{"id":"https://openalex.org/W4414756136","doi":"https://doi.org/10.24170/22-03-7428","title":"Challenges with international normalised ratio control in paediatric patients with rheumatic heart valve replacement surgery in the Eastern Cape Province, South Africa","display_name":"Challenges with international normalised ratio control in paediatric patients with rheumatic heart valve replacement surgery in the Eastern Cape Province, South Africa","publication_year":2025,"publication_date":"2025-01-01","ids":{"openalex":"https://openalex.org/W4414756136","doi":"https://doi.org/10.24170/22-03-7428"},"language":"en","primary_location":{"id":"doi:10.24170/22-03-7428","doi":"https://doi.org/10.24170/22-03-7428","is_oa":true,"landing_page_url":"https://doi.org/10.24170/22-03-7428","pdf_url":"https://www.journals.ac.za/SAHJ/article/download/7428/4564","source":{"id":"https://openalex.org/S4210218468","display_name":"SA Heart","issn_l":"1996-6741","issn":["1996-6741","2071-4602"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/P4310315333","host_organization_name":"South African Heart Association","host_organization_lineage":["https://openalex.org/P4310315333"],"host_organization_lineage_names":["South African Heart Association"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SA Heart","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.journals.ac.za/SAHJ/article/download/7428/4564","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112319758","display_name":"Zongezile Masonwabe Makrexeni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I92579986","display_name":"Walter Sisulu University","ror":"https://ror.org/02svzjn28","country_code":"ZA","type":"education","lineage":["https://openalex.org/I92579986"]}],"countries":["ZA"],"is_corresponding":true,"raw_author_name":"ZM Makrexeni","raw_affiliation_strings":["Walter Sisulu University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Walter Sisulu University","institution_ids":["https://openalex.org/I92579986"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5112319758"],"corresponding_institution_ids":["https://openalex.org/I92579986"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.2903603,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"22","issue":"3","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11153","display_name":"Streptococcal Infections and Treatments","score":0.5913000106811523,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11153","display_name":"Streptococcal Infections and Treatments","score":0.5913000106811523,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10172","display_name":"Cardiac Valve Diseases and Treatments","score":0.271699994802475,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11551","display_name":"Infective Endocarditis Diagnosis and Management","score":0.04839999973773956,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rheumatic-heart-disease","display_name":"rheumatic heart disease","score":0.9990000128746033},{"id":"https://openalex.org/keywords/warfarin-therapy","display_name":"warfarin anticoagulation","score":0.9419999718666077},{"id":"https://openalex.org/keywords/mitral-valve-replacement","display_name":"mitral valve replacement","score":0.7950000166893005},{"id":"https://openalex.org/keywords/prosthetic-valve-thrombosis","display_name":"prosthetic valve thrombosis","score":0.8169999718666077},{"id":"https://openalex.org/keywords/thromboembolic-events","display_name":"thromboembolic events","score":0.8009999990463257},{"id":"https://openalex.org/keywords/anticoagulation-adherence","display_name":"anticoagulation adherence","score":0.796999990940094},{"id":"https://openalex.org/keywords/health-care-access","display_name":"health care access","score":0.9369999766349792},{"id":"https://openalex.org/keywords/acute-rheumatic-fever","display_name":"acute rheumatic fever","score":0.8479999899864197},{"id":"https://openalex.org/keywords/pediatric-patients","display_name":"pediatric patients","score":0.8169999718666077},{"id":"https://openalex.org/keywords/eastern-cape","display_name":"Eastern Cape","score":0.968999981880188}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9311000108718872},{"id":"https://openalex.org/C2775854548","wikidata":"https://www.wikidata.org/wiki/Q6882369","display_name":"Mitral valve replacement","level":3,"score":0.6675000190734863},{"id":"https://openalex.org/C2780074459","wikidata":"https://www.wikidata.org/wiki/Q389735","display_name":"Heart disease","level":2,"score":0.5444999933242798},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.5182999968528748},{"id":"https://openalex.org/C2776301958","wikidata":"https://www.wikidata.org/wiki/Q407431","display_name":"Warfarin","level":3,"score":0.5131000280380249},{"id":"https://openalex.org/C2780026749","wikidata":"https://www.wikidata.org/wiki/Q7912830","display_name":"Valve replacement","level":3,"score":0.5041000247001648},{"id":"https://openalex.org/C2777543888","wikidata":"https://www.wikidata.org/wiki/Q369939","display_name":"Mitral valve","level":2,"score":0.4986000061035156},{"id":"https://openalex.org/C2778789114","wikidata":"https://www.wikidata.org/wiki/Q235007","display_name":"Cardiac surgery","level":2,"score":0.46000000834465027},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.45829999446868896},{"id":"https://openalex.org/C2778881276","wikidata":"https://www.wikidata.org/wiki/Q552304","display_name":"Cardiopulmonary bypass","level":2,"score":0.3465999960899353},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.3370000123977661},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3292999863624573},{"id":"https://openalex.org/C2776229121","wikidata":"https://www.wikidata.org/wiki/Q215620","display_name":"Heart