{"id":"https://openalex.org/W4414835547","doi":"https://doi.org/10.25048/tudod.1648392","title":"Assessment of the Effects of Metformin and DPP-4 Inhibitors on Electrolyte and Vitamin B12 Levels in Patients with Type 2 Diabetes: A Retrospective Study","display_name":"Assessment of the Effects of Metformin and DPP-4 Inhibitors on Electrolyte and Vitamin B12 Levels in Patients with Type 2 Diabetes: A Retrospective Study","publication_year":2025,"publication_date":"2025-08-31","ids":{"openalex":"https://openalex.org/W4414835547","doi":"https://doi.org/10.25048/tudod.1648392"},"language":"en","primary_location":{"id":"doi:10.25048/tudod.1648392","doi":"https://doi.org/10.25048/tudod.1648392","is_oa":true,"landing_page_url":"https://doi.org/10.25048/tudod.1648392","pdf_url":"https://dergipark.org.tr/en/download/article-file/4647882","source":{"id":"https://openalex.org/S4210197571","display_name":"Turkish Journal of Diabetes and Obesity","issn_l":"2587-0335","issn":["2587-0335","2587-0572"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["tr-dizin"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Turkish Journal of Diabetes and Obesity","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://dergipark.org.tr/en/download/article-file/4647882","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020731630","display_name":"Zeynep Gizem Todurga Seven","orcid":"https://orcid.org/0000-0002-2529-0118","observed_orcids":["https://orcid.org/0000-0002-2529-0118"]},"institutions":[{"id":"https://openalex.org/I4210112471","display_name":"Istanbul University-Cerrahpa\u015fa","ror":"https://ror.org/01dzn5f42","country_code":"TR","type":"education","lineage":["https://openalex.org/I4210112471"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Zeynep Gizem Todurga Seven","raw_affiliation_strings":["ISTANBUL UNIVERSITY-CERRAHPASA"],"raw_orcid":"https://orcid.org/0000-0002-2529-0118","affiliations":[{"raw_affiliation_string":"ISTANBUL UNIVERSITY-CERRAHPASA","institution_ids":["https://openalex.org/I4210112471"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040228903","display_name":"K\u00fcbra \u00c7i\u011fdem Pekko\u00e7 Uyan\u0131k","orcid":"https://orcid.org/0000-0002-1056-960X","observed_orcids":["https://orcid.org/0000-0002-1056-960X"]},"institutions":[{"id":"https://openalex.org/I25010766","display_name":"Hali\u00e7 University","ror":"https://ror.org/022xhck05","country_code":"TR","type":"education","lineage":["https://openalex.org/I25010766"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"K\u00fcbra \u00c7i\u011fdem Pekko\u00e7 Uyan\u0131k","raw_affiliation_strings":["HAL\u0130\u00c7 \u00dcN\u0130VERS\u0130TES\u0130"],"raw_orcid":"https://orcid.org/0000-0002-1056-960X","affiliations":[{"raw_affiliation_string":"HAL\u0130\u00c7 \u00dcN\u0130VERS\u0130TES\u0130","institution_ids":["https://openalex.org/I25010766"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073924994","display_name":"Fatma K\u00fcbra Tombult\u00fcrk","orcid":"https://orcid.org/0000-0002-4358-2309","observed_orcids":["https://orcid.org/0000-0002-4358-2309"]},"institutions":[{"id":"https://openalex.org/I4210121333","display_name":"Istinye University","ror":"https://ror.org/03081nz23","country_code":"TR","type":"education","lineage":["https://openalex.org/I4210121333"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Fatma K\u00fcbra Tombult\u00fcrk","raw_affiliation_strings":["\u0130ST\u0130NYE \u00dcN\u0130VERS\u0130TES\u0130"],"raw_orcid":"https://orcid.org/0000-0002-4358-2309","affiliations":[{"raw_affiliation_string":"\u0130ST\u0130NYE \u00dcN\u0130VERS\u0130TES\u0130","institution_ids":["https://openalex.org/I4210121333"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5119852670","display_name":"Erhan Ra\u015fit Agay","orcid":"https://orcid.org/0000-0002-6020-7332","observed_orcids":["https://orcid.org/0000-0002-6020-7332"]},"institutions":[{"id":"https://openalex.org/I4210112471","display_name":"Istanbul University-Cerrahpa\u015fa","ror":"https://ror.org/01dzn5f42","country_code":"TR","type":"education","lineage":["https://openalex.org/I4210112471"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Erhan Ra\u015fit Agay","raw_affiliation_strings":["ISTANBUL UNIVERSITY-CERRAHPASA"],"raw_orcid":"https://orcid.org/0000-0002-6020-7332","affiliations":[{"raw_affiliation_string":"ISTANBUL