{"id":"https://openalex.org/W4414806093","doi":"https://doi.org/10.1016/j.jafr.2025.102411","title":"Morus alba L. polysaccharide as an mTORC1-targeting agent against type 2 diabetes","display_name":"Morus alba L. polysaccharide as an mTORC1-targeting agent against type 2 diabetes","publication_year":2025,"publication_date":"2025-10-04","ids":{"openalex":"https://openalex.org/W4414806093","doi":"https://doi.org/10.1016/j.jafr.2025.102411"},"language":"en","primary_location":{"id":"doi:10.1016/j.jafr.2025.102411","doi":"https://doi.org/10.1016/j.jafr.2025.102411","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jafr.2025.102411","pdf_url":null,"source":{"id":"https://openalex.org/S4210201734","display_name":"Journal of Agriculture and Food Research","issn_l":"2666-1543","issn":["2666-1543"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","norway-1","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Agriculture and Food Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.jafr.2025.102411","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100348377","display_name":"Ziyang Wang","orcid":"https://orcid.org/0000-0001-9481-7625","observed_orcids":["https://orcid.org/0000-0001-9481-7625"]},"institutions":[{"id":"https://openalex.org/I52158045","display_name":"China Agricultural University","ror":"https://ror.org/04v3ywz14","country_code":"CN","type":"education","lineage":["https://openalex.org/I52158045"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ziyang Wang","raw_affiliation_strings":["Department of Nutrition and Health, Key Laboratory of Functional Dairy, China Agricultural University, Beijing 100083, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutrition and Health, Key Laboratory of Functional Dairy, China Agricultural University, Beijing 100083, China","institution_ids":["https://openalex.org/I52158045"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086245013","display_name":"Qinqin Ouyang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52158045","display_name":"China Agricultural University","ror":"https://ror.org/04v3ywz14","country_code":"CN","type":"education","lineage":["https://openalex.org/I52158045"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qinqin Ouyang","raw_affiliation_strings":["Department of Nutrition and Health, Key Laboratory of Functional Dairy, China Agricultural University, Beijing 100083, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutrition and Health, Key Laboratory of Functional Dairy, China Agricultural University, Beijing 100083, China","institution_ids":["https://openalex.org/I52158045"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027778501","display_name":"Xiaolin Liang","orcid":"https://orcid.org/0000-0002-5479-4067","observed_orcids":["https://orcid.org/0000-0002-5479-4067"]},"institutions":[{"id":"https://openalex.org/I52158045","display_name":"China Agricultural University","ror":"https://ror.org/04v3ywz14","country_code":"CN","type":"education","lineage":["https://openalex.org/I52158045"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaolin Liang","raw_affiliation_strings":["Department of Nutrition and Health, Key Laboratory of Functional Dairy, China Agricultural University, Beijing 100083, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutrition and Health, Key Laboratory of Functional Dairy, China Agricultural University, Beijing 100083, China","institution_ids":["https://openalex.org/I52158045"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100383783","display_name":"Hongxia Li","orcid":"https://orcid.org/0000-0001-9695-8341","observed_orcids":["https://orcid.org/0000-0001-9695-8341"]},"institutions":[{"id":"https://openalex.org/I52158045","display_name":"China Agricultural University","ror":"https://ror.org/04v3ywz14","country_code":"CN","type":"education","lineage":["https://openalex.org/I52158045"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongxia Li","raw_affiliation_strings":["Department of Nutrition and Health, Key Laboratory of Functional Dairy, China Agricultural University, Beijing 100083, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutrition and Health, Key Laboratory of Functional Dairy, China Agricultural University, Beijing 100083, China","institution_ids":["https://openalex.org/I52158045"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113749859","display_name":"Haiying Guo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52158045","display_name":"China Agricultural University","ror":"https://ror.org/04v3ywz14","country_code":"CN","type":"education","lineage":["https://openalex.org/I52158045"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haiying