{"id":"https://openalex.org/W4415028704","doi":"https://doi.org/10.1038/s41375-025-02753-w","title":"Heart failure in patients with acute myeloid leukemia (AML) treated with anthracycline agents during remission induction therapy: a systematic review and meta-analysis","display_name":"Heart failure in patients with acute myeloid leukemia (AML) treated with anthracycline agents during remission induction therapy: a systematic review and meta-analysis","publication_year":2025,"publication_date":"2025-10-10","ids":{"openalex":"https://openalex.org/W4415028704","doi":"https://doi.org/10.1038/s41375-025-02753-w","pmid":"https://pubmed.ncbi.nlm.nih.gov/41073560"},"language":"en","primary_location":{"id":"doi:10.1038/s41375-025-02753-w","doi":"https://doi.org/10.1038/s41375-025-02753-w","is_oa":false,"landing_page_url":"https://doi.org/10.1038/s41375-025-02753-w","pdf_url":null,"source":{"id":"https://openalex.org/S149476849","display_name":"Leukemia","issn_l":"0887-6924","issn":["0887-6924","1476-5551"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Leukemia","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.researchsquare.com/article/rs-6327060/latest.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5116054540","display_name":"Jesse Geels","orcid":"https://orcid.org/0009-0004-3858-3157","observed_orcids":["https://orcid.org/0009-0004-3858-3157"]},"institutions":[{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]},{"id":"https://openalex.org/I4210151833","display_name":"Amsterdam University Medical Centers","ror":"https://ror.org/05grdyy37","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833"]},{"id":"https://openalex.org/I4405257531","display_name":"Amsterdam Cardiovascular Sciences","ror":"https://ror.org/05c9qnd49","country_code":"NL","type":"funder","lineage":["https://openalex.org/I4405257531"]},{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Jesse Geels","raw_affiliation_strings":["Department of Cardiology, Amsterdam Cardiovascular Sciences, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands","Department of Hematology, Cancer Center, University Medical Center Utrecht, Utrecht, The Netherlands"],"raw_orcid":"https://orcid.org/0009-0004-3858-3157","affiliations":[{"raw_affiliation_string":"Department of Cardiology, Amsterdam Cardiovascular Sciences, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I4210151833","https://openalex.org/I4405257531","https://openalex.org/I887064364"]},{"raw_affiliation_string":"Department of Hematology, Cancer Center, University Medical Center Utrecht, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I3018483916"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009778676","display_name":"Anna van Rhenen","orcid":"https://orcid.org/0000-0003-2276-8806","observed_orcids":["https://orcid.org/0000-0003-2276-8806"]},"institutions":[{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Anna van Rhenen","raw_affiliation_strings":["Department of Hematology, Cancer Center, University Medical Center Utrecht, Utrecht, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Cancer Center, University Medical Center Utrecht, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I3018483916"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031409310","display_name":"Patrycja L. Gradowska","orcid":"https://orcid.org/0000-0002-4620-9163","observed_orcids":["https://orcid.org/0000-0002-4620-9163"]},"institutions":[{"id":"https://openalex.org/I4210145518","display_name":"Hovon","ror":"https://ror.org/056kpdx27","country_code":"NL","type":"other","lineage":["https://openalex.org/I4210145518"]},{"id":"https://openalex.org/I4210149908","display_name":"Erasmus MC Cancer Institute","ror":"https://ror.org/03r4m3349","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686","https://openalex.org/I4210149908"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Patrycja Gradowska","raw_affiliation_strings":["Department of Hematology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands","HOVON Foundation, Rotterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands","institution_ids":["https://openalex.org/I4210149908"]},{"raw_affiliation_string":"HOVON Foundation, Rotterdam, The Netherlands","institution_ids":["https://openalex.org/I4210145518"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039782389","display_name":"Folkert Wouter Asselbergs","orcid":"https://orcid.org/0000-0002-1692-8669","observed_orcids":["https://orcid.org/0000-0002-1692-8669"]},"institutions":[{"id":"https://openalex.org/I34931013","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08","country_code":"GB","type":"government","lineage":["https://openalex.org/I34931013"]},{"id":"https://openalex.org/I4210138523","display_name":"UCL Biomedical Research