{"id":"https://openalex.org/W4414907259","doi":"https://doi.org/10.52645/mjhs.2025.3.13","title":"Sarcopenia and frailty: risk profiles in patients with chronic heart failure","display_name":"Sarcopenia and frailty: risk profiles in patients with chronic heart failure","publication_year":2025,"publication_date":"2025-09-01","ids":{"openalex":"https://openalex.org/W4414907259","doi":"https://doi.org/10.52645/mjhs.2025.3.13"},"language":"en","primary_location":{"id":"doi:10.52645/mjhs.2025.3.13","doi":"https://doi.org/10.52645/mjhs.2025.3.13","is_oa":true,"landing_page_url":"https://doi.org/10.52645/mjhs.2025.3.13","pdf_url":"https://mjhs.md/sites/default/files/2025-09/MJHS_12_3_2025_Mazur_Nicorici.pdf","source":{"id":"https://openalex.org/S4387280783","display_name":"Moldovan Journal of Health Sciences","issn_l":"2345-1467","issn":["2345-1467"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Moldovan Journal of Health Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://mjhs.md/sites/default/files/2025-09/MJHS_12_3_2025_Mazur_Nicorici.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049243003","display_name":"Anastasia A. Ivanes","orcid":"https://orcid.org/0009-0008-5964-9003","observed_orcids":["https://orcid.org/0009-0008-5964-9003"]},"institutions":[{"id":"https://openalex.org/I4210124354","display_name":"Nicolae Testemi\u021banu State University of Medicine and Pharmacy","ror":"https://ror.org/03xww6m08","country_code":"MD","type":"education","lineage":["https://openalex.org/I4210124354"]}],"countries":["MD"],"is_corresponding":false,"raw_author_name":"Anastasia Ivanes","raw_affiliation_strings":["Discipline of Cardiology, Department of Internal Medicine, Nicolae Testemi\u021banu State University of Medicine and Pharmacy, Chisinau, Republic of Moldova"],"raw_orcid":"https://orcid.org/0009-0008-5964-9003","affiliations":[{"raw_affiliation_string":"Discipline of Cardiology, Department of Internal Medicine, Nicolae Testemi\u021banu State University of Medicine and Pharmacy, Chisinau, Republic of Moldova","institution_ids":["https://openalex.org/I4210124354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057896534","display_name":"Lucia Mazur-Nicorici","orcid":"https://orcid.org/0000-0003-3983-8292","observed_orcids":["https://orcid.org/0000-0003-3983-8292"]},"institutions":[{"id":"https://openalex.org/I4210124354","display_name":"Nicolae Testemi\u021banu State University of Medicine and Pharmacy","ror":"https://ror.org/03xww6m08","country_code":"MD","type":"education","lineage":["https://openalex.org/I4210124354"]}],"countries":["MD"],"is_corresponding":false,"raw_author_name":"Lucia Mazur-Nicorici","raw_affiliation_strings":["Discipline of Cardiology, Department of Internal Medicine, Nicolae Testemi\u021banu State University of Medicine and Pharmacy, Chisinau, Republic of Moldova"],"raw_orcid":"https://orcid.org/0000-0003-3983-8292","affiliations":[{"raw_affiliation_string":"Discipline of Cardiology, Department of Internal Medicine, Nicolae Testemi\u021banu State University of Medicine and Pharmacy, Chisinau, Republic of Moldova","institution_ids":["https://openalex.org/I4210124354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026220432","display_name":"Virginia \u0218alaru","orcid":"https://orcid.org/0000-0003-2683-6917","observed_orcids":["https://orcid.org/0000-0003-2683-6917"]},"institutions":[{"id":"https://openalex.org/I4210124354","display_name":"Nicolae Testemi\u021banu State University of Medicine and Pharmacy","ror":"https://ror.org/03xww6m08","country_code":"MD","type":"education","lineage":["https://openalex.org/I4210124354"]}],"countries":["MD"],"is_corresponding":false,"raw_author_name":"Virginia Salaru","raw_affiliation_strings":["Department of Family Medicine, Nicolae Testemi\u021banu State University of Medicine and Pharmacy, Chisinau, Republic of Moldova"],"raw_orcid":"https://orcid.org/0000-0003-2683-6917","affiliations":[{"raw_affiliation_string":"Department of Family Medicine, Nicolae Testemi\u021banu State University of Medicine and Pharmacy, Chisinau, Republic of Moldova","institution_ids":["https://openalex.org/I4210124354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107980712","display_name":"Livi