{"id":"https://openalex.org/W4414973167","doi":"https://doi.org/10.1101/2025.10.07.25337516","title":"Machine learning to phenotype pain and predict response to pain interventions among young adults with irritable bowel syndrome","display_name":"Machine learning to phenotype pain and predict response to pain interventions among young adults with irritable bowel syndrome","publication_year":2025,"publication_date":"2025-10-08","ids":{"openalex":"https://openalex.org/W4414973167","doi":"https://doi.org/10.1101/2025.10.07.25337516","pmid":"https://pubmed.ncbi.nlm.nih.gov/41282746","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12632650"},"language":"en","primary_location":{"id":"doi:10.1101/2025.10.07.25337516","doi":"https://doi.org/10.1101/2025.10.07.25337516","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.10.07.25337516","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2025/10/08/2025.10.07.25337516.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.medrxiv.org/content/medrxiv/early/2025/10/08/2025.10.07.25337516.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100332891","display_name":"Jie Chen","orcid":"https://orcid.org/0000-0002-1568-8974","observed_orcids":["https://orcid.org/0000-0002-1568-8974"]},"institutions":[{"id":"https://openalex.org/I103163165","display_name":"Florida State University","ror":"https://ror.org/05g3dte14","country_code":"US","type":"education","lineage":["https://openalex.org/I103163165"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jie Chen","raw_affiliation_strings":["College of Nursing, Florida State University, Tallahassee, FL 32306, USA","Florida State University College of Nursing"],"raw_orcid":"https://orcid.org/0000-0002-1568-8974","affiliations":[{"raw_affiliation_string":"College of Nursing, Florida State University, Tallahassee, FL 32306, USA","institution_ids":["https://openalex.org/I103163165"]},{"raw_affiliation_string":"Florida State University College of Nursing","institution_ids":["https://openalex.org/I103163165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008089770","display_name":"A.M. Li","orcid":"https://orcid.org/0009-0009-3525-395X","observed_orcids":["https://orcid.org/0009-0009-3525-395X"]},"institutions":[{"id":"https://openalex.org/I140172145","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97","country_code":"US","type":"education","lineage":["https://openalex.org/I140172145"]},{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aolan Li","raw_affiliation_strings":["Department of Statistics, University of Connecticut, Storrs, CT 06269, USA","Yale School of Nursing, Orange, CT 06477, USA","Yale School of Nursing"],"raw_orcid":"https://orcid.org/0009-0009-3525-395X","affiliations":[{"raw_affiliation_string":"Department of Statistics, University of Connecticut, Storrs, CT 06269, USA","institution_ids":["https://openalex.org/I140172145"]},{"raw_affiliation_string":"Yale School of Nursing, Orange, CT 06477, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Yale School of Nursing","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050758544","display_name":"Weizi Wu","orcid":"https://orcid.org/0000-0002-1885-7198","observed_orcids":["https://orcid.org/0000-0002-1885-7198"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Weizi Wu","raw_affiliation_strings":["Yale School of Nursing, Orange, CT 06477, USA","Yale School of Nursing"],"raw_orcid":"https://orcid.org/0000-0002-1885-7198","affiliations":[{"raw_affiliation_string":"Yale School of Nursing, Orange, CT 06477, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Yale School of Nursing","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005148452","display_name":"Wanli Xu","orcid":"https://orcid.org/0000-0001-5664-6685","observed_orcids":["https://orcid.org/0000-0001-5664-6685"]},"institutions":[{"id":"https://openalex.org/I140172145","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97","country_code":"US","type":"education","lineage":["https://openalex.org/I140172145"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wanli Xu","raw_affiliation_strings":["School of Nursing, University