valve","level":2,"score":0.32760000228881836},{"id":"https://openalex.org/C2909371484","wikidata":"https://www.wikidata.org/wiki/Q7912830","display_name":"Heart valve replacement","level":3,"score":0.3068000078201294},{"id":"https://openalex.org/C2780703314","wikidata":"https://www.wikidata.org/wiki/Q1140794","display_name":"Mitral valve stenosis","level":3,"score":0.30630001425743103},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.29429998993873596},{"id":"https://openalex.org/C2779736815","wikidata":"https://www.wikidata.org/wiki/Q1130519","display_name":"valvular heart disease","level":2,"score":0.28859999775886536},{"id":"https://openalex.org/C2780679668","wikidata":"https://www.wikidata.org/wiki/Q6882374","display_name":"Mitral valve repair","level":3,"score":0.2775000035762787},{"id":"https://openalex.org/C2781236483","wikidata":"https://www.wikidata.org/wiki/Q753904","display_name":"Rheumatic fever","level":2,"score":0.2500999867916107}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.24170/22-03-7428","doi":"https://doi.org/10.24170/22-03-7428","is_oa":true,"landing_page_url":"https://doi.org/10.24170/22-03-7428","pdf_url":"https://www.journals.ac.za/SAHJ/article/download/7428/4564","source":{"id":"https://openalex.org/S4210218468","display_name":"SA Heart","issn_l":"1996-6741","issn":["1996-6741","2071-4602"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/P4310315333","host_organization_name":"South African Heart Association","host_organization_lineage":["https://openalex.org/P4310315333"],"host_organization_lineage_names":["South African Heart Association"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SA Heart","raw_type":"journal-article"},{"id":"pmh:oai:www.journals.ac.za/oai:article/7428","doi":null,"is_oa":true,"landing_page_url":"https://www.journals.ac.za/SAHJ/article/view/7428","pdf_url":null,"source":{"id":"https://openalex.org/S4210218468","display_name":"SA Heart","issn_l":"1996-6741","issn":["1996-6741","2071-4602"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/P4310315333","host_organization_name":"South African Heart Association","host_organization_lineage":["https://openalex.org/P4310315333"],"host_organization_lineage_names":["South African Heart Association"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"1996-6741","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.24170/22-03-7428","doi":"https://doi.org/10.24170/22-03-7428","is_oa":true,"landing_page_url":"https://doi.org/10.24170/22-03-7428","pdf_url":"https://www.journals.ac.za/SAHJ/article/download/7428/4564","source":{"id":"https://openalex.org/S4210218468","display_name":"SA Heart","issn_l":"1996-6741","issn":["1996-6741","2071-4602"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/P4310315333","host_organization_name":"South African Heart Association","host_organization_lineage":["https://openalex.org/P4310315333"],"host_organization_lineage_names":["South African Heart Association"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SA Heart","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"sustainable_development_goals_aurora":[],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4414756136.pdf","grobid_xml":"https://content.openalex.org/works/W4414756136.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Introduction:":[0],"Rheumatic":[1],"heart":[2,13,240],"disease":[3,248],"(RHD)":[4],"is":[5,31],"a":[6,43,168,181,210,223],"preventable":[7],"chronic":[8,201],"condition":[9],"that":[10],"affects":[11],"the":[12,33,64,108,175],"valves.":[14],"The":[15,124],"incidence":[16],"of":[17,45,61,94,174],"acute":[18,236],"rheumatic":[19,79,237,239],"fever":[20],"(ARF)":[21],"and":[22,42,85,117,192,233],"RHD":[23,54,70,98,202],"has":[24],"waned":[25],"in":[26,35,53],"Western":[27],"countries;":[28],"however,":[29],"this":[30],"not":[32],"case":[34],"developing":[36],"countries.":[37],"Poor":[38],"access":[39,232],"to":[40,47,56,155,167,179,190,194,221,229],"healthcare":[41,231],"lack":[44],"adherence":[46],"international":[48,245],"normalised":[49,246],"ratio":[50],"(INR)":[51],"monitoring":[52],"contribute":[55],"thromboembolic":[57],"complications.":[58],"Methods:":[59],"Records":[60],"patients":[62,96,102,126,152,160,176,203,214],"from":[63,188],"Eastern":[65],"Cape":[66],"municipal":[67],"districts":[68],"with":[69,97,104,185,209],"were":[71,83,99,145,161,177,216],"reviewed":[72],"over":[73],"10":[74],"years.":[75],"Patients":[76],"who":[77,127,139,215],"underwent":[78,204],"valve":[80,114,121,130,136,142,157,206,242],"replacement":[81,115,143,207,243],"surgery":[82,132,144,208],"isolated":[84],"analysed":[86],"for":[87,164],"their":[88],"INR":[89,184,226],"control.":[90],"Results:":[91],"A":[92],"total":[93],"30":[95,109],"reviewed.":[100],"All":[101],"presented":[103],"severe":[105],"RHD.":[106],"Of":[107],"patients,":[110],"20":[111],"had":[112,119,128,140],"mitral":[113,120,129,135,141,156,171,205],"surgery,":[116,244],"6":[118,125],"repair":[122,131],"surgery.":[123],"eventually":[133],"required":[134],"replacement.":[137],"Those":[138],"started":[146,217],"on":[147,196,218],"anticoagulation":[148,165],"(warfarin)":[149],"post-operatively.":[150],"Two":[151],"died":[153],"due":[154,166,228],"thrombosis.":[158],"Four":[159],"subsequently":[162],"admitted":[163],"thrombosed":[169],"prosthetic":[170,211],"valve.":[172,212],"Most":[173,200,213],"struggling":[178],"maintain":[180,222],"therapeutic":[182,224],"range":[183,225],"values":[186],"ranging":[187],"1.1":[189],"2,":[191],"up":[193],"8\u201310":[195],"rare":[197],"occasions.":[198],"Conclusion:":[199],"warfarin":[219],"struggled":[220],"postoperatively":[227],"poor":[230],"adherence.":[234],"Keywords:":[235],"fever,":[238],"disease,":[241],"ratio,":[247],"outcomes":[249]},"counts_by_year":[],"updated_date":"2026-10-03T13:16:28.481748","created_date":"2025-10-10T00:00:00"}
