{"id":"https://openalex.org/W4414851981","doi":"https://doi.org/10.1007/s11033-025-11107-9","title":"Investigation of the antitumor effects of deferasirox on prostate cancer cells: insights into proliferation, apoptosis, and invasion mechanisms","display_name":"Investigation of the antitumor effects of deferasirox on prostate cancer cells: insights into proliferation, apoptosis, and invasion mechanisms","publication_year":2025,"publication_date":"2025-10-06","ids":{"openalex":"https://openalex.org/W4414851981","doi":"https://doi.org/10.1007/s11033-025-11107-9","pmid":"https://pubmed.ncbi.nlm.nih.gov/41051585"},"language":"en","primary_location":{"id":"doi:10.1007/s11033-025-11107-9","doi":"https://doi.org/10.1007/s11033-025-11107-9","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s11033-025-11107-9","pdf_url":null,"source":{"id":"https://openalex.org/S197962172","display_name":"Molecular Biology Reports","issn_l":"0301-4851","issn":["0301-4851","1573-4978"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Biology Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067073278","display_name":"Mesut Aky\u00fcz","orcid":"https://orcid.org/0000-0001-8161-2479","observed_orcids":["https://orcid.org/0000-0001-8161-2479"]},"institutions":[{"id":"https://openalex.org/I265519392","display_name":"Erzurum Technical University","ror":"https://ror.org/038pb1155","country_code":"TR","type":"education","lineage":["https://openalex.org/I265519392"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Mesut Aky\u00fcz","raw_affiliation_strings":["Department of Molecular Biology and Genetics, Faculty of Science, Erzurum Technical University, Erzurum, T\u00fcrkiye, Turkey. mesut.akyuz@erzurum.edu.tr","Department of Molecular Biology and Genetics, Faculty of Science, Erzurum Technical University, Erzurum, T\u00fcrkiye, Turkey"],"raw_orcid":"https://orcid.org/0000-0001-8161-2479","affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Genetics, Faculty of Science, Erzurum Technical University, Erzurum, T\u00fcrkiye, Turkey. mesut.akyuz@erzurum.edu.tr","institution_ids":["https://openalex.org/I265519392"]},{"raw_affiliation_string":"Department of Molecular Biology and Genetics, Faculty of Science, Erzurum Technical University, Erzurum, T\u00fcrkiye, Turkey","institution_ids":["https://openalex.org/I265519392"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103222700","display_name":"Elanur Ayd\u0131n Karata\u015f","orcid":"https://orcid.org/0000-0001-8975-1932","observed_orcids":["https://orcid.org/0000-0001-8975-1932","https://orcid.org/0000-0001-8992-6931"]},"institutions":[{"id":"https://openalex.org/I265519392","display_name":"Erzurum Technical University","ror":"https://ror.org/038pb1155","country_code":"TR","type":"education","lineage":["https://openalex.org/I265519392"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Elanur Aydin Karata\u015f","raw_affiliation_strings":["Department of Molecular Biology and Genetics, Faculty of Science, Erzurum Technical University, Erzurum, T\u00fcrkiye, Turkey"],"raw_orcid":"https://orcid.org/0000-0001-8975-1932","affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Genetics, Faculty of Science, Erzurum Technical University, Erzurum, T\u00fcrkiye, Turkey","institution_ids":["https://openalex.org/I265519392"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5067073278"],"corresponding_institution_ids":["https://openalex.org/I265519392"],"apc_list":{"value":4290,"currency":"USD","value_usd":4290},"apc_paid":null,"fwci":0.8415,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.66020811,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"52","issue":"1","first_page":"988","last_page":"988"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.45579999685287476,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.45579999685287476,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.2321999967098236,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.19869999587535858,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/deferasirox","display_name":"deferasirox","score":1.0},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.8989999890327454},{"id":"https://openalex.org/keywords/iron-chelation","display_name":"iron chelation","score":0.9279999732971191},{"id":"https://openalex.org/keywords/iron-starvation","display_name":"iron starvation","score":0.8190000057220459},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.8320000171661377},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8550000190734863},{"id":"https://openalex.org/keywords/cell-cycle-arrest","display_name":"cell cycle arrest","score":0.9890000224113464},{"id":"https://openalex.org/keywords/cell-invasion","display_name":"cell invasion","score":0.7279999852180481},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.7170000076293945},{"id":"https://openalex.org/keywords/ndrg1","display_name":"NDRG1","score":0.9929999709129333},{"id":"https://openalex.org/keywords/pc-3-cells","display_name":"PC-3 cells","score":0.8240000009536743},{"id":"https://openalex.org/keywords/lncap-cells","display_name":"LNCaP cells","score":0.9589999914169312},{"id":"https://openalex.org/keywords/pnt1a-cells","display_name":"PNT1A