{"id":"https://openalex.org/W4414845909","doi":"https://doi.org/10.1038/s41398-025-03613-y","title":"Adolescent methamphetamine exposure drives neuroinflammation and aberrant neurogenesis linked to anxiety and cognitive impairments in adult mice","display_name":"Adolescent methamphetamine exposure drives neuroinflammation and aberrant neurogenesis linked to anxiety and cognitive impairments in adult mice","publication_year":2025,"publication_date":"2025-10-06","ids":{"openalex":"https://openalex.org/W4414845909","doi":"https://doi.org/10.1038/s41398-025-03613-y","pmid":"https://pubmed.ncbi.nlm.nih.gov/41052970","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12501007"},"language":"en","primary_location":{"id":"doi:10.1038/s41398-025-03613-y","doi":"https://doi.org/10.1038/s41398-025-03613-y","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41398-025-03613-y","pdf_url":"https://www.nature.com/articles/s41398-025-03613-y.pdf","source":{"id":"https://openalex.org/S163345920","display_name":"Translational Psychiatry","issn_l":"2158-3188","issn":["2158-3188"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational Psychiatry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41398-025-03613-y.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076963879","display_name":"Akane Ito","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akane Ito","raw_affiliation_strings":["Department of Neuroscience and Cell Biology, Graduate School of Medicine, The University of Osaka, Suita, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience and Cell Biology, Graduate School of Medicine, The University of Osaka, Suita, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076057309","display_name":"Noriyoshi Usui","orcid":"https://orcid.org/0000-0001-8079-8013","observed_orcids":["https://orcid.org/0000-0001-8079-8013"]},"institutions":[{"id":"https://openalex.org/I4405284972","display_name":"Osaka Psychiatric Medical Center","ror":"https://ror.org/04j4q9j26","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4405284972"]},{"id":"https://openalex.org/I4405287051","display_name":"Global Center for Medical Engineering and Informatics, The University of Osaka","ror":"https://ror.org/03zqg6348","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405287051","https://openalex.org/I98285908"]},{"id":"https://openalex.org/I4405287211","display_name":"Center of Medical Innovation and Translational Research, The University of Osaka","ror":"https://ror.org/04eb86b14","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405287211","https://openalex.org/I98285908"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Noriyoshi Usui","raw_affiliation_strings":["Addiction Research Unit, Osaka Psychiatric Research Center, Osaka Psychiatric Medical Center, Osaka, Japan. usui@anat1.med.osaka-u.ac.jp","Department of Neuroscience and Cell Biology, Graduate School of Medicine, The University of Osaka, Suita, Japan. usui@anat1.med.osaka-u.ac.jp","Global Center for Medical Engineering and Informatics, The University of Osaka, Suita, Japan. usui@anat1.med.osaka-u.ac.jp","Omics Center, Center of Medical Innovation and Translational Research, Graduate School of Medicine, The University of Osaka, Suita, Japan. usui@anat1.med.osaka-u.ac.jp","United Graduate School of Child Development, The University of Osaka, Suita, Japan. usui@anat1.med.osaka-u.ac.jp","Department of Neuroscience and Cell Biology, Graduate School of Medicine, The University of Osaka, Suita, Japan"],"raw_orcid":"https://orcid.org/0000-0001-8079-8013","affiliations":[{"raw_affiliation_string":"Addiction Research Unit, Osaka Psychiatric Research Center, Osaka Psychiatric Medical Center, Osaka, Japan. usui@anat1.med.osaka-u.ac.jp","institution_ids":["https://openalex.org/I4405284972"]},{"raw_affiliation_string":"Department of Neuroscience and Cell Biology, Graduate School of Medicine, The University of Osaka, Suita, Japan. usui@anat1.med.osaka-u.ac.jp","institution_ids":["https://openalex.org/I98285908"]},{"raw_affiliation_string":"Global Center for Medical Engineering and Informatics, The University of