Guo","raw_affiliation_strings":["Department of Nutrition and Health, Key Laboratory of Functional Dairy, China Agricultural University, Beijing 100083, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutrition and Health, Key Laboratory of Functional Dairy, China Agricultural University, Beijing 100083, China","institution_ids":["https://openalex.org/I52158045"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101375093","display_name":"Rong Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52158045","display_name":"China Agricultural University","ror":"https://ror.org/04v3ywz14","country_code":"CN","type":"education","lineage":["https://openalex.org/I52158045"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Rong Liu","raw_affiliation_strings":["Department of Nutrition and Health, Key Laboratory of Functional Dairy, China Agricultural University, Beijing 100083, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutrition and Health, Key Laboratory of Functional Dairy, China Agricultural University, Beijing 100083, China","institution_ids":["https://openalex.org/I52158045"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5101375093"],"corresponding_institution_ids":["https://openalex.org/I52158045"],"apc_list":{"value":2530,"currency":"USD","value_usd":2530},"apc_paid":{"value":2530,"currency":"USD","value_usd":2530},"fwci":0.598,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.74373511,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"24","issue":null,"first_page":"102411","last_page":"102411"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11140","display_name":"Natural Antidiabetic Agents Studies","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11140","display_name":"Natural Antidiabetic Agents Studies","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9490000009536743},{"id":"https://openalex.org/keywords/mtorc1-signaling","display_name":"mTORC1 signaling","score":0.9259999990463257},{"id":"https://openalex.org/keywords/foxo1","display_name":"FOXO1","score":0.6489999890327454},{"id":"https://openalex.org/keywords/gluconeogenesis","display_name":"gluconeogenesis","score":0.9649999737739563},{"id":"https://openalex.org/keywords/hepatic-steatosis","display_name":"hepatic steatosis","score":0.8289999961853027},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.875},{"id":"https://openalex.org/keywords/hyperglycemia","display_name":"hyperglycemia","score":0.7419999837875366},{"id":"https://openalex.org/keywords/liver-metabolomics","display_name":"liver metabolomics","score":0.7440000176429749},{"id":"https://openalex.org/keywords/bile-acid-metabolism","display_name":"bile acid metabolism","score":0.9729999899864197},{"id":"https://openalex.org/keywords/glycerolipid-metabolism","display_name":"glycerolipid metabolism","score":0.9860000014305115},{"id":"https://openalex.org/keywords/lipogenesis","display_name":"lipogenesis","score":0.859000027179718},{"id":"https://openalex.org/keywords/fatty-acid-oxidation","display_name":"fatty acid oxidation","score":1.0},{"id":"https://openalex.org/keywords/traditional-chinese-medicine-polysaccharides","display_name":"traditional Chinese medicine polysaccharides","score":0.8999999761581421},{"id":"https://openalex.org/keywords/lycium-barbarum-polysaccharide","display_name":"Lycium barbarum polysaccharide","score":0.972000002861023},{"id":"https://openalex.org/keywords/metabolic-reprogramming","display_name":"metabolic reprogramming","score":0.7549999952316284}],"concepts":[{"id":"https://openalex.org/C100817775","wikidata":"https://www.wikidata.org/wiki/Q134219","display_name":"Polysaccharide","level":2,"score":0.6646000146865845},{"id":"https://openalex.org/C141359234","wikidata":"https://www.wikidata.org/wiki/Q2734301","display_name":"Lipogenesis","level":3,"score":0.6234999895095825},{"id":"https://openalex.org/C4733338","wikidata":"https://www.wikidata.org/wiki/Q2792936","display_name":"Lipid metabolism","level":2,"score":0.5680000185966492},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4629000127315521},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4458000063896179},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4449999928474426},{"id":"https://openalex.org/C2776836740","wikidata":"https://www.wikidata.org/wiki/Q310468","display_name":"Moringa","level":2,"score":0.4147999882698059},{"id":"https://openalex.org/C17093226","wikidata":"https://www.wikidata.org/wiki/Q2734081","display_name":"Carbohydrate