{"id":"https://openalex.org/W4414855415","doi":"https://doi.org/10.1101/2025.10.05.680593","title":"Lipid Landscape of human cells","display_name":"Lipid Landscape of human cells","publication_year":2025,"publication_date":"2025-10-06","ids":{"openalex":"https://openalex.org/W4414855415","doi":"https://doi.org/10.1101/2025.10.05.680593"},"language":"en","primary_location":{"id":"doi:10.1101/2025.10.05.680593","doi":"https://doi.org/10.1101/2025.10.05.680593","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.10.05.680593","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.1101/2025.10.05.680593","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062043756","display_name":"Mads M\u00f8ller Foged","orcid":"https://orcid.org/0000-0003-2225-6114","observed_orcids":["https://orcid.org/0000-0003-2225-6114"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mads M\u00f8ller Foged","raw_affiliation_strings":["Danish Cancer Institute;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Danish Cancer Institute;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108618016","display_name":"Knut Kristoffer Bundgaard Clemmensen","orcid":"https://orcid.org/0000-0002-8610-8009","observed_orcids":["https://orcid.org/0000-0002-8610-8009"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Knut Kristoffer Bundgaard Clemmensen","raw_affiliation_strings":["Danish Cancer Institute;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Danish Cancer Institute;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082657759","display_name":"Lya Katrine Kauffeldt Holland","orcid":"https://orcid.org/0000-0001-5386-5022","observed_orcids":["https://orcid.org/0000-0001-5386-5022"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lya Katrine Kauffeldt Holland","raw_affiliation_strings":["Danish Cancer Institute;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Danish Cancer Institute;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073972688","display_name":"Jano Dicroce Giacobini","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jano Dicroce Giacobini","raw_affiliation_strings":["Danish Cancer Institute;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Danish Cancer Institute;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056571521","display_name":"Mesut Bilgin","orcid":"https://orcid.org/0000-0002-5034-8465","observed_orcids":["https://orcid.org/0000-0002-5034-8465"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mesut Bilgin","raw_affiliation_strings":["Danish Cancer Institute;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Danish Cancer Institute;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089816865","display_name":"Kevin Titeca","orcid":"https://orcid.org/0000-0002-7677-8252","observed_orcids":["https://orcid.org/0000-0002-7677-8252"]},"institutions":[{"id":"https://openalex.org/I114457229","display_name":"University of Geneva","ror":"https://ror.org/01swzsf04","country_code":"CH","type":"education","lineage":["https://openalex.org/I114457229"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Kevin Titeca","raw_affiliation_strings":["University of Geneva;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Geneva;","institution_ids":["https://openalex.org/I114457229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006067126","display_name":"Anne\u2010Claude Gavin","orcid":"https://orcid.org/0000-0003-4917-2340","observed_orcids":["https://orcid.org/0000-0003-4917-2340"]},"institutions":[{"id":"https://openalex.org/I114457229","display_name":"University of Geneva","ror":"https://ror.org/01swzsf04","country_code":"CH","type":"education","lineage":["https://openalex.org/I114457229"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Anne-Claude Gavin","raw_affiliation_strings":["University of Geneva;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Geneva;","institution_ids":["https://openalex.org/I114457229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076112400","display_name":"Marja J\u00e4\u00e4ttel\u00e4","orcid":"https://orcid.org/0000-0001-5950-7111","observed_orcids":["https://orcid.org/0000-0001-5950-7111"]},"institutions":[{"id":"https://openalex.org/I4210148920","display_name":"Danish Cancer Society","ror":"https://ror.org/03ytt7k16","country_code":"DK","type":"nonprofit","lineage":["https://openalex.org/I4210148920"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Marja J\u00e4\u00e4ttel\u00e4","raw_affiliation_strings":["Danish Cancer Society Research Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Danish Cancer Society Research Center","institution_ids":["https://openalex.org/I4210148920"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080450087","display_name":"Kenji Maeda","orcid":"https://orcid.org/0000-0002-9080-5691","observed_orcids":["https://orcid.org/0000-0002-9080-5691"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Kenji Maeda","raw_affiliation_strings":["Danish Cancer Institute;"],"raw_orcid":"https://orcid.org/0000-0002-9080-5691","affiliations":[{"raw_affiliation_string":"Danish Cancer