{"id":"https://openalex.org/W4414710467","doi":"https://doi.org/10.17650/1726-9784-2025-24-3-19-28","title":"Neutralizing ability of monoclonal antibodies directed to epitopes of functionally significant Streptococcus pneumoniae pneumolysin domain","display_name":"Neutralizing ability of monoclonal antibodies directed to epitopes of functionally significant Streptococcus pneumoniae pneumolysin domain","publication_year":2025,"publication_date":"2025-09-30","ids":{"openalex":"https://openalex.org/W4414710467","doi":"https://doi.org/10.17650/1726-9784-2025-24-3-19-28"},"language":"en","primary_location":{"id":"doi:10.17650/1726-9784-2025-24-3-19-28","doi":"https://doi.org/10.17650/1726-9784-2025-24-3-19-28","is_oa":true,"landing_page_url":"https://doi.org/10.17650/1726-9784-2025-24-3-19-28","pdf_url":"https://bioterapevt.elpub.ru/jour/article/download/1566/1360","source":{"id":"https://openalex.org/S4210178968","display_name":"Russian Journal of Biotherapy","issn_l":"1726-9784","issn":["1726-9784","1726-9792"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["russia-white-list-1"],"host_organization":"https://openalex.org/P4310312750","host_organization_name":"Russian Cancer Research Center NN Blokhin","host_organization_lineage":["https://openalex.org/P4310312750"],"host_organization_lineage_names":["Russian Cancer Research Center NN Blokhin"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Russian Journal of Biotherapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://bioterapevt.elpub.ru/jour/article/download/1566/1360","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082971025","display_name":"Ekaterina A. Kurbatova","orcid":"https://orcid.org/0000-0002-0282-4471","observed_orcids":["https://orcid.org/0000-0002-0282-4471","https://orcid.org/0000-0002-4474-7531"]},"institutions":[{"id":"https://openalex.org/I4210130895","display_name":"Research Institute of Vaccines and Sera. Mechnikov of the Russian Academy of Medical Sciences","ror":"https://ror.org/03bk73w20","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210110862","https://openalex.org/I4210130895"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Ekaterina A. Kurbatova","raw_affiliation_strings":["I. I. Mechnikov Research Institute of Vaccines and Sera"],"raw_orcid":"https://orcid.org/0000-0002-0282-4471","affiliations":[{"raw_affiliation_string":"I. I. Mechnikov Research Institute of Vaccines and Sera","institution_ids":["https://openalex.org/I4210130895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087929949","display_name":"Irina V. Yakovleva","orcid":"https://orcid.org/0000-0001-5123-2651","observed_orcids":["https://orcid.org/0000-0001-5123-2651"]},"institutions":[{"id":"https://openalex.org/I4210130895","display_name":"Research Institute of Vaccines and Sera. Mechnikov of the Russian Academy of Medical Sciences","ror":"https://ror.org/03bk73w20","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210110862","https://openalex.org/I4210130895"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Irina V. Yakovleva","raw_affiliation_strings":["I. I. Mechnikov Research Institute of Vaccines and Sera"],"raw_orcid":"https://orcid.org/0000-0001-5123-2651","affiliations":[{"raw_affiliation_string":"I. I. Mechnikov Research Institute of Vaccines and Sera","institution_ids":["https://openalex.org/I4210130895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005952985","display_name":"\u041d. \u0424. \u0413\u0430\u0432\u0440\u0438\u043b\u043e\u0432\u0430","orcid":"https://orcid.org/0000-0001-6704-0339","observed_orcids":["https://orcid.org/0000-0001-6704-0339"]},"institutions":[{"id":"https://openalex.org/I4210130895","display_name":"Research Institute of Vaccines and Sera. Mechnikov of the Russian Academy of Medical Sciences","ror":"https://ror.org/03bk73w20","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210110862","https://openalex.org/I4210130895"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Natalya F. Gavrilova","raw_affiliation_strings":["I. I. Mechnikov