{"id":"https://openalex.org/W4414912970","doi":"https://doi.org/10.1016/j.jep.2025.120710","title":"YiJing Powder activates the HO-1/NRF2/KEAP1 antioxidant axis to remodel lipid metabolism and ameliorate oligoasthenospermia","display_name":"YiJing Powder activates the HO-1/NRF2/KEAP1 antioxidant axis to remodel lipid metabolism and ameliorate oligoasthenospermia","publication_year":2025,"publication_date":"2025-10-07","ids":{"openalex":"https://openalex.org/W4414912970","doi":"https://doi.org/10.1016/j.jep.2025.120710","pmid":"https://pubmed.ncbi.nlm.nih.gov/41061907"},"language":"en","primary_location":{"id":"doi:10.1016/j.jep.2025.120710","doi":"https://doi.org/10.1016/j.jep.2025.120710","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jep.2025.120710","pdf_url":null,"source":{"id":"https://openalex.org/S29564236","display_name":"Journal of Ethnopharmacology","issn_l":"0378-8741","issn":["0378-8741","1872-7573"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Ethnopharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102396039","display_name":"Hui-Fang Ma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I16295237","display_name":"Gansu Agricultural University","ror":"https://ror.org/05ym42410","country_code":"CN","type":"education","lineage":["https://openalex.org/I16295237"]},{"id":"https://openalex.org/I4405281846","display_name":"Nanchong Vocational College of Science and Technology","ror":"https://ror.org/04z656539","country_code":"CN","type":"education","lineage":["https://openalex.org/I4405281846"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huifang Ma","raw_affiliation_strings":["College of Veterinary Medicine, Gansu Agricultural University, No. 1, Yingmen Village, 730070, Lanzhou, Gansu, PR China; College of Advanced Agricultural Sciences, Nanchong Vocational College of Science and Technology, No. 3, Southwest Avenue, 637131, Nanchong, Sichuan, PR China","College of Veterinary Medicine, Gansu Agricultural University, No. 1, Yingmen Village, 730070, Lanzhou, Gansu; College of Advanced Agricultural Sciences, Nanchong Vocational College of Science and Technology, No. 3, Southwest Avenue, 637131, Nanchong, Sichuan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Veterinary Medicine, Gansu Agricultural University, No. 1, Yingmen Village, 730070, Lanzhou, Gansu, PR China; College of Advanced Agricultural Sciences, Nanchong Vocational College of Science and Technology, No. 3, Southwest Avenue, 637131, Nanchong, Sichuan, PR China","institution_ids":["https://openalex.org/I16295237","https://openalex.org/I4405281846"]},{"raw_affiliation_string":"College of Veterinary Medicine, Gansu Agricultural University, No. 1, Yingmen Village, 730070, Lanzhou, Gansu; College of Advanced Agricultural Sciences, Nanchong Vocational College of Science and Technology, No. 3, Southwest Avenue, 637131, Nanchong, Sichuan","institution_ids":["https://openalex.org/I16295237","https://openalex.org/I4405281846"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035070449","display_name":"Baoxia Chen","orcid":"https://orcid.org/0000-0001-6762-1133","observed_orcids":["https://orcid.org/0000-0001-6762-1133"]},"institutions":[{"id":"https://openalex.org/I16295237","display_name":"Gansu Agricultural University","ror":"https://ror.org/05ym42410","country_code":"CN","type":"education","lineage":["https://openalex.org/I16295237"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Baoxia Chen","raw_affiliation_strings":["College of Veterinary Medicine, Gansu Agricultural University, No. 1, Yingmen Village, 730070, Lanzhou, Gansu, PR China","College of Veterinary Medicine, Gansu Agricultural University, No. 1, Yingmen Village, 730070, Lanzhou, Gansu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Veterinary Medicine, Gansu Agricultural University, No. 1, Yingmen Village, 730070, Lanzhou, Gansu, PR China","institution_ids":["https://openalex.org/I16295237"]},{"raw_affiliation_string":"College of Veterinary Medicine, Gansu Agricultural University, No. 1, Yingmen Village, 730070, Lanzhou, Gansu","institution_ids":["https://openalex.org/I16295237"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015660160","display_name":"Yongli Hua","orcid":"https://orcid.org/0000-0002-9129-2381","observed_orcids":["https://orcid.org/0000-0002-9129-2381","https://orcid.org/0009-0004-2666-6772"]},"institutions":[{"id":"https://openalex.org/I16295237","display_name":"Gansu Agricultural University","ror":"https://ror.org/05ym42410","country_code":"CN","type":"education","lineage":["https://openalex.org/I16295237"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yongli Hua","raw_affiliation_strings":["College of Veterinary Medicine, Gansu Agricultural University, No. 1, Yingmen Village, 730070, Lanzhou, Gansu, PR China. Electronic address: huayongli2004@163.com","College of Veterinary Medicine, Gansu Agricultural University, No. 1, Yingmen Village, 730070, Lanzhou, Gansu. Electronic address: huayongli2004@163.com"],"raw_orcid":"https://orcid.org/0000-0002-9129-2381","affiliations":[{"raw_affiliation_string":"College of Veterinary Medicine, Gansu Agricultural University, No. 1, Yingmen Village, 730070, Lanzhou, Gansu, PR