{"id":"https://openalex.org/W4414748627","doi":"https://doi.org/10.1007/s42452-025-06804-w","title":"Effect of gamma irradiation on cytotoxicity and drug delivery applications of borosilicate bioactive glasses","display_name":"Effect of gamma irradiation on cytotoxicity and drug delivery applications of borosilicate bioactive glasses","publication_year":2025,"publication_date":"2025-10-02","ids":{"openalex":"https://openalex.org/W4414748627","doi":"https://doi.org/10.1007/s42452-025-06804-w"},"language":"en","primary_location":{"id":"doi:10.1007/s42452-025-06804-w","doi":"https://doi.org/10.1007/s42452-025-06804-w","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s42452-025-06804-w","pdf_url":"https://link.springer.com/content/pdf/10.1007/s42452-025-06804-w.pdf","source":{"id":"https://openalex.org/S5407042868","display_name":"Discover Applied Sciences","issn_l":"3004-9261","issn":["3004-9261"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","jufo-1","norway-1","russia-white-list-2"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Discover Applied Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://link.springer.com/content/pdf/10.1007/s42452-025-06804-w.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026675449","display_name":"Taha M. Tiama","orcid":"https://orcid.org/0000-0003-0509-1127","observed_orcids":["https://orcid.org/0000-0003-0509-1127"]},"institutions":[{"id":"https://openalex.org/I4210136523","display_name":"October High Institute For Enginnering and Technology","ror":"https://ror.org/03kn6cb12","country_code":"EG","type":"education","lineage":["https://openalex.org/I4210136523"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Taha M. Tiama","raw_affiliation_strings":["Basic Science Department, October High Institute for Engineering & Technology, 6th October City, Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Basic Science Department, October High Institute for Engineering & Technology, 6th October City, Cairo, Egypt","institution_ids":["https://openalex.org/I4210136523"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036112329","display_name":"Ahmed F. Mabied","orcid":"https://orcid.org/0000-0002-1732-6280","observed_orcids":["https://orcid.org/0000-0002-1732-6280"]},"institutions":[{"id":"https://openalex.org/I4210131959","display_name":"National Research Centre","ror":"https://ror.org/02n85j827","country_code":"EG","type":"facility","lineage":["https://openalex.org/I4210131959"]}],"countries":["EG"],"is_corresponding":true,"raw_author_name":"Ahmed F. Mabied","raw_affiliation_strings":["X-ray Crystallography Lab., Solid State Physics Department, National Research Center, 33 Bohouth St., Dokki, 12622, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"X-ray Crystallography Lab., Solid State Physics Department, National Research Center, 33 Bohouth St., Dokki, 12622, Egypt","institution_ids":["https://openalex.org/I4210131959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032257232","display_name":"Noha Gweily","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210131959","display_name":"National Research Centre","ror":"https://ror.org/02n85j827","country_code":"EG","type":"facility","lineage":["https://openalex.org/I4210131959"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Noha Gweily","raw_affiliation_strings":["Spectroscopy Department, National Research Centre, 33 El-Bohouth St., Dokki, Giza, 12622, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Spectroscopy Department, National Research Centre, 33 El-Bohouth St., Dokki, Giza, 12622, Egypt","institution_ids":["https://openalex.org/I4210131959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008925983","display_name":"Medhat Ibrahim","orcid":"https://orcid.org/0000-0002-9698-0837","observed_orcids":["https://orcid.org/0000-0002-9698-0837"]},"institutions":[{"id":"https://openalex.org/I4210131959","display_name":"National Research Centre","ror":"https://ror.org/02n85j827","country_code":"EG","type":"facility","lineage":["https://openalex.org/I4210131959"]}],"countries":["EG"],"is_corresponding":true,"raw_author_name":"Medhat A. Ibrahim","raw_affiliation_strings":["Molecular