Osaka, Suita, Japan. usui@anat1.med.osaka-u.ac.jp","institution_ids":["https://openalex.org/I4405287051","https://openalex.org/I98285908"]},{"raw_affiliation_string":"Omics Center, Center of Medical Innovation and Translational Research, Graduate School of Medicine, The University of Osaka, Suita, Japan. usui@anat1.med.osaka-u.ac.jp","institution_ids":["https://openalex.org/I4405287211","https://openalex.org/I98285908"]},{"raw_affiliation_string":"United Graduate School of Child Development, The University of Osaka, Suita, Japan. usui@anat1.med.osaka-u.ac.jp","institution_ids":["https://openalex.org/I98285908"]},{"raw_affiliation_string":"Department of Neuroscience and Cell Biology, Graduate School of Medicine, The University of Osaka, Suita, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077707532","display_name":"Miyuki Doi","orcid":"https://orcid.org/0009-0007-9847-1861","observed_orcids":["https://orcid.org/0009-0007-9847-1861"]},"institutions":[{"id":"https://openalex.org/I4405284972","display_name":"Osaka Psychiatric Medical Center","ror":"https://ror.org/04j4q9j26","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4405284972"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Miyuki Doi","raw_affiliation_strings":["Addiction Research Unit, Osaka Psychiatric Research Center, Osaka Psychiatric Medical Center, Osaka, Japan","Department of Neuroscience and Cell Biology, Graduate School of Medicine, The University of Osaka, Suita, Japan"],"raw_orcid":"https://orcid.org/0009-0007-9847-1861","affiliations":[{"raw_affiliation_string":"Addiction Research Unit, Osaka Psychiatric Research Center, Osaka Psychiatric Medical Center, Osaka, Japan","institution_ids":["https://openalex.org/I4405284972"]},{"raw_affiliation_string":"Department of Neuroscience and Cell Biology, Graduate School of Medicine, The University of Osaka, Suita, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042583601","display_name":"Shoichi Shimada","orcid":"https://orcid.org/0000-0001-5369-1069","observed_orcids":["https://orcid.org/0000-0001-5369-1069"]},"institutions":[{"id":"https://openalex.org/I4405284972","display_name":"Osaka Psychiatric Medical Center","ror":"https://ror.org/04j4q9j26","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4405284972"]},{"id":"https://openalex.org/I4405287051","display_name":"Global Center for Medical Engineering and Informatics, The University of Osaka","ror":"https://ror.org/03zqg6348","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405287051","https://openalex.org/I98285908"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shoichi Shimada","raw_affiliation_strings":["Addiction Research Unit, Osaka Psychiatric Research Center, Osaka Psychiatric Medical Center, Osaka, Japan","Department of Neuroscience and Cell Biology, Graduate School of Medicine, The University of Osaka, Suita, Japan","Global Center for Medical Engineering and Informatics, The University of Osaka, Suita, Japan","United Graduate School of Child Development, The University of Osaka, Suita, Japan"],"raw_orcid":"https://orcid.org/0000-0001-5369-1069","affiliations":[{"raw_affiliation_string":"Addiction Research Unit, Osaka Psychiatric Research Center, Osaka Psychiatric Medical Center, Osaka, Japan","institution_ids":["https://openalex.org/I4405284972"]},{"raw_affiliation_string":"Department of Neuroscience and Cell Biology, Graduate School of Medicine, The University of Osaka, Suita, Japan","institution_ids":["https://openalex.org/I98285908"]},{"raw_affiliation_string":"Global Center for Medical Engineering and Informatics, The University of Osaka, Suita, Japan","institution_ids":["https://openalex.org/I4405287051","https://openalex.org/I98285908"]},{"raw_affiliation_string":"United Graduate School of Child Development, The University of