Institute;","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5080450087"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.9595000147819519,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.9595000147819519,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.01510000042617321,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.009499999694526196,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/human-cells","display_name":"human cells","score":0.5690000057220459},{"id":"https://openalex.org/keywords/shotgun-lipidomics","display_name":"shotgun lipidomics","score":0.9259999990463257},{"id":"https://openalex.org/keywords/endoplasmic-reticulum","display_name":"endoplasmic reticulum","score":0.9409999847412109},{"id":"https://openalex.org/keywords/plasma-membrane-lipid-composition","display_name":"plasma membrane lipid composition","score":0.7770000100135803},{"id":"https://openalex.org/keywords/phosphatidylserine","display_name":"phosphatidylserine","score":0.8569999933242798},{"id":"https://openalex.org/keywords/sphingolipids","display_name":"sphingolipids","score":0.9610000252723694},{"id":"https://openalex.org/keywords/cholesterol","display_name":"cholesterol","score":0.9419999718666077},{"id":"https://openalex.org/keywords/glycerophospholipids","display_name":"glycerophospholipids","score":0.8550000190734863},{"id":"https://openalex.org/keywords/ether-phospholipids","display_name":"ether phospholipids","score":0.925000011920929},{"id":"https://openalex.org/keywords/monoethanolamine","display_name":"monoethanolamine","score":0.6819999814033508},{"id":"https://openalex.org/keywords/lipogenesis","display_name":"lipogenesis","score":0.675000011920929}],"concepts":[{"id":"https://openalex.org/C2909522894","wikidata":"https://www.wikidata.org/wiki/Q420004","display_name":"Glycerophospholipids","level":4,"score":0.9142000079154968},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.484499990940094},{"id":"https://openalex.org/C2776330855","wikidata":"https://www.wikidata.org/wiki/Q650187","display_name":"Phosphatidylcholine","level":4,"score":0.4496000111103058},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43209999799728394},{"id":"https://openalex.org/C180899940","wikidata":"https://www.wikidata.org/wiki/Q117982","display_name":"Lipid signaling","level":3,"score":0.43209999799728394},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.40950000286102295},{"id":"https://openalex.org/C25095133","wikidata":"https://www.wikidata.org/wiki/Q573950","display_name":"Lipid droplet","level":2,"score":0.4056999981403351},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4016999900341034},{"id":"https://openalex.org/C2776952329","wikidata":"https://www.wikidata.org/wiki/Q420004","display_name":"Glycerophospholipid","level":4,"score":0.3986000120639801},{"id":"https://openalex.org/C168240541","wikidata":"https://www.wikidata.org/wiki/Q45948","display_name":"Organelle","level":2,"score":0.38940000534057617},{"id":"https://openalex.org/C2778918659","wikidata":"https://www.wikidata.org/wiki/Q186915","display_name":"Phospholipid","level":3,"score":0.38760000467300415},{"id":"https://openalex.org/C4733338","wikidata":"https://www.wikidata.org/wiki/Q2792936","display_name":"Lipid metabolism","level":2,"score":0.37310001254081726},{"id":"https://openalex.org/C58017582","wikidata":"https://www.wikidata.org/wiki/Q6556376","display_name":"Lipidomics","level":2,"score":0.37059998512268066},{"id":"https://openalex.org/C2781381752","wikidata":"https://www.wikidata.org/wiki/Q1953597","display_name":"Slug","level":2,"score":0.3301999866962433},{"id":"https://openalex.org/C185154212","wikidata":"https://www.wikidata.org/wiki/Q410454","display_name":"Liposome","level":2,"score":0.3206000030040741},{"id":"https://openalex.org/C44353895","wikidata":"https://www.wikidata.org/wiki/Q6556772","display_name":"Lipotoxicity","level":4,"score":0.31769999861717224},{"id":"https://openalex.org/C107565407","wikidata":"https://www.wikidata.org/wiki/Q6815134","display_name":"Membrane lipids","level":3,"score":0.30410000681877136},{"id":"https://openalex.org/C553450214","wikidata":"https://www.wikidata.org/wiki/Q851162","display_name":"Biosynthesis","level":3,"score":0.30149999260902405},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.2985000014305115},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.2912999987602234},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.28459998965263367},{"id":"https://openalex.org/C2987857752","wikidata":"https://www.wikidata.org/wiki/Q12147","display_name":"Human health","level":2,"score":0.2734000086784363},{"id":"https://openalex.org/C134088382","wikidata":"https://www.wikidata.org/wiki/Q6556364","display_name":"Lipid microdomain","level":3,"score":0.2606000006198883},{"id":"https://openalex.org/C188810444","wikidata":"https://www.wikidata.org/wiki/Q3476415","display_name":"Phospholipid scramblase","level":5,"score":0.2540000081062317},{"id":"https://openalex.org/C75385678","wikidata":"https://www.wikidata.org/wiki/Q4896390","display_name":"Inner mitochondrial