{"id":"https://openalex.org/W4414827191","doi":"https://doi.org/10.1101/2025.10.02.680066","title":"Glutamine-Dependent Slc25a39\u2013Nrf2 Axis Couples Mitochondrial Dynamics with Metabolic Reprogramming to Establish Myogenic Commitment","display_name":"Glutamine-Dependent Slc25a39\u2013Nrf2 Axis Couples Mitochondrial Dynamics with Metabolic Reprogramming to Establish Myogenic Commitment","publication_year":2025,"publication_date":"2025-10-04","ids":{"openalex":"https://openalex.org/W4414827191","doi":"https://doi.org/10.1101/2025.10.02.680066","pmid":"https://pubmed.ncbi.nlm.nih.gov/41256367","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12621991"},"language":"en","primary_location":{"id":"doi:10.1101/2025.10.02.680066","doi":"https://doi.org/10.1101/2025.10.02.680066","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.10.02.680066","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2025/10/04/2025.10.02.680066.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2025/10/04/2025.10.02.680066.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Brian Kelly","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian Kelly","raw_affiliation_strings":["Department of Biology, University of Kentucky, Lexington, Kentucky 40502, USA","Department of Biology, University of Kentucky"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, University of Kentucky, Lexington, Kentucky 40502, USA","institution_ids":["https://openalex.org/I143302722"]},{"raw_affiliation_string":"Department of Biology, University of Kentucky","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042230420","display_name":"Chia-Hua Wu","orcid":"https://orcid.org/0000-0002-5361-5469","observed_orcids":["https://orcid.org/0000-0002-5361-5469"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chia-Hua Wu","raw_affiliation_strings":["Department of Biology, University of Kentucky, Lexington, Kentucky 40502, USA","Department of Biology, University of Kentucky"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, University of Kentucky, Lexington, Kentucky 40502, USA","institution_ids":["https://openalex.org/I143302722"]},{"raw_affiliation_string":"Department of Biology, University of Kentucky","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027285475","display_name":"Kaan Ihsan Eskut","orcid":"https://orcid.org/0000-0002-5730-8917","observed_orcids":["https://orcid.org/0000-0002-5730-8917"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kaan I. Eskut","raw_affiliation_strings":["Department of Biology, University of Kentucky, Lexington, Kentucky 40502, USA","Department of Biology, University of Kentucky"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, University of Kentucky, Lexington, Kentucky 40502, USA","institution_ids":["https://openalex.org/I143302722"]},{"raw_affiliation_string":"Department of Biology, University of Kentucky","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Elizabeth McCauley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth McCauley","raw_affiliation_strings":["Department of Biology, University of Kentucky, Lexington, Kentucky 40502, USA","Department of Biology, University of Kentucky"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, University of Kentucky, Lexington, Kentucky 40502, USA","institution_ids":["https://openalex.org/I143302722"]},{"raw_affiliation_string":"Department of Biology, University of Kentucky","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089833462","display_name":"Sajina Dhungel","orcid":"https://orcid.org/0009-0000-6453-5950","observed_orcids":["https://orcid.org/0009-0000-6453-5950"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sajina Dhungel","raw_affiliation_strings":["Department of Biology, University of Kentucky, Lexington, Kentucky 40502, USA","Department of Biology, University of Kentucky"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, University of Kentucky, Lexington, Kentucky 40502, USA","institution_ids":["https://openalex.org/I143302722"]},{"raw_affiliation_string":"Department of Biology, University of Kentucky","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5118658225","display_name":"Samantha Pavlecic","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samantha Pavlecic","raw_affiliation_strings":["Department of Biology, University of Kentucky, Lexington, Kentucky 40502, USA","Department of Biology, University of Kentucky"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, University of Kentucky, Lexington, Kentucky 40502, USA","institution_ids":["https://openalex.org/I143302722"]},{"raw_affiliation_string":"Department of Biology, University of Kentucky","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029523543","display_name":"Grace Bieghler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Grace Bieghler","raw_affiliation_strings":["Department of Biology, University of Kentucky, Lexington, Kentucky 40502, USA","Department of Biology, University of Kentucky"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, University of Kentucky, Lexington, Kentucky 40502, USA","institution_ids":["https://openalex.org/I143302722"]},{"raw_affiliation_string":"Department of Biology, University of