{"id":"https://openalex.org/W4414643258","doi":"https://doi.org/10.2139/ssrn.5532274","title":"Neuronal Reprogramming Drives Bevacizumab Resistance in Glioblastoma via the NRG3\u2013ERBB4\u2013CTNNB1 Axis","display_name":"Neuronal Reprogramming Drives Bevacizumab Resistance in Glioblastoma via the NRG3\u2013ERBB4\u2013CTNNB1 Axis","publication_year":2025,"publication_date":"2025-01-01","ids":{"openalex":"https://openalex.org/W4414643258","doi":"https://doi.org/10.2139/ssrn.5532274"},"language":"en","primary_location":{"id":"doi:10.2139/ssrn.5532274","doi":"https://doi.org/10.2139/ssrn.5532274","is_oa":true,"landing_page_url":"https://doi.org/10.2139/ssrn.5532274","pdf_url":null,"source":{"id":"https://openalex.org/S4210172589","display_name":"SSRN Electronic Journal","issn_l":"1556-5068","issn":["1556-5068"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1318003438","host_organization_name":"RELX Group (Netherlands)","host_organization_lineage":["https://openalex.org/I1318003438"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.2139/ssrn.5532274","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100337388","display_name":"Sung Soo Kim","orcid":"https://orcid.org/0000-0001-9214-9379","observed_orcids":["https://orcid.org/0000-0001-9214-9379"]},"institutions":[{"id":"https://openalex.org/I2800421839","display_name":"Government of the United States of America","ror":"https://ror.org/02rcrvv70","country_code":"US","type":"government","lineage":["https://openalex.org/I2800421839"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Sung Soo Kim","raw_affiliation_strings":["Government of the United States of America - National Cancer Institute","Government of the United States of America - National Cancer Institute, 9609 Medical Center Drive, Rockville, MD 20850, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Government of the United States of America - National Cancer Institute","institution_ids":["https://openalex.org/I2800421839","https://openalex.org/I4210140884"]},{"raw_affiliation_string":"Government of the United States of America - National Cancer Institute, 9609 Medical Center Drive, Rockville, MD 20850, United States","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100657003","display_name":"Ji Yoon Lee","orcid":"https://orcid.org/0000-0002-7117-2681","observed_orcids":["https://orcid.org/0000-0002-7117-2681","https://orcid.org/0009-0001-4477-7378","https://orcid.org/0009-0001-7500-2129","https://orcid.org/0009-0003-1263-5214","https://orcid.org/0000-0002-8619-1383"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210141458","display_name":"Cancer Hospital of Chinese Academy of Medical Sciences","ror":"https://ror.org/03x937183","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141458"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ji Yoon Lee","raw_affiliation_strings":["Chinese Academy of Medical Sciences - National Cancer Center","Chinese Academy of Medical Sciences - National Cancer Center, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chinese Academy of Medical Sciences - National Cancer Center","institution_ids":["https://openalex.org/I200296433"]},{"raw_affiliation_string":"Chinese Academy of Medical Sciences - National Cancer Center, Beijing, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210141458"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072764713","display_name":"Harim Koo","orcid":"https://orcid.org/0000-0002-6444-2436","observed_orcids":["https://orcid.org/0000-0002-6444-2436"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210141458","display_name":"Cancer Hospital of Chinese Academy of Medical Sciences","ror":"https://ror.org/03x937183","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141458"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Harim Koo","raw_affiliation_strings":["Chinese Academy of Medical Sciences - National Cancer Center","Chinese Academy of Medical Sciences - National Cancer Center, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chinese Academy of Medical Sciences - National Cancer Center","institution_ids":["https://openalex.org/I200296433"]},{"raw_affiliation_string":"Chinese Academy of Medical Sciences - National Cancer Center, Beijing, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210141458"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100608883","display_name":"Kyung\u2010Hee Kim","orcid":"https://orcid.org/0000-0003-0214-0296","observed_orcids":["https://orcid.org/0000-0003-0214-0296","https://orcid.org/0009-0002-7952-9363","https://orcid.org/0009-0007-1950-374X"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210141458","display_name":"Cancer Hospital of Chinese Academy of Medical Sciences","ror":"https://ror.org/03x937183","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141458"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kyung-Hee Kim","raw_affiliation_strings":["Chinese Academy of Medical Sciences - National Cancer Center","Chinese Academy of Medical Sciences - National Cancer Center, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chinese Academy of Medical Sciences - National Cancer Center","institution_ids":["https://openalex.org/I200296433"]},{"raw_affiliation_string":"Chinese Academy of Medical Sciences - National Cancer Center, Beijing, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210141458"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050126097","display_name":"Zheng Yuan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173899330","display_name":"Henan University","ror":"https://ror.org/003xyzq10","country_code":"CN","type":"education","lineage":["https://openalex.org/I173899330"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zheng Yuan","raw_affiliation_strings":["Henan