Osaka, Suita, Japan","institution_ids":["https://openalex.org/I98285908"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5076057309"],"corresponding_institution_ids":["https://openalex.org/I4405284972","https://openalex.org/I4405287051","https://openalex.org/I4405287211","https://openalex.org/I98285908"],"apc_list":{"value":5290,"currency":"USD","value_usd":5290},"apc_paid":{"value":5290,"currency":"USD","value_usd":5290},"fwci":2.9788,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.90295178,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"15","issue":"1","first_page":"364","last_page":"364"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.7211999893188477,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.7211999893188477,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.1151999980211258,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.03139999881386757,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.8830000162124634},{"id":"https://openalex.org/keywords/anxiety-like-behavior","display_name":"anxiety-like behavior","score":0.9800000190734863},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"cognitive impairment","score":0.9829999804496765},{"id":"https://openalex.org/keywords/microglial-activation","display_name":"microglial activation","score":0.8429999947547913},{"id":"https://openalex.org/keywords/medial-prefrontal-cortex","display_name":"medial prefrontal cortex","score":0.9700000286102295},{"id":"https://openalex.org/keywords/dorsal-hippocampus","display_name":"dorsal hippocampus","score":0.9950000047683716},{"id":"https://openalex.org/keywords/nrf2","display_name":"Nrf2","score":0.843999981880188},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8600000143051147},{"id":"https://openalex.org/keywords/psychostimulants","display_name":"psychostimulants","score":0.7839999794960022}],"concepts":[{"id":"https://openalex.org/C2780114369","wikidata":"https://www.wikidata.org/wiki/Q6823535","display_name":"Meth-","level":5,"score":0.904699981212616},{"id":"https://openalex.org/C2780376393","wikidata":"https://www.wikidata.org/wiki/Q191924","display_name":"Methamphetamine","level":2,"score":0.8496999740600586},{"id":"https://openalex.org/C87753298","wikidata":"https://www.wikidata.org/wiki/Q17157137","display_name":"Neuroinflammation","level":3,"score":0.8493000268936157},{"id":"https://openalex.org/C4746552","wikidata":"https://www.wikidata.org/wiki/Q1456827","display_name":"Neurogenesis","level":2,"score":0.786899983882904},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.635699987411499},{"id":"https://openalex.org/C2781195155","wikidata":"https://www.wikidata.org/wiki/Q18680","display_name":"Prefrontal cortex","level":3,"score":0.5972999930381775},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.5005000233650208},{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.4959999918937683},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.48350000381469727},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4805999994277954},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4790000021457672},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.4431000053882599},{"id":"https://openalex.org/C103709681","wikidata":"https://www.wikidata.org/wiki/Q1515727","display_name":"Psychopharmacology","level":2,"score":0.3589000105857849},{"id":"https://openalex.org/C2781176699","wikidata":"https://www.wikidata.org/wiki/Q4445017","display_name":"Subgranular zone","level":5,"score":0.33889999985694885},{"id":"https://openalex.org/C2779727114","wikidata":"https://www.wikidata.org/wiki/Q170082","display_name":"Psychosis","level":2,"score":0.31299999356269836},{"id":"https://openalex.org/C39920043","wikidata":"https://www.wikidata.org/wiki/Q786278","display_name":"Neurochemistry","level":3,"score":0.303600013256073},{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.2953000068664551},{"id":"https://openalex.org/C47611674","wikidata":"https://www.wikidata.org/wiki/Q849491","display_name":"Neuroplasticity","level":2,"score":0.2930000126361847},{"id":"https://openalex.org/C205545832","wikidata":"https://www.wikidata.org/wiki/Q17156455","display_name":"Young adult","level":2,"score":0.29280000925064087},{"id":"https://openalex.org/C2779632907","wikidata":"https://www.wikidata.org/wiki/Q13444883","display_name":"Brain Structure and Function","level":3,"score":0.29030001163482666},{"id":"https://openalex.org/C21963081","wikidata":"https://www.wikidata.org/wiki/Q11337567","display_name":"Working