Kentucky","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091558850","display_name":"Jelena Perovanovi\u0107","orcid":"https://orcid.org/0000-0003-2348-2332","observed_orcids":["https://orcid.org/0000-0003-2348-2332"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]},{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jelena Perovanovic","raw_affiliation_strings":["Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah 84112","Department of Biology, University of Kentucky"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah 84112","institution_ids":["https://openalex.org/I223532165"]},{"raw_affiliation_string":"Department of Biology, University of Kentucky","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091776399","display_name":"Dean R Tantin","orcid":"https://orcid.org/0000-0003-1354-8385","observed_orcids":["https://orcid.org/0000-0003-1354-8385"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dean Tantin","raw_affiliation_strings":["Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah 84112","Department of Pathology, University of Utah"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah 84112","institution_ids":["https://openalex.org/I223532165"]},{"raw_affiliation_string":"Department of Pathology, University of Utah","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083885755","display_name":"Jakub K. Famulski","orcid":"https://orcid.org/0009-0005-3968-1282","observed_orcids":["https://orcid.org/0009-0005-3968-1282","https://orcid.org/0000-0002-3619-4113"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jakub Famulski","raw_affiliation_strings":["Department of Biology, University of Kentucky, Lexington, Kentucky 40502, USA","Department of Biology, University of Kentucky"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, University of Kentucky, Lexington, Kentucky 40502, USA","institution_ids":["https://openalex.org/I143302722"]},{"raw_affiliation_string":"Department of Biology, University of Kentucky","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084622525","display_name":"Jeramiah J. Smith","orcid":"https://orcid.org/0000-0001-5333-5531","observed_orcids":["https://orcid.org/0000-0001-5333-5531"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]},{"id":"https://openalex.org/I2802239656","display_name":"Markey Cancer Center","ror":"https://ror.org/01dhvva97","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285210727","https://openalex.org/I143302722","https://openalex.org/I2802239656"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeramiah Smith","raw_affiliation_strings":["Department of Biology, University of Kentucky, Lexington, Kentucky 40502, USA","Markey Cancer Center, University of Kentucky, Lexington, Kentucky 40502, USA","Department of Biology, University of Kentucky"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, University of Kentucky, Lexington, Kentucky 40502, USA","institution_ids":["https://openalex.org/I143302722"]},{"raw_affiliation_string":"Markey Cancer Center, University of Kentucky, Lexington, Kentucky 40502, USA","institution_ids":["https://openalex.org/I143302722","https://openalex.org/I2802239656"]},{"raw_affiliation_string":"Department of Biology, University of Kentucky","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038537150","display_name":"Chintan K. Kikani","orcid":"https://orcid.org/0000-0003-1140-0192","observed_orcids":["https://orcid.org/0000-0003-1140-0192"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Chintan Kikani","raw_affiliation_strings":["Department of Biology, University of Kentucky, Lexington, Kentucky 40502, USA","Department of Biology, University of Kentucky"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, University of Kentucky, Lexington, Kentucky 40502, USA","institution_ids":["https://openalex.org/I143302722"]},{"raw_affiliation_string":"Department of Biology, University of Kentucky","institution_ids":["https://openalex.org/I143302722"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5038537150"],"corresponding_institution_ids":["https://openalex.org/I143302722"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.9467999935150146,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.9467999935150146,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.006099999882280827,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.006000000052154064,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/myogenesis","display_name":"myogenesis","score":0.8180000185966492},{"id":"https://openalex.org/keywords/glutamine-limitation","display_name":"glutamine limitation","score":0.7099999785423279},{"id":"https://openalex.org/keywords/glutamine-oxidation","display_name":"glutamine oxidation","score":0.8230000138282776},{"id":"https://openalex.org/keywords/nrf2","display_name":"Nrf2","score":0.9539999961853027},{"id":"https://openalex.org/keywords/mitochondrial-dynamics","display_name":"mitochondrial dynamics","score":0.5979999899864197},{"id":"https://openalex.org/keywords/mitochondrial-fission","display_name":"mitochondrial fission","score":0.8809999823570251},{"id":"https://openalex.org/keywords/mitochondrial-elongation","display_name":"mitochondrial