of Connecticut, Storrs, CT 06269, USA","School of Nursing, University of Connecticut"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Nursing, University of Connecticut, Storrs, CT 06269, USA","institution_ids":["https://openalex.org/I140172145"]},{"raw_affiliation_string":"School of Nursing, University of Connecticut","institution_ids":["https://openalex.org/I140172145"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036058946","display_name":"Tingting Zhao","orcid":"https://orcid.org/0000-0003-2856-1048","observed_orcids":["https://orcid.org/0000-0003-2856-1048"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tingting Zhao","raw_affiliation_strings":["School of Nursing, Columbia University, New York, NY 10032, USA","School of Nursing, Columbia University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Nursing, Columbia University, New York, NY 10032, USA","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"School of Nursing, Columbia University","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033126402","display_name":"Angela Renee Starkweather","orcid":"https://orcid.org/0000-0001-7168-0144","observed_orcids":["https://orcid.org/0000-0001-7168-0144"]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]},{"id":"https://openalex.org/I4390039302","display_name":"Rutgers Health","ror":"https://ror.org/029z02k15","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Angela R. Starkweather","raw_affiliation_strings":["Division of Nursing Science, Rutgers School of Nursing, New Brunswick, NJ 08901, USA","Rutgers School of Nursing"],"raw_orcid":"https://orcid.org/0000-0001-7168-0144","affiliations":[{"raw_affiliation_string":"Division of Nursing Science, Rutgers School of Nursing, New Brunswick, NJ 08901, USA","institution_ids":["https://openalex.org/I102322142"]},{"raw_affiliation_string":"Rutgers School of Nursing","institution_ids":["https://openalex.org/I102322142","https://openalex.org/I4390039302"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072377626","display_name":"Leonel Rodriguez","orcid":"https://orcid.org/0000-0002-7128-6048","observed_orcids":["https://orcid.org/0000-0002-7128-6048"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leonel Rodriguez","raw_affiliation_strings":["Yale School of Medicine, New Haven, CT 06510, USA","Yale School of Medicine"],"raw_orcid":"https://orcid.org/0000-0002-7128-6048","affiliations":[{"raw_affiliation_string":"Yale School of Medicine, New Haven, CT 06510, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Yale School of Medicine","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100678189","display_name":"Ming\u2010Hui Chen","orcid":"https://orcid.org/0000-0003-1935-2447","observed_orcids":["https://orcid.org/0000-0003-1935-2447"]},"institutions":[{"id":"https://openalex.org/I140172145","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97","country_code":"US","type":"education","lineage":["https://openalex.org/I140172145"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ming-Hui Chen","raw_affiliation_strings":["Department of Statistics, University of Connecticut, Storrs, CT 06269, USA","Department of Statistics, University of Connecticut"],"raw_orcid":"https://orcid.org/0000-0003-1935-2447","affiliations":[{"raw_affiliation_string":"Department of Statistics, University of Connecticut, Storrs, CT 06269, USA","institution_ids":["https://openalex.org/I140172145"]},{"raw_affiliation_string":"Department of Statistics, University of Connecticut","institution_ids":["https://openalex.org/I140172145"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037042172","display_name":"Xiaomei S. Cong","orcid":"https://orcid.org/0000-0002-4992-199X","observed_orcids":["https://orcid.org/0000-0002-4992-199X"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaomei S. Cong","raw_affiliation_strings":["Yale School of Nursing, Orange, CT 06477, USA","Yale School of Nursing"],"raw_orcid":"https://orcid.org/0000-0002-4992-199X","affiliations":[{"raw_affiliation_string":"Yale School of Nursing, Orange, CT 06477, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Yale School of