{"id":"https://openalex.org/W44147402","doi":null,"title":"Abstract 19709: Increasing Ca2+ Influx After Myocardial Infarction Improves Myocyte Contractility but Depresses Cardiac Pump Function by Increasing Myocyte Death","display_name":"Abstract 19709: Increasing Ca2+ Influx After Myocardial Infarction Improves Myocyte Contractility but Depresses Cardiac Pump Function by Increasing Myocyte Death","publication_year":2010,"publication_date":"2010-11-23","ids":{"openalex":"https://openalex.org/W44147402","mag":"44147402"},"language":"en","primary_location":{"id":"mag:44147402","doi":null,"is_oa":false,"landing_page_url":"https://www.ahajournals.org/doi/10.1161/circ.122.suppl_21.A19709","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Circulation","raw_type":null},"volume":null,"type":"conference-abstract","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100412591","display_name":"Hongyu Zhang","orcid":"https://orcid.org/0000-0002-0836-7806","observed_orcids":["https://orcid.org/0000-0002-0836-7806"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hongyu Zhang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0836-7806","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044556689","display_name":"Erhe Gao","orcid":"https://orcid.org/0000-0002-5151-7857","observed_orcids":["https://orcid.org/0000-0002-5151-7857"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Erhe Gao","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5151-7857","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100772567","display_name":"Wang Wei","orcid":"https://orcid.org/0000-0001-8846-5889","observed_orcids":["https://orcid.org/0000-0001-8846-5889"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wang Wei","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8846-5889","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103251558","display_name":"Hiroyuki Nakayama","orcid":"https://orcid.org/0000-0002-7355-7112","observed_orcids":["https://orcid.org/0000-0002-7355-7112"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hiroyuki Nakayama","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7355-7112","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016018178","display_name":"Hui Gao","orcid":"https://orcid.org/0000-0002-7306-7471","observed_orcids":["https://orcid.org/0000-0002-7306-7471"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hui Gao","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7306-7471","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100321441","display_name":"Fang Wang","orcid":"https://orcid.org/0000-0002-8821-6695","observed_orcids":["https://orcid.org/0000-0002-8821-6695"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fang Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101402497","display_name":"Yingxin Li","orcid":"https://orcid.org/0000-0001-8079-7555","observed_orcids":["https://orcid.org/0000-0001-8079-7555"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yingxin Li","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0004-9399-0708","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074296319","display_name":"Remus M. Berretta","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Remus M. Berretta","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000001455","display_name":"Xiongwen Chen","orcid":"https://orcid.org/0000-0002-3829-5815","observed_orcids":["https://orcid.org/0000-0002-3829-5815"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiongwen Chen","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3829-5815","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075648082","display_name":"Walter J. Koch","orcid":"https://orcid.org/0000-0002-8522-530X","observed_orcids":["https://orcid.org/0000-0002-8522-530X","https://orcid.org/0000-0002-0609-8649"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Walter J. Koch","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075550603","display_name":"Jeffery D. Molkentin","orcid":"https://orcid.org/0000-0002-3558-6529","observed_orcids":["https://orcid.org/0000-0002-3558-6529"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jeffery D. Molkentin","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3558-6529","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069585201","display_name":"Annarosa Leri","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Annarosa Leri","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072597913","display_name":"Jan Kajstura","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jan Kajstura","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5067892109","display_name":"Steven R. Houser","orcid":"https://orcid.org/0000-0001-6359-5425","observed_orcids":["https://orcid.org/0000-0001-6359-5425"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Steven R. Houser","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6359-5425","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"122","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.4934000074863434,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.4934000074863434,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.29739999771118164,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.13830000162124634,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/myocardial-infarction","display_name":"myocardial infarction","score":0.9649999737739563},{"id":"https://openalex.org/keywords/l-type-calcium-channels","display_name":"L-type