UNIVERSITY-CERRAHPASA","institution_ids":["https://openalex.org/I4210112471"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5020731630"],"corresponding_institution_ids":["https://openalex.org/I4210112471"],"apc_list":null,"apc_paid":null,"fwci":0.5087,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.59667066,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"9","issue":"2","first_page":"164","last_page":"178"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.95169997215271,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.95169997215271,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.013799999840557575,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.004600000102072954,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metformin","display_name":"metformin","score":0.9449999928474426},{"id":"https://openalex.org/keywords/dpp-4-inhibitors","display_name":"DPP-4 inhibitors","score":1.0},{"id":"https://openalex.org/keywords/vildagliptin","display_name":"vildagliptin","score":0.8820000290870667},{"id":"https://openalex.org/keywords/linagliptin","display_name":"linagliptin","score":1.0},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9980000257492065},{"id":"https://openalex.org/keywords/electrolyte-concentration","display_name":"electrolyte concentration","score":0.8050000071525574},{"id":"https://openalex.org/keywords/vitamin-b12","display_name":"vitamin B12","score":0.8550000190734863},{"id":"https://openalex.org/keywords/mineral-homeostasis","display_name":"mineral homeostasis","score":0.7990000247955322},{"id":"https://openalex.org/keywords/sodium","display_name":"sodium","score":0.6299999952316284},{"id":"https://openalex.org/keywords/potassium","display_name":"potassium","score":0.9800000190734863},{"id":"https://openalex.org/keywords/calcium","display_name":"calcium","score":0.6539999842643738},{"id":"https://openalex.org/keywords/magnesium","display_name":"magnesium","score":0.9810000061988831},{"id":"https://openalex.org/keywords/chloride","display_name":"chloride","score":0.871999979019165}],"concepts":[{"id":"https://openalex.org/C2780323712","wikidata":"https://www.wikidata.org/wiki/Q19484","display_name":"Metformin","level":3,"score":0.9613000154495239},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7398999929428101},{"id":"https://openalex.org/C2779750884","wikidata":"https://www.wikidata.org/wiki/Q187706","display_name":"Vitamin B12","level":2,"score":0.6534000039100647},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6001999974250793},{"id":"https://openalex.org/C2780473172","wikidata":"https://www.wikidata.org/wiki/Q5572518","display_name":"Glycemic","level":3,"score":0.5803999900817871},{"id":"https://openalex.org/C2910068830","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 Diabetes Mellitus","level":3,"score":0.5771999955177307},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.4650999903678894},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.43220001459121704},{"id":"https://openalex.org/C68801617","wikidata":"https://www.wikidata.org/wiki/Q162908","display_name":"Electrolyte","level":3,"score":0.4230000078678131},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4056999981403351},{"id":"https://openalex.org/C2780022331","wikidata":"https://www.wikidata.org/wiki/Q199678","display_name":"Vitamin C","level":2,"score":0.39719998836517334},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.39410001039505005},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3718999922275543},{"id":"https://openalex.org/C2776940978","wikidata":"https://www.wikidata.org/wiki/Q34956","display_name":"Vitamin","level":2,"score":0.37139999866485596},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.3450999855995178},{"id":"https://openalex.org/C146304588","wikidata":"https://www.wikidata.org/wiki/Q961652","display_name":"Case-control study","level":2,"score":0.3025999963283539},{"id":"https://openalex.org/C2780829489","wikidata":"https://www.wikidata.org/wiki/Q252251","display_name":"Cyanocobalamin","level":3,"score":0.2773999869823456},{"id":"https://openalex.org/C537181965","wikidata":"https://www.wikidata.org/wiki/Q658","display_name":"Sodium","level":2,"score":0.258899986743927}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.25048/tudod.1648392","doi":"https://doi.org/10.25048/tudod.1648392","is_oa":true,"landing_page_url":"https://doi.org/10.25048/tudod.1648392","pdf_url":"https://dergipark.org.tr/en/download/article-file/4647882","source":{"id":"https://openalex.org/S4210197571","display_name":"Turkish Journal of Diabetes and Obesity","issn_l":"2587-0335","issn":["2587-0335","2587-0572"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["tr-dizin"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Turkish Journal of Diabetes and Obesity","raw_type":"journal-article"},{"id":"pmh:oai:dergipark.org.tr:article/1648392","doi":null,"is_oa":true,"landing_page_url":"https://dergipark.org.tr/en/pub/tudod/article/1648392","pdf_url":null,"source":{"id":"https://openalex.org/S4210197571","display_name":"Turkish Journal of Diabetes and