metabolism","level":2,"score":0.40310001373291016},{"id":"https://openalex.org/C20904676","wikidata":"https://www.wikidata.org/wiki/Q191835","display_name":"Gluconeogenesis","level":3,"score":0.39559999108314514},{"id":"https://openalex.org/C98490376","wikidata":"https://www.wikidata.org/wiki/Q14876060","display_name":"mTORC1","level":4,"score":0.38940000534057617},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.3573000133037567},{"id":"https://openalex.org/C543025807","wikidata":"https://www.wikidata.org/wiki/Q61476","display_name":"Fatty acid","level":2,"score":0.3547999858856201},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35109999775886536},{"id":"https://openalex.org/C2778772119","wikidata":"https://www.wikidata.org/wiki/Q6058862","display_name":"Fatty liver","level":3,"score":0.3425000011920929},{"id":"https://openalex.org/C2775909754","wikidata":"https://www.wikidata.org/wiki/Q1144687","display_name":"Fucoidan","level":3,"score":0.3305000066757202},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.32359999418258667},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.313400000333786},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.2953999936580658},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.29249998927116394},{"id":"https://openalex.org/C2778564307","wikidata":"https://www.wikidata.org/wiki/Q207653","display_name":"Saponin","level":3,"score":0.2800999879837036},{"id":"https://openalex.org/C2776991927","wikidata":"https://www.wikidata.org/wiki/Q14860867","display_name":"Fatty acid metabolism","level":3,"score":0.2797999978065491},{"id":"https://openalex.org/C2910068830","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 Diabetes Mellitus","level":3,"score":0.27790001034736633},{"id":"https://openalex.org/C2777866211","wikidata":"https://www.wikidata.org/wiki/Q5572349","display_name":"Glucose uptake","level":3,"score":0.27559998631477356},{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.2720000147819519},{"id":"https://openalex.org/C2779399885","wikidata":"https://www.wikidata.org/wiki/Q413288","display_name":"Bile acid","level":2,"score":0.2574999928474426},{"id":"https://openalex.org/C188947578","wikidata":"https://www.wikidata.org/wiki/Q200253","display_name":"Traditional Chinese medicine","level":3,"score":0.2533999979496002},{"id":"https://openalex.org/C116073593","wikidata":"https://www.wikidata.org/wiki/Q864491","display_name":"Biological activity","level":3,"score":0.2529999911785126}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1016/j.jafr.2025.102411","doi":"https://doi.org/10.1016/j.jafr.2025.102411","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jafr.2025.102411","pdf_url":null,"source":{"id":"https://openalex.org/S4210201734","display_name":"Journal of Agriculture and Food Research","issn_l":"2666-1543","issn":["2666-1543"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","norway-1","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Agriculture and Food Research","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:dfbe92e8f0d744a78490c9a18d611258","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/dfbe92e8f0d744a78490c9a18d611258","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Agriculture and Food Research, Vol 24, Iss , Pp 102411- (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.jafr.2025.102411","doi":"https://doi.org/10.1016/j.jafr.2025.102411","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jafr.2025.102411","pdf_url":null,"source":{"id":"https://openalex.org/S4210201734","display_name":"Journal of Agriculture and Food Research","issn_l":"2666-1543","issn":["2666-1543"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","norway-1","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Agriculture and Food Research","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G527760967","display_name":null,"funder_award_id":"2024YFF1106000","funder_id":"https://openalex.org/F4320336026","funder_display_name":"National Key Research and Development Program of China Stem Cell and Translational Research"}],"funders":[{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null},{"id":"https://openalex.org/F4320336026","display_name":"National Key Research and Development Program of China Stem Cell and Translational