{"id":"https://openalex.org/W4414745554","doi":"https://doi.org/10.1007/s11883-025-01352-5","title":"Self-DNA by Activating the CGAS-STING1 Pathway Contributes to the Pathogenesis of Atherosclerosis","display_name":"Self-DNA by Activating the CGAS-STING1 Pathway Contributes to the Pathogenesis of Atherosclerosis","publication_year":2025,"publication_date":"2025-10-02","ids":{"openalex":"https://openalex.org/W4414745554","doi":"https://doi.org/10.1007/s11883-025-01352-5","pmid":"https://pubmed.ncbi.nlm.nih.gov/41037234"},"language":"en","primary_location":{"id":"doi:10.1007/s11883-025-01352-5","doi":"https://doi.org/10.1007/s11883-025-01352-5","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s11883-025-01352-5","pdf_url":null,"source":{"id":"https://openalex.org/S129765729","display_name":"Current Atherosclerosis Reports","issn_l":"1523-3804","issn":["1523-3804","1534-6242"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Atherosclerosis Reports","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025407796","display_name":"Ali J. Marian","orcid":"https://orcid.org/0000-0002-1252-7120","observed_orcids":["https://orcid.org/0000-0002-1252-7120"]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"A. J. Marian","raw_affiliation_strings":["Center for Cardiovascular Genetic Studies, Institute of Molecular Medicine, The University of Texas Health Science Center, 6770 Bertner Street, Suite C900A, Houston, TX, 77030, US. Ali.J.Marian@uth.tmc.edu","Center for Cardiovascular Genetic Studies, Institute of Molecular Medicine, The University of Texas Health Science Center, 6770 Bertner Street, Suite C900A, Houston, TX, 77030, US"],"raw_orcid":"https://orcid.org/0000-0002-1252-7120","affiliations":[{"raw_affiliation_string":"Center for Cardiovascular Genetic Studies, Institute of Molecular Medicine, The University of Texas Health Science Center, 6770 Bertner Street, Suite C900A, Houston, TX, 77030, US. Ali.J.Marian@uth.tmc.edu","institution_ids":["https://openalex.org/I919571938"]},{"raw_affiliation_string":"Center for Cardiovascular Genetic Studies, Institute of Molecular Medicine, The University of Texas Health Science Center, 6770 Bertner Street, Suite C900A, Houston, TX, 77030, US","institution_ids":["https://openalex.org/I919571938"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5025407796"],"corresponding_institution_ids":["https://openalex.org/I919571938"],"apc_list":{"value":5190,"currency":"USD","value_usd":5190},"apc_paid":null,"fwci":0.1788,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.23824701,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":97},"biblio":{"volume":"27","issue":"1","first_page":"96","last_page":"96"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.8687000274658203,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.8687000274658203,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.1234000027179718,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11078","display_name":"Inflammasome and immune disorders","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/self-dna","display_name":"self-DNA","score":0.8920000195503235},{"id":"https://openalex.org/keywords/cytosolic-dna-sensing","display_name":"cytosolic DNA sensing","score":0.8730000257492065},{"id":"https://openalex.org/keywords/coronary-artery-disease","display_name":"coronary artery disease","score":0.9210000038146973},{"id":"https://openalex.org/keywords/chronic-low-grade-inflammation","display_name":"low-grade inflammation","score":0.9440000057220459},{"id":"https://openalex.org/keywords/mitochondrial-dna-release","display_name":"mitochondrial DNA release","score":0.5690000057220459},{"id":"https://openalex.org/keywords/interferon-stimulated-genes","display_name":"interferon-stimulated genes","score":0.9350000023841858},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.9800000190734863},{"id":"https://openalex.org/keywords/cardiac-remodeling","display_name":"cardiac remodeling","score":0.9330000281333923},{"id":"https://openalex.org/keywords/myocardial-infarction","display_name":"myocardial infarction","score":0.9980000257492065}],"concepts":[{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.8162000179290771},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6926000118255615},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.6818000078201294},{"id":"https://openalex.org/C98539663","wikidata":"https://www.wikidata.org/wiki/Q220599","display_name":"Cytosol","level":3,"score":0.6355000138282776},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.6273999810218811},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.436599999666214},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.42260000109672546},{"id":"https://openalex.org/C111566952","wikidata":"https://www.wikidata.org/wiki/Q1303462","display_name":"Cardiac function curve","level":3,"score":0.38449999690055847},{"id":"https://openalex.org/C3020196126","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammatory response","level":3,"score":0.37540000677108765},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.36090001463890076},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3488999903202057},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.34360000491142273},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.33230000734329224},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3142000138759613},{"id":"https://openalex.org/C2778213512","wikidata":"https://www.wikidata.org/wiki/Q844935","display_name":"Coronary artery disease","level":2,"score":0.3091000020503998},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.29910001158714294},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2953999936580658},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.2858000099658966},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.274399995803833},{"id":"https://openalex.org/C2991716557","wikidata":"https://www.wikidata.org/wiki/Q12252367","display_name":"Coronary