{"id":"https://openalex.org/W4414529356","doi":"https://doi.org/10.3390/medicina61101745","title":"Effectiveness of Classic Triple Therapy Compared with Alternative Regimens for Eradicating H. pylori: A Systematic Review","display_name":"Effectiveness of Classic Triple Therapy Compared with Alternative Regimens for Eradicating H. pylori: A Systematic Review","publication_year":2025,"publication_date":"2025-09-25","ids":{"openalex":"https://openalex.org/W4414529356","doi":"https://doi.org/10.3390/medicina61101745","pmid":"https://pubmed.ncbi.nlm.nih.gov/41155732","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12566408"},"language":"en","primary_location":{"id":"doi:10.3390/medicina61101745","doi":"https://doi.org/10.3390/medicina61101745","is_oa":true,"landing_page_url":"https://doi.org/10.3390/medicina61101745","pdf_url":"https://www.mdpi.com/1648-9144/61/10/1745/pdf?version=1758796401","source":{"id":"https://openalex.org/S1008817457","display_name":"Medicina","issn_l":"1010-660X","issn":["1010-660X","1648-9144"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicina","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1648-9144/61/10/1745/pdf?version=1758796401","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085323663","display_name":"Majid Ahmed Darraj","orcid":"https://orcid.org/0000-0003-2291-1254","observed_orcids":["https://orcid.org/0000-0003-2291-1254"]},"institutions":[{"id":"https://openalex.org/I91450128","display_name":"Jazan University","ror":"https://ror.org/02bjnq803","country_code":"SA","type":"education","lineage":["https://openalex.org/I91450128"]}],"countries":["SA"],"is_corresponding":true,"raw_author_name":"Majid Darraj","raw_affiliation_strings":["Department of Internal Medicine, College of Medicine, Jazan University, Jazan 45142, Saudi Arabia"],"raw_orcid":"https://orcid.org/0000-0003-2291-1254","affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, College of Medicine, Jazan University, Jazan 45142, Saudi Arabia","institution_ids":["https://openalex.org/I91450128"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5085323663"],"corresponding_institution_ids":["https://openalex.org/I91450128"],"apc_list":{"value":2200,"currency":"CHF","value_usd":2654},"apc_paid":{"value":2200,"currency":"CHF","value_usd":2654},"fwci":0.5567,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.48681148,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"61","issue":"10","first_page":"1745","last_page":"1745"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10276","display_name":"Helicobacter pylori-related gastroenterology studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10276","display_name":"Helicobacter pylori-related gastroenterology studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11378","display_name":"Gastrointestinal Bleeding Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/helicobacter-pylori-eradication","display_name":"Helicobacter pylori eradication","score":0.9440000057220459},{"id":"https://openalex.org/keywords/bismuth-quadruple-therapy","display_name":"bismuth quadruple therapy","score":0.8579999804496765},{"id":"https://openalex.org/keywords/sequential-therapy","display_name":"sequential therapy","score":0.8339999914169312},{"id":"https://openalex.org/keywords/high-dose-proton-pump-inhibitors","display_name":"high-dose proton pump inhibitors","score":0.9179999828338623},{"id":"https://openalex.org/keywords/antibiotic-resistance","display_name":"antibiotic resistance","score":0.9390000104904175},{"id":"https://openalex.org/keywords/eradication-rate","display_name":"eradication rate","score":0.7940000295639038},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.9259999990463257},{"id":"https://openalex.org/keywords/treatment-adherence","display_name":"medication adherence","score":0.9240000247955322},{"id":"https://openalex.org/keywords/susceptibility-testing","display_name":"susceptibility testing","score":0.7450000047683716},{"id":"https://openalex.org/keywords/peptic-ulcer","display_name":"peptic ulcer","score":0.8019999861717224},{"id":"https://openalex.org/keywords/chronic-gastritis","display_name":"chronic