membrane","level":3,"score":0.2517000138759613}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1101/2025.10.05.680593","doi":"https://doi.org/10.1101/2025.10.05.680593","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.10.05.680593","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1101/2025.10.05.680593","doi":"https://doi.org/10.1101/2025.10.05.680593","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.10.05.680593","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.4000000059604645,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8168427686","display_name":"Center for Autophagy, Recycling and Disease (CARD)","funder_award_id":"DNRF125","funder_id":"https://openalex.org/F4320320943","funder_display_name":"Danmarks Grundforskningsfond"}],"funders":[{"id":"https://openalex.org/F4320320943","display_name":"Danmarks Grundforskningsfond","ror":"https://ror.org/00znyv691"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W1495951828","https://openalex.org/W1563184306","https://openalex.org/W1878733133","https://openalex.org/W1967190893","https://openalex.org/W1986477156","https://openalex.org/W1989378845","https://openalex.org/W2001956269","https://openalex.org/W2006221512","https://openalex.org/W2019351415","https://openalex.org/W2027737365","https://openalex.org/W2029589437","https://openalex.org/W2046138985","https://openalex.org/W2046189032","https://openalex.org/W2050721857","https://openalex.org/W2068262899","https://openalex.org/W2089860059","https://openalex.org/W2099133435","https://openalex.org/W2107099939","https://openalex.org/W2110065044","https://openalex.org/W2116687544","https://openalex.org/W2125872855","https://openalex.org/W2127031535","https://openalex.org/W2147621341","https://openalex.org/W2160694503","https://openalex.org/W2163182699","https://openalex.org/W2168635425","https://openalex.org/W2599649240","https://openalex.org/W2614874662","https://openalex.org/W2766127467","https://openalex.org/W2790612835","https://openalex.org/W2790705492","https://openalex.org/W2791180019","https://openalex.org/W2885910759","https://openalex.org/W2896758254","https://openalex.org/W3008166401","https://openalex.org/W3011299576","https://openalex.org/W3023677370","https://openalex.org/W3081379347","https://openalex.org/W3091953196","https://openalex.org/W4214834615","https://openalex.org/W4221090868","https://openalex.org/W4285388811","https://openalex.org/W4295757764","https://openalex.org/W4309511756","https://openalex.org/W4311676725","https://openalex.org/W4321595486","https://openalex.org/W4386736884","https://openalex.org/W4389991955","https://openalex.org/W4403486104","https://openalex.org/W4413345632","https://openalex.org/W4414395106"],"related_works":["https://openalex.org/W2532302047","https://openalex.org/W2776110803","https://openalex.org/W2163182699","https://openalex.org/W4245480366","https://openalex.org/W7140074888","https://openalex.org/W7095217759","https://openalex.org/W7221545361","https://openalex.org/W4392206785","https://openalex.org/W2490403655","https://openalex.org/W2794771344"],"abstract_inverted_index":{"Abstract":[0],"Eukaryotic":[1],"cells":[2,39],"synthesise":[3],"thousands":[4],"of":[5,37,44,49,90,99],"lipid":[6,32,45,51,140],"species,":[7],"yet":[8],"the":[9,60,70,84],"principles":[10],"that":[11,128],"organise":[12],"them":[13],"across":[14,34,103],"compartments":[15,36],"remain":[16],"unclear.":[17],"Here":[18],"we":[19],"introduce":[20],"PAP-SL,":[21],"parallel":[22],"(immuno)affinity":[23],"purification":[24],"coupled":[25],"to":[26,29,119,138],"shotgun":[27],"lipidomics,":[28],"map":[30],"\u223c300":[31],"species":[33,108],"six":[35],"human":[38],"and":[40,63,93,142,148],"uncover":[41],"general":[42],"rules":[43],"organisation.":[46],"Correlation":[47],"analyses":[48],"stoichiometric":[50],"compositions":[52],"resolved":[53],"archetypal":[54],"distribution":[55],"trajectories.":[56],"Biosynthetic":[57],"origin":[58],"set":[59],"baseline:":[61],"mitochondrial":[62],"lysosomal":[64],"pathways":[65],"generated":[66],"confined":[67],"pools,":[68],"whereas":[69],"ER":[71,82,114],"acted":[72],"as":[73],"a":[74,122,136],"dispatch":[75],"hub":[76],"shaping":[77],"downstream":[78],"membrane":[79,87],"territories.":[80],"The":[81,113],"established":[83],"saturated":[85,101],"plasma":[86],"through":[88],"transfer":[89],"phosphatidylserine,":[91],"sphingolipids,":[92],"cholesterol,":[94],"together":[95],"with":[96],"species-level":[97],"selection":[98],"more":[100],"glycerophospholipids":[102,118],"diverse":[104],"headgroups,":[105],"while":[106],"less-saturated":[107],"moved":[109],"unselectively":[110],"into":[111],"mitochondria.":[112],"also":[115],"channelled":[116],"ether-linked":[117],"lysosomes,":[120],"forming":[121],"territory":[123],"dominated":[124],"by":[125],"ether":[126],"phosphatidylcholine":[127],"collapsed":[129],"under":[130],"ethanolamine-driven":[131],"metabolic":[132,144],"rewiring.":[133],"PAP-SL":[134],"defines":[135],"framework":[137],"resolve":[139],"organisation":[141],"its":[143],"plasticity":[145],"in":[146],"health":[147],"disease.":[149]},"counts_by_year":[{"year":2026,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2025-10-10T00:00:00"}