atherosclerosis","level":3,"score":0.27140000462532043},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.26910001039505005},{"id":"https://openalex.org/C2779676291","wikidata":"https://www.wikidata.org/wiki/Q25325349","display_name":"Cardioprotection","level":3,"score":0.25920000672340393},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2590000033378601},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.2563000023365021},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2563000023365021},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.2542000114917755},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2531999945640564}],"mesh":[{"descriptor_ui":"D000099197","descriptor_name":"STING Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000099235","descriptor_name":"Cyclic Guanosine Monophosphate-Adenosine Monophosphate Synthase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009713","descriptor_name":"Nucleotidyltransferases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050197","descriptor_name":"Atherosclerosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D050197","descriptor_name":"Atherosclerosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1007/s11883-025-01352-5","doi":"https://doi.org/10.1007/s11883-025-01352-5","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s11883-025-01352-5","pdf_url":null,"source":{"id":"https://openalex.org/S129765729","display_name":"Current Atherosclerosis Reports","issn_l":"1523-3804","issn":["1523-3804","1534-6242"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Atherosclerosis Reports","raw_type":"journal-article"},{"id":"pmid:41037234","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41037234","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current atherosclerosis reports","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5400097132","display_name":"Cell type-Specific Therapeutic Targeting of canonical WNT Pathway in Arrhythmogenic Cardiomyopathy","funder_award_id":"R01HL151737","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000863674","display_name":"Mechanisms and Therapeutic Targeting of DNA Damage in Dilated Cardiomyopathy Caused by LMNA Mutations","funder_award_id":"R01HL132401","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000885346","display_name":"Cytosolic DNA is the Link Between Genomic Instability and Cardiovascular Aging","funder_award_id":"R01AG082751","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":90,"referenced_works":["https://openalex.org/W1514540900","https://openalex.org/W1559113813","https://openalex.org/W1966408457","https://openalex.org/W2010677667","https://openalex.org/W2015310325","https://openalex.org/W2044192315","https://openalex.org/W2047906547","https://openalex.org/W2061194981","https://openalex.org/W2069357463","https://openalex.org/W2071556127","https://openalex.org/W2078540517","https://openalex.org/W2085192138","https://openalex.org/W2094992876","https://openalex.org/W2095160367","https://openalex.org/W2097750604","https://openalex.org/W2099610218","https://openalex.org/W2101873043","https://openalex.org/W2113495231","https://openalex.org/W2115435531","https://openalex.org/W2119864130","https://openalex.org/W2131617804","https://openalex.org/W2147424761","https://openalex.org/W2151775798","https://openalex.org/W2152000030","https://openalex.org/W2156054547","https://openalex.org/W2162470976","https://openalex.org/W2168169019","https://openalex.org/W2299422902","https://openalex.org/W2324841714","https://openalex.org/W2461916920","https://openalex.org/W2469317767","https://openalex.org/W2587610309","https://openalex.org/W2588219496","https://openalex.org/W2738136165","https://openalex.org/W2754087313","https://openalex.org/W2767983921","https://openalex.org/W2768027311","https://openalex.org/W2786396437","https://openalex.org/W2789915165","https://openalex.org/W2790318061","https://openalex.org/W2793873744","https://openalex.org/W2797633816","https://openalex.org/W2810612816","https://openalex.org/W2884661296","https://openalex.org/W2892170438","https://openalex.org/W2897219144","https://openalex.org/W2911642321","https://openalex.org/W2916717448","https://openalex.org/W2916856097","https://openalex.org/W2919692138","https://openalex.org/W2919704769","https://openalex.org/W2921819114","https://openalex.org/W2924610177","https://openalex.org/W2975658692","https://openalex.org/W2994585472","https://openalex.org/W3011113661","https://openalex.org/W3012709102","https://openalex.org/W3024191006","https://openalex.org/W3083971280","https://openalex.org/W3087617819","https://openalex.org/W3093008524","https://openalex.org/W3158635115","https://openalex.org/W3178184824","https://openalex.org/W3186191183","https://openalex.org/W3190205340","https://openalex.org/W4210402574","https://openalex.org/W4281398472","https://openalex.org/W4287447395","https://openalex.org/W4312911509","https://openalex.org/W4313489120","https://openalex.org/W4377289383","https://openalex.org/W4381682244","https://openalex.org/W4382241824","https://openalex.org/W4385498418","https://openalex.org/W4385618169","https://openalex.org/W4387216516","https://openalex.org/W4387675477","https://openalex.org/W4389264124","https://openalex.org/W4390837189","https://openalex.org/W4391138568","https://openalex.org/W4401882411","https://openalex.org/W4401947398","https://openalex.org/W4402470714","https://openalex.org/W4402697781","https://openalex.org/W4403136521","https://openalex.org/W4403425948","https://openalex.org/W4403729629","https://openalex.org/W4407018224","https://openalex.org/W4408562960","https://openalex.org/W4409546165"],"related_works":["https://openalex.org/W7166703389","https://openalex.org/W4400845356","https://openalex.org/W4396747351","https://openalex.org/W3183871295","https://openalex.org/W4387216516","https://openalex.org/W3179471261","https://openalex.org/W4213126480","https://openalex.org/W4410977612","https://openalex.org/W3178184824","https://openalex.org/W4380763354"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2025-10-10T00:00:00"}