Centre","ror":"https://ror.org/03r9qc142","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I124357947","https://openalex.org/I1340918713","https://openalex.org/I34931013","https://openalex.org/I4210138523","https://openalex.org/I45129253"]},{"id":"https://openalex.org/I4210151833","display_name":"Amsterdam University Medical Centers","ror":"https://ror.org/05grdyy37","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833"]},{"id":"https://openalex.org/I4405257531","display_name":"Amsterdam Cardiovascular Sciences","ror":"https://ror.org/05c9qnd49","country_code":"NL","type":"funder","lineage":["https://openalex.org/I4405257531"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]},{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["GB","NL"],"is_corresponding":false,"raw_author_name":"Folkert W. Asselbergs","raw_affiliation_strings":["Department of Cardiology, Amsterdam Cardiovascular Sciences, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands","Institute of Health Informatics, University College London, London, United Kingdom","The National Institute for Health Research University College London Hospitals Biomedical Research Centre, University College London, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Amsterdam Cardiovascular Sciences, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I4210151833","https://openalex.org/I4405257531","https://openalex.org/I887064364"]},{"raw_affiliation_string":"Institute of Health Informatics, University College London, London, United Kingdom","institution_ids":["https://openalex.org/I45129253"]},{"raw_affiliation_string":"The National Institute for Health Research University College London Hospitals Biomedical Research Centre, University College London, London, United Kingdom","institution_ids":["https://openalex.org/I34931013","https://openalex.org/I4210138523","https://openalex.org/I45129253"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021132662","display_name":"Marijke Linschoten","orcid":"https://orcid.org/0000-0002-4541-080X","observed_orcids":["https://orcid.org/0000-0002-4541-080X"]},"institutions":[{"id":"https://openalex.org/I4210105827","display_name":"Netherlands Heart Institute","ror":"https://ror.org/01mh6b283","country_code":"NL","type":"facility","lineage":["https://openalex.org/I4210105827"]},{"id":"https://openalex.org/I4210151833","display_name":"Amsterdam University Medical Centers","ror":"https://ror.org/05grdyy37","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833"]},{"id":"https://openalex.org/I4405257531","display_name":"Amsterdam Cardiovascular Sciences","ror":"https://ror.org/05c9qnd49","country_code":"NL","type":"funder","lineage":["https://openalex.org/I4405257531"]},{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Marijke Linschoten","raw_affiliation_strings":["Department of Cardiology, Amsterdam Cardiovascular Sciences, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands. m.p.m.linschoten@amsterdamumc.nl","Netherlands Heart Institute, Utrecht, The Netherlands. m.p.m.linschoten@amsterdamumc.nl","Department of Cardiology, Amsterdam Cardiovascular Sciences, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Amsterdam Cardiovascular Sciences, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands. m.p.m.linschoten@amsterdamumc.nl","institution_ids":["https://openalex.org/I4210151833","https://openalex.org/I4405257531","https://openalex.org/I887064364"]},{"raw_affiliation_string":"Netherlands Heart Institute, Utrecht, The Netherlands. m.p.m.linschoten@amsterdamumc.nl","institution_ids":["https://openalex.org/I4210105827"]},{"raw_affiliation_string":"Department of Cardiology, Amsterdam Cardiovascular Sciences, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I4210151833","https://openalex.org/I4405257531","https://openalex.org/I887064364"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5021132662"],"corresponding_institution_ids":["https://openalex.org/I4210105827","https://openalex.org/I4210151833","https://openalex.org/I4405257531","https://openalex.org/I887064364"],"apc_list":{"value":5190,"currency":"USD","value_usd":5190},"apc_paid":null,"fwci":0.5026,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.5413109,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":98},"biblio":{"volume":"40","issue":"1","first_page":"120","last_page":"129"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11535","display_name":"Chemotherapy-induced cardiotoxicity and mitigation","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11535","display_name":"Chemotherapy-induced cardiotoxicity and mitigation","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11638","display_name":"Cardiac tumors and