Modeling and Spectroscopy Laboratory, Centre of Excellence for Advanced Science, National Research Centre, 33 El-Bohouth St., Dokki, Giza, 12622, Egypt","Spectroscopy Department, National Research Centre, 33 El-Bohouth St., Dokki, Giza, 12622, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Modeling and Spectroscopy Laboratory, Centre of Excellence for Advanced Science, National Research Centre, 33 El-Bohouth St., Dokki, Giza, 12622, Egypt","institution_ids":["https://openalex.org/I4210131959"]},{"raw_affiliation_string":"Spectroscopy Department, National Research Centre, 33 El-Bohouth St., Dokki, Giza, 12622, Egypt","institution_ids":["https://openalex.org/I4210131959"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044280020","display_name":"Yasser H. Elshaer","orcid":"https://orcid.org/0009-0005-4179-5369","observed_orcids":["https://orcid.org/0009-0005-4179-5369"]},"institutions":[{"id":"https://openalex.org/I3089115","display_name":"Egyptian Atomic Energy Authority","ror":"https://ror.org/04hd0yz67","country_code":"EG","type":"government","lineage":["https://openalex.org/I3089115"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Yasser H. Elshaer","raw_affiliation_strings":["Reactor Physics Department, Nuclear Research Center, Atomic Energy Authority (EAEA), Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Reactor Physics Department, Nuclear Research Center, Atomic Energy Authority (EAEA), Cairo, Egypt","institution_ids":["https://openalex.org/I3089115"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5008925983","https://openalex.org/A5036112329"],"corresponding_institution_ids":["https://openalex.org/I4210131959"],"apc_list":null,"apc_paid":null,"fwci":0.2029,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.33064219,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"7","issue":"10","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.9330999851226807,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.9330999851226807,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10544","display_name":"Glass properties and applications","score":0.06120000034570694,"subfield":{"id":"https://openalex.org/subfields/2503","display_name":"Ceramics and Composites"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12299","display_name":"Radiation Shielding Materials Analysis","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gamma-irradiation","display_name":"gamma irradiation","score":0.9950000047683716},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.8220000267028809},{"id":"https://openalex.org/keywords/drug-delivery","display_name":"drug delivery","score":0.8169999718666077},{"id":"https://openalex.org/keywords/sustained-release","display_name":"sustained drug release","score":0.8489999771118164},{"id":"https://openalex.org/keywords/non-bridging-oxygen","display_name":"non-bridging oxygen","score":0.8669999837875366},{"id":"https://openalex.org/keywords/bioactivity-biomaterials","display_name":"bioactivity (biomaterials)","score":0.7870000004768372},{"id":"https://openalex.org/keywords/antibiotic-loaded-biomaterials","display_name":"antibiotic-loaded biomaterials","score":0.718999981880188},{"id":"https://openalex.org/keywords/bacterial-bone-infection","display_name":"bacterial infection of bone","score":0.6299999952316284},{"id":"https://openalex.org/keywords/higuchi-kinetics","display_name":"Higuchi model","score":0.8679999709129333}],"concepts":[{"id":"https://openalex.org/C206802598","wikidata":"https://www.wikidata.org/wiki/Q1422588","display_name":"Borosilicate glass","level":2,"score":0.9383000135421753},{"id":"https://openalex.org/C2777230088","wikidata":"https://www.wikidata.org/wiki/Q864426","display_name":"Biocompatibility","level":2,"score":0.8260999917984009},{"id":"https://openalex.org/C111337013","wikidata":"https://www.wikidata.org/wiki/Q2737837","display_name":"Irradiation","level":2,"score":0.592199981212616},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.5662999749183655},{"id":"https://openalex.org/C13965031","wikidata":"https://www.wikidata.org/wiki/Q243545","display_name":"Nuclear