cells","score":0.8220000267028809},{"id":"https://openalex.org/keywords/cell-viability","display_name":"cell viability","score":0.5609999895095825}],"concepts":[{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.8744999766349792},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6736000180244446},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6116999983787537},{"id":"https://openalex.org/C2781053155","wikidata":"https://www.wikidata.org/wiki/Q5251502","display_name":"Deferasirox","level":3,"score":0.586899995803833},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.388700008392334},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.33489999175071716},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3294000029563904},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32179999351501465},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2590999901294708},{"id":"https://openalex.org/C2994223898","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate disease","level":4,"score":0.1972000002861023}],"mesh":[{"descriptor_ui":"D000077588","descriptor_name":"Deferasirox","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000078722","descriptor_name":"PC-3 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007501","descriptor_name":"Iron","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007502","descriptor_name":"Iron Chelating Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009361","descriptor_name":"Neoplasm Invasiveness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D059447","descriptor_name":"Cell Cycle Checkpoints","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/s11033-025-11107-9","doi":"https://doi.org/10.1007/s11033-025-11107-9","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s11033-025-11107-9","pdf_url":null,"source":{"id":"https://openalex.org/S197962172","display_name":"Molecular Biology Reports","issn_l":"0301-4851","issn":["0301-4851","1573-4978"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Biology Reports","raw_type":"journal-article"},{"id":"pmid:41051585","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41051585","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular biology reports","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7529822010","display_name":null,"funder_award_id":"124Z037","funder_id":"https://openalex.org/F4320322626","funder_display_name":"T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ft\u0131rma Kurumu"}],"funders":[{"id":"https://openalex.org/F4320322626","display_name":"T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ft\u0131rma Kurumu","ror":"https://ror.org/04w9kkr77"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":58,"referenced_works":["https://openalex.org/W1564930378","https://openalex.org/W1566772021","https://openalex.org/W1575278276","https://openalex.org/W1605281376","https://openalex.org/W1965618865","https://openalex.org/W1999576743","https://openalex.org/W2002526053","https://openalex.org/W2022216262","https://openalex.org/W2029548767","https://openalex.org/W2036148514","https://openalex.org/W2056477869","https://openalex.org/W2056880902","https://openalex.org/W2062107099","https://openalex.org/W2085892106","https://openalex.org/W2091849811","https://openalex.org/W2094864890","https://openalex.org/W2095217879","https://openalex.org/W2107277218","https://openalex.org/W2109837506","https://openalex.org/W2114360920","https://openalex.org/W2119692077","https://openalex.org/W2121242732","https://openalex.org/W2138364046","https://openalex.org/W2153654059","https://openalex.org/W2159519702","https://openalex.org/W2279566464","https://openalex.org/W2320529499","https://openalex.org/W2506464204","https://openalex.org/W2576006617","https://openalex.org/W2583934405","https://openalex.org/W2592105910","https://openalex.org/W2599245395","https://openalex.org/W2604533446","https://openalex.org/W2608234050","https://openalex.org/W2611332446","https://openalex.org/W2738548714","https://openalex.org/W2800122808","https://openalex.org/W2904391185","https://openalex.org/W2905124135","https://openalex.org/W2910083100","https://openalex.org/W2944257777","https://openalex.org/W2945861626","https://openalex.org/W2956596526","https://openalex.org/W2973119946","https://openalex.org/W2997177665","https://openalex.org/W3000124456","https://openalex.org/W3006230803","https://openalex.org/W3035324372","https://openalex.org/W3048906709","https://openalex.org/W3124120955","https://openalex.org/W3191900730","https://openalex.org/W3213451896","https://openalex.org/W4200460633","https://openalex.org/W4232013301","https://openalex.org/W4281982640","https://openalex.org/W4307181652","https://openalex.org/W4309721940","https://openalex.org/W4312140507"],"related_works":["https://openalex.org/W2036148514","https://openalex.org/W7108338701","https://openalex.org/W2592105910","https://openalex.org/W2906951571","https://openalex.org/W4403185570","https://openalex.org/W2045480559","https://openalex.org/W2902223111","https://openalex.org/W2606335433","https://openalex.org/W1575278276","https://openalex.org/W3176406662"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-10-10T00:00:00"}