{"id":"https://openalex.org/W4414540769","doi":"https://doi.org/10.1073/pnas.2516527122","title":"IFN-inducible human phospholipid scramblase 1 (PLSCR1) protein restricts HIV-1 infection by inhibiting membrane fusion","display_name":"IFN-inducible human phospholipid scramblase 1 (PLSCR1) protein restricts HIV-1 infection by inhibiting membrane fusion","publication_year":2025,"publication_date":"2025-09-26","ids":{"openalex":"https://openalex.org/W4414540769","doi":"https://doi.org/10.1073/pnas.2516527122","pmid":"https://pubmed.ncbi.nlm.nih.gov/41004226","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12501134"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.2516527122","doi":"https://doi.org/10.1073/pnas.2516527122","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.2516527122","pdf_url":"https://www.pnas.org/doi/pdf/10.1073/pnas.2516527122","source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.pnas.org/doi/pdf/10.1073/pnas.2516527122","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100338961","display_name":"Yajie Liu","orcid":"https://orcid.org/0000-0002-4555-3472","observed_orcids":["https://orcid.org/0000-0002-4555-3472"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yajie Liu","raw_affiliation_strings":["Center for Retrovirus Research, The Ohio State University","Department of Veterinary Biosciences, The Ohio State University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Retrovirus Research, The Ohio State University","institution_ids":["https://openalex.org/I52357470"]},{"raw_affiliation_string":"Department of Veterinary Biosciences, The Ohio State University","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114131754","display_name":"Pei Li","orcid":"https://orcid.org/0009-0006-6617-1824","observed_orcids":["https://orcid.org/0009-0006-6617-1824"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Pei Li","raw_affiliation_strings":["Center for Retrovirus Research, The Ohio State University","Department of Veterinary Biosciences, The Ohio State University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Retrovirus Research, The Ohio State University","institution_ids":["https://openalex.org/I52357470"]},{"raw_affiliation_string":"Department of Veterinary Biosciences, The Ohio State University","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yi-Min Zheng","orcid":"https://orcid.org/0000-0001-9364-7636","observed_orcids":["https://orcid.org/0000-0001-9364-7636"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yi-Min Zheng","raw_affiliation_strings":["Center for Retrovirus Research, The Ohio State University","Department of Veterinary Biosciences, The Ohio State University"],"raw_orcid":"https://orcid.org/0000-0001-9364-7636","affiliations":[{"raw_affiliation_string":"Center for Retrovirus Research, The Ohio State University","institution_ids":["https://openalex.org/I52357470"]},{"raw_affiliation_string":"Department of Veterinary Biosciences, The Ohio State University","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041030808","display_name":"Yuta Hikichi","orcid":"https://orcid.org/0000-0002-6762-3179","observed_orcids":["https://orcid.org/0000-0002-6762-3179"]},"institutions":[{"id":"https://openalex.org/I4210123359","display_name":"National Cancer Institute","ror":"https://ror.org/02t771148","country_code":"UA","type":"facility","lineage":["https://openalex.org/I4210123359"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["UA","US"],"is_corresponding":false,"raw_author_name":"Yuta Hikichi","raw_affiliation_strings":["Virus-Cell Interaction Section, HIV Dynamics and Replication Program, Center for Cancer Research, National Cancer Institute"],"raw_orcid":"https://orcid.org/0000-0002-6762-3179","affiliations":[{"raw_affiliation_string":"Virus-Cell Interaction Section, HIV Dynamics and Replication Program, Center for Cancer Research, National Cancer Institute","institution_ids":["https://openalex.org/I4210123359","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053248401","display_name":"Sherimay D. Ablan","orcid":"https://orcid.org/0000-0001-9466-8332","observed_orcids":["https://orcid.org/0000-0001-9466-8332"]},"institutions":[{"id":"https://openalex.org/I4210123359","display_name":"National Cancer Institute","ror":"https://ror.org/02t771148","country_code":"UA","type":"facility","lineage":["https://openalex.org/I4210123359"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["UA","US"],"is_corresponding":false,"raw_author_name":"Sherimay D. Ablan","raw_affiliation_strings":["Virus-Cell Interaction Section, HIV Dynamics and Replication Program, Center for Cancer Research, National Cancer Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Virus-Cell Interaction Section, HIV Dynamics and Replication Program, Center for Cancer Research, National Cancer