chemistry","level":1,"score":0.5426999926567078},{"id":"https://openalex.org/C160892712","wikidata":"https://www.wikidata.org/wiki/Q901559","display_name":"Fourier transform infrared spectroscopy","level":2,"score":0.5264000296592712},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.516700029373169},{"id":"https://openalex.org/C2778414984","wikidata":"https://www.wikidata.org/wiki/Q865663","display_name":"Biomaterial","level":2,"score":0.4749999940395355},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.4596000015735626},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.415800005197525},{"id":"https://openalex.org/C26771246","wikidata":"https://www.wikidata.org/wiki/Q321095","display_name":"Scanning electron microscope","level":2,"score":0.3961000144481659},{"id":"https://openalex.org/C153642686","wikidata":"https://www.wikidata.org/wiki/Q70906","display_name":"Infrared spectroscopy","level":2,"score":0.34599998593330383},{"id":"https://openalex.org/C3017806408","wikidata":"https://www.wikidata.org/wiki/Q92772955","display_name":"Gamma irradiation","level":3,"score":0.3391999900341034},{"id":"https://openalex.org/C177322064","wikidata":"https://www.wikidata.org/wiki/Q750955","display_name":"Radiochemistry","level":1,"score":0.33309999108314514},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.29829999804496765},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.29510000348091125},{"id":"https://openalex.org/C13245373","wikidata":"https://www.wikidata.org/wiki/Q3715494","display_name":"Drug carrier","level":3,"score":0.2851000130176544},{"id":"https://openalex.org/C7910260","wikidata":"https://www.wikidata.org/wiki/Q11523","display_name":"Gamma ray","level":2,"score":0.2806999981403351},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.27549999952316284},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.27390000224113464},{"id":"https://openalex.org/C2778519171","wikidata":"https://www.wikidata.org/wiki/Q3556054","display_name":"Bioactive glass","level":2,"score":0.26899999380111694},{"id":"https://openalex.org/C56052488","wikidata":"https://www.wikidata.org/wiki/Q103382","display_name":"Amorphous solid","level":2,"score":0.26840001344680786}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1007/s42452-025-06804-w","doi":"https://doi.org/10.1007/s42452-025-06804-w","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s42452-025-06804-w","pdf_url":"https://link.springer.com/content/pdf/10.1007/s42452-025-06804-w.pdf","source":{"id":"https://openalex.org/S5407042868","display_name":"Discover Applied Sciences","issn_l":"3004-9261","issn":["3004-9261"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","jufo-1","norway-1","russia-white-list-2"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Discover Applied Sciences","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:ab54147e7b0a481fb353ecdee892affb","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/ab54147e7b0a481fb353ecdee892affb","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Discover Applied Sciences, Vol 7, Iss 10, Pp 1-15 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1007/s42452-025-06804-w","doi":"https://doi.org/10.1007/s42452-025-06804-w","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s42452-025-06804-w","pdf_url":"https://link.springer.com/content/pdf/10.1007/s42452-025-06804-w.pdf","source":{"id":"https://openalex.org/S5407042868","display_name":"Discover Applied Sciences","issn_l":"3004-9261","issn":["3004-9261"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","jufo-1","norway-1","russia-white-list-2"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Discover