{"id":"https://openalex.org/W4414804746","doi":"https://doi.org/10.56557/upjoz/2025/v46i195265","title":"Quinic Acid as a Potential Therapeutic Agent in Drosophila Model of Rotenone-induced Parkinson\u2019s Disease","display_name":"Quinic Acid as a Potential Therapeutic Agent in Drosophila Model of Rotenone-induced Parkinson\u2019s Disease","publication_year":2025,"publication_date":"2025-10-03","ids":{"openalex":"https://openalex.org/W4414804746","doi":"https://doi.org/10.56557/upjoz/2025/v46i195265"},"language":"en","primary_location":{"id":"doi:10.56557/upjoz/2025/v46i195265","doi":"https://doi.org/10.56557/upjoz/2025/v46i195265","is_oa":true,"landing_page_url":"https://doi.org/10.56557/upjoz/2025/v46i195265","pdf_url":null,"source":{"id":"https://openalex.org/S2764565682","display_name":"UTTAR PRADESH JOURNAL OF ZOOLOGY","issn_l":"0256-971X","issn":["0256-971X"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310318718","host_organization_name":"Uttar Pradesh Zoological Society","host_organization_lineage":["https://openalex.org/P4310318718"],"host_organization_lineage_names":["Uttar Pradesh Zoological Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"UTTAR PRADESH JOURNAL OF ZOOLOGY","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.56557/upjoz/2025/v46i195265","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5114098884","display_name":"Ravi Surya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197081775","display_name":"Annamalai University","ror":"https://ror.org/01x24z140","country_code":"IN","type":"education","lineage":["https://openalex.org/I197081775"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Ravi Surya","raw_affiliation_strings":["Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar, Tamil Nadu, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar, Tamil Nadu, India","institution_ids":["https://openalex.org/I197081775"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5119312770","display_name":"Pandian Subasri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197081775","display_name":"Annamalai University","ror":"https://ror.org/01x24z140","country_code":"IN","type":"education","lineage":["https://openalex.org/I197081775"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Pandian Subasri","raw_affiliation_strings":["Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar, Tamil Nadu, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar, Tamil Nadu, India","institution_ids":["https://openalex.org/I197081775"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033759468","display_name":"Arokiasamy Justin Thenmozhi","orcid":"https://orcid.org/0000-0001-8822-4751","observed_orcids":["https://orcid.org/0000-0001-8822-4751"]},"institutions":[{"id":"https://openalex.org/I13268429","display_name":"Madurai Kamaraj University","ror":"https://ror.org/04c8e9019","country_code":"IN","type":"education","lineage":["https://openalex.org/I13268429"]},{"id":"https://openalex.org/I197081775","display_name":"Annamalai University","ror":"https://ror.org/01x24z140","country_code":"IN","type":"education","lineage":["https://openalex.org/I197081775"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Arokiasamy Justin Thenmozhi","raw_affiliation_strings":["Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar, Tamil Nadu, India and Department of Biochemistry, School of Biological Sciences, Madurai Kamaraj University, Madurai, Tamil Nadu, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar, Tamil Nadu, India and Department of Biochemistry, School of Biological Sciences, Madurai Kamaraj University, Madurai, Tamil Nadu, India","institution_ids":["https://openalex.org/I13268429","https://openalex.org/I197081775"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052925147","display_name":"Thamilarasan Manivasagam","orcid":"https://orcid.org/0000-0002-3948-8328","observed_orcids":["https://orcid.org/0000-0002-3948-8328"]},"institutions":[{"id":"https://openalex.org/I197081775","display_name":"Annamalai University","ror":"https://ror.org/01x24z140","country_code":"IN","type":"education","lineage":["https://openalex.org/I197081775"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Thamilarasan Manivasagam","raw_affiliation_strings":["Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar, Tamil Nadu, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar, Tamil Nadu, India","institution_ids":["https://openalex.org/I197081775"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5119839299","display_name":"Sathiavakoo Vigilanbiah","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sathiavakoo Vigilanbiah","raw_affiliation_strings":["Department of Animal Husbandry, Central