Institute","institution_ids":["https://openalex.org/I4210123359","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054660762","display_name":"Eric O. Freed","orcid":"https://orcid.org/0000-0003-3345-022X","observed_orcids":["https://orcid.org/0000-0003-3345-022X"]},"institutions":[{"id":"https://openalex.org/I4210123359","display_name":"National Cancer Institute","ror":"https://ror.org/02t771148","country_code":"UA","type":"facility","lineage":["https://openalex.org/I4210123359"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["UA","US"],"is_corresponding":false,"raw_author_name":"Eric O. Freed","raw_affiliation_strings":["Virus-Cell Interaction Section, HIV Dynamics and Replication Program, Center for Cancer Research, National Cancer Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Virus-Cell Interaction Section, HIV Dynamics and Replication Program, Center for Cancer Research, National Cancer Institute","institution_ids":["https://openalex.org/I4210123359","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062868933","display_name":"Shan\u2010Lu Liu","orcid":"https://orcid.org/0000-0003-1620-3817","observed_orcids":["https://orcid.org/0000-0003-1620-3817"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Shan-Lu Liu","raw_affiliation_strings":["Center for Retrovirus Research, The Ohio State University","Department of Microbial Infection and Immunity, The Ohio State University","Department of Veterinary Biosciences, The Ohio State University","Viruses and Emerging Pathogens Program, Infectious Diseases Institute, The Ohio State University"],"raw_orcid":"https://orcid.org/0000-0003-1620-3817","affiliations":[{"raw_affiliation_string":"Center for Retrovirus Research, The Ohio State University","institution_ids":["https://openalex.org/I52357470"]},{"raw_affiliation_string":"Department of Microbial Infection and Immunity, The Ohio State University","institution_ids":["https://openalex.org/I52357470"]},{"raw_affiliation_string":"Department of Veterinary Biosciences, The Ohio State University","institution_ids":["https://openalex.org/I52357470"]},{"raw_affiliation_string":"Viruses and Emerging Pathogens Program, Infectious Diseases Institute, The Ohio State University","institution_ids":["https://openalex.org/I52357470"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5062868933","https://openalex.org/A5100338961","https://openalex.org/A5114131754"],"corresponding_institution_ids":["https://openalex.org/I52357470"],"apc_list":null,"apc_paid":null,"fwci":2.284,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.88014706,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"122","issue":"39","first_page":"e2516527122","last_page":"e2516527122"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.004100000020116568,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/plscr1","display_name":"PLSCR1","score":0.9860000014305115},{"id":"https://openalex.org/keywords/hiv-1","display_name":"HIV-1","score":0.8059999942779541},{"id":"https://openalex.org/keywords/restriction-factors","display_name":"host restriction factors","score":0.7919999957084656},{"id":"https://openalex.org/keywords/interferon-stimulated-genes","display_name":"interferon-stimulated genes","score":0.8500000238418579},{"id":"https://openalex.org/keywords/viral-membrane-fusion","display_name":"viral fusion","score":0.765999972820282},{"id":"https://openalex.org/keywords/envelope-glycoprotein","display_name":"envelope glycoprotein","score":0.8330000042915344},{"id":"https://openalex.org/keywords/hiv-2","display_name":"HIV-2","score":0.7390000224113464},{"id":"https://openalex.org/keywords/simian-immunodeficiency-virus","display_name":"simian immunodeficiency virus","score":0.9100000262260437},{"id":"https://openalex.org/keywords/cell-to-cell-spread","display_name":"cell-to-cell transmission","score":0.9380000233650208},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.8169999718666077},{"id":"https://openalex.org/keywords/antiviral-defense","display_name":"antiviral defense","score":0.7170000076293945}],"concepts":[{"id":"https://openalex.org/C188810444","wikidata":"https://www.wikidata.org/wiki/Q3476415","display_name":"Phospholipid scramblase","level":5,"score":0.972599983215332},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6126000285148621},{"id":"https://openalex.org/C103038307","wikidata":"https://www.wikidata.org/wiki/Q6556360","display_name":"Lipid bilayer fusion","level":3,"score":0.6083999872207642},{"id":"https://openalex.org/C58475186","wikidata":"https://www.wikidata.org/wiki/Q4118894","display_name":"Viral entry","level":4,"score":0.5479999780654907},{"id":"https://openalex.org/C92488253","wikidata":"https://www.wikidata.org/wiki/Q56592403","display_name":"Cell