elongation","score":0.6830000281333923},{"id":"https://openalex.org/keywords/metabolic-reprogramming","display_name":"metabolic reprogramming","score":0.8809999823570251},{"id":"https://openalex.org/keywords/glycolysis","display_name":"glycolysis","score":0.9100000262260437},{"id":"https://openalex.org/keywords/glutathione-synthesis","display_name":"glutathione synthesis","score":0.8550000190734863},{"id":"https://openalex.org/keywords/mitochondrial-glutathione","display_name":"mitochondrial glutathione","score":0.6449999809265137},{"id":"https://openalex.org/keywords/redox-homeostasis","display_name":"redox homeostasis","score":0.7950000166893005},{"id":"https://openalex.org/keywords/sprouty1","display_name":"Sprouty1","score":0.9079999923706055},{"id":"https://openalex.org/keywords/myod","display_name":"MyoD","score":0.9160000085830688},{"id":"https://openalex.org/keywords/mki67","display_name":"MKI67","score":0.7979999780654907},{"id":"https://openalex.org/keywords/skeletal-muscle-regeneration","display_name":"skeletal muscle regeneration","score":0.8600000143051147},{"id":"https://openalex.org/keywords/metabolic-arrest","display_name":"metabolic arrest","score":0.3959999978542328}],"concepts":[{"id":"https://openalex.org/C2779349466","wikidata":"https://www.wikidata.org/wiki/Q181619","display_name":"Glutamine","level":3,"score":0.7979000210762024},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.667900025844574},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6399000287055969},{"id":"https://openalex.org/C207200792","wikidata":"https://www.wikidata.org/wiki/Q428914","display_name":"Myocyte","level":2,"score":0.5666999816894531},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.5149999856948853},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.429500013589859},{"id":"https://openalex.org/C75385678","wikidata":"https://www.wikidata.org/wiki/Q4896390","display_name":"Inner mitochondrial membrane","level":3,"score":0.42480000853538513},{"id":"https://openalex.org/C77255625","wikidata":"https://www.wikidata.org/wiki/Q402093","display_name":"Reprogramming","level":3,"score":0.4147999882698059},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.4050000011920929},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.3864000141620636},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.3490000069141388},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.34850001335144043},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.34630000591278076},{"id":"https://openalex.org/C3763915","wikidata":"https://www.wikidata.org/wiki/Q3331437","display_name":"Myogenesis","level":3,"score":0.34130001068115234},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.33169999718666077},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.32030001282691956},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.28610000014305115},{"id":"https://openalex.org/C2779289688","wikidata":"https://www.wikidata.org/wiki/Q418306","display_name":"Glutamine synthetase","level":4,"score":0.2849999964237213},{"id":"https://openalex.org/C163950672","wikidata":"https://www.wikidata.org/wiki/Q14905375","display_name":"mitochondrial fusion","level":4,"score":0.26820001006126404},{"id":"https://openalex.org/C98539663","wikidata":"https://www.wikidata.org/wiki/Q220599","display_name":"Cytosol","level":3,"score":0.260699987411499}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1101/2025.10.02.680066","doi":"https://doi.org/10.1101/2025.10.02.680066","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.10.02.680066","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2025/10/04/2025.10.02.680066.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:41256367","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41256367","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12621991","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12621991/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv","raw_type":"Text"},{"id":"pmh:oai:europepmc.org:11430166","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12621991","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1101/2025.10.02.680066","doi":"https://doi.org/10.1101/2025.10.02.680066","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.10.02.680066","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2025/10/04/2025.10.02.680066.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.46810001134872437,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2308215543","display_name":"Epigenetic control of muscle stem cell function by PASK-Wdr5 signaling","funder_award_id":"R01AR073906","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G9000862527","display_name":"Functional Analysis of Programmed Genome Rearrangement","funder_award_id":"R35GM130349","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4414827191.pdf","grobid_xml":"https://content.openalex.org/works/W4414827191.