Animal House, Cuddalore Medical College and Hospital, Cuddalore, Tamil Nadu, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Animal Husbandry, Central Animal House, Cuddalore Medical College and Hospital, Cuddalore, Tamil Nadu, India","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.29715068,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"46","issue":"19","first_page":"9","last_page":"26"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13991","display_name":"Nuclear Receptors and Signaling","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13012","display_name":"Coenzyme Q10 studies and effects","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/quinic-acid","display_name":"quinic acid","score":1.0},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.9580000042915344},{"id":"https://openalex.org/keywords/rotenone","display_name":"rotenone","score":0.9480000138282776},{"id":"https://openalex.org/keywords/drosophila-melanogaster","display_name":"Drosophila melanogaster","score":0.9869999885559082},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.7870000004768372},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.7670000195503235},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9800000190734863},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"cognitive impairment","score":0.8379999995231628},{"id":"https://openalex.org/keywords/locomotor-behavior","display_name":"locomotor behavior","score":0.75},{"id":"https://openalex.org/keywords/antioxidant-enzymes","display_name":"antioxidant enzymes","score":0.4569999873638153},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.6269999742507935},{"id":"https://openalex.org/keywords/protein-carbonylation","display_name":"protein carbonylation","score":0.7229999899864197},{"id":"https://openalex.org/keywords/glutathione","display_name":"glutathione","score":0.8420000076293945}],"concepts":[{"id":"https://openalex.org/C2778389096","wikidata":"https://www.wikidata.org/wiki/Q412388","display_name":"Rotenone","level":3,"score":0.921999990940094},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.638700008392334},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.6373999714851379},{"id":"https://openalex.org/C2778979269","wikidata":"https://www.wikidata.org/wiki/Q106951292","display_name":"Catalase","level":3,"score":0.6189000010490417},{"id":"https://openalex.org/C2776041557","wikidata":"https://www.wikidata.org/wiki/Q3715451","display_name":"Drosophila (subgenus)","level":3,"score":0.5335999727249146},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.5038999915122986},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.48429998755455017},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4740999937057495},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.47269999980926514},{"id":"https://openalex.org/C2775838275","wikidata":"https://www.wikidata.org/wiki/Q410776","display_name":"Superoxide dismutase","level":3,"score":0.4271000027656555},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.423799991607666},{"id":"https://openalex.org/C2780104201","wikidata":"https://www.wikidata.org/wiki/Q130888","display_name":"Drosophila melanogaster","level":3,"score":0.3603000044822693},{"id":"https://openalex.org/C2778117688","wikidata":"https://www.wikidata.org/wiki/Q264024","display_name":"Animal model","level":2,"score":0.3416000008583069},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33899998664855957},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2953999936580658},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.28839999437332153},{"id":"https://openalex.org/C2777379243","wikidata":"https://www.wikidata.org/wiki/Q1054318","display_name":"Drosophilidae","level":4,"score":0.2863999903202057},{"id":"https://openalex.org/C8868529","wikidata":"https://www.wikidata.org/wiki/Q124794","display_name":"Taste","level":2,"score":0.2797999978065491},{"id":"https://openalex.org/C60642223","wikidata":"https://www.wikidata.org/wiki/Q1129576","display_name":"Free-radical theory of aging","level":3,"score":0.2752000093460083},{"id":"https://openalex.org/C2780497538","wikidata":"https://www.wikidata.org/wiki/Q1192006","display_name":"Detoxification (alternative medicine)","level":3,"score":0.2741999924182892},{"id":"https://openalex.org/C33070731","wikidata":"https://www.wikidata.org/wiki/Q7218","display_name":"Toxicology","level":1,"score":0.2547999918460846},{"id":"https://openalex.org/C2779085643","wikidata":"https://www.wikidata.org/wiki/Q7096029","display_name":"Open