Research Institute of Vaccines and Sera"],"raw_orcid":"https://orcid.org/0000-0001-6704-0339","affiliations":[{"raw_affiliation_string":"I. I. Mechnikov Research Institute of Vaccines and Sera","institution_ids":["https://openalex.org/I4210130895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110991187","display_name":"Denis S. Vorobyev","orcid":"https://orcid.org/0000-0002-1926-8803","observed_orcids":["https://orcid.org/0000-0002-1926-8803"]},"institutions":[{"id":"https://openalex.org/I4210130895","display_name":"Research Institute of Vaccines and Sera. Mechnikov of the Russian Academy of Medical Sciences","ror":"https://ror.org/03bk73w20","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210110862","https://openalex.org/I4210130895"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Denis S. Vorobyev","raw_affiliation_strings":["I. I. Mechnikov Research Institute of Vaccines and Sera"],"raw_orcid":"https://orcid.org/0000-0002-1926-8803","affiliations":[{"raw_affiliation_string":"I. I. Mechnikov Research Institute of Vaccines and Sera","institution_ids":["https://openalex.org/I4210130895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058599221","display_name":"\u0415. \u0421. \u041f\u0435\u0442\u0443\u0445\u043e\u0432\u0430","orcid":"https://orcid.org/0000-0003-0796-5764","observed_orcids":["https://orcid.org/0000-0003-0796-5764"]},"institutions":[{"id":"https://openalex.org/I4210130895","display_name":"Research Institute of Vaccines and Sera. Mechnikov of the Russian Academy of Medical Sciences","ror":"https://ror.org/03bk73w20","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210110862","https://openalex.org/I4210130895"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Ekaterina E. Petukhova","raw_affiliation_strings":["I. I. Mechnikov Research Institute of Vaccines and Sera"],"raw_orcid":"https://orcid.org/0000-0003-0796-5764","affiliations":[{"raw_affiliation_string":"I. I. Mechnikov Research Institute of Vaccines and Sera","institution_ids":["https://openalex.org/I4210130895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079405150","display_name":"Irina B. Semenova","orcid":"https://orcid.org/0000-0002-6630-4838","observed_orcids":["https://orcid.org/0000-0002-6630-4838"]},"institutions":[{"id":"https://openalex.org/I4210130895","display_name":"Research Institute of Vaccines and Sera. Mechnikov of the Russian Academy of Medical Sciences","ror":"https://ror.org/03bk73w20","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210110862","https://openalex.org/I4210130895"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Irina B. Semenova","raw_affiliation_strings":["I. I. Mechnikov Research Institute of Vaccines and Sera"],"raw_orcid":"https://orcid.org/0000-0002-6630-4838","affiliations":[{"raw_affiliation_string":"I. I. Mechnikov Research Institute of Vaccines and Sera","institution_ids":["https://openalex.org/I4210130895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004473215","display_name":"Anton E. Zaitsev","orcid":"https://orcid.org/0000-0002-8434-231X","observed_orcids":["https://orcid.org/0000-0002-8434-231X"]},"institutions":[{"id":"https://openalex.org/I4210130895","display_name":"Research Institute of Vaccines and Sera. Mechnikov of the Russian Academy of Medical Sciences","ror":"https://ror.org/03bk73w20","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210110862","https://openalex.org/I4210130895"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Anton E. Zaitsev","raw_affiliation_strings":["I. I. Mechnikov Research Institute of Vaccines and Sera"],"raw_orcid":"https://orcid.org/0000-0002-8434-231X","affiliations":[{"raw_affiliation_string":"I. I. Mechnikov Research Institute of Vaccines and Sera","institution_ids":["https://openalex.org/I4210130895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086364455","display_name":"Yu. V. Volokh","orcid":"https://orcid.org/0000-0002-5161-4964","observed_orcids":["https://orcid.org/0000-0002-5161-4964"]},"institutions":[{"id":"https://openalex.org/I4210130895","display_name":"Research