memory","level":3,"score":0.28220000863075256},{"id":"https://openalex.org/C2780352252","wikidata":"https://www.wikidata.org/wiki/Q422543","display_name":"Corticosterone","level":3,"score":0.27900001406669617},{"id":"https://openalex.org/C136834591","wikidata":"https://www.wikidata.org/wiki/Q2944097","display_name":"Neural stem cell","level":3,"score":0.2784999907016754},{"id":"https://openalex.org/C48856860","wikidata":"https://www.wikidata.org/wiki/Q12029","display_name":"Addiction","level":2,"score":0.2624000012874603},{"id":"https://openalex.org/C2776412080","wikidata":"https://www.wikidata.org/wiki/Q7431605","display_name":"Schizophrenia (object-oriented programming)","level":2,"score":0.25049999356269836}],"mesh":[{"descriptor_ui":"D000090862","descriptor_name":"Neuroinflammatory Diseases","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D000697","descriptor_name":"Central Nervous System Stimulants","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001007","descriptor_name":"Anxiety","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D001522","descriptor_name":"Behavior, Animal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008694","descriptor_name":"Methamphetamine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D008694","descriptor_name":"Methamphetamine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D008694","descriptor_name":"Methamphetamine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017397","descriptor_name":"Prefrontal Cortex","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017397","descriptor_name":"Prefrontal Cortex","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D017628","descriptor_name":"Microglia","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051267","descriptor_name":"NF-E2-Related Factor 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055495","descriptor_name":"Neurogenesis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true}],"locations_count":7,"locations":[{"id":"doi:10.1038/s41398-025-03613-y","doi":"https://doi.org/10.1038/s41398-025-03613-y","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41398-025-03613-y","pdf_url":"https://www.nature.com/articles/s41398-025-03613-y.pdf","source":{"id":"https://openalex.org/S163345920","display_name":"Translational Psychiatry","issn_l":"2158-3188","issn":["2158-3188"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational Psychiatry","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:11309093","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12501007","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:41052970","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41052970","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational psychiatry","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12501007","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12501007/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transl Psychiatry","raw_type":"Text"},{"id":"pmh:oai:irdb.nii.ac.jp:01056:0007222820","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11094/103493","pdf_url":"https://ir.library.osaka-u.ac.jp/repo/ouka/all/103493/TranslPsychiatry_15_364.pdf","source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Translational Psychiatry","raw_type":"journal article"},{"id":"pmh:oai:doaj.org/article:4d9fec499c0a4389aaff4720cc6da653","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/4d9fec499c0a4389aaff4720cc6da653","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Translational Psychiatry, Vol 15, Iss 1, Pp 1-12 (2025)","raw_type":"article"},{"id":"pmh:oai:ir.library.osaka-u.ac.jp:11094/103493","doi":null,"is_oa":false,"landing_page_url":"https://doi.org/10.1038/s41398-025-03613-y","pdf_url":null,"source":{"id":"https://openalex.org/S4306402540","display_name":"OUKA (Osaka University Knowledge Archive) (Osaka University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I98285908","host_organization_name":"The University of Osaka","host_organization_lineage":["https://openalex.org/I98285908"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"}],"best_oa_location":{"id":"doi:10.1038/s41398-025-03613-y","doi":"https://doi.org/10.1038/s41398-025-03613-y","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41398-025-03613-y","pdf_url":"https://www.nature.com/articles/s41398-025-03613-y.pdf","source":{"id":"https://openalex.org/S163345920","display_name":"Translational