University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Henan University","institution_ids":["https://openalex.org/I173899330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011856967","display_name":"Hyung Joon Kwon","orcid":"https://orcid.org/0000-0001-7846-8779","observed_orcids":["https://orcid.org/0000-0001-7846-8779"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210141458","display_name":"Cancer Hospital of Chinese Academy of Medical Sciences","ror":"https://ror.org/03x937183","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141458"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hyung Joon Kwon","raw_affiliation_strings":["Chinese Academy of Medical Sciences - National Cancer Center","Chinese Academy of Medical Sciences - National Cancer Center, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chinese Academy of Medical Sciences - National Cancer Center","institution_ids":["https://openalex.org/I200296433"]},{"raw_affiliation_string":"Chinese Academy of Medical Sciences - National Cancer Center, Beijing, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210141458"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Sewhan Park","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210141458","display_name":"Cancer Hospital of Chinese Academy of Medical Sciences","ror":"https://ror.org/03x937183","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141458"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Sewhan Park","raw_affiliation_strings":["Chinese Academy of Medical Sciences - National Cancer Center","Chinese Academy of Medical Sciences - National Cancer Center, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chinese Academy of Medical Sciences - National Cancer Center","institution_ids":["https://openalex.org/I200296433"]},{"raw_affiliation_string":"Chinese Academy of Medical Sciences - National Cancer Center, Beijing, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210141458"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Sunil Choi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210141458","display_name":"Cancer Hospital of Chinese Academy of Medical Sciences","ror":"https://ror.org/03x937183","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141458"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Sunil Choi","raw_affiliation_strings":["Chinese Academy of Medical Sciences - National Cancer Center","Chinese Academy of Medical Sciences - National Cancer Center, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chinese Academy of Medical Sciences - National Cancer Center","institution_ids":["https://openalex.org/I200296433"]},{"raw_affiliation_string":"Chinese Academy of Medical Sciences - National Cancer Center, Beijing, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210141458"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017324954","display_name":"Yong\u2010Seok Oh","orcid":"https://orcid.org/0000-0002-9039-2014","observed_orcids":["https://orcid.org/0000-0002-9039-2014"]},"institutions":[{"id":"https://openalex.org/I193352282","display_name":"Daegu Gyeongbuk Institute of Science and Technology","ror":"https://ror.org/03frjya69","country_code":"KR","type":"education","lineage":["https://openalex.org/I193352282"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Yong-Seok Oh","raw_affiliation_strings":["Daegu Gyeongbuk Institute of Science and Technology (DGIST)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Daegu Gyeongbuk Institute of Science and Technology (DGIST)","institution_ids":["https://openalex.org/I193352282"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Bingyang Shi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I99043593","display_name":"Macquarie University","ror":"https://ror.org/01sf06y89","country_code":"AU","type":"education","lineage":["https://openalex.org/I99043593"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Bingyang Shi","raw_affiliation_strings":["Macquarie University","Macquarie University, North Ryde, Sydney, 2109, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Macquarie University","institution_ids":["https://openalex.org/I99043593"]},{"raw_affiliation_string":"Macquarie University, North Ryde, Sydney, 2109, Australia","institution_ids":["https://openalex.org/I99043593"]}]},{"author_position":"middle","author":{"id":null,"display_name":"xuechen Tian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47449453","display_name":"Kean University","ror":"https://ror.org/04wzzqn13","country_code":"US","type":"education","lineage":["https://openalex.org/I47449453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"xuechen Tian","raw_affiliation_strings":["Kean University","Kean University, 1000 Morris Ave, Union, NJ 07083, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kean University","institution_ids":["https://openalex.org/I47449453"]},{"raw_affiliation_string":"Kean University, 1000 Morris Ave, Union, NJ 07083, United States","institution_ids":["https://openalex.org/I47449453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101416988","display_name":"Yixin Yang","orcid":"https://orcid.org/0000-0002-1245-8014","observed_orcids":["https://orcid.org/0000-0002-1245-8014"]},"institutions":[{"id":"https://openalex.org/I47449453","display_name":"Kean University","ror":"https://ror.org/04wzzqn13","country_code":"US","type":"education","lineage":["https://openalex.org/I47449453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yixin Yang","raw_affiliation_strings":["Kean University","Kean University, 1000 Morris Ave, Union, NJ 07083, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kean University","institution_ids":["https://openalex.org/I47449453"]},{"raw_affiliation_string":"Kean University, 1000 