Nursing","institution_ids":["https://openalex.org/I32971472"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5100332891"],"corresponding_institution_ids":["https://openalex.org/I103163165"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11282","display_name":"Fibromyalgia and Chronic Fatigue Syndrome Research","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11292","display_name":"Pediatric Pain Management Techniques","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/irritable-bowel-syndrome","display_name":"irritable bowel syndrome","score":0.9990000128746033},{"id":"https://openalex.org/keywords/pain-phenotyping","display_name":"pain phenotyping","score":0.7379999756813049},{"id":"https://openalex.org/keywords/treatment-response-prediction","display_name":"treatment response prediction","score":0.8140000104904175},{"id":"https://openalex.org/keywords/bayesian-additive-regression-trees","display_name":"Bayesian additive regression trees","score":0.8700000047683716},{"id":"https://openalex.org/keywords/pain-intensity","display_name":"pain intensity","score":0.6460000276565552},{"id":"https://openalex.org/keywords/pain-interference","display_name":"pain interference","score":0.9990000128746033},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.9919999837875366},{"id":"https://openalex.org/keywords/comt-val158met-polymorphism","display_name":"COMT Val158Met polymorphism","score":0.8809999823570251},{"id":"https://openalex.org/keywords/pain-catastrophizing","display_name":"pain catastrophizing","score":0.8299999833106995},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.7139999866485596},{"id":"https://openalex.org/keywords/quantitative-sensory-testing","display_name":"quantitative sensory testing","score":0.7889999747276306},{"id":"https://openalex.org/keywords/mechanical-pain-threshold","display_name":"mechanical pain threshold","score":0.8999999761581421},{"id":"https://openalex.org/keywords/food-consumption","display_name":"dietary intake","score":0.6880000233650208},{"id":"https://openalex.org/keywords/psychosocial-factors","display_name":"psychosocial factors","score":0.8830000162124634},{"id":"https://openalex.org/keywords/precision-medicine","display_name":"precision medicine","score":0.6629999876022339},{"id":"https://openalex.org/keywords/young-adults","display_name":"young adults","score":0.7009999752044678},{"id":"https://openalex.org/keywords/gut-brain-axis","display_name":"gut-brain axis","score":0.6840000152587891}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7297999858856201},{"id":"https://openalex.org/C2778271842","wikidata":"https://www.wikidata.org/wiki/Q838966","display_name":"Irritable bowel syndrome","level":2,"score":0.7003999948501587},{"id":"https://openalex.org/C205545832","wikidata":"https://www.wikidata.org/wiki/Q17156455","display_name":"Young adult","level":2,"score":0.644599974155426},{"id":"https://openalex.org/C27415008","wikidata":"https://www.wikidata.org/wiki/Q7256382","display_name":"Psychological intervention","level":2,"score":0.5996000170707703},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.4465999901294708},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.4449999928474426},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4348999857902527},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.3328000009059906},{"id":"https://openalex.org/C163763905","wikidata":"https://www.wikidata.org/wiki/Q17075943","display_name":"Precision medicine","level":2,"score":0.29249998927116394},{"id":"https://openalex.org/C99508421","wikidata":"https://www.wikidata.org/wiki/Q2678675","display_name":"Physical medicine and rehabilitation","level":1,"score":0.27950000762939453},{"id":"https://openalex.org/C2984752397","wikidata":"https://www.wikidata.org/wiki/Q3259956","display_name":"Primary care","level":2,"score":0.2720000147819519},{"id":"https://openalex.org/C2780665704","wikidata":"https://www.wikidata.org/wiki/Q959298","display_name":"Intervention (counseling)","level":2,"score":0.26919999718666077},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.26409998536109924},{"id":"https://openalex.org/C2779974597","wikidata":"https://www.wikidata.org/wiki/Q28448986","display_name":"Clinical Practice","level":2,"score":0.2606000006198883}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1101/2025.10.07.25337516","doi":"https://doi.org/10.1101/2025.10.07.25337516","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.10.07.25337516","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2025/10/08/2025.10.07.25337516.