{"id":"https://openalex.org/W4414802107","doi":"https://doi.org/10.1016/j.hpb.2025.07.316","title":"\u03b3\u03b4 T Cells: Potential Targets for Immunotherapy in Hepatocellular Carcinoma","display_name":"\u03b3\u03b4 T Cells: Potential Targets for Immunotherapy in Hepatocellular Carcinoma","publication_year":2025,"publication_date":"2025-01-01","ids":{"openalex":"https://openalex.org/W4414802107","doi":"https://doi.org/10.1016/j.hpb.2025.07.316"},"language":"en","primary_location":{"id":"doi:10.1016/j.hpb.2025.07.316","doi":"https://doi.org/10.1016/j.hpb.2025.07.316","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.hpb.2025.07.316","pdf_url":null,"source":{"id":"https://openalex.org/S185605772","display_name":"HPB","issn_l":"1365-182X","issn":["1365-182X","1477-2574"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"HPB","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://doi.org/10.1016/j.hpb.2025.07.316","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5119846547","display_name":"Andreea V Atanasescu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205274468","display_name":"Trinity College Dublin","ror":"https://ror.org/02tyrky19","country_code":"IE","type":"education","lineage":["https://openalex.org/I205274468"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"A. Atanasescu","raw_affiliation_strings":["Trinity College Dublin, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Trinity College Dublin, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Dublin, Ireland","institution_ids":["https://openalex.org/I205274468"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101808612","display_name":"Paul R. Armstrong","orcid":"https://orcid.org/0000-0001-7520-9050","observed_orcids":["https://orcid.org/0000-0001-7520-9050"]},"institutions":[{"id":"https://openalex.org/I100930933","display_name":"University College Dublin","ror":"https://ror.org/05m7pjf47","country_code":"IE","type":"education","lineage":["https://openalex.org/I100930933"]},{"id":"https://openalex.org/I2803071314","display_name":"Mater Misericordiae University Hospital","ror":"https://ror.org/040hqpc16","country_code":"IE","type":"healthcare","lineage":["https://openalex.org/I2803071314"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"P. Armstrong","raw_affiliation_strings":["Mater Misericordiae University Hospital, Department of Hepatology, Dublin, Ireland","University College Dublin, Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mater Misericordiae University Hospital, Department of Hepatology, Dublin, Ireland","institution_ids":["https://openalex.org/I2803071314"]},{"raw_affiliation_string":"University College Dublin, Dublin, Ireland","institution_ids":["https://openalex.org/I100930933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009705247","display_name":"T. F. Gallagher","orcid":"https://orcid.org/0000-0001-6381-6902","observed_orcids":["https://orcid.org/0000-0001-6381-6902"]},"institutions":[{"id":"https://openalex.org/I4210115218","display_name":"St. Vincent's University Hospital","ror":"https://ror.org/029tkqm80","country_code":"IE","type":"healthcare","lineage":["https://openalex.org/I4210115218"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"T. Gallagher","raw_affiliation_strings":["St. Vincent\u2019s University Hospital, National Liver Unit, Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St. Vincent\u2019s University Hospital, National Liver Unit, Dublin, Ireland","institution_ids":["https://openalex.org/I4210115218"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109915682","display_name":"Emir Hoti","orcid":"https://orcid.org/0000-0003-3799-8866","observed_orcids":["https://orcid.org/0000-0003-3799-8866"]},"institutions":[{"id":"https://openalex.org/I4210115218","display_name":"St. Vincent's University Hospital","ror":"https://ror.org/029tkqm80","country_code":"IE","type":"healthcare","lineage":["https://openalex.org/I4210115218"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"E. Hoti","raw_affiliation_strings":["St. Vincent\u2019s University Hospital, National Liver Unit, Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St. Vincent\u2019s University Hospital, National Liver Unit, Dublin, Ireland","institution_ids":["https://openalex.org/I4210115218"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5119838167","display_name":"V. Korovanenko","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205274468","display_name":"Trinity College Dublin","ror":"https://ror.org/02tyrky19","country_code":"IE","type":"education","lineage":["https://openalex.org/I205274468"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"V. Korovanenko","raw_affiliation_strings":["Trinity College Dublin, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Trinity College Dublin, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Dublin, Ireland","institution_ids":["https://openalex.org/I205274468"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090735389","display_name":"Omar El Sherif","orcid":"https://orcid.org/0000-0002-5564-8141","observed_orcids":["https://orcid.org/0000-0002-5564-8141"]},"institutions":[{"id":"https://openalex.org/I4210115218","display_name":"St. Vincent's University Hospital","ror":"https://ror.org/029tkqm80","country_code":"IE","type":"healthcare","lineage":["https://openalex.org/I4210115218"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"O. El Sherif","raw_affiliation_strings":["St. Vincent\u2019s University Hospital, National Liver Unit, Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St. Vincent\u2019s University Hospital, National Liver Unit, Dublin, Ireland","institution_ids":["https://openalex.org/I4210115218"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082399313","display_name":"Lydia Lynch","orcid":"https://orcid.org/0000-0002-4273-4681","observed_orcids":["https://orcid.org/0000-0002-4273-4681"]},"institutions":[{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L. Lynch","raw_affiliation_strings":["Princeton