Psychiatry","issn_l":"2158-3188","issn":["2158-3188"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational Psychiatry","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4452352137","display_name":null,"funder_award_id":"24K22230","funder_id":"https://openalex.org/F4320320912","funder_display_name":"Ministry of Education, Culture, Sports, Science and Technology"},{"id":"https://openalex.org/G5084661154","display_name":null,"funder_award_id":"23K14443","funder_id":"https://openalex.org/F4320320912","funder_display_name":"Ministry of Education, Culture, Sports, Science and Technology"},{"id":"https://openalex.org/G5804462795","display_name":"\u85ac\u7269\u4f9d\u5b58\u306e\u5f62\u6210\u3092\u5236\u5fa1\u3059\u308b\u795e\u7d4c\u57fa\u76e4\u306e\u89e3\u660e","funder_award_id":"23K14443","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G6644894536","display_name":null,"funder_award_id":"23H02837","funder_id":"https://openalex.org/F4320320912","funder_display_name":"Ministry of Education, Culture, Sports, Science and Technology"},{"id":"https://openalex.org/G7344353983","display_name":"\u30b3\u30db\u30fc\u30c8\u81cd\u5e2f\u8840\u3068\u542b\u6709\u5fae\u91cf\u5143\u7d20\u3092\u5229\u7528\u3057\u305f\u5b50\u3069\u3082\u306e\u767a\u9054\u7279\u6027\u30fb\u5065\u5eb7\u30ea\u30b9\u30af\u691c\u67fb\u6cd5\u306e\u958b\u767a","funder_award_id":"24K22230","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G8819506201","display_name":null,"funder_award_id":"23H02837","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320309785","display_name":"Naito Foundation","ror":"https://ror.org/02s016q17"},{"id":"https://openalex.org/F4320309807","display_name":"Takeda Science Foundation","ror":"https://ror.org/02y123g31"},{"id":"https://openalex.org/F4320310760","display_name":"Uehara Memorial Foundation","ror":"https://ror.org/00gc20a07"},{"id":"https://openalex.org/F4320319500","display_name":"Hirose Foundation","ror":"https://ror.org/05tr29253"},{"id":"https://openalex.org/F4320320912","display_name":"Ministry of Education, Culture, Sports, Science and Technology","ror":"https://ror.org/048rj2z13"},{"id":"https://openalex.org/F4320322210","display_name":"Inamori Foundation","ror":"https://ror.org/00ht8je70"},{"id":"https://openalex.org/F4320323467","display_name":"Mochida Memorial Foundation for Medical and Pharmaceutical Research","ror":"https://ror.org/045p8e908"},{"id":"https://openalex.org/F4320325285","display_name":"Osaka Medical Research Foundation for Intractable Diseases","ror":"https://ror.org/04meywz55"},{"id":"https://openalex.org/F4320325287","display_name":"SENSHIN Medical Research Foundation","ror":"https://ror.org/021tj4g88"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4414845909.pdf","grobid_xml":"https://content.openalex.org/works/W4414845909.grobid-xml"},"referenced_works_count":83,"referenced_works":["https://openalex.org/W1967108243","https://openalex.org/W1984785346","https://openalex.org/W1987593166","https://openalex.org/W1990253537","https://openalex.org/W1991094289","https://openalex.org/W1996348906","https://openalex.org/W1998294971","https://openalex.org/W1999836898","https://openalex.org/W2001515438","https://openalex.org/W2002015567","https://openalex.org/W2004664745","https://openalex.org/W2029183246","https://openalex.org/W2029190354","https://openalex.org/W2033443881","https://openalex.org/W2037750770","https://openalex.org/W2038071695","https://openalex.org/W2038074738","https://openalex.org/W2043313694","https://openalex.org/W2068311250","https://openalex.org/W2068540484","https://openalex.org/W2076874426","https://openalex.org/W2078802567","https://openalex.org/W2080093346","https://openalex.org/W2084644507","https://openalex.org/W2085864665","https://openalex.org/W2086525688","https://openalex.org/W2089155165","https://openalex.org/W2094712734","https://openalex.org/W2098139332","https://openalex.org/W2105691693","https://openalex.org/W2117792476","https://openalex.org/W2117800935","https://openalex.org/W2121123285","https://openalex.org/W2139752141","https://openalex.org/W2141041835","https://openalex.org/W2144176