Institute of Vaccines and Sera. Mechnikov of the Russian Academy of Medical Sciences","ror":"https://ror.org/03bk73w20","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210110862","https://openalex.org/I4210130895"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Yuri V. Volokh","raw_affiliation_strings":["I. I. Mechnikov Research Institute of Vaccines and Sera"],"raw_orcid":"https://orcid.org/0000-0002-5161-4964","affiliations":[{"raw_affiliation_string":"I. I. Mechnikov Research Institute of Vaccines and Sera","institution_ids":["https://openalex.org/I4210130895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006176167","display_name":"Nune O. Vartanova","orcid":"https://orcid.org/0000-0002-6372-9910","observed_orcids":["https://orcid.org/0000-0002-6372-9910"]},"institutions":[{"id":"https://openalex.org/I4210130895","display_name":"Research Institute of Vaccines and Sera. Mechnikov of the Russian Academy of Medical Sciences","ror":"https://ror.org/03bk73w20","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210110862","https://openalex.org/I4210130895"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Nune O. Vartanova","raw_affiliation_strings":["I. I. Mechnikov Research Institute of Vaccines and Sera"],"raw_orcid":"https://orcid.org/0000-0002-6372-9910","affiliations":[{"raw_affiliation_string":"I. I. Mechnikov Research Institute of Vaccines and Sera","institution_ids":["https://openalex.org/I4210130895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011926690","display_name":"\u0410. \u0412. \u041f\u043e\u0434\u0434\u0443\u0431\u0438\u043a\u043e\u0432","orcid":"https://orcid.org/0000-0001-8962-4765","observed_orcids":["https://orcid.org/0000-0001-8962-4765"]},"institutions":[{"id":"https://openalex.org/I4210130895","display_name":"Research Institute of Vaccines and Sera. Mechnikov of the Russian Academy of Medical Sciences","ror":"https://ror.org/03bk73w20","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210110862","https://openalex.org/I4210130895"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Alexander V. Poddubikov","raw_affiliation_strings":["I. I. Mechnikov Research Institute of Vaccines and Sera"],"raw_orcid":"https://orcid.org/0000-0001-8962-4765","affiliations":[{"raw_affiliation_string":"I. I. Mechnikov Research Institute of Vaccines and Sera","institution_ids":["https://openalex.org/I4210130895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112882558","display_name":"Olga M. Afanasyeva","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130895","display_name":"Research Institute of Vaccines and Sera. Mechnikov of the Russian Academy of Medical Sciences","ror":"https://ror.org/03bk73w20","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210110862","https://openalex.org/I4210130895"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Olga M. Afanasyeva","raw_affiliation_strings":["I. I. Mechnikov Research Institute of Vaccines and Sera"],"raw_orcid":"https://orcid.org/0000-0003-0875-4141","affiliations":[{"raw_affiliation_string":"I. I. Mechnikov Research Institute of Vaccines and Sera","institution_ids":["https://openalex.org/I4210130895"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085709262","display_name":"Alexander V. Zubkov","orcid":"https://orcid.org/0000-0002-0056-5082","observed_orcids":["https://orcid.org/0000-0002-0056-5082"]},"institutions":[{"id":"https://openalex.org/I4210130895","display_name":"Research Institute of Vaccines and Sera. Mechnikov of the Russian Academy of Medical Sciences","ror":"https://ror.org/03bk73w20","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210110862","https://openalex.org/I4210130895"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Alexander A. Zubkov","raw_affiliation_strings":["I. I. Mechnikov Research Institute of Vaccines and Sera"],"raw_orcid":"https://orcid.org/0000-0002-0056-5082","affiliations":[{"raw_affiliation_string":"I. I. Mechnikov Research Institute of Vaccines and