Morris Ave, Union, NJ 07083, United States","institution_ids":["https://openalex.org/I47449453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078024735","display_name":"Antonio Iavarone","orcid":"https://orcid.org/0000-0002-0683-4634","observed_orcids":["https://orcid.org/0000-0002-0683-4634"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210141458","display_name":"Cancer Hospital of Chinese Academy of Medical Sciences","ror":"https://ror.org/03x937183","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141458"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Antonio Iavarone","raw_affiliation_strings":["Chinese Academy of Medical Sciences - National Cancer Center","Chinese Academy of Medical Sciences - National Cancer Center, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chinese Academy of Medical Sciences - National Cancer Center","institution_ids":["https://openalex.org/I200296433"]},{"raw_affiliation_string":"Chinese Academy of Medical Sciences - National Cancer Center, Beijing, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210141458"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073174440","display_name":"Ho\u2010Shin Gwak","orcid":"https://orcid.org/0000-0001-7175-4553","observed_orcids":["https://orcid.org/0000-0001-7175-4553"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210141458","display_name":"Cancer Hospital of Chinese Academy of Medical Sciences","ror":"https://ror.org/03x937183","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141458"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ho-Shin Gwak","raw_affiliation_strings":["Chinese Academy of Medical Sciences - National Cancer Center","Chinese Academy of Medical Sciences - National Cancer Center, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chinese Academy of Medical Sciences - National Cancer Center","institution_ids":["https://openalex.org/I200296433"]},{"raw_affiliation_string":"Chinese Academy of Medical Sciences - National Cancer Center, Beijing, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210141458"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088738470","display_name":"Heon Yoo","orcid":"https://orcid.org/0000-0002-9223-4300","observed_orcids":["https://orcid.org/0000-0002-9223-4300"]},"institutions":[{"id":"https://openalex.org/I4210120052","display_name":"National Cancer Center","ror":"https://ror.org/02tsanh21","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I1290491151","https://openalex.org/I2801339556","https://openalex.org/I4210120052"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Heon Yoo","raw_affiliation_strings":["National Cancer Center, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cancer Center, Korea","institution_ids":["https://openalex.org/I4210120052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100762907","display_name":"Seongmin Park","orcid":"https://orcid.org/0000-0002-1030-4935","observed_orcids":["https://orcid.org/0000-0002-1030-4935"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210141458","display_name":"Cancer Hospital of Chinese Academy of Medical Sciences","ror":"https://ror.org/03x937183","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141458"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Seong-Min Park","raw_affiliation_strings":["Chinese Academy of Medical Sciences - National Cancer Center","Chinese Academy of Medical Sciences - National Cancer Center, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chinese Academy of Medical Sciences - National Cancer Center","institution_ids":["https://openalex.org/I200296433"]},{"raw_affiliation_string":"Chinese Academy of Medical Sciences - National Cancer Center, Beijing, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210141458"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069767881","display_name":"Jason K. Sa","orcid":"https://orcid.org/0000-0002-3251-5004","observed_orcids":["https://orcid.org/0000-0002-3251-5004"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210141458","display_name":"Cancer Hospital of Chinese Academy of Medical Sciences","ror":"https://ror.org/03x937183","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141458"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jason K. Sa","raw_affiliation_strings":["Chinese Academy of Medical Sciences - National Cancer Center","Chinese Academy of Medical Sciences - National Cancer Center, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chinese Academy of Medical Sciences - National Cancer Center","institution_ids":["https://openalex.org/I200296433"]},{"raw_affiliation_string":"Chinese Academy of Medical Sciences - National Cancer Center, Beijing, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210141458"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082170088","display_name":"Jinlong Yin","orcid":"https://orcid.org/0000-0003-3143-7240","observed_orcids":["https://orcid.org/0000-0003-3143-7240"]},"institutions":[{"id":"https://openalex.org/I4405285273","display_name":"National Cancer Center Hospital","ror":"https://ror.org/053hhpd64","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210087348","https://openalex.org/I4405285273"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Jinlong Yin","raw_affiliation_strings":["National Cancer Center Hospital","National Cancer Center Hospital, Research Center for Cancer Prevention and Screenin, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cancer Center Hospital","institution_ids":["https://openalex.org/I4405285273"]},{"raw_affiliation_string":"National Cancer Center Hospital, Research Center for Cancer Prevention and Screenin, Tokyo, Japan","institution_ids":["https://openalex.org/I4405285273"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101798629","display_name":"Jong