{"id":"https://openalex.org/W4415009103","doi":"https://doi.org/10.1101/2025.10.08.25337553","title":"Genetic Architecture of Placental Efficiency for Term Infants: Monoaminergic Pathways and Placental Tissue Expression","display_name":"Genetic Architecture of Placental Efficiency for Term Infants: Monoaminergic Pathways and Placental Tissue Expression","publication_year":2025,"publication_date":"2025-10-09","ids":{"openalex":"https://openalex.org/W4415009103","doi":"https://doi.org/10.1101/2025.10.08.25337553"},"language":"en","primary_location":{"id":"doi:10.1101/2025.10.08.25337553","doi":"https://doi.org/10.1101/2025.10.08.25337553","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.10.08.25337553","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2025/10/09/2025.10.08.25337553.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.medrxiv.org/content/medrxiv/early/2025/10/09/2025.10.08.25337553.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060339242","display_name":"Jonas Oesterhaug Andersen","orcid":"https://orcid.org/0009-0007-8151-8328","observed_orcids":["https://orcid.org/0009-0007-8151-8328"]},"institutions":[{"id":"https://openalex.org/I184942183","display_name":"University of Oslo","ror":"https://ror.org/01xtthb56","country_code":"NO","type":"education","lineage":["https://openalex.org/I184942183"]},{"id":"https://openalex.org/I4210117451","display_name":"Diakonhjemmet Hospital","ror":"https://ror.org/02jvh3a15","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I4210117451"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Jonas \u00d8sterhaug Andersen","raw_affiliation_strings":["Department of Adult Psychiatry, Division for Mental Health and Substance Abuse, Diakonhjemmet Hospital, Oslo, Norway","Division of Mental Health and Addiction, Institute of Clinical Medicine, University of Oslo, Oslo, Norway","Diakonhjemmet Hospital"],"raw_orcid":"https://orcid.org/0009-0007-8151-8328","affiliations":[{"raw_affiliation_string":"Department of Adult Psychiatry, Division for Mental Health and Substance Abuse, Diakonhjemmet Hospital, Oslo, Norway","institution_ids":["https://openalex.org/I4210117451"]},{"raw_affiliation_string":"Division of Mental Health and Addiction, Institute of Clinical Medicine, University of Oslo, Oslo, Norway","institution_ids":["https://openalex.org/I184942183"]},{"raw_affiliation_string":"Diakonhjemmet Hospital","institution_ids":["https://openalex.org/I4210117451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041354805","display_name":"Stener Nerland","orcid":"https://orcid.org/0000-0001-8771-8856","observed_orcids":["https://orcid.org/0000-0001-8771-8856"]},"institutions":[{"id":"https://openalex.org/I184942183","display_name":"University of Oslo","ror":"https://ror.org/01xtthb56","country_code":"NO","type":"education","lineage":["https://openalex.org/I184942183"]},{"id":"https://openalex.org/I4210117451","display_name":"Diakonhjemmet Hospital","ror":"https://ror.org/02jvh3a15","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I4210117451"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Stener Nerland","raw_affiliation_strings":["Department of Adult Psychiatry, Division for Mental Health and Substance Abuse, Diakonhjemmet Hospital, Oslo, Norway","Division of Mental Health and Addiction, Institute of Clinical Medicine, University of Oslo, Oslo, Norway","Diakonhjemmet Hospital"],"raw_orcid":"https://orcid.org/0000-0001-8771-8856","affiliations":[{"raw_affiliation_string":"Department of Adult Psychiatry, Division for Mental Health and Substance Abuse, Diakonhjemmet Hospital, Oslo, Norway","institution_ids":["https://openalex.org/I4210117451"]},{"raw_affiliation_string":"Division of Mental Health and Addiction, Institute of Clinical Medicine, University of Oslo, Oslo, Norway","institution_ids":["https://openalex.org/I184942183"]},{"raw_affiliation_string":"Diakonhjemmet Hospital","institution_ids":["https://openalex.org/I4210117451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013418533","display_name":"Piotr Pawel Jaholkowski","orcid":"https://orcid.org/0000-0001-9408-3107","observed_orcids":["https://orcid.org/0000-0001-9408-3107"]},"institutions":[{"id":"https://openalex.org/I184942183","display_name":"University of Oslo","ror":"https://ror.org/01xtthb56","country_code":"NO","type":"education","lineage":["https://openalex.org/I184942183"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Piotr Pawel Jaholkowski","raw_affiliation_strings":["Centre for Precision Psychiatry, Division of Mental Health and Addiction, Institute of Clinical Medicine, University of Oslo, Oslo, Norway","University of Oslo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Precision Psychiatry, Division