China. Electronic address: huayongli2004@163.com","institution_ids":["https://openalex.org/I16295237"]},{"raw_affiliation_string":"College of Veterinary Medicine, Gansu Agricultural University, No. 1, Yingmen Village, 730070, Lanzhou, Gansu. Electronic address: huayongli2004@163.com","institution_ids":["https://openalex.org/I16295237"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064151828","display_name":"Wei Ma","orcid":"https://orcid.org/0000-0002-1301-5119","observed_orcids":["https://orcid.org/0000-0002-1301-5119"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Weidong Ma","raw_affiliation_strings":["Shaanxi Provincial Agricultural and Livestock Breeding Farm, Baoji, Shaanxi Province, 722203, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shaanxi Provincial Agricultural and Livestock Breeding Farm, Baoji, Shaanxi Province, 722203, PR China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111407906","display_name":"Xiangying Kong","orcid":"https://orcid.org/0000-0003-3769-3368","observed_orcids":["https://orcid.org/0000-0003-3769-3368"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiangying Kong","raw_affiliation_strings":["Qinghai Haibei Animal Husbandry and Veterinary Science Research Institute, Haibei, 812200, PR China","Qinghai Haibei Animal Husbandry and Veterinary Science Research Institute, Haibei, 812200, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Qinghai Haibei Animal Husbandry and Veterinary Science Research Institute, Haibei, 812200, PR China","institution_ids":[]},{"raw_affiliation_string":"Qinghai Haibei Animal Husbandry and Veterinary Science Research Institute, Haibei, 812200, China","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5015660160"],"corresponding_institution_ids":["https://openalex.org/I16295237"],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":1.7376,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.84854369,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":97},"biblio":{"volume":"355","issue":"Pt B","first_page":"120710","last_page":"120710"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11332","display_name":"Genomics, phytochemicals, and oxidative stress","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oligoasthenozoospermia","display_name":"oligoasthenozoospermia","score":0.9980000257492065},{"id":"https://openalex.org/keywords/male-infertility","display_name":"male infertility","score":0.9929999709129333},{"id":"https://openalex.org/keywords/antioxidant-defense","display_name":"antioxidant defense","score":0.531000018119812},{"id":"https://openalex.org/keywords/lipid-metabolism","display_name":"lipid metabolism","score":0.9539999961853027},{"id":"https://openalex.org/keywords/glycerophospholipid-metabolism","display_name":"glycerophospholipid metabolism","score":0.9340000152587891},{"id":"https://openalex.org/keywords/sphingolipid-metabolism","display_name":"sphingolipid metabolism","score":0.9980000257492065},{"id":"https://openalex.org/keywords/sperm-membrane-integrity","display_name":"sperm membrane integrity","score":0.8569999933242798},{"id":"https://openalex.org/keywords/sperm-motility","display_name":"sperm motility","score":0.6610000133514404},{"id":"https://openalex.org/keywords/kidney-yang-deficiency-syndrome","display_name":"kidney yang deficiency","score":0.777999997138977},{"id":"https://openalex.org/keywords/traditional-chinese-medicine","display_name":"traditional Chinese medicine","score":0.640999972820282},{"id":"https://openalex.org/keywords/testicular-histopathology","display_name":"testicular histopathology","score":0.7139999866485596},{"id":"https://openalex.org/keywords/redox-homeostasis","display_name":"redox homeostasis","score":0.7139999866485596}],"concepts":[{"id":"https://openalex.org/C4733338","wikidata":"https://www.wikidata.org/wiki/Q2792936","display_name":"Lipid metabolism","level":2,"score":0.7321000099182129},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.685699999332428},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6783000230789185},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.6044999957084656},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5249999761581421},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.40849998593330383},{"id":"https://openalex.org/C39944091","wikidata":"https://www.wikidata.org/wiki/Q423279","display_name":"Lipid bilayer","level":3,"score":0.3919000029563904},{"id":"https://openalex.org/C55904794","wikidata":"https://www.wikidata.org/wiki/Q82682","display_name":"Redox","level":2,"score":0.3772999942302704},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.35839998722076416},{"id":"https://openalex.org/C2994212657","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Cellular metabolism","level":3,"score":0.3296999931335449},{"id":"https://openalex.org/C116073593","wikidata":"https://www.wikidata.org/wiki/Q864491","display_name":"Biological activity","level":3,"score":0.3262999951839447},{"id":"https://openalex.org/C2778106830","wikidata":"https://www.wikidata.org/wiki/Q29548","display_name":"Cell membrane","level":3,"score":0.3183000087738037},{"id":"https://openalex.org/C107565407","wikidata":"https://www.wikidata.org/wiki/Q6815134","display_name":"Membrane