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},{"id":"pmid:41282746","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41282746","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"medRxiv : the preprint server for health sciences","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:11440209","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12632650","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1101/2025.10.07.25337516","doi":"https://doi.org/10.1101/2025.10.07.25337516","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.10.07.25337516","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2025/10/08/2025.10.07.25337516.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4547853270","display_name":null,"funder_award_id":"NINR P20NR016605","funder_id":"https://openalex.org/F4320337353","funder_display_name":"National Institute of Nursing Research"},{"id":"https://openalex.org/G701035394","display_name":"Center for Accelerating Precision Pain Self-Management","funder_award_id":"P20NR016605","funder_id":"https://openalex.org/F4320337353","funder_display_name":"National Institute of Nursing Research"},{"id":"https://openalex.org/G7052153431","display_name":"Multi-Omics Analysis of Pain/Stress Impact on Neurodevelopment in Preterm Infants","funder_award_id":"R01NR016928","funder_id":"https://openalex.org/F4320337353","funder_display_name":"National Institute of Nursing Research"}],"funders":[{"id":"https://openalex.org/F4320309170","display_name":"Florida State University","ror":"https://ror.org/05g3dte14"},{"id":"https://openalex.org/F4320310017","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337353","display_name":"National Institute of Nursing Research","ror":"https://ror.org/01y3zfr79"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4414973167.pdf","grobid_xml":"https://content.openalex.org/works/W4414973167.grobid-xml"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W1143889087","https://openalex.org/W1566386407","https://openalex.org/W1894174368","https://openalex.org/W1960007129","https://openalex.org/W1963704444","https://openalex.org/W1965680147","https://openalex.org/W1979113309","https://openalex.org/W2005769638","https://openalex.org/W2016124588","https://openalex.org/W2047147003","https://openalex.org/W2062100046","https://openalex.org/W2073926673","https://openalex.org/W2084330407","https://openalex.org/W2090072011","https://openalex.org/W2129388504","https://openalex.org/W2131076700","https://openalex.org/W2162420979","https://openalex.org/W2271206729","https://openalex.org/W2321560423","https://openalex.org/W2329552564","https://openalex.org/W2340717842","https://openalex.org/W2342696216","https://openalex.org/W2409244823","https://openalex.org/W2590344642","https://openalex.org/W2752431154","https://openalex.org/W2766963630","https://openalex.org/W2792866754","https://openalex.org/W2793433002","https://openalex.org/W2886222488","https://openalex.org/W2895055688","https://openalex.org/W2945395086","https://openalex.org/W2996661506","https://openalex.org/W3016802365","https://openalex.org/W3119909222","https://openalex.org/W3159143441","https://openalex.org/W3194134413","https://openalex.org/W4205727587","https://openalex.org/W4206084606","https://openalex.org/W4210296643","https://openalex.org/W4220980706","https://openalex.org/W4226391315","https://openalex.org/W4281621109","https://openalex.org/W4296277377","https://openalex.org/W4319003751","https://openalex.org/W4321763687","https://openalex.org/W4360614605","https://openalex.org/W4382363441","https://openalex.org/W4392168320","https://openalex.org/W4413793355"],"related_works":["https://openalex.org/W7144202