{"id":"https://openalex.org/W4414767987","doi":"https://doi.org/10.3390/ijms26199635","title":"Catalytic IgG Antibodies Hydrolyze DNA, Histones, and HMGB1 in Systemic Lupus Erythematosus","display_name":"Catalytic IgG Antibodies Hydrolyze DNA, Histones, and HMGB1 in Systemic Lupus Erythematosus","publication_year":2025,"publication_date":"2025-10-02","ids":{"openalex":"https://openalex.org/W4414767987","doi":"https://doi.org/10.3390/ijms26199635","pmid":"https://pubmed.ncbi.nlm.nih.gov/41096902","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12524583"},"language":"en","primary_location":{"id":"doi:10.3390/ijms26199635","doi":"https://doi.org/10.3390/ijms26199635","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms26199635","pdf_url":"https://www.mdpi.com/1422-0067/26/19/9635/pdf?version=1759408702","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1422-0067/26/19/9635/pdf?version=1759408702","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026945619","display_name":"Mark M. Melamud","orcid":"https://orcid.org/0000-0003-4276-4597","observed_orcids":["https://orcid.org/0000-0003-4276-4597"]},"institutions":[{"id":"https://openalex.org/I4210091979","display_name":"Institute of Chemical Biology and Fundamental Medicine","ror":"https://ror.org/00gmz2d02","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210091979","https://openalex.org/I4210129690"]},{"id":"https://openalex.org/I4210127387","display_name":"Siberian Branch of the Russian Academy of Sciences","ror":"https://ror.org/02frkq021","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210127387"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Mark M. Melamud","raw_affiliation_strings":["Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia","institution_ids":["https://openalex.org/I4210091979","https://openalex.org/I4210127387"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024586103","display_name":"Evgeny A. Ermakov","orcid":"https://orcid.org/0000-0002-1084-6419","observed_orcids":["https://orcid.org/0000-0002-1084-6419"]},"institutions":[{"id":"https://openalex.org/I188973947","display_name":"Novosibirsk State University","ror":"https://ror.org/04t2ss102","country_code":"RU","type":"education","lineage":["https://openalex.org/I188973947"]},{"id":"https://openalex.org/I4210091979","display_name":"Institute of Chemical Biology and Fundamental Medicine","ror":"https://ror.org/00gmz2d02","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210091979","https://openalex.org/I4210129690"]},{"id":"https://openalex.org/I4210127387","display_name":"Siberian Branch of the Russian Academy of Sciences","ror":"https://ror.org/02frkq021","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210127387"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Evgeny A. Ermakov","raw_affiliation_strings":["Department of Natural Sciences, Novosibirsk State University, 630090 Novosibirsk, Russia","Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia"],"raw_orcid":"https://orcid.org/0000-0002-1084-6419","affiliations":[{"raw_affiliation_string":"Department of Natural Sciences, Novosibirsk State University, 630090 Novosibirsk, Russia","institution_ids":["https://openalex.org/I188973947"]},{"raw_affiliation_string":"Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia","institution_ids":["https://openalex.org/I4210091979","https://openalex.org/I4210127387"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070394564","display_name":"Anna S. Tolmacheva","orcid":"https://orcid.org/0000-0002-0984-0810","observed_orcids":["https://orcid.org/0000-0002-0984-0810"]},"institutions":[{"id":"https://openalex.org/I4210091979","display_name":"Institute of Chemical Biology and Fundamental Medicine","ror":"https://ror.org/00gmz2d02","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210091979","https://openalex.org/I4210129690"]},{"id":"https://openalex.org/I4210127387","display_name":"Siberian Branch of the Russian Academy of Sciences","ror":"https://ror.org/02frkq021","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210127387"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Anna S. Tolmacheva","raw_affiliation_strings":["Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia"],"raw_orcid":"https://orcid.org/0000-0002-0984-0810","affiliations":[{"raw_affiliation_string":"Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia","institution_ids":["https://openalex.org/I4210091979","https://openalex.org/I4210127387"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036757787","display_name":"Irina A. Kostrikina","orcid":"https://orcid.org/0000-0002-0987-7066","observed_orcids":["https://orcid.org/0000-0002-0987-7066"]},"institutions":[{"id":"https://openalex.org/I4210091979","display_name":"Institute of Chemical Biology and Fundamental