{"id":"https://openalex.org/W4414528124","doi":"https://doi.org/10.1080/22297928.2025.2564845","title":"Design, synthesis of substituted oxadiazol-2-yl-methanimine derivatives and evaluation for their anti-alzheimer activity","display_name":"Design, synthesis of substituted oxadiazol-2-yl-methanimine derivatives and evaluation for their anti-alzheimer activity","publication_year":2025,"publication_date":"2025-09-03","ids":{"openalex":"https://openalex.org/W4414528124","doi":"https://doi.org/10.1080/22297928.2025.2564845"},"language":"en","primary_location":{"id":"doi:10.1080/22297928.2025.2564845","doi":"https://doi.org/10.1080/22297928.2025.2564845","is_oa":false,"landing_page_url":"https://doi.org/10.1080/22297928.2025.2564845","pdf_url":null,"source":{"id":"https://openalex.org/S2764633598","display_name":"Analytical Chemistry Letters","issn_l":"2229-7928","issn":["2229-7928","2230-7532"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical Chemistry Letters","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071084871","display_name":"Ramakrishnan Gandhimathi","orcid":"https://orcid.org/0000-0002-0595-8766","observed_orcids":["https://orcid.org/0000-0002-0595-8766","https://orcid.org/0009-0009-1333-3940"]},"institutions":[{"id":"https://openalex.org/I138876546","display_name":"Vels University","ror":"https://ror.org/00tscx035","country_code":"IN","type":"education","lineage":["https://openalex.org/I138876546"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"R. Gandhimathi","raw_affiliation_strings":["School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies (VISTAS)","Department of Pharmaceutical Chemistry and Analysis, School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies (VISTAS), Pallavaram, Chennai-600117, Tamil Nadu, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies (VISTAS)","institution_ids":["https://openalex.org/I138876546"]},{"raw_affiliation_string":"Department of Pharmaceutical Chemistry and Analysis, School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies (VISTAS), Pallavaram, Chennai-600117, Tamil Nadu, India","institution_ids":["https://openalex.org/I138876546"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073142112","display_name":"Mohan Magesh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I85461943","display_name":"Saveetha University","ror":"https://ror.org/0034me914","country_code":"IN","type":"education","lineage":["https://openalex.org/I85461943"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"M. Magesh","raw_affiliation_strings":["Saveetha College of Pharmacy, Saveetha Institute of Medical and Technical Sciences","Department of Pharmaceutical Chemistry, Saveetha College of Pharmacy, Saveetha Institute of Medical and Technical Sciences, Thandalam, Chennai602105, Tamil Nadu, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Saveetha College of Pharmacy, Saveetha Institute of Medical and Technical Sciences","institution_ids":["https://openalex.org/I85461943"]},{"raw_affiliation_string":"Department of Pharmaceutical Chemistry, Saveetha College of Pharmacy, Saveetha Institute of Medical and Technical Sciences, Thandalam, Chennai602105, Tamil Nadu, India","institution_ids":["https://openalex.org/I85461943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083891140","display_name":"Kaviarasan Lakshmanan","orcid":"https://orcid.org/0000-0002-6986-4777","observed_orcids":["https://orcid.org/0000-0002-6986-4777"]},"institutions":[{"id":"https://openalex.org/I43814544","display_name":"Sathyabama Institute of Science and Technology","ror":"https://ror.org/01defpn95","country_code":"IN","type":"education","lineage":["https://openalex.org/I43814544"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"L. Kaviarasan","raw_affiliation_strings":["School of Pharmacy, Sathyabama Institute of Science and Technology","Department of Pharmaceutical Chemistry, School of Pharmacy, Sathyabama Institute of Science and Technology, Chennai, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, Sathyabama Institute of Science and Technology","institution_ids":["https://openalex.org/I43814544"]},{"raw_affiliation_string":"Department of Pharmaceutical Chemistry, School of Pharmacy, Sathyabama Institute