{"id":"https://openalex.org/W4414844504","doi":"https://doi.org/10.3923/pjbs.2025.490.504","title":"LC-MS/MS Profiling and Antimicrobial Evaluation of Marine Alkaloids from Pseudoceratina purpurea","display_name":"LC-MS/MS Profiling and Antimicrobial Evaluation of Marine Alkaloids from Pseudoceratina purpurea","publication_year":2025,"publication_date":"2025-10-04","ids":{"openalex":"https://openalex.org/W4414844504","doi":"https://doi.org/10.3923/pjbs.2025.490.504","pmid":"https://pubmed.ncbi.nlm.nih.gov/41392564"},"language":"en","primary_location":{"id":"doi:10.3923/pjbs.2025.490.504","doi":"https://doi.org/10.3923/pjbs.2025.490.504","is_oa":true,"landing_page_url":"https://doi.org/10.3923/pjbs.2025.490.504","pdf_url":null,"source":{"id":"https://openalex.org/S49288575","display_name":"Pakistan Journal of Biological Sciences","issn_l":"1028-8880","issn":["1028-8880","1812-5735"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","medline"],"host_organization":"https://openalex.org/P4322697005","host_organization_name":"Asian Network for Scientific Information","host_organization_lineage":["https://openalex.org/P4322697005"],"host_organization_lineage_names":["Asian Network for Scientific Information"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pakistan Journal of Biological Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.3923/pjbs.2025.490.504","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076728542","display_name":"Baru Sadarun","orcid":"https://orcid.org/0009-0001-6868-5128","observed_orcids":["https://orcid.org/0009-0001-6868-5128"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Baru Sadarun","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0001-6868-5128","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031630931","display_name":"Haslianti Haslianti","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Haslianti .","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Dzaky Aulia Rahman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dzaky Aulia Rahman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103013760","display_name":"Nur Saadah Daud","orcid":"https://orcid.org/0000-0002-7773-3857","observed_orcids":["https://orcid.org/0000-0002-7773-3857"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nur Saadah Daud","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7773-3857","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086201117","display_name":"Agung Wibawa Mahatva Yodha","orcid":"https://orcid.org/0000-0003-0281-596X","observed_orcids":["https://orcid.org/0000-0003-0281-596X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Agung Wibawa Mahatva Yodha","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0281-596X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015113887","display_name":"Angriani Fusvita","orcid":"https://orcid.org/0000-0003-1003-2842","observed_orcids":["https://orcid.org/0000-0003-1003-2842"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Angriani Fusvita","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1003-2842","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033205735","display_name":"Adryan Fristiohady","orcid":"https://orcid.org/0000-0002-3499-0511","observed_orcids":["https://orcid.org/0000-0002-3499-0511"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Adryan Fristiohad","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3499-0511","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5034322778","display_name":"Idin Sahidin","orcid":"https://orcid.org/0000-0003-0997-0065","observed_orcids":["https://orcid.org/0000-0003-0997-0065"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sahidin .","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0997-0065","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.17429769,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"28","issue":"7","first_page":"490","last_page":"504"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11340","display_name":"Marine Sponges and Natural Products","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11340","display_name":"Marine Sponges and Natural Products","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13971","display_name":"Synthesis and Biological Activity","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/marine-sponges","display_name":"marine sponges","score":0.6669999957084656},{"id":"https://openalex.org/keywords/marine-alkaloids","display_name":"marine alkaloids","score":0.9729999899864197},{"id":"https://openalex.org/keywords/alkaloid-profiling","display_name":"alkaloid profiling","score":0.8180000185966492},{"id":"https://openalex.org/keywords/antimicrobial-activity","display_name":"antimicrobial activity","score":0.9800000190734863},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.9580000042915344},{"id":"https://openalex.org/keywords/staphylococcus-aureus","display_name":"Staphylococcus aureus","score":1.0},{"id":"https://openalex.org/keywords/candida-albicans","display_name":"Candida albicans","score":1.0},{"id":"https://openalex.org/keywords/indole-alkaloids","display_name":"indole