Research","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":73,"referenced_works":["https://openalex.org/W751952818","https://openalex.org/W2011550183","https://openalex.org/W2016505696","https://openalex.org/W2044261098","https://openalex.org/W2046887127","https://openalex.org/W2072362233","https://openalex.org/W2104523229","https://openalex.org/W2105031386","https://openalex.org/W2176389459","https://openalex.org/W2178122576","https://openalex.org/W2509220708","https://openalex.org/W2537384499","https://openalex.org/W2588409721","https://openalex.org/W2588805744","https://openalex.org/W2604226850","https://openalex.org/W2776637676","https://openalex.org/W2802818151","https://openalex.org/W2897782627","https://openalex.org/W2980639864","https://openalex.org/W2992666626","https://openalex.org/W2999421965","https://openalex.org/W3004812588","https://openalex.org/W3010613199","https://openalex.org/W3092161393","https://openalex.org/W3105585465","https://openalex.org/W3107516840","https://openalex.org/W3119007449","https://openalex.org/W3132255180","https://openalex.org/W3169495197","https://openalex.org/W3177214008","https://openalex.org/W3179139117","https://openalex.org/W3184273258","https://openalex.org/W3186342291","https://openalex.org/W3202368727","https://openalex.org/W3203890349","https://openalex.org/W3206715277","https://openalex.org/W3207171826","https://openalex.org/W3211514217","https://openalex.org/W4200006096","https://openalex.org/W4200530196","https://openalex.org/W4223538140","https://openalex.org/W4280613781","https://openalex.org/W4283075997","https://openalex.org/W4283511731","https://openalex.org/W4284962315","https://openalex.org/W4307705325","https://openalex.org/W4310067448","https://openalex.org/W4324135601","https://openalex.org/W4364321432","https://openalex.org/W4383376082","https://openalex.org/W4386102105","https://openalex.org/W4386271618","https://openalex.org/W4386423057","https://openalex.org/W4387230320","https://openalex.org/W4388440693","https://openalex.org/W4388997591","https://openalex.org/W4390744429","https://openalex.org/W4391466814","https://openalex.org/W4391844873","https://openalex.org/W4392875669","https://openalex.org/W4399549928","https://openalex.org/W4401171321","https://openalex.org/W4402996007","https://openalex.org/W4403909557","https://openalex.org/W4406315077","https://openalex.org/W4406374700","https://openalex.org/W4406846918","https://openalex.org/W4406853614","https://openalex.org/W4406959823","https://openalex.org/W4407587892","https://openalex.org/W4408386290","https://openalex.org/W4408673651","https://openalex.org/W4411177920"],"related_works":[],"abstract_inverted_index":{"Traditional":[0],"Chinese":[1],"medicine":[2],"polysaccharides":[3,172],"(TCMPs)":[4],"have":[5],"attracted":[6],"growing":[7],"attention":[8],"due":[9],"to":[10,114],"their":[11],"multi-target":[12],"and":[13,45,71,88,95,117,134,180,186],"multi-level":[14],"therapeutic":[15,62,158,197],"effects":[16,147,168],"in":[17,50,74,173],"the":[18,28,55,59,75,109,127,165],"treatment":[19],"of":[20,31,108],"diabetes.":[21],"In":[22],"this":[23],"study,":[24],"we":[25,99],"systematically":[26],"evaluated":[27],"antidiabetic":[29,104,146],"effect":[30],"three":[32,170],"TCMPs,":[33],"including":[34],"Moringa":[35],"oleifera":[36],"Lam.":[37],"polysaccharide":[38,43,48],"(MOP),":[39],"Morus":[40],"alba":[41],"L.":[42],"(MLP)":[44],"Lycium":[46],"barbarum":[47],"(LBP)":[49],"T2DM":[51,174],"mouse":[52],"model.":[53],"Among":[54],"three,":[56],"MLP":[57,83,101,143,163,177,190],"exhibited":[58],"most":[60],"pronounced":[61],"efficacy,":[63],"markedly":[64],"alleviating":[65],"hyperglycemia,":[66],"insulin":[67],"resistance,":[68],"hepatic":[69],"steatosis,":[70],"pathological":[72],"lesions":[73],"liver,":[76],"pancreas.":[77],"Liver":[78],"metabolomic":[79],"profiling":[80],"revealed":[81],"that":[82,142],"significantly":[84],"modulated":[85,178],"key":[86],"glucose":[87,137,179],"lipid":[89,181],"metabolic":[90,151],"pathways,":[91],"particularly":[92],"bile":[93],"acid":[94,120],"glycerolipid":[96],"metabolism.":[97],"Furthermore,":[98],"found":[100],"exerted":[102],"its":[103],"action":[105],"through":[106],"inhibition":[107,125,185],"mTORC1":[110,124,184],"signaling":[111],"pathway,":[112],"leading":[113],"suppressed":[115],"lipogenesis":[116],"enhanced":[118],"fatty":[119],"oxidation.":[121],"Notably,":[122],"MLP-mediated":[123],"activated":[126],"PPAR\u03b1\u2013SIRT1":[128],"axis,":[129],"thereby":[130],"downregulating":[131],"FOXO1-driven":[132],"gluconeogenesis":[133],"promoting":[135],"GLUT4-mediated":[136],"uptake.":[138],"These":[139],"findings":[140],"suggest":[141],"exerts":[144],"comprehensive":[145],"by":[148],"targeting":[149],"mTORC1-mediated":[150],"reprogramming,":[152],"offering":[153],"promise":[154],"as":[155,192],"a":[156,193],"natural":[157],"agent":[159],"for":[160,199],"T2DM.":[161,200],"\u2022":[162,176,189],"showed":[164],"strongest":[166],"anti-diabetic":[167],"among":[169],"tested":[171],"mice.":[175],"metabolism":[182],"via":[183],"PPAR\u03b1":[187],"activation.":[188],"presents":[191],"promising":[194],"natural,":[195],"low-toxicity":[196],"candidate":[198]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-10-11T09:32:39.932853","created_date":"2025-10-10T00:00:00"}