T. Grib","orcid":"https://orcid.org/0000-0001-6913-0864","observed_orcids":["https://orcid.org/0000-0001-6913-0864"]},"institutions":[{"id":"https://openalex.org/I4210124354","display_name":"Nicolae Testemi\u021banu State University of Medicine and Pharmacy","ror":"https://ror.org/03xww6m08","country_code":"MD","type":"education","lineage":["https://openalex.org/I4210124354"]}],"countries":["MD"],"is_corresponding":false,"raw_author_name":"Liviu Grib","raw_affiliation_strings":["Discipline of Cardiology, Department of Internal Medicine, Nicolae Testemi\u021banu State University of Medicine and Pharmacy, Chisinau, Republic of Moldova"],"raw_orcid":"https://orcid.org/0000-0001-6913-0864","affiliations":[{"raw_affiliation_string":"Discipline of Cardiology, Department of Internal Medicine, Nicolae Testemi\u021banu State University of Medicine and Pharmacy, Chisinau, Republic of Moldova","institution_ids":["https://openalex.org/I4210124354"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059505226","display_name":"Snejana B. Vetrila","orcid":"https://orcid.org/0000-0003-0834-8901","observed_orcids":["https://orcid.org/0000-0003-0834-8901"]},"institutions":[{"id":"https://openalex.org/I4210124354","display_name":"Nicolae Testemi\u021banu State University of Medicine and Pharmacy","ror":"https://ror.org/03xww6m08","country_code":"MD","type":"education","lineage":["https://openalex.org/I4210124354"]}],"countries":["MD"],"is_corresponding":false,"raw_author_name":"Snejana Vetrila","raw_affiliation_strings":["Discipline of Cardiology, Department of Internal Medicine, Nicolae Testemi\u021banu State University of Medicine and Pharmacy, Chisinau, Republic of Moldova"],"raw_orcid":"https://orcid.org/0000-0003-0834-8901","affiliations":[{"raw_affiliation_string":"Discipline of Cardiology, Department of Internal Medicine, Nicolae Testemi\u021banu State University of Medicine and Pharmacy, Chisinau, Republic of Moldova","institution_ids":["https://openalex.org/I4210124354"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210124354"],"apc_list":null,"apc_paid":null,"fwci":0.5161,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.63094733,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"12","issue":"3","first_page":"80","last_page":"85"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10397","display_name":"Nutrition and Health in Aging","score":0.9336000084877014,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10397","display_name":"Nutrition and Health in Aging","score":0.9336000084877014,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11011","display_name":"Frailty in Older Adults","score":0.050700001418590546,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.006599999964237213,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sarcopenia","display_name":"sarcopenia","score":0.9919999837875366},{"id":"https://openalex.org/keywords/frailty","display_name":"frailty","score":0.9959999918937683},{"id":"https://openalex.org/keywords/chronic-heart-failure","display_name":"chronic heart failure","score":0.9980000257492065},{"id":"https://openalex.org/keywords/risk-factors","display_name":"risk factors","score":0.7839999794960022},{"id":"https://openalex.org/keywords/edmonton-frail-scale","display_name":"Edmonton Frail Scale","score":0.9049999713897705},{"id":"https://openalex.org/keywords/functional-disability","display_name":"functional disability","score":0.6940000057220459},{"id":"https://openalex.org/keywords/walking-speed","display_name":"walking speed","score":0.6899999976158142},{"id":"https://openalex.org/keywords/timed-up-and-go-test","display_name":"Timed Up and Go test","score":0.8119999766349792},{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":0.8489999771118164},{"id":"https://openalex.org/keywords/nt-probnp","display_name":"NT-proBNP","score":0.996999979019165},{"id":"https://openalex.org/keywords/metformin","display_name":"metformin","score":0.972000002861023},{"id":"https://openalex.org/keywords/statins","display_name":"statins","score":0.5960000157356262},{"id":"https://openalex.org/keywords/exercise","display_name":"physical activity","score":0.8379999995231628},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.5889999866485596},{"id":"https://openalex.org/keywords/heart-failure-with-reduced-ejection-fraction","display_name":"heart