of Mental Health and Addiction, Institute of Clinical Medicine, University of Oslo, Oslo, Norway","institution_ids":["https://openalex.org/I184942183"]},{"raw_affiliation_string":"University of Oslo","institution_ids":["https://openalex.org/I184942183"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001502438","display_name":"Gianluca Ursini","orcid":"https://orcid.org/0000-0002-4733-5196","observed_orcids":["https://orcid.org/0000-0002-4733-5196"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I4210151493","display_name":"Lieber Institute for Brain Development","ror":"https://ror.org/04q36wn27","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210151493"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gianluca Ursini","raw_affiliation_strings":["Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA","Lieber Institute for Brain Development, Johns Hopkins University Medical Campus, Baltimore, MD, USA","Lieber Institute for Brain Development"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"Lieber Institute for Brain Development, Johns Hopkins University Medical Campus, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436","https://openalex.org/I4210151493"]},{"raw_affiliation_string":"Lieber Institute for Brain Development","institution_ids":["https://openalex.org/I4210151493"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052826567","display_name":"Srdjan Djurovic","orcid":"https://orcid.org/0000-0002-8140-8061","observed_orcids":["https://orcid.org/0000-0002-8140-8061"]},"institutions":[{"id":"https://openalex.org/I1281400175","display_name":"Oslo University Hospital","ror":"https://ror.org/00j9c2840","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I1281400175"]},{"id":"https://openalex.org/I184942183","display_name":"University of Oslo","ror":"https://ror.org/01xtthb56","country_code":"NO","type":"education","lineage":["https://openalex.org/I184942183"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Srdjan Djurovic","raw_affiliation_strings":["Centre for Precision Psychiatry, Division of Mental Health and Addiction, Institute of Clinical Medicine, University of Oslo, Oslo, Norway","Department of Medical Genetics, Oslo University Hospital and University of Oslo, Oslo, Norway","Oslo University Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Precision Psychiatry, Division of Mental Health and Addiction, Institute of Clinical Medicine, University of Oslo, Oslo, Norway","institution_ids":["https://openalex.org/I184942183"]},{"raw_affiliation_string":"Department of Medical Genetics, Oslo University Hospital and University of Oslo, Oslo, Norway","institution_ids":["https://openalex.org/I1281400175","https://openalex.org/I184942183"]},{"raw_affiliation_string":"Oslo University Hospital","institution_ids":["https://openalex.org/I1281400175"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103529233","display_name":"Anne Cathrine Staff","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1281400175","display_name":"Oslo University Hospital","ror":"https://ror.org/00j9c2840","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I1281400175"]},{"id":"https://openalex.org/I184942183","display_name":"University of Oslo","ror":"https://ror.org/01xtthb56","country_code":"NO","type":"education","lineage":["https://openalex.org/I184942183"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Anne Cathrine Staff","raw_affiliation_strings":["Division of Obstetrics and Gynaecology, Oslo University Hospital, Oslo, Norway","Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway","University of Oslo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Obstetrics and Gynaecology, Oslo University Hospital, Oslo, Norway","institution_ids":["https://openalex.org/I1281400175"]},{"raw_affiliation_string":"Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway","institution_ids":["https://openalex.org/I184942183"]},{"raw_affiliation_string":"University of Oslo","institution_ids":["https://openalex.org/I184942183"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087626511","display_name":"Anders Martin Dale","orcid":"https://orcid.org/0000-0002-6126-2966","observed_orcids":["https://orcid.org/0000-0002-6126-2966"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anders Dale","raw_affiliation_strings":["Center for Multimodal Imaging and Genetics, University of California, San Diego School of Medicine, La Jolla, CA, USA","Department of Cognitive Science, University of California, San Diego, La Jolla, CA, USA","Department of Neurosciences, University of California, San Diego School of Medicine, La Jolla, CA, USA","Department of Psychiatry, University of California, San Diego School of Medicine, La Jolla, CA, USA","Department