Applied Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4414748627.pdf","grobid_xml":"https://content.openalex.org/works/W4414748627.grobid-xml"},"referenced_works_count":45,"referenced_works":["https://openalex.org/W1603872480","https://openalex.org/W1995331939","https://openalex.org/W2011439223","https://openalex.org/W2023059067","https://openalex.org/W2026682684","https://openalex.org/W2044646198","https://openalex.org/W2062210005","https://openalex.org/W2066470222","https://openalex.org/W2086699454","https://openalex.org/W2093310889","https://openalex.org/W2115572590","https://openalex.org/W2119626516","https://openalex.org/W2250962880","https://openalex.org/W2337626939","https://openalex.org/W2489914422","https://openalex.org/W2548963507","https://openalex.org/W2586707394","https://openalex.org/W2602016219","https://openalex.org/W2764228413","https://openalex.org/W2780719111","https://openalex.org/W2791014655","https://openalex.org/W2797099384","https://openalex.org/W2800396656","https://openalex.org/W2889243662","https://openalex.org/W2919262181","https://openalex.org/W2919740045","https://openalex.org/W3016200451","https://openalex.org/W3036266124","https://openalex.org/W3116123688","https://openalex.org/W3173368621","https://openalex.org/W3174682403","https://openalex.org/W4214891198","https://openalex.org/W4226214199","https://openalex.org/W4310251722","https://openalex.org/W4311531541","https://openalex.org/W4312195177","https://openalex.org/W4317666032","https://openalex.org/W4361212069","https://openalex.org/W4380538244","https://openalex.org/W4385456725","https://openalex.org/W4388277677","https://openalex.org/W4388521032","https://openalex.org/W4389273126","https://openalex.org/W4391228183","https://openalex.org/W4408099718"],"related_works":["https://openalex.org/W4324348664","https://openalex.org/W4206939100","https://openalex.org/W1972581049","https://openalex.org/W4416528464","https://openalex.org/W2586707394","https://openalex.org/W4385456725","https://openalex.org/W4362593904","https://openalex.org/W4411644395","https://openalex.org/W4415733092","https://openalex.org/W6884907044"],"abstract_inverted_index":{"This":[0],"study":[1],"investigates":[2],"the":[3,12,21,38,74,80,112,133,136,140,151,156],"synthesis":[4],"and":[5,29,41,50,64],"characterization":[6],"of":[7,23,47,76,108,119],"borosilicate":[8,123,175],"bioactive":[9],"glass":[10,81,124,176],"with":[11,100,104,135,167],"composition":[13],"[50":[14],"B2O3\u20135":[15],"SiO2\u201315":[16],"ZnO\u201330":[17],"CaO],":[18],"focusing":[19],"on":[20,26],"effects":[22],"gamma":[24,44,71],"irradiation":[25,72,102],"its":[27,84,88],"properties":[28],"drug":[30,146,183],"delivery":[31,184],"capabilities.":[32],"The":[33,91,116,170],"samples":[34,130,165],"were":[35],"prepared":[36],"through":[37],"melt-quenching":[39],"method":[40],"subjected":[42],"to":[43,155],"radiation":[45],"doses":[46],"0.5,":[48],"1,":[49],"2":[51,168],"mGy.":[52,169],"Characterization":[53],"techniques,":[54],"including":[55],"X-ray":[56],"diffraction":[57],"(XRD),":[58],"Fourier":[59],"transform":[60],"infrared":[61],"spectroscopy":[62],"(FTIR),":[63],"scanning":[65],"electron":[66],"microscopy":[67],"(SEM/EDX),":[68],"revealed":[69],"that":[70,128,150,173],"increased":[73],"number":[75],"non-bridging":[77],"oxygens":[78],"in":[79,122,164,188],"network,":[82],"enhancing":[83],"bioactivity":[85],"while":[86],"maintaining":[87],"amorphous":[89],"structure.":[90],"cytotoxicity":[92],"assay":[93],"using":[94],"Vero":[95],"cells":[96],"demonstrated":[97],"improved":[98],"biocompatibility":[99],"higher":[101],"doses,":[103],"an":[105],"IC50":[106],"value":[107],"463.21":[109],"\u03bcg/ml":[110],"for":[111,182],"most":[113],"irradiated":[114,166],"sample.":[115],"encapsulation":[117],"efficiency":[118,142],"ciprofloxacin":[120],"(CFX)":[121],"was":[125],"confirmed,":[126],"showing":[127],"all":[129],"successfully":[131],"loaded":[132],"drug,":[134],"non-irradiated":[137],"sample":[138],"achieving":[139],"highest":[141],"(53.65%).":[143],"In":[144],"vitro":[145],"release":[147,152,161,196],"studies":[148],"indicated":[149],"profiles":[153],"conformed":[154],"Higuchi":[157],"model,":[158],"highlighting":[159],"sustained":[160,194],"characteristics,":[162],"particularly":[163],"research":[171],"suggests":[172],"gamma-irradiated":[174],"may":[177],"be":[178],"a":[179],"promising":[180],"biomaterial":[181],"applications":[185],"as":[186],"antibiotics":[187],"treating":[189],"bacterial":[190],"bone":[191],"infections,":[192],"providing":[193],"antibiotic":[195],"over":[197],"extended":[198],"periods.":[199]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-10-03T13:16:28.481748","created_date":"2025-10-10T00:00:00"}