Bae Park","orcid":"https://orcid.org/0000-0003-0207-0697","observed_orcids":["https://orcid.org/0000-0003-0207-0697","https://orcid.org/0000-0002-1091-8099"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210141458","display_name":"Cancer Hospital of Chinese Academy of Medical Sciences","ror":"https://ror.org/03x937183","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141458"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jong Bae Park","raw_affiliation_strings":["Chinese Academy of Medical Sciences - National Cancer Center","Chinese Academy of Medical Sciences - National Cancer Center, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chinese Academy of Medical Sciences - National Cancer Center","institution_ids":["https://openalex.org/I200296433"]},{"raw_affiliation_string":"Chinese Academy of Medical Sciences - National Cancer Center, Beijing, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210141458"]}]}],"institutions":[],"countries_distinct_count":5,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5100337388"],"corresponding_institution_ids":["https://openalex.org/I2800421839","https://openalex.org/I4210140884"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.9959999918937683},{"id":"https://openalex.org/keywords/bevacizumab-resistance","display_name":"bevacizumab resistance","score":0.9990000128746033},{"id":"https://openalex.org/keywords/recurrent-glioblastoma","display_name":"recurrent glioblastoma","score":0.8230000138282776},{"id":"https://openalex.org/keywords/neuregulin-3","display_name":"NRG3","score":0.7369999885559082},{"id":"https://openalex.org/keywords/erbb4","display_name":"ErbB4","score":0.9950000047683716},{"id":"https://openalex.org/keywords/ctnnb1","display_name":"CTNNB1","score":0.8930000066757202},{"id":"https://openalex.org/keywords/beta-catenin-signaling","display_name":"\u03b2-catenin signaling","score":0.8870000243186951},{"id":"https://openalex.org/keywords/neuronal-reprogramming","display_name":"neuronal reprogramming","score":0.9760000109672546},{"id":"https://openalex.org/keywords/pri-724","display_name":"PRI-724","score":0.8209999799728394},{"id":"https://openalex.org/keywords/patient-derived-xenografts","display_name":"patient-derived xenografts","score":0.7319999933242798},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.6600000262260437}],"concepts":[{"id":"https://openalex.org/C2777802072","wikidata":"https://www.wikidata.org/wiki/Q413299","display_name":"Bevacizumab","level":3,"score":0.7542999982833862},{"id":"https://openalex.org/C77255625","wikidata":"https://www.wikidata.org/wiki/Q402093","display_name":"Reprogramming","level":3,"score":0.6690000295639038},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6097000241279602},{"id":"https://openalex.org/C2776194525","wikidata":"https://www.wikidata.org/wiki/Q282142","display_name":"Glioblastoma","level":2,"score":0.5728999972343445},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.4546999931335449},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.444599986076355},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.4325999915599823},{"id":"https://openalex.org/C2994294914","wikidata":"https://www.wikidata.org/wiki/Q1645075","display_name":"Acquired resistance","level":3,"score":0.4025999903678894},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4002000093460083},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.38040000200271606},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3422999978065491},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.302700012922287},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.2987000048160553},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.2786000072956085},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.2759999930858612},{"id":"https://openalex.org/C6675166","wikidata":"https://www.wikidata.org/wiki/Q7187538","display_name":"Phosphoproteomics","level":5,"score":0.27390000224113464},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.26759999990463257},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.26759999990463257},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2669000029563904},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.25679999589920044}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.2139/ssrn.5532274","doi":"https://doi.org/10.2139/ssrn.5532274","is_oa":true,"landing_page_url":"https://doi.org/10.2139/ssrn.5532274","pdf_url":null,"source":{"id":"https://openalex.org/S4210172589","display_name":"SSRN Electronic Journal","issn_l":"1556-5068","issn":["1556-5068"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1318003438","host_organization_name":"RELX Group (Netherlands)","host_organization_lineage":["https://openalex.org/I1318003438"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.2139/ssrn.5532274","doi":"https://doi.org/10.2139/ssrn.5532274","is_oa":true,"landing_page_url":"https://doi.org/10.2139/ssrn.5532274","pdf_url":null,"source":{"id":"https://openalex.org/S4210172589","display_name":"SSRN Electronic Journal","issn_l":"1556-5068","issn":["1556-5068"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1318003438","host_organization_name":"RELX Group (Netherlands)","host_organization_lineage":["https://openalex.org/I1318003438"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2340940115","https://openalex.org/W4415407715","https://openalex.org/W2092373644","https://openalex.org/W2587318780","https://openalex.org/W2606519264","https://openalex.org/W2142218571","https://openalex.org/W2089305679","https://openalex.org/W4362595156","https://openalex.org/W3006163888","https://openalex.org/W2756591964"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-10-10T00:00:00"}