of Radiology, University of California, San Diego School of Medicine, La Jolla, CA, USA","University of California San Diego"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Multimodal Imaging and Genetics, University of California, San Diego School of Medicine, La Jolla, CA, USA","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Department of Cognitive Science, University of California, San Diego, La Jolla, CA, USA","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Department of Neurosciences, University of California, San Diego School of Medicine, La Jolla, CA, USA","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Department of Psychiatry, University of California, San Diego School of Medicine, La Jolla, CA, USA","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Department of Radiology, University of California, San Diego School of Medicine, La Jolla, CA, USA","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"University of California San Diego","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020215901","display_name":"Ole A. Andreassen","orcid":"https://orcid.org/0000-0002-4461-3568","observed_orcids":["https://orcid.org/0000-0002-4461-3568"]},"institutions":[{"id":"https://openalex.org/I1281400175","display_name":"Oslo University Hospital","ror":"https://ror.org/00j9c2840","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I1281400175"]},{"id":"https://openalex.org/I184942183","display_name":"University of Oslo","ror":"https://ror.org/01xtthb56","country_code":"NO","type":"education","lineage":["https://openalex.org/I184942183"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Ole A. Andreassen","raw_affiliation_strings":["Centre for Precision Psychiatry, Division of Mental Health and Addiction, Institute of Clinical Medicine, University of Oslo, Oslo, Norway","KG Jebsen Centre for Neurodevelopmental disorders, University of Oslo, Oslo, Norway","Oslo University Hospital and University of Oslo"],"raw_orcid":"https://orcid.org/0000-0002-4461-3568","affiliations":[{"raw_affiliation_string":"Centre for Precision Psychiatry, Division of Mental Health and Addiction, Institute of Clinical Medicine, University of Oslo, Oslo, Norway","institution_ids":["https://openalex.org/I184942183"]},{"raw_affiliation_string":"KG Jebsen Centre for Neurodevelopmental disorders, University of Oslo, Oslo, Norway","institution_ids":["https://openalex.org/I184942183"]},{"raw_affiliation_string":"Oslo University Hospital and University of Oslo","institution_ids":["https://openalex.org/I1281400175","https://openalex.org/I184942183"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016103514","display_name":"Ingrid Agartz","orcid":"https://orcid.org/0000-0002-9839-5391","observed_orcids":["https://orcid.org/0000-0002-9839-5391"]},"institutions":[{"id":"https://openalex.org/I184942183","display_name":"University of Oslo","ror":"https://ror.org/01xtthb56","country_code":"NO","type":"education","lineage":["https://openalex.org/I184942183"]},{"id":"https://openalex.org/I2801939835","display_name":"Region Stockholm","ror":"https://ror.org/02zrae794","country_code":"SE","type":"government","lineage":["https://openalex.org/I2801939835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]},{"id":"https://openalex.org/I4210117451","display_name":"Diakonhjemmet Hospital","ror":"https://ror.org/02jvh3a15","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I4210117451"]}],"countries":["NO","SE"],"is_corresponding":false,"raw_author_name":"Ingrid Agartz","raw_affiliation_strings":["Centre for Precision Psychiatry, Division of Mental Health and Addiction, Institute of Clinical Medicine, University of Oslo, Oslo, Norway","Centre for Psychiatric Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Sciences, Stockholm Region, Stockholm, Sweden","Department of Adult Psychiatry, Division for Mental Health and Substance Abuse, Diakonhjemmet Hospital, Oslo, Norway","Diakonhjemmet Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Precision Psychiatry, Division of Mental Health and Addiction, Institute of Clinical Medicine, University of Oslo, Oslo, Norway","institution_ids":["https://openalex.org/I184942183"]},{"raw_affiliation_string":"Centre for Psychiatric Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Sciences, Stockholm Region, Stockholm, Sweden","institution_ids":["https://openalex.org/I2801939835","https://openalex.org/I28166907"]},{"raw_affiliation_string":"Department of Adult Psychiatry, Division for Mental Health and Substance Abuse, Diakonhjemmet Hospital, Oslo, Norway","institution_ids":["https://openalex.org/I4210117451"]},{"raw_affiliation_string":"Diakonhjemmet