Medicine","ror":"https://ror.org/00gmz2d02","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210091979","https://openalex.org/I4210129690"]},{"id":"https://openalex.org/I4210127387","display_name":"Siberian Branch of the Russian Academy of Sciences","ror":"https://ror.org/02frkq021","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210127387"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Irina A. Kostrikina","raw_affiliation_strings":["Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia"],"raw_orcid":"https://orcid.org/0000-0002-0987-7066","affiliations":[{"raw_affiliation_string":"Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia","institution_ids":["https://openalex.org/I4210091979","https://openalex.org/I4210127387"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057314613","display_name":"\u0410. \u042d. \u0421\u0438\u0437\u0438\u043a\u043e\u0432","orcid":"https://orcid.org/0000-0002-7213-7482","observed_orcids":["https://orcid.org/0000-0002-7213-7482"]},"institutions":[{"id":"https://openalex.org/I4210091979","display_name":"Institute of Chemical Biology and Fundamental Medicine","ror":"https://ror.org/00gmz2d02","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210091979","https://openalex.org/I4210129690"]},{"id":"https://openalex.org/I4210102846","display_name":"Research Institute of Fundamental and Clinical Immunology","ror":"https://ror.org/01b3qhp76","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210102846","https://openalex.org/I4210110862"]},{"id":"https://openalex.org/I4210127387","display_name":"Siberian Branch of the Russian Academy of Sciences","ror":"https://ror.org/02frkq021","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210127387"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Alexey E. Sizikov","raw_affiliation_strings":["Department of Rheumatology, Immunopathology Clinic, Research Institute of Fundamental and Clinical Immunology, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia","Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia"],"raw_orcid":"https://orcid.org/0000-0002-7213-7482","affiliations":[{"raw_affiliation_string":"Department of Rheumatology, Immunopathology Clinic, Research Institute of Fundamental and Clinical Immunology, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia","institution_ids":["https://openalex.org/I4210102846","https://openalex.org/I4210127387"]},{"raw_affiliation_string":"Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia","institution_ids":["https://openalex.org/I4210091979","https://openalex.org/I4210127387"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081504559","display_name":"Georgy A. Nevinsky","orcid":"https://orcid.org/0000-0002-4988-8923","observed_orcids":["https://orcid.org/0000-0002-4988-8923"]},"institutions":[{"id":"https://openalex.org/I188973947","display_name":"Novosibirsk State University","ror":"https://ror.org/04t2ss102","country_code":"RU","type":"education","lineage":["https://openalex.org/I188973947"]},{"id":"https://openalex.org/I4210091979","display_name":"Institute of Chemical Biology and Fundamental Medicine","ror":"https://ror.org/00gmz2d02","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210091979","https://openalex.org/I4210129690"]},{"id":"https://openalex.org/I4210127387","display_name":"Siberian Branch of the Russian Academy of Sciences","ror":"https://ror.org/02frkq021","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210127387"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Georgy A. Nevinsky","raw_affiliation_strings":["Department of Natural Sciences, Novosibirsk State University, 630090 Novosibirsk, Russia","Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia"],"raw_orcid":"https://orcid.org/0000-0002-4988-8923","affiliations":[{"raw_affiliation_string":"Department of Natural Sciences, Novosibirsk State University, 630090 Novosibirsk, Russia","institution_ids":["https://openalex.org/I188973947"]},{"raw_affiliation_string":"Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia","institution_ids":["https://openalex.org/I4210091979","https://openalex.org/I4210127387"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087864126","display_name":"Valentina N. Buneva","orcid":"https://orcid.org/0000-0003-2556-979X","observed_orcids":["https://orcid.org/0000-0003-2556-979X"]},"institutions":[{"id":"https://openalex.org/I188973947","display_name":"Novosibirsk State University","ror":"https://ror.org/04t2ss102","country_code":"RU","type":"education","lineage":["https://openalex.org/I188973947"]},{"id":"https://openalex.org/I4210091979","display_name":"Institute of Chemical Biology and Fundamental Medicine","ror":"https://ror.org/00gmz2d02","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210091979","https://openalex.org/I4210129690"]},{"id":"https://openalex.org/I4210127387","display_name":"Siberian Branch of the Russian Academy of