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W1949973946","https://openalex.org/W2014988241","https://openalex.org/W2017075649","https://openalex.org/W2078339523","https://openalex.org/W2102186262","https://openalex.org/W2119518512","https://openalex.org/W2121077787","https://openalex.org/W2134581695","https://openalex.org/W2135793165","https://openalex.org/W2156131965","https://openalex.org/W2165129832","https://openalex.org/W2403934794","https://openalex.org/W2606901660","https://openalex.org/W2801988573","https://openalex.org/W2885885985","https://openalex.org/W2889326414","https://openalex.org/W2895137021","https://openalex.org/W2904456109","https://openalex.org/W2983091663","https://openalex.org/W3010379875","https://openalex.org/W3029529179","https://openalex.org/W3045824878","https://openalex.org/W3087165503","https://openalex.org/W3095074479","https://openalex.org/W3172606224","https://openalex.org/W3187333436","https://openalex.org/W3209079142","https://openalex.org/W4224092504","https://openalex.org/W4229016802","https://openalex.org/W4289262199","https://openalex.org/W4292646795","https://openalex.org/W4292646798","https://openalex.org/W4361204548","https://openalex.org/W4362723476","https://openalex.org/W4365442931","https://openalex.org/W4383065765","https://openalex.org/W4387949494","https://openalex.org/W4388214872","https://openalex.org/W4390350694","https://openalex.org/W4391112647","https://openalex.org/W4391849194","https://openalex.org/W4396609248","https://openalex.org/W4398219567","https://openalex.org/W4400735955","https://openalex.org/W4401209506","https://openalex.org/W4401419168","https://openalex.org/W4401471986","https://openalex.org/W4403843268","https://openalex.org/W4403881077","https://openalex.org/W4405307463","https://openalex.org/W4408156770"],"related_works":["https://openalex.org/W6903600442","https://openalex.org/W3087365518","https://openalex.org/W4417051417","https://openalex.org/W1975432480","https://openalex.org/W3042055562","https://openalex.org/W3045824878","https://openalex.org/W7160893684","https://openalex.org/W4416730353","https://openalex.org/W4225329038","https://openalex.org/W6910038056"],"abstract_inverted_index":{"Abstract":[0],"Myogenic":[1],"commitment":[2],"is":[3,28,78,141,167,184,213],"a":[4,88,102,134,156,239,246],"decisive":[5],"and":[6,42,59,86,111,125,145,175,220,229,255],"irreversible":[7,261],"step":[8],"in":[9,227,232],"skeletal":[10],"muscle":[11],"regeneration,":[12],"necessitating":[13],"proliferating":[14],"myoblasts":[15,48,100],"to":[16,31,39,53,80,117,159,207,252,259],"integrate":[17],"metabolic":[18,256],"cues":[19],"with":[20,216],"nuclear":[21],"transcriptional":[22],"programs.":[23],"Among":[24],"amino":[25],"acids,":[26],"glutamine":[27,51,70,76,160,183,212,250],"uniquely":[29],"positioned":[30],"influence":[32],"this":[33,62,150,197],"transition":[34],"by":[35,63,106,129,169],"coupling":[36,249],"energy":[37],"production":[38],"macromolecule":[40],"biosynthesis":[41,174],"epigenetic":[43],"regulation.":[44],"We":[45,72,148],"reasoned":[46],"that":[47,74,91,138,238],"must":[49],"sense":[50],"availability":[52,251],"ensure":[54],"orderly":[55],"progression":[56,93],"toward":[57],"commitment,":[58],"we":[60],"tested":[61],"examining":[64],"the":[65],"molecular":[66],"consequences":[67],"of":[68,113,177,222],"acute":[69],"withdrawal.":[71],"find":[73],"continued":[75],"oxidation":[77],"required":[79],"sustain":[81],"glycolysis,":[82,114],"maintain":[83],"mitochondrial":[84,107,178,187,253],"fission,":[85],"preserve":[87,208],"redox":[89,242],"balance":[90],"supports":[92],"towards":[94],"myogenic":[95,163,262],"commitment.":[96,263],"In":[97],"its":[98],"absence,":[99],"undergo":[101],"reductive":[103],"shift,":[104],"characterized":[105],"elongation,":[108],"membrane":[109],"depolarization,":[110],"suppression":[112],"ultimately":[115],"leading":[116],"growth":[118],"arrest.":[119],"Transcriptomic":[120],"profiling":[121],"reveals":[122],"reduced":[123],"MyoD":[124],"MKi67":[126],",":[127],"accompanied":[128],"increased":[130,171],"Sprouty1":[131],"levels,":[132],"defining":[133],"reversible":[135],"non-proliferative":[136],"state":[137,151],"resembles":[139],"but":[140],"distinct":[142],"from":[143,194],"quiescent":[144],"reserve":[146],"cells.":[147],"term":[149],"Poised":[152],"Metabolic":[153],"Arrest":[154],"(PMA),":[155],"cellular":[157],"response":[158],"limitation":[161],"during":[162],"progression.":[164],"Mechanistically,":[165],"PMA":[166,205],"driven":[168],"Nrf2-dependent":[170],"glutathione":[172,188],"(GSH)":[173],"upregulation":[176],"GSH":[179],"carrier":[180],"Slc25a39":[181,191,223],"when":[182,211],"limited.":[185,214],"Depleting":[186],"or":[189],"silencing":[190],"forces":[192],"exit":[193,199],"PMA.":[195],"However,":[196],"premature":[198],"compromises":[200],"subsequent":[201],"differentiation":[202,209,226],"potential,":[203],"indicating":[204],"serves":[206],"competence":[210],"Consistent":[215],"this,":[217],"both":[218],"loss":[219],"overexpression":[221],"impair":[224],"myoblast":[225],"vitro":[228],"disrupt":[230],"regeneration":[231],"vivo.":[233],"Together,":[234],"these":[235],"data":[236],"suggest":[237],"reciprocal":[240],"Slc25a39\u2013Nrf2":[241],"axis":[243],"functions":[244],"as":[245],"nutrient-dependent":[247],"checkpoint,":[248],"remodeling":[254],"reprogramming,":[257],"necessary":[258],"establish":[260]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2025-10-10T00:00:00"}