Hospital","institution_ids":["https://openalex.org/I4210117451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042733882","display_name":"Alexey A. Shadrin","orcid":"https://orcid.org/0000-0002-7467-250X","observed_orcids":["https://orcid.org/0000-0002-7467-250X"]},"institutions":[{"id":"https://openalex.org/I184942183","display_name":"University of Oslo","ror":"https://ror.org/01xtthb56","country_code":"NO","type":"education","lineage":["https://openalex.org/I184942183"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Alexey Shadrin","raw_affiliation_strings":["Centre for Precision Psychiatry, Division of Mental Health and Addiction, Institute of Clinical Medicine, University of Oslo, Oslo, Norway","KG Jebsen Centre for Neurodevelopmental disorders, University of Oslo, Oslo, Norway","University of Oslo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Precision Psychiatry, Division of Mental Health and Addiction, Institute of Clinical Medicine, University of Oslo, Oslo, Norway","institution_ids":["https://openalex.org/I184942183"]},{"raw_affiliation_string":"KG Jebsen Centre for Neurodevelopmental disorders, University of Oslo, Oslo, Norway","institution_ids":["https://openalex.org/I184942183"]},{"raw_affiliation_string":"University of Oslo","institution_ids":["https://openalex.org/I184942183"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041779991","display_name":"Laura Anne Wortinger","orcid":"https://orcid.org/0000-0003-2721-3172","observed_orcids":["https://orcid.org/0000-0003-2721-3172"]},"institutions":[{"id":"https://openalex.org/I184942183","display_name":"University of Oslo","ror":"https://ror.org/01xtthb56","country_code":"NO","type":"education","lineage":["https://openalex.org/I184942183"]},{"id":"https://openalex.org/I4210117451","display_name":"Diakonhjemmet Hospital","ror":"https://ror.org/02jvh3a15","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I4210117451"]}],"countries":["NO"],"is_corresponding":true,"raw_author_name":"Laura A. Wortinger","raw_affiliation_strings":["Department of Adult Psychiatry, Division for Mental Health and Substance Abuse, Diakonhjemmet Hospital, Oslo, Norway","Department of Psychology, Oslo New University College, Oslo, Norway","Division of Mental Health and Addiction, Institute of Clinical Medicine, University of Oslo, Oslo, Norway","Diakonhjemmet Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Adult Psychiatry, Division for Mental Health and Substance Abuse, Diakonhjemmet Hospital, Oslo, Norway","institution_ids":["https://openalex.org/I4210117451"]},{"raw_affiliation_string":"Department of Psychology, Oslo New University College, Oslo, Norway","institution_ids":[]},{"raw_affiliation_string":"Division of Mental Health and Addiction, Institute of Clinical Medicine, University of Oslo, Oslo, Norway","institution_ids":["https://openalex.org/I184942183"]},{"raw_affiliation_string":"Diakonhjemmet Hospital","institution_ids":["https://openalex.org/I4210117451"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5041779991"],"corresponding_institution_ids":["https://openalex.org/I184942183","https://openalex.org/I4210117451"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.3903999924659729,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.3903999924659729,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10290","display_name":"Pregnancy and preeclampsia studies","score":0.2996000051498413,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11629","display_name":"Birth, Development, and Health","score":0.25949999690055847,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/placental-efficiency","display_name":"placental efficiency","score":0.9990000128746033},{"id":"https://openalex.org/keywords/monoaminergic-pathways","display_name":"monoaminergic pathways","score":0.753000020980835},{"id":"https://openalex.org/keywords/norepinephrine-uptake","display_name":"norepinephrine uptake","score":0.8740000128746033},{"id":"https://openalex.org/keywords/placental-weight","display_name":"placental weight","score":0.7760000228881836},{"id":"https://openalex.org/keywords/term-singleton-births","display_name":"term singleton births","score":0.5759999752044678},{"id":"https://openalex.org/keywords/genetic-correlation","display_name":"genetic correlation","score":0.6700000166893005},{"id":"https://openalex.org/keywords/norepinephrine-transporter","display_name":"norepinephrine transporter","score":0.8109999895095825},{"id":"https://openalex.org/keywords/slc22a2","display_name":"SLC22A2","score":0.9789999723434448},{"id":"https://openalex.org/keywords/slc22a3","display_name":"SLC22A3","score":1.0},{"id":"https://openalex.org/keywords/fetal-growth","display_name":"fetal growth","score":0.578000009059906},{"id":"https://openalex.org/keywords/brain-development","display_name":"brain