failure with reduced ejection fraction","score":0.7310000061988831},{"id":"https://openalex.org/keywords/heart-failure-with-preserved-ejection-fraction","display_name":"heart failure with preserved ejection fraction","score":0.996999979019165}],"concepts":[{"id":"https://openalex.org/C2776214593","wikidata":"https://www.wikidata.org/wiki/Q1787939","display_name":"Sarcopenia","level":2,"score":0.9305999875068665},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8608999848365784},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.8396999835968018},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6068999767303467},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.546999990940094},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.54339998960495},{"id":"https://openalex.org/C78085059","wikidata":"https://www.wikidata.org/wiki/Q641303","display_name":"Ejection fraction","level":3,"score":0.5419999957084656},{"id":"https://openalex.org/C61427482","wikidata":"https://www.wikidata.org/wiki/Q6656244","display_name":"Anthropometry","level":2,"score":0.4975999891757965},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.4343000054359436},{"id":"https://openalex.org/C23131810","wikidata":"https://www.wikidata.org/wiki/Q818574","display_name":"Observational study","level":2,"score":0.4154999852180481},{"id":"https://openalex.org/C2779159551","wikidata":"https://www.wikidata.org/wiki/Q1414874","display_name":"Comorbidity","level":2,"score":0.3411000072956085},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.3361000120639801},{"id":"https://openalex.org/C2777099384","wikidata":"https://www.wikidata.org/wiki/Q3799239","display_name":"Heart failure with preserved ejection fraction","level":4,"score":0.296999990940094},{"id":"https://openalex.org/C2780074459","wikidata":"https://www.wikidata.org/wiki/Q389735","display_name":"Heart disease","level":2,"score":0.290800005197525},{"id":"https://openalex.org/C143095724","wikidata":"https://www.wikidata.org/wiki/Q515895","display_name":"Odds","level":3,"score":0.2879999876022339},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.2858999967575073},{"id":"https://openalex.org/C11783203","wikidata":"https://www.wikidata.org/wiki/Q5478027","display_name":"Framingham Risk Score","level":3,"score":0.26030001044273376},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.257999986410141},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.2563999891281128}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.52645/mjhs.2025.3.13","doi":"https://doi.org/10.52645/mjhs.2025.3.13","is_oa":true,"landing_page_url":"https://doi.org/10.52645/mjhs.2025.3.13","pdf_url":"https://mjhs.md/sites/default/files/2025-09/MJHS_12_3_2025_Mazur_Nicorici.pdf","source":{"id":"https://openalex.org/S4387280783","display_name":"Moldovan Journal of Health Sciences","issn_l":"2345-1467","issn":["2345-1467"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Moldovan Journal of Health Sciences","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.52645/mjhs.2025.3.13","doi":"https://doi.org/10.52645/mjhs.2025.3.13","is_oa":true,"landing_page_url":"https://doi.org/10.52645/mjhs.2025.3.13","pdf_url":"https://mjhs.md/sites/default/files/2025-09/MJHS_12_3_2025_Mazur_Nicorici.pdf","source":{"id":"https://openalex.org/S4387280783","display_name":"Moldovan Journal of Health Sciences","issn_l":"2345-1467","issn":["2345-1467"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Moldovan Journal of Health Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4414907259.pdf","grobid_xml":"https://content.openalex.org/works/W4414907259.grobid-xml"},"referenced_works_count":14,"referenced_works":["https://openalex.org/W2583122059","https://openalex.org/W2587686068","https://openalex.org/W3034004005","https://openalex.org/W3110397180","https://openalex.org/W4220857088","https://openalex.org/W4306836038","https://openalex.org/W4383720844","https://openalex.org/W4387100950","https://openalex.org/W4391434082","https://openalex.org/W4391609327","https://openalex.org/W4401038584","https://openalex.org/W4401483254","https://openalex.org/W4405455452","https://openalex.org/W4408681860"],"related_works":["https://openalex.org/W4316467589","https://openalex.org/W4327621374","https://openalex.org/W3123204931","