813","https://openalex.org/W2171802424","https://openalex.org/W2279555465","https://openalex.org/W2281896430","https://openalex.org/W2340338776","https://openalex.org/W2343855628","https://openalex.org/W2415959686","https://openalex.org/W2521685058","https://openalex.org/W2527645962","https://openalex.org/W2556362435","https://openalex.org/W2563377673","https://openalex.org/W2604092826","https://openalex.org/W2761242880","https://openalex.org/W2762946595","https://openalex.org/W2767397051","https://openalex.org/W2769071992","https://openalex.org/W2784673699","https://openalex.org/W2802211044","https://openalex.org/W2804769516","https://openalex.org/W2883859451","https://openalex.org/W2944659957","https://openalex.org/W2958025173","https://openalex.org/W2981665735","https://openalex.org/W2994335873","https://openalex.org/W2999510601","https://openalex.org/W3042486277","https://openalex.org/W3091812918","https://openalex.org/W3129250549","https://openalex.org/W3155993059","https://openalex.org/W3158426985","https://openalex.org/W3173240733","https://openalex.org/W3192189855","https://openalex.org/W3194723118","https://openalex.org/W3207990800","https://openalex.org/W4224135191","https://openalex.org/W4280564394","https://openalex.org/W4292295118","https://openalex.org/W4292581561","https://openalex.org/W4293676974","https://openalex.org/W4307267883","https://openalex.org/W4368373672","https://openalex.org/W4376132878","https://openalex.org/W4385327281","https://openalex.org/W4385496608","https://openalex.org/W4386895319","https://openalex.org/W4392955821","https://openalex.org/W4396690982","https://openalex.org/W4402982154"],"related_works":["https://openalex.org/W2086525688","https://openalex.org/W2037750770","https://openalex.org/W2767397051","https://openalex.org/W4399389349","https://openalex.org/W2521685058","https://openalex.org/W3163372099","https://openalex.org/W4404800561","https://openalex.org/W2089471117","https://openalex.org/W2030030436","https://openalex.org/W1980743626"],"abstract_inverted_index":{"The":[0],"adolescent":[1,52,64,157],"brain,":[2],"characterized":[3],"by":[4,138],"its":[5],"high":[6],"plasticity,":[7],"is":[8,28,46],"particularly":[9],"vulnerable":[10],"to":[11,15,133,170],"substance":[12],"abuse,":[13],"leading":[14],"long-term":[16,61],"impacts":[17],"on":[18,40,67],"brain":[19,68],"function":[20,69],"and":[21,33,70,87,103,113,135,144],"behavior.":[22],"Methamphetamine":[23],"(METH),":[24],"a":[25,75],"potent":[26],"psychostimulant,":[27],"associated":[29],"with":[30],"severe":[31],"neurological":[32],"psychiatric":[34],"consequences.":[35],"While":[36],"most":[37],"studies":[38],"focus":[39],"METH":[41,53,65,81,118,127,158],"exposure":[42,66,119,128,159,169],"in":[43,72,92,107,124,147],"adulthood,":[44,162],"little":[45],"known":[47],"about":[48],"the":[49,60,108,140,153,164],"effects":[50,62,155],"of":[51,63,156,167],"exposure.":[54],"In":[55],"this":[56],"study,":[57],"we":[58],"explored":[59],"behavior":[71,89],"adulthood":[73],"using":[74],"mouse":[76],"model.":[77],"Mice":[78],"were":[79],"administered":[80],"for":[82],"8":[83],"days":[84],"during":[85,120],"adolescence,":[86],"their":[88],"was":[90],"analyzed":[91],"adulthood.":[93,125,148],"METH-exposed":[94],"mice":[95],"(METH":[96],"mice)":[97],"displayed":[98],"anxiety-like":[99],"behaviors,":[100],"cognitive":[101],"decline,":[102],"increased":[104],"microglial":[105],"numbers":[106],"medial":[109],"prefrontal":[110],"cortex":[111],"(mPFC)":[112],"dorsal":[114],"hippocampus":[115],"(dHIP).":[116],"Additionally,":[117],"adolescence":[121],"induced":[122],"neuroinflammation":[123,134],"Adolescent":[126],"also":[129],"enhances":[130],"defensive":[131],"reactivity":[132],"oxidative":[136],"stress":[137],"activating":[139],"NFE2L2-mediated":[141],"redox":[142],"system":[143],"promotes":[145],"neurogenesis":[146],"These":[149],"findings":[150],"suggest":[151],"that":[152],"detrimental":[154],"extend":[160],"into":[161],"emphasizing":[163],"delayed-onset":[165],"impact":[166],"early":[168],"psychostimulants.":[171]},"counts_by_year":[{"year":2026,"cited_by_count":9}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-10-10T00:00:00"}