development","score":0.675000011920929}],"concepts":[{"id":"https://openalex.org/C42251903","wikidata":"https://www.wikidata.org/wiki/Q18391002","display_name":"Monoaminergic","level":4,"score":0.7807999849319458},{"id":"https://openalex.org/C112672928","wikidata":"https://www.wikidata.org/wiki/Q239526","display_name":"Offspring","level":3,"score":0.7200999855995178},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6879000067710876},{"id":"https://openalex.org/C9287583","wikidata":"https://www.wikidata.org/wiki/Q5532883","display_name":"Genetic architecture","level":4,"score":0.6114000082015991},{"id":"https://openalex.org/C2776953305","wikidata":"https://www.wikidata.org/wiki/Q1212935","display_name":"Placenta","level":4,"score":0.58160001039505},{"id":"https://openalex.org/C63428231","wikidata":"https://www.wikidata.org/wiki/Q9043","display_name":"Norwegian","level":2,"score":0.5123000144958496},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.43799999356269836},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.4171999990940094},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3986000120639801},{"id":"https://openalex.org/C187714386","wikidata":"https://www.wikidata.org/wiki/Q420225","display_name":"Monoamine neurotransmitter","level":4,"score":0.3743000030517578},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.3515999913215637},{"id":"https://openalex.org/C2779315647","wikidata":"https://www.wikidata.org/wiki/Q2745412","display_name":"Syncytiotrophoblast","level":5,"score":0.3467000126838684},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.3343999981880188},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.3237000107765198},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.3172999918460846},{"id":"https://openalex.org/C180838311","wikidata":"https://www.wikidata.org/wiki/Q3720208","display_name":"Maternal effect","level":4,"score":0.30570000410079956},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3010999858379364},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.3003999888896942},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2937999963760376},{"id":"https://openalex.org/C66322754","wikidata":"https://www.wikidata.org/wiki/Q4128476","display_name":"Birth weight","level":3,"score":0.2919999957084656},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.28790000081062317},{"id":"https://openalex.org/C169594400","wikidata":"https://www.wikidata.org/wiki/Q244775","display_name":"Twin study","level":3,"score":0.28290000557899475},{"id":"https://openalex.org/C2781332025","wikidata":"https://www.wikidata.org/wiki/Q5508153","display_name":"Full Term","level":3,"score":0.27619999647140503},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.262800008058548},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2619999945163727},{"id":"https://openalex.org/C179463898","wikidata":"https://www.wikidata.org/wiki/Q10273301","display_name":"Epigenesis","level":5,"score":0.25459998846054077},{"id":"https://openalex.org/C68873052","wikidata":"https://www.wikidata.org/wiki/Q349856","display_name":"Genetic variation","level":3,"score":0.25440001487731934},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.2526000142097473},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.25130000710487366}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1101/2025.10.08.25337553","doi":"https://doi.org/10.1101/2025.10.08.25337553","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.10.08.25337553","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2025/10/09/2025.10.08.25337553.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1101/2025.10.08.25337553","doi":"https://doi.org/10.1101/2025.10.08.25337553","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.10.08.25337553","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2025/10/09/2025.10.08.25337553.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6240000128746033}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320316417","display_name":"Trond Mohn stiftelse","ror":"https://ror.org/018zj6955"},{"id":"https://openalex.org/F4320322436","display_name":"Novo Nordisk","ror":"https://ror.org/0435rc536"},{"id":"https://openalex.org/F4320323078","display_name":"Universitetet i Bergen","ror":"https://ror.org/03zga2b32"},{"id":"https://openalex.org/F4320323260","display_name":"Universitetet i Oslo","ror":"https://ror.org/01xtthb56"},{"id":"https://openalex.org/F4320323299","display_name":"Norges Forskningsr\u00e5d","ror":"https://ror.org/00epmv149"},{"id":"https://openalex.org/F4320337091","display_name":"Norwegian Institute of Public Health","ror":"https://ror.org/046nvst19"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4415009103.pdf","grobid_xml":"https://content.openalex.org/works/W4415009103.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W1527063384","https://openalex.org/W1980253852","https://openalex.org/W1988641142","https://openalex.org/W1991328327","https://openalex.org/W2035782892","https://openalex.org/W2055466946","https://openalex.org/W2065941654","https://openalex.org/W2065990925","https://openalex.org/W2097297452","https://openalex.org/W2107279242","https://openalex.org/W2112007464","https://openalex.org/W2112162189","https://openalex.org/W2116408515","https://openalex.org/W2122546244","https://openalex.org/W2135772494","https://openalex.org/W2139425213","https://openalex.org/W2150949422","https://openalex.org/W2256039026","https://openalex.org/W2324647411","https://openalex.org/W2341504574","https://openalex.org/W2345080251","https://openalex.org/W2510028748","https://openalex.org/W2584278634","https://openalex.org/W2770092353","https://openalex.org/W2792956190","https://openalex.org/W2801085348","https://openalex.org/W2867216954","https://openalex.org/W2883408277","https://openalex.org/W2894756767","https://openalex.org/W2896958236","https://openalex.org/W2935716359","https://openalex.org/W2995543767","https://openalex.org/W3007243612","https://openalex.org/W3008780590","https://openalex.org/W3016136518","https://openalex.org/W3126281164","https://openalex.org/W3161510330","https://openalex.org/W3162800482","https://openalex.org/W4224495124","https://openalex.org/W4226343892","https://openalex.org/W4280491857","https://openalex.org/W4283589759","https://openalex.org/W4284883035","https://openalex.org/W4293032483","https://openalex.org/W4310942085","https://openalex.org/W4387363979","https://openalex.org/W4388491228","https://openalex.org/W4391862501","https://openalex.org/W4402339438","https://openalex.org/W4408459093","https://openalex.org/W4413348638"],"related_works":["https://openalex.org/W7213918788","https://openalex.org/W4414824533","https://openalex.org/W4387363979","https://openalex.org/W4387363908","https://openalex.org/W4225274956","https://openalex.org/W2907021876","https://openalex.org/W4313639922","https://openalex.org/W7147439070","https://openalex.org/W2784771192","https://openalex.org/W2942726762"],"abstract_inverted_index":{"Abstract":[0],"The":[1,11],"placenta":[2],"plays":[3],"a":[4,16,172,180],"central":[5],"role":[6],"in":[7,41,124],"supporting":[8],"fetal":[9,29],"growth.":[10,108],"birthweight-to-placental":[12],"weight":[13,129],"ratio":[14],"is":[15],"key":[17],"index":[18],"of":[19,39,103,184],"placental":[20,90,104,125,131,151,173,190],"efficiency":[21],"(PLE)":[22],"and":[23,51,61,69,89,117,119,134,146,149,163,186,192],"its":[24],"capacity":[25],"to":[26,28,167,175],"adapt":[27],"demands.":[30],"We":[31],"conducted":[32],"the":[33,47],"first":[34],"genome-wide":[35,75],"association":[36],"study":[37],"(GWAS)":[38],"PLE":[40,88,100,145,166,185],"63,875":[42],"term":[43],"singleton":[44],"births":[45],"from":[46],"Norwegian":[48],"Mother,":[49],"Father":[50],"Child":[52],"cohort":[53],"(MoBa),":[54],"with":[55,78,95,171],"complementary":[56],"maternal":[57,70],"(N":[58,63],"=":[59,64],"60,472)":[60],"paternal":[62,150,155],"40,116)":[65],"analyses.":[66],"Across":[67],"offspring":[68,193],"genomes,":[71],"we":[72],"identified":[73],"multiple":[74],"significant":[76],"loci,":[77],"TSNAX-DISC1":[79],"consistently":[80],"implicated.":[81],"Comparative":[82],"genetic":[83,136,182],"analyses":[84,121,138],"showed":[85],"overlap":[86,94],"between":[87,144],"weight,":[91,97,152],"but":[92],"minimal":[93],"birth":[96,128],"indicating":[98],"that":[99],"captures":[101],"aspects":[102],"adaptation":[105],"beyond":[106],"overall":[107],"Gene-set":[109],"enrichment":[110,123],"highlighted":[111],"monoaminergic":[112],"pathways,":[113],"particularly":[114],"norepinephrine":[115],"uptake":[116],"transport,":[118],"gene-property":[120],"demonstrated":[122],"tissue,":[126],"unlike":[127],"or":[130],"weight.":[132],"Global":[133],"local":[135],"correlation":[137],"revealed":[139],"predominantly":[140],"strong":[141],"negative":[142],"correlations":[143],"offspring,":[147],"maternal,":[148],"strongest":[153],"for":[154],"genomes.":[156],"Notably,":[157],"mapped":[158],"genes":[159],"including":[160],"SLC6A2,":[161],"SLC22A2,":[162],"SLC22A3":[164],"connect":[165],"monoamine":[168],"signaling,":[169],"consistent":[170],"contribution":[174],"neurodevelopment.":[176],"These":[177],"findings":[178],"reveal":[179],"distinct":[181],"architecture":[183],"shared":[187],"pathways":[188],"linking":[189],"function":[191],"brain":[194],"development.":[195]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2025-10-10T00:00:00"}