thrombi","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":0.8389999866485596},{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":1.0},{"id":"https://openalex.org/keywords/anthracyclines","display_name":"anthracyclines","score":0.9150000214576721},{"id":"https://openalex.org/keywords/cardiotoxicity","display_name":"cardiotoxicity","score":0.9340000152587891},{"id":"https://openalex.org/keywords/adverse-cardiovascular-events","display_name":"cardiovascular adverse events","score":0.8349999785423279},{"id":"https://openalex.org/keywords/daunorubicin","display_name":"daunorubicin","score":0.8989999890327454},{"id":"https://openalex.org/keywords/idarubicin","display_name":"idarubicin","score":1.0},{"id":"https://openalex.org/keywords/mitoxantrone","display_name":"mitoxantrone","score":0.9990000128746033},{"id":"https://openalex.org/keywords/remission-induction","display_name":"remission induction","score":0.9729999899864197},{"id":"https://openalex.org/keywords/cardiac-function-monitoring","display_name":"cardiac function monitoring","score":0.8519999980926514}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8847000002861023},{"id":"https://openalex.org/C2779117419","wikidata":"https://www.wikidata.org/wiki/Q1063862","display_name":"Idarubicin","level":4,"score":0.8151000142097473},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.7732999920845032},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7577000260353088},{"id":"https://openalex.org/C2776802502","wikidata":"https://www.wikidata.org/wiki/Q417589","display_name":"Anthracycline","level":4,"score":0.704800009727478},{"id":"https://openalex.org/C2778233292","wikidata":"https://www.wikidata.org/wiki/Q2118956","display_name":"Cardiotoxicity","level":3,"score":0.6802999973297119},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.6240000128746033},{"id":"https://openalex.org/C2780923524","wikidata":"https://www.wikidata.org/wiki/Q239426","display_name":"Mitoxantrone","level":3,"score":0.5896000266075134},{"id":"https://openalex.org/C2777910003","wikidata":"https://www.wikidata.org/wiki/Q1707292","display_name":"Asymptomatic","level":2,"score":0.5454000234603882},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5220999717712402},{"id":"https://openalex.org/C113280763","wikidata":"https://www.wikidata.org/wiki/Q2326546","display_name":"Subclinical infection","level":2,"score":0.4952000081539154},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4609000086784363},{"id":"https://openalex.org/C78085059","wikidata":"https://www.wikidata.org/wiki/Q641303","display_name":"Ejection fraction","level":3,"score":0.38179999589920044},{"id":"https://openalex.org/C2776611710","wikidata":"https://www.wikidata.org/wiki/Q16888295","display_name":"Induction chemotherapy","level":3,"score":0.3799999952316284},{"id":"https://openalex.org/C111566952","wikidata":"https://www.wikidata.org/wiki/Q1303462","display_name":"Cardiac function curve","level":3,"score":0.37299999594688416},{"id":"https://openalex.org/C2778797674","wikidata":"https://www.wikidata.org/wiki/Q847583","display_name":"Cardiomyopathy","level":3,"score":0.33799999952316284},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.3359000086784363},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.3231000006198883},{"id":"https://openalex.org/C2776601000","wikidata":"https://www.wikidata.org/wiki/Q612108","display_name":"Acute promyelocytic leukemia","level":4,"score":0.31679999828338623},{"id":"https://openalex.org/C194409129","wikidata":"https://www.wikidata.org/wiki/Q103824","display_name":"Hematology","level":2,"score":0.3061999976634979},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3050999939441681},{"id":"https://openalex.org/C2779786085","wikidata":"https://www.wikidata.org/wiki/Q412616","display_name":"Trastuzumab","level":4,"score":0.2946999967098236},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2791999876499176},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.2786000072956085},{"id":"https://openalex.org/C77350462","wikidata":"https://www.wikidata.org/wiki/Q1125472","display_name":"Confounding","level":2,"score":0.2741999924182892},{"id":"https://openalex.org/C88879693","wikidata":"https://www.wikidata.org/wiki/Q217690","display_name":"Cumulative incidence","level":3,"score":0.2685000002384186},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.2669999897480011},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.25949999690055847},{"id":"https://openalex.org/C36036425","wikidata":"https://www.wikidata.org/wiki/Q7846262","display_name":"Troponin","level":3,"score":0.25609999895095825}],"mesh":[{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012074","descriptor_name":"Remission Induction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D018943","descriptor_name":"Anthracyclines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D018943","descriptor_name":"Anthracyclines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D060828","descriptor_name":"Induction