Function Studies","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10971","display_name":"Olfactory and Sensory Function Studies","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11584","display_name":"Biochemical Analysis and Sensing Techniques","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/olfactory-receptors","display_name":"olfactory receptors","score":0.925000011920929},{"id":"https://openalex.org/keywords/human-olfaction","display_name":"human olfaction","score":0.9729999899864197},{"id":"https://openalex.org/keywords/heterologous-expression","display_name":"heterologous expression","score":0.7919999957084656},{"id":"https://openalex.org/keywords/ambrox","display_name":"ambrox","score":0.800000011920929},{"id":"https://openalex.org/keywords/rotundone","display_name":"rotundone","score":0.7210000157356262},{"id":"https://openalex.org/keywords/nootkatone","display_name":"nootkatone","score":0.9890000224113464},{"id":"https://openalex.org/keywords/2-4-6-trichloroanisole","display_name":"2,4,6-trichloroanisole","score":0.9819999933242798},{"id":"https://openalex.org/keywords/stereoselectivity","display_name":"stereoselectivity","score":0.7319999933242798},{"id":"https://openalex.org/keywords/olfactory-coding","display_name":"odor coding","score":0.5740000009536743},{"id":"https://openalex.org/keywords/receptor-sensitivity","display_name":"receptor sensitivity","score":0.4749999940395355},{"id":"https://openalex.org/keywords/ambergris","display_name":"ambergris","score":0.4779999852180481}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8216000199317932},{"id":"https://openalex.org/C163214680","wikidata":"https://www.wikidata.org/wiki/Q1541064","display_name":"Olfaction","level":2,"score":0.6661999821662903},{"id":"https://openalex.org/C2780115692","wikidata":"https://www.wikidata.org/wiki/Q5747302","display_name":"Heterologous","level":3,"score":0.5558000206947327},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5328999757766724},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5087000131607056},{"id":"https://openalex.org/C108305142","wikidata":"https://www.wikidata.org/wiki/Q3062286","display_name":"Heterologous expression","level":4,"score":0.45829999446868896},{"id":"https://openalex.org/C2778916471","wikidata":"https://www.wikidata.org/wiki/Q485537","display_name":"Odor","level":2,"score":0.4343999922275543},{"id":"https://openalex.org/C2779980732","wikidata":"https://www.wikidata.org/wiki/Q24774756","display_name":"Olfactory receptor","level":3,"score":0.42149999737739563},{"id":"https://openalex.org/C135285700","wikidata":"https://www.wikidata.org/wiki/Q38173","display_name":"G protein-coupled receptor","level":3,"score":0.3950999975204468},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3555999994277954},{"id":"https://openalex.org/C26517878","wikidata":"https://www.wikidata.org/wiki/Q228039","display_name":"Key (lock)","level":2,"score":0.35409998893737793},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.35409998893737793},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.33629998564720154},{"id":"https://openalex.org/C2777328355","wikidata":"https://www.wikidata.org/wiki/Q167377","display_name":"Pheromone","level":2,"score":0.3091000020503998},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3021000027656555},{"id":"https://openalex.org/C21200559","wikidata":"https://www.wikidata.org/wiki/Q7451068","display_name":"Sensitivity (control systems)","level":2,"score":0.2768999934196472},{"id":"https://openalex.org/C91779695","wikidata":"https://www.wikidata.org/wiki/Q3780824","display_name":"Coding region","level":3,"score":0.26170000433921814},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.25850000977516174},{"id":"https://openalex.org/C174510640","wikidata":"https://www.wikidata.org/wiki/Q489618","display_name":"HEK 293 cells","level":3,"score":0.2583000063896179},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.25609999895095825}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009812","descriptor_name":"Odorants","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D012903","descriptor_name":"Smell","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018035","descriptor_name":"Receptors, Odorant","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018035","descriptor_name":"Receptors, Odorant","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.cub.2025.09.041","doi":"https://doi.org/10.1016/j.cub.2025.09.041","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cub.2025.09.041","pdf_url":null,"source":{"id":"https://openalex.org/S128425624","display_name":"Current Biology","issn_l":"0960-9822","issn":["0960-9822","1879-0445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Biology","raw_type":"journal-article"},{"id":"pmid:41075782","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41075782","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current biology : CB","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.cub.2025.09.041","doi":"https://doi.org/10.1016/j.cub.2025.09.041","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cub.2025.09.041","pdf_url":null,"source":{"id":"https://openalex.org/S128425624","display_name":"Current Biology","issn_l":"0960-9822","issn":["0960-9822","1879-0445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F2234137713","display_name":"Givaudan","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W1503588279","https://openalex.org/W1674744817","https://openalex.org/W1976426916","https://openalex.org/W1977767206","https://openalex.org/W1985966332","https://openalex.org/W1988715808","https://openalex.org/W2012056998","https://openalex.org/W2013083006","https://openalex.org/W2013105734","https://openalex.org/W2032341259","https://openalex.org/W2057129522","https://openalex.org/W2065687144","https://openalex.org/W2068926119","https://openalex.org/W2073913395","https://openalex.org/W2077142888","https://openalex.org/W2097186487","https://openalex.org/W2099641023","https://openalex.org/W2101503618","https://openalex.org/W2124427838","https://openalex.org/W2126083312","https://openalex.org/W2133097188","https://openalex.org/W2133754427","https://openalex.org/W2134246002","https://openalex.org/W2267570377","https://openalex.org/W2581429909","https://openalex.org/W2766479272","https://openalex.org/W3002869006","https://openalex.org/W3011447097","https://openalex.org/W3013197332","https://openalex.org/W3047618975","https://openalex.org/W3196416507","https://openalex.org/W4286110904","https://openalex.org/W4308890610","https://openalex.org/W4322744873","https://openalex.org/W4379057592","https://openalex.org/W4386569137","https://openalex.org/W4387865275","https://openalex.org/W4392093630","https://openalex.org/W4394695756","https://openalex.org/W4396733478","https://openalex.org/W4400224240","https://openalex.org/W4403381623"],"related_works":["https://openalex.org/W1997056893","https://openalex.org/W7214991650","https://openalex.org/W7214769059","https://openalex.org/W2018498268","https://openalex.org/W4403381623","https://openalex.org/W2115071709","https://openalex.org/W2127517102","https://openalex.org/W2591634032","https://openalex.org/W2907241546","https://openalex.org/W7101149267"],"abstract_inverted_index":{"Humans":[0],"have":[1,160],"391":[2],"odorant":[3,116],"receptor":[4],"(OR)":[5],"genes.":[6],"Due":[7],"to":[8,64,102],"their":[9],"poor":[10],"functional":[11],"expression":[12,80],"in":[13,149,162],"vitro,":[14],"reproducible":[15],"receptor-ligand":[16],"pairs":[17],"are":[18],"known":[19],"for":[20,89,106,139],"only":[21],"a":[22,37,41,178,198],"minority":[23],"of":[24,29,46,61,86,155,172,180,188,194,197,206,211,219],"them,":[25],"and":[26,52,81,130,134,166,174,209,214],"the":[27,43,84,87,114,118,123,143,163,195,207,216,223],"pharmacology":[28],"human":[30,93,199,212],"olfaction":[31],"is":[32],"still":[33],"poorly":[34],"understood.":[35],"Using":[36],"well-expressed":[38],"OR":[39,94,144,181,224],"as":[40,112,142],"template,":[42],"C-terminal":[44,75],"domains":[45,76],"two":[47],"weakly":[48],"expressed":[49],"class":[50,53],"I":[51],"II":[54],"ORs":[55,105,138,159,213],"were":[56],"engineered":[57],"by":[58,69,183],"several":[59],"rounds":[60],"mutations,":[62],"leading":[63],"dramatically":[65],"increased":[66,70,83],"sensitivity":[67,85,208],"paralleled":[68],"cell-surface":[71],"expression.":[72],"These":[73,201],"optimized":[74],"facilitated":[77],"high":[78],"surface":[79],"strongly":[82],"assay":[88],"many":[90],"ORs.":[91],"A":[92],"library":[95],"with":[96],"these":[97,156],"C":[98],"termini":[99],"allowed":[100],"us":[101],"identify":[103],"novel":[104],"key":[107,115],"natural":[108],"signature":[109],"odorants":[110],"such":[111,141],"(-)ambrox,":[113],"from":[117,128],"sperm":[119],"whale":[120],"secretion":[121],"Ambergris;":[122],"pepper":[124],"note":[125,148],"rotundone;":[126],"(+)-nootkatone":[127],"grapefruit;":[129],"various":[131],"floral,":[132],"fruity,":[133],"food-related":[135],"impact":[136],"odorants.":[137],"off-odors,":[140],"detecting":[145],"2,4,6-trichloroanisole-the":[146],"cork":[147],"wine-could":[150],"equally":[151],"be":[152],"identified.":[153],"Many":[154],"newly":[157],"de-orphanized":[158],"sensitivities":[161],"nanomolar":[164],"range":[165],"unique":[167],"specificities":[168],"based":[169],"on":[170],"screening":[171],"stereoisomers":[173,187],"structural":[175],"analogs.":[176],"Thus,":[177],"comparison":[179],"activation":[182],"13":[184],"differently":[185],"smelling":[186],"ambrox":[189],"reveals":[190],"an":[191],"unprecedented":[192],"view":[193,205],"stereoselectivity":[196],"OR.":[200],"data":[202],"refine":[203],"our":[204],"specificity":[210],"challenge":[215],"combinatorial":[217],"model":[218],"odor":[220],"coding":[221],"at":[222],"level.":[225]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2025-10-11T00:00:00"}