Sera","institution_ids":["https://openalex.org/I4210130895"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210130895"],"apc_list":null,"apc_paid":null,"fwci":0.571,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.5863391,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"24","issue":"3","first_page":"19","last_page":"28"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10654","display_name":"Pneumonia and Respiratory Infections","score":0.7807999849319458,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10654","display_name":"Pneumonia and Respiratory Infections","score":0.7807999849319458,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10873","display_name":"Bacterial Infections and Vaccines","score":0.06539999693632126,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11688","display_name":"Microbial infections and disease research","score":0.034699998795986176,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/streptococcus-pneumoniae","display_name":"Streptococcus pneumoniae","score":0.9990000128746033},{"id":"https://openalex.org/keywords/monoclonal-antibodies","display_name":"monoclonal antibodies","score":0.9919999837875366},{"id":"https://openalex.org/keywords/neutralizing-antibodies","display_name":"neutralizing antibodies","score":0.7960000038146973},{"id":"https://openalex.org/keywords/cholesterol-dependent-cytolysins","display_name":"cholesterol-dependent cytolysins","score":0.8309999704360962},{"id":"https://openalex.org/keywords/erythrocyte-hemolysis","display_name":"erythrocyte hemolysis","score":0.9210000038146973},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8080000281333923},{"id":"https://openalex.org/keywords/protective-immunity","display_name":"protective immunity","score":0.6340000033378601},{"id":"https://openalex.org/keywords/pneumococcal-virulence","display_name":"pneumococcal virulence","score":0.656000018119812}],"concepts":[{"id":"https://openalex.org/C2776088486","wikidata":"https://www.wikidata.org/wiki/Q7205996","display_name":"Pneumolysin","level":4,"score":0.9010999798774719},{"id":"https://openalex.org/C2779902561","wikidata":"https://www.wikidata.org/wiki/Q471706","display_name":"Hemolysis","level":2,"score":0.8719000220298767},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.7533000111579895},{"id":"https://openalex.org/C80595800","wikidata":"https://www.wikidata.org/wiki/Q937863","display_name":"Cytolysin","level":4,"score":0.7123000025749207},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.6730999946594238},{"id":"https://openalex.org/C73588182","wikidata":"https://www.wikidata.org/wiki/Q2663023","display_name":"Cytolysis","level":4,"score":0.6290000081062317},{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.5734999775886536},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.515999972820282},{"id":"https://openalex.org/C956191","wikidata":"https://www.wikidata.org/wiki/Q930144","display_name":"Polyclonal antibodies","level":3,"score":0.5026999711990356},{"id":"https://openalex.org/C57409179","wikidata":"https://www.wikidata.org/wiki/Q1218293","display_name":"Lysis","level":2,"score":0.5019999742507935},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.46470001339912415},{"id":"https://openalex.org/C14086860","wikidata":"https://www.wikidata.org/wiki/Q337120","display_name":"Neutralization","level":3,"score":0.4269999861717224},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.42590001225471497},{"id":"https://openalex.org/C2910801743","wikidata":"https://www.wikidata.org/wiki/Q471706","display_name":"Haemolysis","level":2,"score":0.4142000079154968},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.414000004529953},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.414000004529953},{"id":"https://openalex.org/C175656101","wikidata":"https://www.wikidata.org/wiki/Q56646","display_name":"Chinese hamster ovary cell","level":3,"score":0.4099999964237213},{"id":"https://openalex.org/C81089528","wikidata":"https://www.wikidata.org/wiki/Q5134986","display_name":"clone (Java