322","https://openalex.org/W7171697746","https://openalex.org/W4412785885","https://openalex.org/W3044970847","https://openalex.org/W4318214641","https://openalex.org/W2921003543","https://openalex.org/W4220980706","https://openalex.org/W1648481394","https://openalex.org/W2793433002","https://openalex.org/W7203835675"],"abstract_inverted_index":{"Abstract":[0],"Introduction":[1],"Irritable":[2],"bowel":[3],"syndrome":[4],"(IBS)":[5],"is":[6,14,250],"a":[7,46,93,159,192,210,275,296],"prevalent":[8],"disorder":[9],"whose":[10],"most":[11,140],"debilitating":[12],"symptom":[13],"pain.":[15,281],"The":[16,134,154,206],"complex,":[17,244],"multifactorial":[18],"nature":[19],"of":[20,45,84,97,131,162,286],"IBS":[21,201,241,280],"pain":[22,78,80,156,163,169,174,202,242,263,301],"leads":[23],"to":[24,31,71,126,255,289,299],"highly":[25,251],"variable":[26,252],"and":[27,82,89,108,176,181,203,253],"often":[28],"inadequate":[29],"responses":[30],"self-management,":[32],"underscoring":[33],"the":[34,63,119,139],"urgent":[35],"need":[36],"for":[37,77,173,213,234,279],"personalized":[38],"prediction":[39,285],"models.":[40,153],"Methods":[41],"This":[42,189,294],"ancillary":[43],"analysis":[44],"randomized":[47],"controlled":[48],"trial":[49],"(":[50],"NCT03332537":[51],")":[52],"utilized":[53],"data":[54],"from":[55,124],"80":[56],"young":[57],"adults":[58],"with":[59,116],"IBS.":[60,304],"We":[61],"applied":[62],"Bayesian":[64],"Additive":[65],"Regression":[66],"Trees":[67],"machine":[68],"learning":[69,258,270,283],"algorithm":[70],"develop":[72],"27":[73],"distinct":[74,223],"predictive":[75],"models":[76,273],"severity,":[79,164],"interference,":[81],"quality":[83],"life":[85],"(QOL)":[86],"at":[87],"baseline":[88],"post-intervention.":[90],"Predictors":[91],"included":[92],"comprehensive,":[94,193],"multi-domain":[95],"set":[96],"variables":[98],"spanning":[99],"genetics,":[100],"quantitative":[101],"sensory":[102],"testing,":[103],"gut":[104],"microbiota,":[105],"psychosocial":[106,166],"factors,":[107,167],"food":[109,182],"intake.":[110],"Results":[111],"Model":[112],"performance":[113],"was":[114,138,158],"strong,":[115],"area":[117],"under":[118],"curve":[120],"(AUC)":[121],"values":[122],"ranging":[123],"0.753":[125],"0.981.":[127],"A":[128],"consistent":[129],"hierarchy":[130],"predictors":[132,208],"emerged.":[133],"COMT":[135],"rs4680":[136],"polymorphism":[137],"significant":[141],"predictor,":[142],"featuring":[143],"in":[144,151,200,303],"26":[145],"models,":[146],"followed":[147],"by":[148],"ADRA1D":[149],"rs1556832":[150],"24":[152],"mechanical":[155],"threshold":[157],"key":[160],"predictor":[161],"while":[165],"particularly":[168],"catastrophizing,":[170],"were":[171,184],"crucial":[172],"interference":[175],"QOL.":[177],"Gut":[178],"microbiota":[179],"features":[180],"intake":[183],"also":[185],"consistently":[186],"important.":[187],"Discussion":[188],"study":[190],"establishes":[191],"multi-omics":[194],"framework":[195],"that":[196],"explains":[197],"individual":[198,287],"differences":[199],"treatment":[204,292],"response.":[205],"identified":[207],"provide":[209],"practical":[211],"tool":[212],"advancing":[214],"precision":[215,300],"medicine.":[216],"By":[217],"classifying":[218],"patients":[219],"based":[220,271,284],"on":[221],"their":[222],"profiles,":[224],"clinicians":[225],"can":[226,259],"proactively":[227],"customize":[228],"self-management":[229,290],"strategies,":[230],"potentially":[231],"transforming":[232],"care":[233],"this":[235],"complex":[236,262],"condition.":[237],"WHAT":[238,265],"IS":[239,266],"KNOWN":[240],"involves":[243],"dysregulated":[245],"gut-brain":[246],"interactions.":[247],"Treatment":[248],"response":[249,288],"difficult":[254],"predict.":[256],"Machine":[257,269,282],"help":[260],"phenotype":[261],"conditions.":[264],"NEW":[267],"HERE":[268],"hierarchical":[272],"identify":[274],"core":[276],"neurogenetic":[277],"predisposition":[278],"before":[291],"begins.":[293],"provides":[295],"direct":[297],"pathway":[298],"management":[302]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2025-10-10T00:00:00"}