Sciences","ror":"https://ror.org/02frkq021","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210127387"]}],"countries":["RU"],"is_corresponding":true,"raw_author_name":"Valentina N. Buneva","raw_affiliation_strings":["Department of Natural Sciences, Novosibirsk State University, 630090 Novosibirsk, Russia","Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia"],"raw_orcid":"https://orcid.org/0000-0003-2556-979X","affiliations":[{"raw_affiliation_string":"Department of Natural Sciences, Novosibirsk State University, 630090 Novosibirsk, Russia","institution_ids":["https://openalex.org/I188973947"]},{"raw_affiliation_string":"Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia","institution_ids":["https://openalex.org/I4210091979","https://openalex.org/I4210127387"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5087864126"],"corresponding_institution_ids":["https://openalex.org/I188973947","https://openalex.org/I4210091979","https://openalex.org/I4210127387"],"apc_list":{"value":2900,"currency":"CHF","value_usd":3499},"apc_paid":{"value":2900,"currency":"CHF","value_usd":3499},"fwci":0.5465,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.59623044,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"26","issue":"19","first_page":"9635","last_page":"9635"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11330","display_name":"Systemic Sclerosis and Related Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10697","display_name":"Vasculitis and related conditions","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/systemic-lupus-erythematosus","display_name":"systemic lupus erythematosus","score":0.9929999709129333},{"id":"https://openalex.org/keywords/anti-dna-antibodies","display_name":"anti-DNA antibodies","score":0.9620000123977661},{"id":"https://openalex.org/keywords/antinuclear-antibodies","display_name":"antinuclear antibodies","score":0.8190000057220459},{"id":"https://openalex.org/keywords/hmgb1","display_name":"HMGB1","score":0.8240000009536743},{"id":"https://openalex.org/keywords/catalase-like-activity","display_name":"catalase-like activity","score":0.9309999942779541},{"id":"https://openalex.org/keywords/autoantibody-heterogeneity","display_name":"autoantibody heterogeneity","score":0.8619999885559082},{"id":"https://openalex.org/keywords/clinical-course","display_name":"clinical course","score":0.5820000171661377},{"id":"https://openalex.org/keywords/disease-duration","display_name":"disease duration","score":0.753000020980835}],"concepts":[{"id":"https://openalex.org/C149443304","wikidata":"https://www.wikidata.org/wiki/Q185390","display_name":"Anti-nuclear antibody","level":4,"score":0.8309999704360962},{"id":"https://openalex.org/C163764329","wikidata":"https://www.wikidata.org/wiki/Q785022","display_name":"Autoantibody","level":3,"score":0.796999990940094},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.7641000151634216},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.5569000244140625},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.512499988079071},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5095000267028809},{"id":"https://openalex.org/C2775915377","wikidata":"https://www.wikidata.org/wiki/Q188297","display_name":"Lupus erythematosus","level":3,"score":0.48190000653266907},{"id":"https://openalex.org/C2779075594","wikidata":"https://www.wikidata.org/wiki/Q8084905","display_name":"Autoimmune disease","level":3,"score":0.47839999198913574},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.4226999878883362},{"id":"https://openalex.org/C2780545709","wikidata":"https://www.wikidata.org/wiki/Q21130552","display_name":"HMGB1","level":3,"score":0.39989998936653137},{"id":"https://openalex.org/C94412978","wikidata":"https://www.wikidata.org/wiki/Q103135","display_name":"Hydrolysis","level":2,"score":0.37470000982284546},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.3718999922275543},{"id":"https://openalex.org/C2776912625","wikidata":"https://www.wikidata.org/wiki/Q1485","display_name":"Systemic lupus erythematosus","level":3,"score":0.3684999942779541},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.3621000051498413},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.35850000381469727},{"id":"https://openalex.org/C81566733","wikidata":"https://www.wikidata.org/wiki/Q1047544","display_name":"Hypervariable region","level":3,"score":0.3095000088214874},{"id":"https://openalex.org/C63363279","wikidata":"https://www.wikidata.org/wiki/Q5133848","display_name":"Clinical significance","level":2,"score":0.30809998512268066},{"id":"https://openalex.org/C2780898057","wikidata":"https://www.wikidata.org/wiki/Q79448","display_name":"Immunoglobulin G","level":3,"score":0.3050000071525574},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.29089999198913574},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27889999747276306},{"id":"https://openalex.org/C2776232647","wikidata":"https://www.wikidata.org/wiki/Q702883","display_name":"Rheumatoid