gastritis","score":0.7720000147819519}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9150000214576721},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.7268999814987183},{"id":"https://openalex.org/C2776478404","wikidata":"https://www.wikidata.org/wiki/Q1105187","display_name":"Cochrane Library","level":3,"score":0.6577000021934509},{"id":"https://openalex.org/C23131810","wikidata":"https://www.wikidata.org/wiki/Q818574","display_name":"Observational study","level":2,"score":0.6317999958992004},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.5683000087738037},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.5037999749183655},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.49779999256134033},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.48590001463890076},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.43479999899864197},{"id":"https://openalex.org/C189708586","wikidata":"https://www.wikidata.org/wiki/Q1504425","display_name":"Systematic review","level":3,"score":0.41510000824928284},{"id":"https://openalex.org/C2776409635","wikidata":"https://www.wikidata.org/wiki/Q180556","display_name":"Helicobacter pylori","level":2,"score":0.3151000142097473},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.3122999966144562},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.30559998750686646},{"id":"https://openalex.org/C94665300","wikidata":"https://www.wikidata.org/wiki/Q63391344","display_name":"Antibiotic resistance","level":3,"score":0.2964000105857849},{"id":"https://openalex.org/C3019203764","wikidata":"https://www.wikidata.org/wiki/Q1105202","display_name":"Cochrane collaboration","level":4,"score":0.2793000042438507},{"id":"https://openalex.org/C19648533","wikidata":"https://www.wikidata.org/wiki/Q691640","display_name":"Evidence-based medicine","level":3,"score":0.26330000162124634},{"id":"https://openalex.org/C3018095205","wikidata":"https://www.wikidata.org/wiki/Q55641553","display_name":"Real world evidence","level":2,"score":0.2628999948501587}],"mesh":[{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016480","descriptor_name":"Helicobacter pylori","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D016480","descriptor_name":"Helicobacter pylori","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":true},{"descriptor_ui":"D016481","descriptor_name":"Helicobacter Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054328","descriptor_name":"Proton Pump Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.3390/medicina61101745","doi":"https://doi.org/10.3390/medicina61101745","is_oa":true,"landing_page_url":"https://doi.org/10.3390/medicina61101745","pdf_url":"https://www.mdpi.com/1648-9144/61/10/1745/pdf?version=1758796401","source":{"id":"https://openalex.org/S1008817457","display_name":"Medicina","issn_l":"1010-660X","issn":["1010-660X","1648-9144"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicina","raw_type":"journal-article"},{"id":"pmid:41155732","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41155732","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicina (Kaunas, Lithuania)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12566408","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12566408/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicina (Kaunas)","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:ea31b00f97314b4ca3a646d021dba950","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/ea31b00f97314b4ca3a646d021dba950","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Medicina, Vol 61, Iss 10, p 1745 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/medicina61101745","doi":"https://doi.org/10.3390/medicina61101745","is_oa":true,"landing_page_url":"https://doi.org/10.3390/medicina61101745","pdf_url":"https://www.mdpi.com/1648-9144/61/10/1745/pdf?version=1758796401","source":{"id":"https://openalex.org/S1008817457","display_name":"Medicina","issn_l":"1010-660X","issn":["1010-660X","1648-9144"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicina","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4414529356.pdf","grobid_xml":"https://content.openalex.org/works/W4414529356.