https://openalex.org/W7166463748","https://openalex.org/W3211159471","https://openalex.org/W4389339799","https://openalex.org/W2560624383","https://openalex.org/W4224988223","https://openalex.org/W2999133936","https://openalex.org/W4312221522"],"abstract_inverted_index":{"Introduction.":[0],"Patients":[1,152],"with":[2,7,42,58,62,79,89,102,127,198,227,296],"heart":[3,46,63,77,87,104,129,334],"failure":[4,78,88,105,335],"frequently":[5],"present":[6,255],"varying":[8],"degrees":[9],"of":[10,26,36,71,231,258,263,268,308],"skeletal":[11],"muscle":[12,27],"dysfunction,":[13,341],"from":[14,74],"early":[15,353],"fatigue":[16],"to":[17,32,66,96,107,160,306],"sarcopenia":[18,49,72,98,246,297,309],"and":[19,50,83,106,111,115,136,145,149,181,192,223,244,266,277,291,319,343,355],"cachexia.":[20],"Sarcopenia,":[21],"defined":[22],"as":[23],"the":[24,33,69,140,146,165,215,350],"loss":[25],"mass":[28],"and/or":[29],"function,":[30],"contributes":[31],"physical":[34,315],"dimension":[35],"frailty.":[37,187],"Both":[38],"conditions":[39],"are":[40,55,346],"associated":[41,109,295],"adverse":[43],"outcomes":[44],"in":[45,76,86,242,247,256,324,332],"failure.":[47,64,130],"Although":[48],"frailty":[51,161],"often":[52],"coexist,":[53],"they":[54],"distinct":[56],"syndromes":[57],"a":[59,228],"bidirectional":[60],"relationship":[61],"According":[65],"European":[67],"data,":[68],"prevalence":[70],"ranges":[73],"20-50%":[75],"reduced":[80],"ejection":[81,91],"fraction":[82],"approximately":[84],"18%":[85],"preserved":[90],"fraction.":[92],"This":[93],"study":[94,120,157],"aimed":[95],"evaluate":[97],"among":[99,250,283,338],"frail":[100,125,333],"patients":[101,126,217],"chronic":[103,128],"identify":[108],"risk":[110,237,298],"protective":[112],"factors.":[113],"Material":[114],"methods.":[116],"A":[117,204],"cross-sectional":[118],"observational":[119],"was":[121,209,240,254,304,329],"conducted":[122],"on":[123],"44":[124,216],"Data":[131],"collection":[132],"included":[133,190],"clinical,":[134],"functional,":[135],"anthropometric":[137],"parameters,":[138],"using":[139],"SARC-Calf":[141],"questionnaire,":[142],"gait":[143],"speed":[144],"Timed":[147],"Up":[148],"Go":[150],"test.":[151],"were":[153,202,221,280,294,321],"stratified":[154],"into":[155],"three":[156],"groups":[158],"according":[159],"severity":[162],"assessed":[163],"by":[164],"Edmonton":[166],"Frail":[167],"Scale:":[168],"Study":[169,175,182,259],"Group":[170,176,183,260,264,269],"1":[171],"-":[172,178,185],"mild":[173],"frailty,":[174,180],"2":[177],"moderate":[179],"3":[184],"severe":[186,245],"Statistical":[188],"analysis":[189],"Chi-square":[191],"Fisher's":[193],"exact":[194],"tests.":[195],"Odds":[196],"Ratios":[197],"95%":[199],"Confidence":[200],"Intervals":[201],"calculated.":[203],"p":[205],"less":[206],"than":[207],"0.05":[208],"considered":[210],"statistically":[211],"significant.":[212],"Results.":[213],"Of":[214],"included,":[218],"32":[219],"(72.7%)":[220],"women":[222],"12":[224],"(27.3%)":[225],"men,":[226],"mean":[229],"age":[230],"67.3":[232],"\u00b1":[233],"8.9":[234],"years.":[235],"Sarcopenia":[236,328],"(SARC-Calf":[238],"\u22654)":[239],"identified":[241],"56.8%,":[243],"15.9%,":[248],"exclusively":[249],"women.":[251,339],"Functional":[252],"impairment":[253],"88.9%":[257],"1,":[261],"91.7%":[262],"2,":[265],"100%":[267],"3.":[270],"Arterial":[271],"hypertension":[272],"(71.4%),":[273],"diabetes":[274],"mellitus":[275],"(57.1%),":[276],"obesity":[278],"(42.8%)":[279],"more":[281,322],"prevalent":[282,331],"sarcopenic":[284,325],"patients.":[285,326],"C-reactive":[286],"protein":[287],"levels":[288],">6":[289],"mg/L":[290],"elevated":[292],"NT-proBNP":[293],"(p":[299,310],"=":[300,311],"0.039).":[301],"Metformin":[302],"use":[303],"linked":[305],"absence":[307],"0.008),":[312],"while":[313],"low":[314],"activity,":[316],"statin":[317],"use,":[318],"inflammation":[320],"frequent":[323],"Conclusions.":[327],"highly":[330],"patients,":[336],"particularly":[337],"Cardiac":[340],"inflammation,":[342],"metabolic":[344],"comorbidities":[345],"key":[347],"contributors,":[348],"highlighting":[349],"need":[351],"for":[352],"screening":[354],"tailored":[356],"interventions":[357]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-10-10T00:00:00"}