lipids","level":3,"score":0.29429998993873596},{"id":"https://openalex.org/C2780829032","wikidata":"https://www.wikidata.org/wiki/Q898539","display_name":"Lipid peroxidation","level":3,"score":0.2906000018119812},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2890999913215637},{"id":"https://openalex.org/C125501631","wikidata":"https://www.wikidata.org/wiki/Q1587185","display_name":"Biological membrane","level":3,"score":0.2865000069141388},{"id":"https://openalex.org/C2992125399","wikidata":"https://www.wikidata.org/wiki/Q2824461","display_name":"Lipid accumulation","level":2,"score":0.2700999975204468},{"id":"https://openalex.org/C2780183148","wikidata":"https://www.wikidata.org/wiki/Q21099571","display_name":"Lipid II","level":4,"score":0.2694999873638153},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.2506999969482422}],"mesh":[{"descriptor_ui":"D000072019","descriptor_name":"Kelch-Like ECH-Associated Protein 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004365","descriptor_name":"Drugs, Chinese Herbal","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004365","descriptor_name":"Drugs, Chinese Herbal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006419","descriptor_name":"Heme Oxygenase (Decyclizing)","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009845","descriptor_name":"Oligospermia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009845","descriptor_name":"Oligospermia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011208","descriptor_name":"Powders","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013737","descriptor_name":"Testis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013737","descriptor_name":"Testis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050356","descriptor_name":"Lipid Metabolism","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D051267","descriptor_name":"NF-E2-Related Factor 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051547","descriptor_name":"Heme Oxygenase-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.jep.2025.120710","doi":"https://doi.org/10.1016/j.jep.2025.120710","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jep.2025.120710","pdf_url":null,"source":{"id":"https://openalex.org/S29564236","display_name":"Journal of Ethnopharmacology","issn_l":"0378-8741","issn":["0378-8741","1872-7573"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Ethnopharmacology","raw_type":"journal-article"},{"id":"pmid:41061907","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41061907","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of ethnopharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3224418758","display_name":null,"funder_award_id":"Gaufx-03J01","funder_id":"https://openalex.org/F4320324782","funder_display_name":"Gansu Agricultural University"},{"id":"https://openalex.org/G3407547937","display_name":null,"funder_award_id":"CARS 37","funder_id":"https://openalex.org/F4320327287","funder_display_name":"Ministry of Agriculture and Rural Affairs of the People's Republic of China"}],"funders":[{"id":"https://openalex.org/F4320324782","display_name":"Gansu Agricultural University","ror":"https://ror.org/05ym42410"},{"id":"https://openalex.org/F4320326266","display_name":"Agriculture Research System of China","ror":null},{"id":"https://openalex.org/F4320327287","display_name":"Ministry of Agriculture and Rural Affairs of the People's Republic of China","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W1973019265","https://openalex.org/W2008740971","https://openalex.org/W2014972719","https://openalex.org/W2019018556","https://openalex.org/W2054227830","https://openalex.org/W2140112227","https://openalex.org/W2564669559","https://openalex.org/W2779339038","https://openalex.org/W2917491985","https://openalex.org/W2939766037","https://openalex.org/W2960682600","https://openalex.org/W2988033841","https://openalex.org/W3013723415","https://openalex.org/W3191552195","https://openalex.org/W3204213274","https://openalex.org/W3214364491","https://openalex.org/W3215996865","https://openalex.org/W4281760784","https://openalex.org/W4283701282","https://openalex.org/W4285684551","https://openalex.org/W4295182808","https://openalex.org/W4308032670","https://openalex.org/W4309159250","https://openalex.org/W4311330770","https://openalex.org/W4361275931","https://openalex.org/W4390616120","https://openalex.org/W4392107826","https://openalex.org/W4396661295","https://openalex.org/W4402034920","https://openalex.org/W4402722923","https://openalex.org/W4403950696","https://openalex.org/W4409481866","https://openalex.org/W4410746531","https://openalex.org/W4411234657","https://openalex.org/W4411989616"],"related_works":["https://openalex.org/W4415746798","https://openalex.org/W4410392912","https://openalex.org/W4403837875","https://openalex.org/W4388503659","https://openalex.org/W3119668267","https://openalex.org/W7162136059","https://openalex.org/W2291015010","https://openalex.org/W3197181856","https://openalex.org/W4367054084","https://openalex.org/W7170048135"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2025-10-10T00:00:00"}