fusion","level":3,"score":0.5044999718666077},{"id":"https://openalex.org/C2776855506","wikidata":"https://www.wikidata.org/wiki/Q21100505","display_name":"Tetherin","level":4,"score":0.5034999847412109},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4821999967098236},{"id":"https://openalex.org/C97380033","wikidata":"https://www.wikidata.org/wiki/Q994215","display_name":"Viral envelope","level":3,"score":0.4634000062942505},{"id":"https://openalex.org/C108625454","wikidata":"https://www.wikidata.org/wiki/Q187126","display_name":"Glycoprotein","level":2,"score":0.453900009393692},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.43849998712539673},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4032999873161316},{"id":"https://openalex.org/C2776258796","wikidata":"https://www.wikidata.org/wiki/Q5590520","display_name":"Gp41","level":4,"score":0.4020000100135803},{"id":"https://openalex.org/C2777019660","wikidata":"https://www.wikidata.org/wiki/Q106947147","display_name":"Flippase","level":5,"score":0.397599995136261},{"id":"https://openalex.org/C2777459641","wikidata":"https://www.wikidata.org/wiki/Q6815130","display_name":"Membrane glycoproteins","level":3,"score":0.3928000032901764},{"id":"https://openalex.org/C51639874","wikidata":"https://www.wikidata.org/wiki/Q167149","display_name":"Plasma protein binding","level":2,"score":0.38199999928474426},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3646000027656555},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.34790000319480896},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.34630000591278076},{"id":"https://openalex.org/C2778106830","wikidata":"https://www.wikidata.org/wiki/Q29548","display_name":"Cell membrane","level":3,"score":0.3328000009059906},{"id":"https://openalex.org/C123894998","wikidata":"https://www.wikidata.org/wiki/Q425158","display_name":"Fusion protein","level":4,"score":0.3327000141143799},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.33090001344680786},{"id":"https://openalex.org/C20518536","wikidata":"https://www.wikidata.org/wiki/Q6840469","display_name":"Microvesicles","level":4,"score":0.32089999318122864},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.30979999899864197},{"id":"https://openalex.org/C2777627835","wikidata":"https://www.wikidata.org/wiki/Q16963978","display_name":"Host factor","level":3,"score":0.3093000054359436},{"id":"https://openalex.org/C144647389","wikidata":"https://www.wikidata.org/wiki/Q423042","display_name":"Membrane protein","level":3,"score":0.3025999963283539},{"id":"https://openalex.org/C174510640","wikidata":"https://www.wikidata.org/wiki/Q489618","display_name":"HEK 293 cells","level":3,"score":0.29899999499320984},{"id":"https://openalex.org/C166703698","wikidata":"https://www.wikidata.org/wiki/Q201993","display_name":"RNA interference","level":4,"score":0.2896000146865845},{"id":"https://openalex.org/C2778918659","wikidata":"https://www.wikidata.org/wiki/Q186915","display_name":"Phospholipid","level":3,"score":0.28529998660087585},{"id":"https://openalex.org/C179464577","wikidata":"https://www.wikidata.org/wiki/Q1632589","display_name":"Jurkat cells","level":4,"score":0.2824000120162964},{"id":"https://openalex.org/C24530287","wikidata":"https://www.wikidata.org/wiki/Q424204","display_name":"Transmembrane protein","level":3,"score":0.28189998865127563},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.2754000127315521},{"id":"https://openalex.org/C111829193","wikidata":"https://www.wikidata.org/wiki/Q1108970","display_name":"Fusion gene","level":3,"score":0.2694000005722046},{"id":"https://openalex.org/C202878990","wikidata":"https://www.wikidata.org/wiki/Q830465","display_name":"Capsid","level":3,"score":0.26910001039505005},{"id":"https://openalex.org/C158525013","wikidata":"https://www.wikidata.org/wiki/Q2593739","display_name":"Fusion","level":2,"score":0.26899999380111694},{"id":"https://openalex.org/C139770010","wikidata":"https://www.wikidata.org/wiki/Q1339807","display_name":"Internalization","level":3,"score":0.2567000091075897},{"id":"https://openalex.org/C2779637612","wikidata":"https://www.wikidata.org/wiki/Q2354337","display_name":"Phosphatidylserine","level":4,"score":0.2563999891281128}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007372","descriptor_name":"Interferons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008561","descriptor_name":"Membrane Fusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D049294","descriptor_name":"Phospholipid Transfer Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D049294","descriptor_name":"Phospholipid Transfer Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D053586","descriptor_name":"Virus Internalization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1073/pnas.2516527122","doi":"https://doi.org/10.1073/pnas.2516527122","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.2516527122","pdf_url":"https://www.pnas.org/doi/pdf/10.1073/pnas.2516527122","source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"doi:10.1101/2025.06.23.661195","doi":"https://doi.org/10.1101/2025.06.23.661195","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.06.23.661195","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2025/06/24/2025.06.23.661195.