Chemotherapy","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D066126","descriptor_name":"Cardiotoxicity","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1038/s41375-025-02753-w","doi":"https://doi.org/10.1038/s41375-025-02753-w","is_oa":false,"landing_page_url":"https://doi.org/10.1038/s41375-025-02753-w","pdf_url":null,"source":{"id":"https://openalex.org/S149476849","display_name":"Leukemia","issn_l":"0887-6924","issn":["0887-6924","1476-5551"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Leukemia","raw_type":"journal-article"},{"id":"doi:10.21203/rs.3.rs-6327060/v1","doi":"https://doi.org/10.21203/rs.3.rs-6327060/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-6327060/v1","pdf_url":"https://www.researchsquare.com/article/rs-6327060/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},{"id":"pmid:41073560","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41073560","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Leukemia","raw_type":"Journal Article"},{"id":"pmh:oai:pure.amsterdamumc.nl:openaire/4146f763-0525-43b6-8569-f2258ee8f20e","doi":null,"is_oa":true,"landing_page_url":"https://pure.amsterdamumc.nl/en/publications/4146f763-0525-43b6-8569-f2258ee8f20e","pdf_url":null,"source":{"id":"https://openalex.org/S7407055222","display_name":"Pure Amsterdam UMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Geels, J, van Rhenen, A, Gradowska, P, Asselbergs, F W & Linschoten, M 2025, 'Heart failure in patients with acute myeloid leukemia (AML) treated with anthracycline agents during remission induction therapy : a systematic review and meta-analysis', Leukemia. https://doi.org/10.1038/s41375-025-02753-w","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pure.eur.nl:openaire/aa638dd1-62b6-4955-816e-856c8c3f8768","doi":null,"is_oa":true,"landing_page_url":"https://pure.eur.nl/en/publications/aa638dd1-62b6-4955-816e-856c8c3f8768","pdf_url":null,"source":{"id":"https://openalex.org/S4306401266","display_name":"EUR Research Repository (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Geels, J, van Rhenen, A, Gradowska, P, Asselbergs, F W & Linschoten, M 2026, 'Heart failure in patients with acute myeloid leukemia (AML) treated with anthracycline agents during remission induction therapy : a systematic review and meta-analysis', Leukemia, vol. 40, no. 1, pp. 120-129. https://doi.org/10.1038/s41375-025-02753-w","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:dspace.library.uu.nl:1874/467946","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/467946","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-6327060/v1","doi":"https://doi.org/10.21203/rs.3.rs-6327060/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-6327060/v1","pdf_url":"https://www.researchsquare.com/article/rs-6327060/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"},{"id":"https://openalex.org/study-designs/meta-analysis","display_name":"Meta-Analysis"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320319990","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08"},{"id":"https://openalex.org/F4320322140","display_name":"Universitair Medisch Centrum Utrecht","ror":"https://ror.org/0575yy874"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4415028704.pdf","grobid_xml":"https://content.openalex.org/works/W4415028704.grobid-xml"},"referenced_works_count":93,"referenced_works":["https://openalex.org/W67759340","https://openalex.org/W99886386","https://openalex.org/W203809443","https://openalex.org/W1492360552","https://openalex.org/W1828224642","https://openalex.org/W1861929829","https://openalex.org/W1976112739","https://openalex.org/W1991058838","https://openalex.org/W1993862617","https://openalex.org/W2007386979","https://openalex.org/W2008285775","https://openalex.org/W2019793347","https://openalex.org/W2022181869","https://openalex.org/W2025086811","https://openalex.org/W2055884944","https://openalex.org/W2069448515","https://openalex.org/W2072273091","https://openalex.org/W2079025304","https://openalex.org/W2081190745","https://openalex.org/W2092010726","https://openalex.org/W2092923243","https://openalex.org/W2101451567","https://openalex.org/W2109775164","https://openalex.org/W2116490529","https://openalex.org/W2117844516","https://openalex.org/W2120321741","https://openalex.org/W2134069813","https://openalex.org/W2137233375","https://openalex.org/W2139168999","https://openalex.org/W2142830602","https://openalex.org/W2142877037","https://openalex.org/W2147646179","https://openalex.org/W2152363012","https://openalex.org/W2159256284","https://openalex.org/W2160746673","https://openalex.org/W2161014244","https://openalex.org/W2165189985","https://openalex.org/W2169265522","https://openalex.org/W2195520254","https://openalex.org/W2343567742","https://openalex.org/W2508734629","https://openalex.org/W2800400752","