calcium channels","score":0.9390000104904175},{"id":"https://openalex.org/keywords/calcium-influx","display_name":"calcium influx","score":0.6209999918937683},{"id":"https://openalex.org/keywords/myocyte-contractility","display_name":"myocyte contractility","score":0.9160000085830688},{"id":"https://openalex.org/keywords/cardiac-pump-function","display_name":"cardiac pump function","score":0.5720000267028809},{"id":"https://openalex.org/keywords/myocyte-death","display_name":"myocyte death","score":0.7250000238418579},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8949999809265137},{"id":"https://openalex.org/keywords/myocardial-fibrosis","display_name":"myocardial fibrosis","score":0.7540000081062317},{"id":"https://openalex.org/keywords/myocyte-proliferation","display_name":"myocyte proliferation","score":0.8970000147819519},{"id":"https://openalex.org/keywords/beta2a-subunit","display_name":"beta2a subunit","score":0.7689999938011169},{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":0.46700000762939453},{"id":"https://openalex.org/keywords/inotropic-support","display_name":"inotropic support","score":0.5590000152587891}],"concepts":[{"id":"https://openalex.org/C39133596","wikidata":"https://www.wikidata.org/wiki/Q5165683","display_name":"Contractility","level":2,"score":0.8643614649772644},{"id":"https://openalex.org/C3018686881","wikidata":"https://www.wikidata.org/wiki/Q10334846","display_name":"Cardiac myocyte","level":3,"score":0.8607414960861206},{"id":"https://openalex.org/C207200792","wikidata":"https://www.wikidata.org/wiki/Q428914","display_name":"Myocyte","level":2,"score":0.8239718675613403},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.780369222164154},{"id":"https://openalex.org/C155710745","wikidata":"https://www.wikidata.org/wiki/Q575278","display_name":"Inotrope","level":2,"score":0.7053929567337036},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6671953201293945},{"id":"https://openalex.org/C111566952","wikidata":"https://www.wikidata.org/wiki/Q1303462","display_name":"Cardiac function curve","level":3,"score":0.5984267592430115},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5844613313674927},{"id":"https://openalex.org/C196795494","wikidata":"https://www.wikidata.org/wiki/Q1624817","display_name":"TUNEL assay","level":3,"score":0.5427347421646118},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.5353031754493713},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.4826648533344269},{"id":"https://openalex.org/C163031210","wikidata":"https://www.wikidata.org/wiki/Q3325848","display_name":"Masson's trichrome stain","level":3,"score":0.43087825179100037},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4195875823497772},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.26683616638183594},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.09236085414886475}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:44147402","doi":null,"is_oa":false,"landing_page_url":"https://www.ahajournals.org/doi/10.1161/circ.122.suppl_21.A19709","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Circulation","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.8700000047683716,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2793291945","https://openalex.org/W4245592451","https://openalex.org/W7096562933","https://openalex.org/W2092498995","https://openalex.org/W3181169364","https://openalex.org/W2096667649","https://openalex.org/W2306055648","https://openalex.org/W2399958088","https://openalex.org/W2135461267","https://openalex.org/W2168293002"],"abstract_inverted_index":{"Introduction:":[0],"Myocardial":[1],"infarction":[2],"(MI)":[3],"causes":[4],"death":[5,42],"of":[6,17,29,81,85,135],"cardiac":[7,11,77,104],"tissue":[8],"and":[9,43,76,96,101,112,116,127,142],"depresses":[10],"pump":[12],"performance.":[13],"Increasing":[14],"the":[15,18,27,30,82,86],"contractility":[16,51],"surviving":[19],"myocytes":[20],"is":[21],"one":[22],"therapy":[23,35],"thought":[24],"to":[25,92],"improve":[26,62],"function":[28,105],"failing":[31],"heart.":[32],"However":[33],"inotropic":[34],"involving":[36],"sympathetic":[37,54],"agonists":[38],"can":[39],"induce":[40,44],"cell":[41],"arrhythmias.":[45],"We":[46],"tested":[47],"if":[48],"increasing":[49,57],"myocyte":[50,78,97,128],"without":[52],"activating":[53],"signaling,":[55],"by":[56],"Ca":[58],"influx":[59],"(ICa-L),":[60],"would":[61],"post":[63],"MI":[64],"heart":[65],"function.":[66],"Methods:":[67],"Double":[68],"transgenic":[69],"mouse":[70],"lines":[71],"with":[72],"inducible":[73],"(Tet-off":[74],"system)":[75],"specific":[79],"overexpression":[80],"\u03b22a":[83,113],"subunit":[84],"L-type":[87],"Ca2+":[88],"channel":[89],"were":[90,106,138],"used":[91],"increase":[93],"ICa-L.":[94],"ICa-L,":[95],"fractional":[98],"shortening":[99],"(FS)":[100],"in":[102,108],"vivo":[103],"measured":[107],"wild":[109],"type":[110],"(WT)":[111],"hearts":[114],"before,":[115],"3":[117],"weeks":[118],"after":[119],"MI.":[120],"Apoptosis":[121],"(TUNEL),":[122],"fibrosis":[123],"(Masson's":[124],"Trichrome":[125],"staining)":[126],"proliferation":[129],"(Ki67":[130],"staining,":[131],"a":[132],"nuclear":[133],"marker":[134],"cellular":[136],"replication),":[137],"measured.":[139],"Results:":[140],"ICa-L":[141],"FS":[143],"...":[144]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}