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:europepmc.org:11309202","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12501134","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:41004226","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41004226","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"},{"id":"pmid:41031002","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41031002","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12478404","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12478404/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:12501134","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12501134/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmh:oai:europepmc.org:11289114","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12478404","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1073/pnas.2516527122","doi":"https://doi.org/10.1073/pnas.2516527122","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.2516527122","pdf_url":"https://www.pnas.org/doi/pdf/10.1073/pnas.2516527122","source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6240000128746033,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320309374","display_name":"Ohio State University","ror":"https://ror.org/00rs6vg23"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4414540769.pdf","grobid_xml":"https://content.openalex.org/works/W4414540769.grobid-xml"},"referenced_works_count":22,"referenced_works":["https://openalex.org/W297808834","https://openalex.org/W1659719610","https://openalex.org/W1946734657","https://openalex.org/W1977069053","https://openalex.org/W2003812878","https://openalex.org/W2027814475","https://openalex.org/W2034178719","https://openalex.org/W2053592784","https://openalex.org/W2090124674","https://openalex.org/W2141199943","https://openalex.org/W2165070219","https://openalex.org/W2334579861","https://openalex.org/W2783838768","https://openalex.org/W2919901342","https://openalex.org/W2934429271","https://openalex.org/W2969504857","https://openalex.org/W3205197857","https://openalex.org/W4210917133","https://openalex.org/W4281894550","https://openalex.org/W4384024945","https://openalex.org/W4402802222","https://openalex.org/W4409114242"],"related_works":["https://openalex.org/W2027814475","https://openalex.org/W4409114242","https://openalex.org/W2123582660","https://openalex.org/W7092282806","https://openalex.org/W4200394279","https://openalex.org/W2918874639","https://openalex.org/W2053592784","https://openalex.org/W2039711185","https://openalex.org/W3015349077","https://openalex.org/W6958314341"],"abstract_inverted_index":{"Human":[0],"phospholipid":[1],"scramblase":[2],"1":[3],"(PLSCR1)":[4],"is":[5,113],"an":[6],"interferon-stimulated":[7],"gene":[8],"(ISG)":[9],"that":[10,26,58,79,131],"inhibits":[11,27,60],"viral":[12,82,111],"infections":[13],"through":[14],"various":[15],"mechanisms.":[16],"Here,":[17],"we":[18,56,77],"identify":[19],"PLSCR1":[20,59,80,124],"as":[21,70,72,125],"a":[22,126],"host":[23],"restriction":[24,109,129],"factor":[25,130],"HIV-1":[28,64,89],"entry":[29,83,112],"by":[30,35,87],"impairing":[31],"membrane":[32,135],"fusion":[33,93,136],"mediated":[34],"the":[36,45,61,104,134],"envelope":[37],"glycoprotein":[38],"(Env).":[39],"Using":[40],"multiple":[41],"cell":[42,49,105],"types":[43],"including":[44],"human":[46],"SupT1":[47],"T":[48,54],"line":[50],"and":[51,68,74,84,91],"purified":[52],"CD4+":[53],"cells,":[55],"demonstrate":[57],"replication":[62],"of":[63,110,115,142],"with":[65],"diverse":[66],"tropisms":[67],"subtypes,":[69],"well":[71],"HIV-2":[73],"SIV.":[75],"Mechanistically,":[76],"find":[78],"blocks":[81],"cell-to-cell":[85],"transmission":[86],"restricting":[88],"virion-cell":[90],"cell-cell":[92],"without":[94],"affecting":[95],"CD4":[96],"or":[97,100],"CXCR4":[98],"expression":[99],"virus":[101],"binding":[102],"to":[103],"surface.":[106],"Notably,":[107],"PLSCR1-mediated":[108],"independent":[114],"type":[116],"I":[117],"interferon":[118],"signaling.":[119],"Collectively,":[120],"these":[121],"findings":[122],"establish":[123],"broad-spectrum":[127],"lentiviral":[128],"acts":[132],"at":[133],"stage,":[137],"thereby":[138],"expanding":[139],"our":[140],"understanding":[141],"ISG-mediated":[143],"antiviral":[144],"defense.":[145]},"counts_by_year":[{"year":2026,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-10-10T00:00:00"}