method)","level":3,"score":0.38920000195503235},{"id":"https://openalex.org/C2776557347","wikidata":"https://www.wikidata.org/wiki/Q37187","display_name":"Red blood cell","level":2,"score":0.37950000166893005},{"id":"https://openalex.org/C2780159080","wikidata":"https://www.wikidata.org/wiki/Q1400536","display_name":"Intraperitoneal injection","level":2,"score":0.36649999022483826},{"id":"https://openalex.org/C2776993315","wikidata":"https://www.wikidata.org/wiki/Q418187","display_name":"Streptolysin","level":4,"score":0.35249999165534973},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.3467000126838684},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3391999900341034},{"id":"https://openalex.org/C2777544843","wikidata":"https://www.wikidata.org/wiki/Q21136","display_name":"Lethal dose","level":2,"score":0.3384999930858612},{"id":"https://openalex.org/C40677261","wikidata":"https://www.wikidata.org/wiki/Q21418091","display_name":"Antibody-dependent cell-mediated cytotoxicity","level":4,"score":0.3296999931335449},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.32600000500679016},{"id":"https://openalex.org/C2779026604","wikidata":"https://www.wikidata.org/wiki/Q4774742","display_name":"Antigenicity","level":3,"score":0.31690001487731934},{"id":"https://openalex.org/C136139683","wikidata":"https://www.wikidata.org/wiki/Q2746278","display_name":"Hemolysin","level":4,"score":0.3147999942302704},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.28949999809265137},{"id":"https://openalex.org/C163864487","wikidata":"https://www.wikidata.org/wiki/Q6901461","display_name":"Monoclonal","level":4,"score":0.28060001134872437},{"id":"https://openalex.org/C2778575167","wikidata":"https://www.wikidata.org/wiki/Q6573","display_name":"Hamster","level":2,"score":0.2784999907016754}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.17650/1726-9784-2025-24-3-19-28","doi":"https://doi.org/10.17650/1726-9784-2025-24-3-19-28","is_oa":true,"landing_page_url":"https://doi.org/10.17650/1726-9784-2025-24-3-19-28","pdf_url":"https://bioterapevt.elpub.ru/jour/article/download/1566/1360","source":{"id":"https://openalex.org/S4210178968","display_name":"Russian Journal of Biotherapy","issn_l":"1726-9784","issn":["1726-9784","1726-9792"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["russia-white-list-1"],"host_organization":"https://openalex.org/P4310312750","host_organization_name":"Russian Cancer Research Center NN Blokhin","host_organization_lineage":["https://openalex.org/P4310312750"],"host_organization_lineage_names":["Russian Cancer Research Center NN Blokhin"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Russian Journal of Biotherapy","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.17650/1726-9784-2025-24-3-19-28","doi":"https://doi.org/10.17650/1726-9784-2025-24-3-19-28","is_oa":true,"landing_page_url":"https://doi.org/10.17650/1726-9784-2025-24-3-19-28","pdf_url":"https://bioterapevt.elpub.ru/jour/article/download/1566/1360","source":{"id":"https://openalex.org/S4210178968","display_name":"Russian Journal of Biotherapy","issn_l":"1726-9784","issn":["1726-9784","1726-9792"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["russia-white-list-1"],"host_organization":"https://openalex.org/P4310312750","host_organization_name":"Russian Cancer Research Center NN Blokhin","host_organization_lineage":["https://openalex.org/P4310312750"],"host_organization_lineage_names":["Russian Cancer Research Center NN Blokhin"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Russian Journal of