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W1483492159","https://openalex.org/W1587967575","https://openalex.org/W1974893818","https://openalex.org/W1996813172","https://openalex.org/W2020603703","https://openalex.org/W2043786942","https://openalex.org/W2085466538","https://openalex.org/W2097521996","https://openalex.org/W2130569918","https://openalex.org/W2154134791","https://openalex.org/W2199203801","https://openalex.org/W2288860082","https://openalex.org/W2326391300","https://openalex.org/W2368437084","https://openalex.org/W2521330433","https://openalex.org/W2556509473","https://openalex.org/W2611781744","https://openalex.org/W2774891491","https://openalex.org/W2909448652","https://openalex.org/W2939212240","https://openalex.org/W2968747441","https://openalex.org/W2972783296","https://openalex.org/W3042692441","https://openalex.org/W3044222828","https://openalex.org/W3088546215","https://openalex.org/W3092938408","https://openalex.org/W3095719490","https://openalex.org/W3110286336","https://openalex.org/W4317605997","https://openalex.org/W4318832406","https://openalex.org/W4377103649","https://openalex.org/W4391103850","https://openalex.org/W4394853062","https://openalex.org/W4399963468"],"related_works":["https://openalex.org/W2144487124","https://openalex.org/W4376871709","https://openalex.org/W3215248716","https://openalex.org/W2041638520","https://openalex.org/W2978392346","https://openalex.org/W4286266719","https://openalex.org/W6987249973","https://openalex.org/W2066955421","https://openalex.org/W2036910155","https://openalex.org/W2080839245"],"abstract_inverted_index":{"Background:":[0],"Helicobacter":[1],"pylori":[2],"infection":[3],"is":[4,163,184],"associated":[5],"with":[6,39],"peptic":[7],"ulcer":[8],"disease,":[9],"chronic":[10],"gastritis,":[11],"and":[12,42,47,57,68,84,100,121,136,171],"gastric":[13],"cancer.":[14],"Classic":[15],"triple":[16],"therapy":[17],"(CTT)":[18],"has":[19,27],"been":[20],"widely":[21],"used,":[22],"but":[23],"increasing":[24],"antibiotic":[25],"resistance":[26,158],"reduced":[28],"its":[29],"effectiveness.":[30],"Objectives:":[31],"To":[32],"evaluate":[33],"the":[34,80,91],"effectiveness":[35],"of":[36,55],"CTT":[37,110,162],"compared":[38],"alternative":[40],"regimens":[41,124,174],"to":[43,63,116,150],"summarize":[44],"adverse":[45,98],"events":[46,133],"adherence.":[48,101],"Methods:":[49],"We":[50],"searched":[51],"PubMed,":[52],"Scopus,":[53],"Web":[54],"Science,":[56],"Cochrane":[58,88],"Library":[59],"from":[60,114],"January":[61],"2000":[62],"March":[64],"2025.":[65],"Randomized":[66],"trials":[67],"observational":[69],"studies":[70,104],"assessing":[71],"eradication":[72,96,111],"rates":[73,112,127],"were":[74,108,134],"included.":[75,109],"Two":[76],"reviewers":[77],"independently":[78],"screened":[79],"studies,":[81],"extracted":[82],"data,":[83],"assessed":[85],"bias":[86],"using":[87],"RoB":[89],"or":[90],"Newcastle\u2013Ottawa":[92],"Scale.":[93],"Outcomes":[94],"included":[95],"rate,":[97],"events,":[99],"Results:":[102],"Thirteen":[103],"(n":[105],"=":[106],"3490)":[107],"ranged":[113],"61.9%":[115],"88.8%.":[117],"Sequential,":[118],"bismuth-based":[119],"quadruple":[120,140],"high-dose":[122,172],"PPI":[123,173],"achieved":[125],"higher":[126],"(>90%":[128],"in":[129,139,152,157,166],"several":[130],"trials).":[131],"Adverse":[132],"mild\u2013moderate":[135],"most":[137,153],"frequent":[138],"therapy,":[141],"though":[142],"adherence":[143],"remained":[144],">90%.":[145],"Evidence":[146],"certainty":[147],"varied":[148],"(moderate":[149],"low":[151],"comparisons).":[154],"Geographic":[155],"variation":[156],"limited":[159],"generalizability.":[160],"Conclusions:":[161],"less":[164],"effective":[165],"high-resistance":[167],"regions.":[168],"Quadruple,":[169],"sequential,":[170],"provide":[175],"superior":[176],"outcomes.":[177],"Region-specific":[178],"treatment":[179],"guided":[180],"by":[181],"susceptibility":[182],"testing":[183],"recommended.":[185],"Registration:":[186],"Not":[187],"registered.":[188]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2025-10-10T00:00:00"}