https://openalex.org/W2888522505","https://openalex.org/W2894296830","https://openalex.org/W2899304092","https://openalex.org/W2913640959","https://openalex.org/W2913869848","https://openalex.org/W2921418804","https://openalex.org/W2969413625","https://openalex.org/W2970684805","https://openalex.org/W2973179055","https://openalex.org/W2982133945","https://openalex.org/W2994960976","https://openalex.org/W3012405276","https://openalex.org/W3035440978","https://openalex.org/W3085579364","https://openalex.org/W3089731105","https://openalex.org/W3093860253","https://openalex.org/W3118615836","https://openalex.org/W3130903278","https://openalex.org/W3176370909","https://openalex.org/W3178765071","https://openalex.org/W3215337877","https://openalex.org/W4221083501","https://openalex.org/W4221098374","https://openalex.org/W4224293098","https://openalex.org/W4284884567","https://openalex.org/W4293068501","https://openalex.org/W4293217929","https://openalex.org/W4294605240","https://openalex.org/W4295242229","https://openalex.org/W4297257599","https://openalex.org/W4313647848","https://openalex.org/W4365448675","https://openalex.org/W4366974898","https://openalex.org/W4367549649","https://openalex.org/W4384028208","https://openalex.org/W4385658384","https://openalex.org/W4386865788","https://openalex.org/W4388109297","https://openalex.org/W4388455931","https://openalex.org/W4388779157","https://openalex.org/W4390904952","https://openalex.org/W4391484645","https://openalex.org/W4392625555","https://openalex.org/W4394692624","https://openalex.org/W4400390799","https://openalex.org/W4401385406","https://openalex.org/W4402581224","https://openalex.org/W4405231044","https://openalex.org/W4406881524","https://openalex.org/W4406899571","https://openalex.org/W4409152208"],"related_works":["https://openalex.org/W4412548293","https://openalex.org/W1409436829","https://openalex.org/W2973179055","https://openalex.org/W4417001994","https://openalex.org/W2764064848","https://openalex.org/W2753077626","https://openalex.org/W4206499539","https://openalex.org/W3007225300","https://openalex.org/W296971820","https://openalex.org/W4379339529"],"abstract_inverted_index":{"Abstract":[0],"Patients":[1],"with":[2,34,74,121],"acute":[3],"myeloid":[4],"leukemia":[5],"(AML)":[6],"are":[7,18,166],"at":[8],"high":[9],"risk":[10],"of":[11,39,99,186,195],"cardiovascular":[12,44],"disease,":[13],"particularly":[14],"heart":[15,40,100,187],"failure.":[16,188],"Anthracyclines":[17],"integral":[19],"to":[20,149,168,179,182],"remission":[21,77],"induction":[22],"in":[23,70,155,173],"patients":[24,72,119],"eligible":[25],"for":[26,31,67,118],"intensive":[27],"treatment":[28],"and":[29,42,65,91,107,114,132,164],"well-known":[30],"their":[32],"association":[33],"cardiotoxicity.":[35],"However,":[36],"the":[37],"incidence":[38],"failure":[41,101],"other":[43],"adverse":[45,140],"events":[46],"(CVAEs),":[47],"as":[48,50],"well":[49],"differences":[51],"across":[52],"various":[53],"anthracycline":[54],"agents,":[55],"has":[56],"not":[57],"been":[58],"comprehensively":[59],"assessed.":[60],"We":[61],"systematically":[62],"searched":[63],"PubMed":[64],"EMBASE":[66],"studies":[68,80],"conducted":[69],"AML":[71,174],"treated":[73,120],"anthracyclines":[75],"during":[76],"induction.":[78],"Forty-one":[79],"(5":[81],"995":[82],"patients),":[83],"primarily":[84,144],"clinical":[85,147],"trials,":[86],"published":[87],"between":[88],"February":[89],"1991":[90],"March":[92],"2024":[93],"were":[94],"included.":[95],"The":[96],"pooled":[97],"proportion":[98],"was":[102,129],"3.2%":[103],"(95%CI":[104,109,112,116],"1.0\u20136.2)":[105],"overall":[106],"2.3%":[108],"1.4\u20133.3),":[110],"5.0%":[111],"0.3\u201314.1)":[113],"10.2%":[115],"2.4\u201321.7)":[117],"daunorubicin,":[122],"idarubicin":[123],"or":[124],"mitoxantrone":[125],"respectively.":[126],"Cardiac":[127],"function":[128,157],"infrequently":[130],"monitored,":[131],"CVAE":[133,162],"reporting":[134,165],"often":[135],"lacked":[136],"detail.":[137],"Since":[138],"current":[139],"event":[141],"grading":[142],"systems":[143],"rely":[145],"on":[146],"symptoms":[148],"determine":[150],"severity,":[151],"significant":[152],"asymptomatic":[153],"declines":[154],"cardiac":[156],"frequently":[158],"go":[159],"undetected.":[160],"Enhanced":[161],"monitoring":[163],"needed":[167],"better":[169],"identify":[170],"subclinical":[171],"cardiotoxicity":[172],"patients,":[175],"enabling":[176],"timely":[177],"intervention":[178],"prevent":[180,193],"progression":[181],"more":[183],"advanced":[184],"stages":[185],"Furthermore,":[189],"early":[190],"management":[191],"might":[192],"delay":[194],"consolidation":[196],"treatment.":[197]},"counts_by_year":[{"year":2026,"cited_by_count":3}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2025-10-10T00:00:00"}