Biotherapy","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4414710467.pdf","grobid_xml":"https://content.openalex.org/works/W4414710467.grobid-xml"},"referenced_works_count":19,"referenced_works":["https://openalex.org/W1660726501","https://openalex.org/W1851677292","https://openalex.org/W2027903397","https://openalex.org/W2033090269","https://openalex.org/W2086329609","https://openalex.org/W2137536958","https://openalex.org/W2245269023","https://openalex.org/W2278606495","https://openalex.org/W2951391808","https://openalex.org/W3009226793","https://openalex.org/W3041036445","https://openalex.org/W4280531340","https://openalex.org/W4376121603","https://openalex.org/W4383873560","https://openalex.org/W4388941593","https://openalex.org/W4393158932","https://openalex.org/W4394985042","https://openalex.org/W4400337470","https://openalex.org/W4407555035"],"related_works":["https://openalex.org/W2137536958","https://openalex.org/W2070186759","https://openalex.org/W3041036445","https://openalex.org/W4393158932","https://openalex.org/W2027903397","https://openalex.org/W4412654468","https://openalex.org/W2110878867","https://openalex.org/W4407555035","https://openalex.org/W3196518011","https://openalex.org/W4243672511"],"abstract_inverted_index":{"Background.":[0],"Pneumolysin":[1],"(Ply)":[2],"\u2013":[3],"bacterial":[4,56],"cholesterol-dependent":[5],"cytolysin":[6],"produced":[7],"by":[8,114,132,150,187,241,269],"almost":[9],"all":[10],"strains":[11],"of":[12,32,35,46,51,55,71,83,91,102,109,118,129,137,145,154,164,169,179,182,193,205,212,219,234,238,244,260,278,287,305,314,321,333],"Streptococcus":[13],"pneumoniae.":[14],"Antibodies":[15],"induced":[16,131],"to":[17,24,39,77,157,184,207,282,329],"pneumolysin":[18],"for":[19],"some":[20],"extend":[21],"are":[22],"able":[23],"neutralize":[25],"its":[26],"pathogenic":[27],"effect":[28,34,313],"on":[29,48,64,141,309],"cells.Aim.":[30],"Investigation":[31],"the":[33,49,52,78,88,100,115,142,146,151,170,209,213,225,242,258,279,293,302,311,319,331],"monoclonal":[36],"antibodies":[37,94,138,155,171,183,281,322],"obtained":[38,86,98],"native":[40],"(nPly)":[41],"and":[42,60,74,80,123,216,236,250,256,272],"recombinant":[43],"(rPly)":[44,96,122,249,252,271],"forms":[45,82,218],"Ply":[47,57,84,315],"neutralization":[50],"cytolytic":[53],"activity":[54,266,304],"in":[58,224,228,301],"vitro":[59,229],"their":[61,288],"preventive":[62],"properties":[63,168],"mice":[65,283],"challenged":[66],"with":[67,105,174,189,292,318],"a":[68,175,190,285,327],"virulent":[69],"strain":[70],"S.":[72,194,294,316],"pneumoniae.Materials":[73],"methods.":[75],"mAbs":[76,119,246,248,270],"nPly":[79,206,231],"rPly":[81],"was":[85,112,139,197,267],"from":[87,99,160],"ascitic":[89],"fluid":[90],"mice.":[92],"Polyclonal":[93],"pAbs":[95,121,124,251,273],"were":[97,172,298],"serum":[101],"rabbits":[103],"immunized":[104],"rPly.":[106],"The":[107,134,166,263],"inhibition":[108],"erythrocyte":[110,254],"hemolysis":[111,233,255],"assessed":[113],"minimum":[116,152],"concentration":[117,153],"(nPly),":[120,247],"(rPly),":[125],"which":[126],"prevents":[127],"lysis":[128],"erythrocytes":[130,235],"nPly.":[133,165],"neutralizing":[135,265,310],"ability":[136],"evaluated":[140],"ovarian":[143],"cells":[144,159,222,240],"Chinese":[147],"hamster":[148],"CHO-K1":[149,239,261],"necessary":[156],"protect":[158],"4":[161],"cytopathogenic":[162],"doses":[163],"protective":[167,303],"studied":[173,280],"single":[176,276],"intraperitoneal":[177,203],"injection":[178,277],"200":[180],"\u00b5g":[181],"mice,":[185,208],"followed":[186],"challenge":[188],"lethal":[191],"dose":[192],"pneumoniae.Results.":[195],"It":[196],"shown":[198,268],"that":[199],"24":[200],"hours":[201],"after":[202],"administration":[204],"body":[210],"weight":[211],"animals":[214],"decreased":[215],"degenerative":[217],"red":[220],"blood":[221],"appeared":[223],"blood.":[226],"In":[227],"experiments,":[230],"caused":[232,284],"destruction":[237,259],"mechanism":[243],"apoptosis.":[245],"inhibited":[253],"neutralized":[257],"cells.":[262],"highest":[264],"(rPly).":[274],"A":[275],"decrease":[286],"death":[289],"when":[290],"infected":[291],"pneumoniae":[295,317],"strain.":[296],"There":[297],"no":[299],"differences":[300],"antibodies.Conclusion.":[306],"Methods":[307],"based":[308],"toxic":[312],"help":[320],"can":[323],"be":[324],"considered":[325],"as":[326],"tool":[328],"reduce":[330],"pathogenicity":[332],"pneumococci.":[334]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}