Obesity","issn_l":"2587-0335","issn":["2587-0335","2587-0572"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["tr-dizin"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.25048/tudod.1648392","doi":"https://doi.org/10.25048/tudod.1648392","is_oa":true,"landing_page_url":"https://doi.org/10.25048/tudod.1648392","pdf_url":"https://dergipark.org.tr/en/download/article-file/4647882","source":{"id":"https://openalex.org/S4210197571","display_name":"Turkish Journal of Diabetes and Obesity","issn_l":"2587-0335","issn":["2587-0335","2587-0572"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["tr-dizin"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Turkish Journal of Diabetes and Obesity","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4414835547.pdf","grobid_xml":"https://content.openalex.org/works/W4414835547.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W15104804","https://openalex.org/W1807093050","https://openalex.org/W1914773534","https://openalex.org/W1928771048","https://openalex.org/W1975856754","https://openalex.org/W1998038574","https://openalex.org/W2017190445","https://openalex.org/W2056791334","https://openalex.org/W2062703082","https://openalex.org/W2079308475","https://openalex.org/W2136119122","https://openalex.org/W2570591870","https://openalex.org/W2571476906","https://openalex.org/W2741027917","https://openalex.org/W2776837711","https://openalex.org/W2791525896","https://openalex.org/W2914844848","https://openalex.org/W2981467081","https://openalex.org/W3036245280","https://openalex.org/W3081655479","https://openalex.org/W3110294629","https://openalex.org/W3123073211","https://openalex.org/W3146208376","https://openalex.org/W3182099302","https://openalex.org/W4220961453","https://openalex.org/W4294554863","https://openalex.org/W4315786202","https://openalex.org/W4376619182","https://openalex.org/W4389670448","https://openalex.org/W4400040599","https://openalex.org/W4403032517"],"related_works":["https://openalex.org/W4403032517","https://openalex.org/W4387264554","https://openalex.org/W2082815442","https://openalex.org/W4409435784","https://openalex.org/W2998355810","https://openalex.org/W1530881428","https://openalex.org/W2610714544","https://openalex.org/W3000300628","https://openalex.org/W4411200387","https://openalex.org/W4402636619"],"abstract_inverted_index":{"Aim:":[0],"Type":[1],"2":[2],"diabetes":[3],"mellitus":[4],"(T2DM)":[5],"is":[6],"commonly":[7],"managed":[8],"using":[9],"metformin":[10,43,89,138,149,192],"and":[11,26,44,54,59,62,70,90,117,151,162,193,198,210],"DPP-4":[12,45,91,153,194],"inhibitors":[13,46,195],"(vildagliptin,":[14],"linagliptin)":[15],"to":[16,38,136,179],"improve":[17],"glycemic":[18],"control.":[19],"However,":[20],"their":[21],"effects":[22],"on":[23,47,196],"electrolyte,":[24],"mineral,":[25],"vitamin":[27,55,74,211],"B12":[28,56,75,166,212],"levels":[29,64,126,209],"remain":[30],"unclear.":[31],"The":[32,104],"aim":[33],"of":[34,42,191,204,207],"this":[35],"research":[36],"was":[37],"evaluate":[39],"the":[40,110,114,118,131,137,148,152,158,174,180,188,202],"impact":[41,190],"electrolyte":[48,199,208],"levels,":[49],"as":[50,52,93,95],"well":[51,94],"mineral":[53,63,197],"levels.":[57],"Material":[58],"Methods:":[60],"Electrolyte":[61],"(including":[65],"sodium,":[66],"potassium,":[67],"calcium,":[68],"magnesium,":[69],"chloride),":[71],"along":[72],"with":[73,113,121],"concentrations,":[76],"measured":[77],"through":[78],"standard":[79],"laboratory":[80],"methods":[81],"in":[82,130,146,157,173,214],"blood":[83],"samples":[84],"from":[85,101],"T2DM":[86],"patients":[87],"receiving":[88,216],"inhibitors,":[92],"healthy":[96],"controls,":[97],"were":[98,106,127,143],"retrospectively":[99],"obtained":[100],"medical":[102],"records.":[103],"results":[105],"analyzed":[107],"by":[108],"comparing":[109],"control":[111,159,181],"group":[112,134,139,150,155,160,177,182],"treatment":[115,119],"groups":[116,120],"each":[122],"other.":[123],"Results:":[124],"Sodium":[125],"decreased":[128],"significantly":[129],"metformin+DPP-4":[132,175],"inhibitor":[133,154,176],"compared":[135],"(p=0.034).":[140],"Potassium":[141],"concentrations":[142,167],"considerably":[144],"elevated":[145],"both":[147],"than":[156],"(p=0.010":[161],"p=0.006,":[163],"respectively).":[164],"Vitamin":[165],"demonstrated":[168],"a":[169],"statistically":[170],"significant":[171],"reduction":[172],"relative":[178],"(p=0.006).":[183],"Conclusion:":[184],"These":[185],"findings":[186],"highlight":[187],"potential":[189],"homeostasis,":[200],"emphasizing":[201],"importance":[203],"regular":[205],"assessment":[206],"status":[213],"individuals":[215],"these":[217],"treatments.":[218]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2025-10-10T00:00:00"}