alkaloids","score":0.6620000004768372},{"id":"https://openalex.org/keywords/isoquinoline-alkaloids","display_name":"isoquinoline alkaloids","score":0.9570000171661377},{"id":"https://openalex.org/keywords/purine-alkaloids","display_name":"purine alkaloids","score":0.7799999713897705},{"id":"https://openalex.org/keywords/pyridine-alkaloids","display_name":"pyridine alkaloids","score":0.9290000200271606},{"id":"https://openalex.org/keywords/steroidal-alkaloids","display_name":"steroidal alkaloids","score":0.7789999842643738},{"id":"https://openalex.org/keywords/minimum-inhibitory-concentration","display_name":"minimum inhibitory concentration","score":0.675000011920929},{"id":"https://openalex.org/keywords/natural-product-isolation","display_name":"natural product isolation","score":0.6639999747276306}],"concepts":[{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.8895999789237976},{"id":"https://openalex.org/C2777667214","wikidata":"https://www.wikidata.org/wiki/Q70702","display_name":"Alkaloid","level":2,"score":0.8023999929428101},{"id":"https://openalex.org/C2776923262","wikidata":"https://www.wikidata.org/wiki/Q412316","display_name":"Isoquinoline","level":2,"score":0.5802000164985657},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5455999970436096},{"id":"https://openalex.org/C2776734949","wikidata":"https://www.wikidata.org/wiki/Q408452","display_name":"Indole alkaloid","level":3,"score":0.4690000116825104},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.44020000100135803},{"id":"https://openalex.org/C2777762789","wikidata":"https://www.wikidata.org/wiki/Q251005","display_name":"Nystatin","level":3,"score":0.4207000136375427},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3734000027179718},{"id":"https://openalex.org/C176947019","wikidata":"https://www.wikidata.org/wiki/Q597889","display_name":"Minimum inhibitory concentration","level":3,"score":0.34709998965263367},{"id":"https://openalex.org/C2781338088","wikidata":"https://www.wikidata.org/wiki/Q903495","display_name":"Residue (chemistry)","level":2,"score":0.3411000072956085},{"id":"https://openalex.org/C2779607525","wikidata":"https://www.wikidata.org/wiki/Q14982","display_name":"Methanol","level":2,"score":0.32350000739097595},{"id":"https://openalex.org/C2779548794","wikidata":"https://www.wikidata.org/wiki/Q578726","display_name":"Antifungal","level":2,"score":0.2806999981403351},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.2685999870300293},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.2655999958515167},{"id":"https://openalex.org/C2780116568","wikidata":"https://www.wikidata.org/wiki/Q176525","display_name":"Berberine","level":2,"score":0.2565000057220459},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.2533999979496002}],"mesh":[{"descriptor_ui":"D000097922","descriptor_name":"Liquid Chromatography-Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000097922","descriptor_name":"Liquid Chromatography-Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000470","descriptor_name":"Alkaloids","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D000470","descriptor_name":"Alkaloids","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D000470","descriptor_name":"Alkaloids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000470","descriptor_name":"Alkaloids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000470","descriptor_name":"Alkaloids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000470","descriptor_name":"Alkaloids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000890","descriptor_name":"Anti-Infective Agents","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D000890","descriptor_name":"Anti-Infective Agents","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D000890","descriptor_name":"Anti-Infective Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000890","descriptor_name":"Anti-Infective Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000935","descriptor_name":"Antifungal Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000935","descriptor_name":"Antifungal Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002176","descriptor_name":"Candida albicans","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002176","descriptor_name":"Candida albicans","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002853","descriptor_name":"Chromatography, Liquid","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D002853","descriptor_name":"Chromatography, Liquid","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D011161","descriptor_name":"Porifera","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011161","descriptor_name":"Porifera","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013211","descriptor_name":"Staphylococcus aureus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013211","descriptor_name":"Staphylococcus aureus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D053719","descriptor_name":"Tandem Mass Spectrometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D053719","descriptor_name":"Tandem Mass Spectrometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.3923/pjbs.2025.490.504","doi":"https://doi.org/10.3923/pjbs.2025.490.504","is_oa":true,"landing_page_url":"https://doi.org/10.3923/pjbs.2025.490.504","pdf_url":null,"source":{"id":"https://openalex.org/S49288575","display_name":"Pakistan Journal of Biological Sciences","issn_l":"1028-8880","issn":["1028-8880","1812-5735"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","medline"],"host_organization":"https://openalex.org/P4322697005","host_organization_name":"Asian Network for Scientific Information","host_organization_lineage":["https://openalex.org/P4322697005"],"host_organization_lineage_names":["Asian Network for Scientific Information"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pakistan Journal of Biological Sciences","raw_type":"journal-article"},{"id":"pmid:41392564","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41392564","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pakistan journal of biological sciences : PJBS","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3923/pjbs.2025.490.504","doi":"https://doi.org/10.3923/pjbs.2025.490.504","is_oa":true,"landing_page_url":"https://doi.org/10.3923/pjbs.2025.490.504","pdf_url":null,"source":{"id":"https://openalex.org/S49288575","display_name":"Pakistan Journal of Biological Sciences","issn_l":"1028-8880","issn":["1028-8880","1812-5735"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","medline"],"host_organization":"https://openalex.org/P4322697005","host_organization_name":"Asian Network for Scientific Information","host_organization_lineage":["https://openalex.org/P4322697005"],"host_organization_lineage_names":["Asian Network for Scientific Information"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pakistan Journal of Biological Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W1959960271","https://openalex.org/W1967748656","https://openalex.org/W1987838004","https://openalex.org/W2040877406","https://openalex.org/W2063380937","https://openalex.org/W2067768467","https://openalex.org/W2086151910","https://openalex.org/W2089167288","https://openalex.org/W2114176091","https://openalex.org/W2116338204","https://openalex.org/W2120696744","https://openalex.org/W2136322984","https://openalex.org/W2150190443","https://openalex.org/W2159539711","https://openalex.org/W2185564569","https://openalex.org/W2790931141","https://openalex.org/W2886363386","https://openalex.org/W2955737403","https://openalex.org/W4312968642","https://openalex.org/W4361000531"],"related_works":[],"abstract_inverted_index":{"Background":[0],"and":[1,20,26,29,39,53,76,118,130,147,174,196],"Objective:":[2],"Alkaloids":[3],"are":[4],"a":[5,200],"group":[6],"of":[7,42,124,163,206],"naturally":[8],"occurring":[9],"compounds":[10,127],"with":[11,157],"diverse":[12],"pharmacological":[13],"properties,":[14],"including":[15],"their":[16],"use":[17],"as":[18,24,199],"antibacterial":[19],"antifungal":[21],"agents":[22],"such":[23],"chloramphenicol":[25],"nystatin":[27],"(CY":[28],"NY).":[30],"This":[31],"study":[32],"aimed":[33],"to":[34,59,71,88],"investigate":[35],"the":[36,43,61,73,86,90,105,185,204],"alkaloid":[37,91,126,186],"profile":[38],"antimicrobial":[40,111,155,194,208],"potential":[41,201],"marine":[44],"sponge":[45],"Pseudoceratina":[46],"purpurea":[47,190],"collected":[48],"from":[49,188],"Southeast":[50],"Sulawesi.":[51],"Materials":[52],"Methods:":[54],"Methanol":[55],"extraction":[56],"was":[57,66,83,96,108],"performed":[58],"obtain":[60,89],"methanol":[62,77],"extract":[63,75,78],"(ME),":[64],"which":[65],"then":[67],"fractionated":[68],"using":[69,99],"n-hexane":[70,74],"yield":[72],"residue":[79],"(MER).":[80],"Alkaloid":[81],"isolation":[82],"conducted":[84],"on":[85],"MER":[87],"isolate":[92,187],"(AI).":[93],"The":[94,151],"AI":[95,152],"partially":[97],"analyzed":[98],"UPLC-HRMS":[100],"for":[101,110,203],"compound":[102],"identification,":[103],"while":[104],"remaining":[106],"portion":[107],"tested":[109],"activity":[112],"against":[113,166,171,177],"Escherichia":[114],"coli,":[115,168],"Staphylococcus":[116],"aureus":[117,173],"Candida":[119],"albicans.":[120,179],"Results:":[121],"A":[122],"total":[123],"117":[125],"were":[128],"identified":[129],"classified":[131],"into":[132],"seven":[133],"subclasses:":[134],"Indole":[135],"(1.8%),":[136],"isoquinoline":[137],"(4.14%),":[138],"lipid":[139],"(32.66%),":[140],"proto":[141],"(52.90%),":[142],"purine":[143],"(2.02%),":[144],"pyridine":[145],"(6.39%)":[146],"steroidal":[148],"alkaloids":[149],"(0.1%).":[150],"demonstrated":[153],"strong":[154],"activity,":[156],"minimum":[158],"inhibitory":[159],"concentration":[160],"(MIC)":[161],"values":[162],"4\u00b10.064":[164],"ppm":[165,170,176],"E.":[167],"8\u00b10.09":[169],"S.":[172],"4\u00b10.05":[175],"C.":[178],"Conclusion:":[180],"These":[181],"findings":[182],"suggest":[183],"that":[184],"P.":[189],"possesses":[191],"promising":[192],"broad-spectrum":[193],"properties":[195],"may":[197],"serve":[198],"candidate":[202],"development":[205],"novel":[207],"agents.":[209]},"counts_by_year":[],"updated_date":"2026-09-21T07:43:02.447757","created_date":"2025-10-10T00:00:00"}