field","level":2,"score":0.25060001015663147}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.56557/upjoz/2025/v46i195265","doi":"https://doi.org/10.56557/upjoz/2025/v46i195265","is_oa":true,"landing_page_url":"https://doi.org/10.56557/upjoz/2025/v46i195265","pdf_url":null,"source":{"id":"https://openalex.org/S2764565682","display_name":"UTTAR PRADESH JOURNAL OF ZOOLOGY","issn_l":"0256-971X","issn":["0256-971X"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310318718","host_organization_name":"Uttar Pradesh Zoological Society","host_organization_lineage":["https://openalex.org/P4310318718"],"host_organization_lineage_names":["Uttar Pradesh Zoological Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"UTTAR PRADESH JOURNAL OF ZOOLOGY","raw_type":"journal-article"},{"id":"pmh:oai:ojs.mbimph.com:article/5265","doi":null,"is_oa":true,"landing_page_url":"https://mbimph.com/index.php/UPJOZ/article/view/5265","pdf_url":null,"source":{"id":"https://openalex.org/S2764565682","display_name":"UTTAR PRADESH JOURNAL OF ZOOLOGY","issn_l":"0256-971X","issn":["0256-971X"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310318718","host_organization_name":"Uttar Pradesh Zoological Society","host_organization_lineage":["https://openalex.org/P4310318718"],"host_organization_lineage_names":["Uttar Pradesh Zoological Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"0256-971X","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:HAL:hal-05299303v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-05299303","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL (Le Centre pour la Communication Scientifique Directe)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1294671590","host_organization_name":"Centre National de la Recherche Scientifique","host_organization_lineage":["https://openalex.org/I1294671590"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"UTTAR PRADESH JOURNAL OF ZOOLOGY, 2025, 46 (19), pp.9-26","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.56557/upjoz/2025/v46i195265","doi":"https://doi.org/10.56557/upjoz/2025/v46i195265","is_oa":true,"landing_page_url":"https://doi.org/10.56557/upjoz/2025/v46i195265","pdf_url":null,"source":{"id":"https://openalex.org/S2764565682","display_name":"UTTAR PRADESH JOURNAL OF ZOOLOGY","issn_l":"0256-971X","issn":["0256-971X"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310318718","host_organization_name":"Uttar Pradesh Zoological Society","host_organization_lineage":["https://openalex.org/P4310318718"],"host_organization_lineage_names":["Uttar Pradesh Zoological Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"UTTAR PRADESH JOURNAL OF ZOOLOGY","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Background:":[0],"Quinic":[1],"acid":[2],"(QA),":[3],"a":[4],"cyclic":[5],"polyol":[6],"is":[7,159],"reported":[8],"to":[9,151,161],"possess":[10],"antioxidant,":[11],"anti-inflammatory":[12],"and":[13,33,40,62,65,81,87,99,102,112,116,121,126,169],"anti-apoptotic":[14],"properties.":[15,136],"The":[16,42],"present":[17],"experiment":[18],"studied":[19],"the":[20,94,142,163],"protective":[21,143],"role":[22,44],"of":[23,45,54,119,123,145,172],"QA":[24,46,70,91,107,146],"against":[25],"rotenone":[26,50,75,129],"mediated":[27],"reduction":[28],"in":[29,36,49,74,84,128,166],"viability,":[30],"cognitive":[31,61,95],"dysfunction":[32],"oxidative":[34],"stress":[35],"Drosophila":[37,52],"melanogaster.":[38],"Materials":[39],"Methods:":[41],"antiparkinsonian":[43],"was":[47],"assessed":[48],"induced":[51,104],"model":[53],"PD":[55],"by":[56,105],"performing":[57],"life":[58],"span":[59],"assay,":[60],"behaviour":[63],"studies":[64],"biochemical":[66],"(oxidant-antioxidant)":[67],"assays.":[68],"Results:":[69],"exposure":[71],"enhanced":[72,82,117],"viability":[73],"(500":[76],"\u00b5M)":[77],"exposed":[78,130],"fruit":[79],"flies":[80,131],"locomotion":[83],"open":[85],"field":[86],"negative":[88],"geotaxis":[89],"assay.":[90],"significantly":[92,108],"attenuated":[93],"impairment":[96],"(thermotaxis,":[97],"smell":[98],"taste":[100],"chemotaxis":[101],"phototaxis)":[103],"rotenone.":[106],"reduced":[109],"TBARS,":[110],"ROS":[111],"protein":[113],"carbonyl":[114],"levels":[115,118],"GSH":[120],"activities":[122],"SOD,":[124],"catalase":[125],"GST":[127],"through":[132],"its":[133,152],"potent":[134,153],"antioxidant":[135,154],"Conclusion:":[137],"These":[138],"results":[139],"demonstrated":[140],"that":[141],"effect":[144],"may":[147],"be":[148],"partially":[149],"due":[150],"activity.":[155],"However":[156],"further":[157],"research":[158],"needed":[160],"understand":[162],"underlying":[164],"mechanisms":[165],"other":[167],"cellular":[168],"animal":[170],"models":[171],"PD.":[173]},"counts_by_year":[],"updated_date":"2026-10-03T13:16:28.481748","created_date":"2025-10-10T00:00:00"}