University, Department of Molecular Biology, New Jersey, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Princeton University, Department of Molecular Biology, New Jersey, United States","institution_ids":["https://openalex.org/I20089843"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091548602","display_name":"Cliona O\u2019Farrelly","orcid":"https://orcid.org/0000-0002-0616-2874","observed_orcids":["https://orcid.org/0000-0002-0616-2874"]},"institutions":[{"id":"https://openalex.org/I205274468","display_name":"Trinity College Dublin","ror":"https://ror.org/02tyrky19","country_code":"IE","type":"education","lineage":["https://openalex.org/I205274468"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"C. O'Farrelly","raw_affiliation_strings":["Trinity College Dublin, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Dublin, Ireland","Trinity College Dublin, School of Medicine, Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Trinity College Dublin, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Dublin, Ireland","institution_ids":["https://openalex.org/I205274468"]},{"raw_affiliation_string":"Trinity College Dublin, School of Medicine, Dublin, Ireland","institution_ids":["https://openalex.org/I205274468"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4100,"currency":"USD","value_usd":4100},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"27","issue":null,"first_page":"S393","last_page":"S393"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.6366999745368958,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.6366999745368958,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.26899999380111694,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.026200000196695328,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gamma-delta-t-cells","display_name":"\u03b3\u03b4 T cells","score":0.9089999794960022},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9980000257492065},{"id":"https://openalex.org/keywords/immunotherapy-targets","display_name":"immunotherapy targets","score":0.7390000224113464},{"id":"https://openalex.org/keywords/pd-1-expression","display_name":"PD-1 expression","score":0.8799999952316284},{"id":"https://openalex.org/keywords/antitumour-activity","display_name":"antitumour activity","score":0.7879999876022339},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitor-resistance","display_name":"immune checkpoint inhibitor resistance","score":0.8259999752044678},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.6859999895095825},{"id":"https://openalex.org/keywords/liver-cancer","display_name":"liver cancer","score":0.7580000162124634}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9089999794960022},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.8579000234603882},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.789900004863739},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6162999868392944},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.576200008392334},{"id":"https://openalex.org/C2780851360","wikidata":"https://www.wikidata.org/wiki/Q21686041","display_name":"Immune checkpoint","level":4,"score":0.41659998893737793},{"id":"https://openalex.org/C2776231280","wikidata":"https://www.wikidata.org/wiki/Q623031","display_name":"Liver cancer","level":3,"score":0.4081999957561493},{"id":"https://openalex.org/C207936829","wikidata":"https://www.wikidata.org/wiki/Q423163","display_name":"Major histocompatibility complex","level":3,"score":0.3747999966144562},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.37470000982284546},{"id":"https://openalex.org/C2780674031","wikidata":"https://www.wikidata.org/wiki/Q2012719","display_name":"Cancer immunotherapy","level":4,"score":0.3727000057697296},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.36809998750686646},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.34040001034736633},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3357999920845032},{"id":"https://openalex.org/C2781053074","wikidata":"https://www.wikidata.org/wiki/Q21100639","display_name":"PD-L1","level":4,"score":0.3271999955177307},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.29980000853538513},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.2953999936580658},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.28299999237060547},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.27880001068115234},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.26089999079704285}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.hpb.2025.07.316","doi":"https://doi.org/10.1016/j.hpb.2025.07.316","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.hpb.2025.07.316","pdf_url":null,"source":{"id":"https://openalex.org/S185605772","display_name":"HPB","issn_l":"1365-182X","issn":["1365-182X","1477-2574"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"HPB","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.hpb.2025.07.316","doi":"https://doi.org/10.1016/j.hpb.2025.07.316","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.hpb.2025.07.316","pdf_url":null,"source":{"id":"https://openalex.org/S185605772","display_name":"HPB","issn_l":"1365-182X","issn":["1365-182X","1477-2574"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"HPB","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9922999739646912,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4391136498","https://openalex.org/W4385450134","https://openalex.org/W4414823442","https://openalex.org/W4224224913","https://openalex.org/W7055398364","https://openalex.org/W4220656480","https://openalex.org/W2788115666","https://openalex.org/W3201579214","https://openalex.org/W7127136691","https://openalex.org/W7117245440"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2025-10-10T00:00:00"}