factor","level":3,"score":0.2721000015735626},{"id":"https://openalex.org/C2776670291","wikidata":"https://www.wikidata.org/wiki/Q1779300","display_name":"Connective tissue disease","level":4,"score":0.2614000141620636},{"id":"https://openalex.org/C2780648854","wikidata":"https://www.wikidata.org/wiki/Q2745824","display_name":"Immunopathology","level":2,"score":0.2531999945640564}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000974","descriptor_name":"Antibodies, Antinuclear","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000974","descriptor_name":"Antibodies, Antinuclear","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006868","descriptor_name":"Hydrolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008180","descriptor_name":"Lupus Erythematosus, Systemic","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D008180","descriptor_name":"Lupus Erythematosus, Systemic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008180","descriptor_name":"Lupus Erythematosus, Systemic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017151","descriptor_name":"Antibodies, Catalytic","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D017151","descriptor_name":"Antibodies, Catalytic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D017151","descriptor_name":"Antibodies, Catalytic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D024243","descriptor_name":"HMGB1 Protein","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D024243","descriptor_name":"HMGB1 Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.3390/ijms26199635","doi":"https://doi.org/10.3390/ijms26199635","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms26199635","pdf_url":"https://www.mdpi.com/1422-0067/26/19/9635/pdf?version=1759408702","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12524583","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12524583","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12524583/pdf/ijms-26-09635.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Sci","raw_type":"Text"},{"id":"pmh:oai:europepmc.org:11336263","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12524583","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:41096902","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41096902","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3390/ijms26199635","doi":"https://doi.org/10.3390/ijms26199635","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms26199635","pdf_url":"https://www.mdpi.com/1422-0067/26/19/9635/pdf?version=1759408702","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1414145070","display_name":null,"funder_award_id":"23-15-00357","funder_id":"https://openalex.org/F4320324099","funder_display_name":"Russian Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320321770","display_name":"Siberian Branch, Russian Academy of Sciences","ror":"https://ror.org/02frkq021"},{"id":"https://openalex.org/F4320324099","display_name":"Russian Science Foundation","ror":"https://ror.org/03y2gwe85"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4414767987.pdf","grobid_xml":"https://content.openalex.org/works/W4414767987.grobid-xml"},"referenced_works_count":87,"referenced_works":["https://openalex.org/W191793640","https://openalex.org/W929754317","https://openalex.org/W1605213317","https://openalex.org/W1768247331","https://openalex.org/W1803399375","https://openalex.org/W1987131443","https://openalex.org/W1987479282","https://openalex.org/W2000477706","https://openalex.org/W2010664601","https://openalex.org/W2017870766","https://openalex.org/W2039470228","https://openalex.org/W2051165942","https://openalex.org/W2058678072","https://openalex.org/W2060483771","https://openalex.org/W2071314849","https://openalex.org/W2078472057","https://openalex.org/W2082211176","https://openalex.org/W2083106799","https://openalex.org/W2091058032","https://openalex.org/W2103615263","https://openalex.org/W2109268320","https://openalex.org/W2113954415","https://openalex.org/W2116700955","https://openalex.org/W2122859968","https://openalex.org/W2141455950","https://openalex.org/W2149656504","https://openalex.org/W2154341021","https://openalex.org/W2160411095","https://openalex.org/W2161367998","https://openalex.org/W2163937136","https://openalex.org/W2171165028","https://openalex.org/W2177459785","https://openalex.org/W2182812412","https://openalex.org/W2216732451","https://openalex.org/W2222074825","https://openalex.org/W2228305902","https://openalex.org/W2261479737","https://openalex.org/W2311115959","https://openalex.org/W2323518718","https://openalex.org/W2340988493","https://openalex.org/W2402560296","https://openalex.org/W2425516388","https://openalex.org/W2514582747","https://openalex.org/W2584677044","https://openalex.org/W2724612748","https://openalex.org/W2758787877","https://openalex.org/W2786451303","https://openalex.org/W2793077245","https://openalex.org/W2801097217","https://openalex.org/W2885056734","https://openalex.org/W2891132054","https://openalex.org/W2893500120","https://openalex.org/W2924420961","https://openalex.org/W2962616530","https://openalex.org/W2966041078","https://openalex.org/W2972002224","https://openalex.org/W2979688933","https://openalex.org/W2990856869","https://openalex.org/W3014847810","https://openalex.org/W3045703858","https://openalex.org/W3091618216","https://openalex.org/W3092074931","https://openalex.org/W3132724913","https://openalex.org/W3142871091","https://openalex.org/W3177828909","https://openalex.org/W3186993962","https://openalex.org/W4200470662","https://openalex.org/W4206395907","https://openalex.org/W4220687191","https://openalex.org/W4228998244","https://openalex.org/W4286587639","https://openalex.org/W4304688917","https://openalex.org/W4321460291","https://openalex.org/W4328048365","https://openalex.org/W4380681857","https://openalex.org/W4380792003","https://openalex.org/W4381549586","https://openalex.org/W4384339918","https://openalex.org/W4386963668","https://openalex.org/W4388832057","https://openalex.org/W4389479432","https://openalex.org/W4391023344","https://openalex.org/W4394873432","https://openalex.org/W4397010908","https://openalex.org/W4400746150","https://openalex.org/W4402905588","https://openalex.org/W4408892881"],"related_works":["https://openalex.org/W2885056734","https://openalex.org/W1994615797","https://openalex.org/W2153633670","https://openalex.org/W1987131443","https://openalex.org/W1970524545","https://openalex.org/W7097125858","https://openalex.org/W2031870975","https://openalex.org/W4229801262","https://openalex.org/W4389479432","https://openalex.org/W2436742007"],"abstract_inverted_index":{"Antinuclear":[0],"antibodies,":[1,4],"especially":[2],"anti-DNA":[3,169],"are":[5],"known":[6],"to":[7,88],"be":[8],"a":[9,18,182,197,201],"hallmark":[10],"of":[11,21,51,69,94,96,185,204,213,237,248,251,254],"systemic":[12],"lupus":[13],"erythematosus":[14],"(SLE)":[15],"and":[16,28,48,75,81,98,138,191,240],"represent":[17],"diverse":[19],"pool":[20,223],"autoantibodies":[22,231,256],"with":[23,32,145,158,177],"different":[24],"origins,":[25],"antigenic":[26],"properties,":[27],"physicochemical":[29],"features.":[30],"Antibodies":[31],"catalytic":[33,234,255],"properties":[34],"have":[35,54],"been":[36,56],"found":[37],"among":[38,257],"the":[39,45,67,92,105,113,142,146,175,186,205,221,249,252],"antibody":[40,222],"repertoire":[41,253],"in":[42,168,218,224],"SLE,":[43],"but":[44,232],"specific":[46],"features":[47],"clinical":[49],"associations":[50],"such":[52,78],"antibodies":[53,109,170,235],"not":[55,111,122,227],"sufficiently":[57],"studied.":[58],"This":[59],"study":[60],"showed":[61],"that":[62],"chromatographically":[63],"purified":[64],"IgG":[65,126,160,214],"from":[66],"serum":[68],"SLE":[70,225,258],"patients":[71,133],"effectively":[72],"hydrolyzed":[73],"DNA":[74,97,239],"DNA-associated":[76,99,241],"proteins":[77,100],"as":[79],"histones":[80],"high-mobility":[82],"group":[83],"box":[84],"1":[85],"(HMGB1)":[86],"compared":[87],"healthy":[89],"individuals.":[90],"Remarkably,":[91],"level":[93],"hydrolysis":[95],"was":[101,163,192,215],"closely":[102],"correlated.":[103],"At":[104],"same":[106],"time,":[107],"these":[108],"did":[110],"hydrolyze":[112],"control":[114],"protein,":[115],"tumor":[116],"necrosis":[117],"factor-\u03b1":[118],"(TNF\u03b1),":[119],"which":[120,180],"does":[121],"possess":[123],"DNA-binding":[124],"properties.":[125],"DNase":[127,161],"activity":[128,162,212],"levels":[129],"varied":[130],"significantly,":[131],"so":[132],"were":[134],"divided":[135],"into":[136],"high-":[137],"low-activity":[139],"subgroups":[140],"using":[141],"DBSCAN":[143],"algorithm,":[144],"difference":[147],"between":[148],"median":[149],"values":[150],"being":[151],"greater":[152],"than":[153,174,200],"49":[154],"times.":[155],"The":[156],"subgroup":[157,176],"high":[159],"characterized":[164,195],"by":[165,196],"an":[166],"increase":[167],"(p":[171,188,207],"<":[172],"0.04)":[173],"low":[178],"activity,":[179],"had":[181],"shorter":[183],"duration":[184],"disease":[187,206],"=":[189,208],"0.03)":[190],"more":[193],"often":[194],"subacute":[198],"rather":[199],"non-chronic":[202],"course":[203],"0.048).":[209],"High":[210],"catalase-like":[211],"also":[216,233],"detected":[217],"SLE.":[219],"Thus,":[220],"contains":[226],"only":[228],"high-affinity":[229],"antinuclear":[230],"capable":[236],"hydrolyzing":[238],"proteins.":[242],"These":[243],"findings":[244],"expand":[245],"our":[246],"understanding":[247],"heterogeneity":[250],"patients.":[259]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2025-10-10T00:00:00"}