of Science and Technology, Chennai, India","institution_ids":["https://openalex.org/I43814544"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050815666","display_name":"Madhurilatha Thadanki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177001074","display_name":"Acharya Nagarjuna University","ror":"https://ror.org/02mfapa96","country_code":"IN","type":"education","lineage":["https://openalex.org/I177001074"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Madhuri Latha Thadanki","raw_affiliation_strings":["College of Pharmaceutical Sciences, Acharya Nagarjuna University","Department of Pharmaceutical Chemistry, College of Pharmaceutical Sciences, Acharya Nagarjuna University, Guntur, Andhra Pradesh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmaceutical Sciences, Acharya Nagarjuna University","institution_ids":["https://openalex.org/I177001074"]},{"raw_affiliation_string":"Department of Pharmaceutical Chemistry, College of Pharmaceutical Sciences, Acharya Nagarjuna University, Guntur, Andhra Pradesh, India","institution_ids":["https://openalex.org/I177001074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019638805","display_name":"Vijaya Kishore Kanakaraju","orcid":"https://orcid.org/0000-0003-4189-324X","observed_orcids":["https://orcid.org/0000-0003-4189-324X"]},"institutions":[{"id":"https://openalex.org/I4405257354","display_name":"Nalla Narasimha Reddy Education Society's Group of Institutions","ror":"https://ror.org/0560stp04","country_code":"IN","type":"education","lineage":["https://openalex.org/I4405257354"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Vijaya Kishore Kanakaraju","raw_affiliation_strings":["NNRG school of pharmacy, Chowdariguda(V), Korremula X Roads","Department of Pharmaceutics, NNRG school of pharmacy, Chowdariguda(V), Korremula X Roads, Ghatkesar (M), Medchel-Malkajigiri Dt, Hyderabad, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NNRG school of pharmacy, Chowdariguda(V), Korremula X Roads","institution_ids":[]},{"raw_affiliation_string":"Department of Pharmaceutics, NNRG school of pharmacy, Chowdariguda(V), Korremula X Roads, Ghatkesar (M), Medchel-Malkajigiri Dt, Hyderabad, India","institution_ids":["https://openalex.org/I4405257354"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081311036","display_name":"D. Bharathi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405275187","display_name":"PSG College of Pharmacy","ror":"https://ror.org/033xjms15","country_code":"IN","type":"education","lineage":["https://openalex.org/I4405275187"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"D. Bharathi","raw_affiliation_strings":["PSG College of Pharmacy","PSG College of Pharmacy, Department of Pharmaceutical Chemistry, Coimbatore, Tamil Nadu, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PSG College of Pharmacy","institution_ids":["https://openalex.org/I4405275187"]},{"raw_affiliation_string":"PSG College of Pharmacy, Department of Pharmaceutical Chemistry, Coimbatore, Tamil Nadu, India","institution_ids":["https://openalex.org/I4405275187"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5073142112"],"corresponding_institution_ids":["https://openalex.org/I85461943"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"15","issue":"5","first_page":"816","last_page":"829"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12410","display_name":"Structural and Chemical Analysis of Organic and Inorganic Compounds","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.8970000147819519},{"id":"https://openalex.org/keywords/acetylcholinesterase-inhibitors","display_name":"acetylcholinesterase inhibitors","score":0.9190000295639038},{"id":"https://openalex.org/keywords/1-3-4-oxadiazoles","display_name":"1,3,4-oxadiazoles","score":0.9599999785423279},{"id":"https://openalex.org/keywords/cholinergic-dysfunction","display_name":"cholinergic dysfunction","score":0.8989999890327454},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.6949999928474426},{"id":"https://openalex.org/keywords/sh-sy5y-cells","display_name":"SH-SY5Y cells","score":0.8840000033378601},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.9020000100135803},{"id":"https://openalex.org/keywords/molecular-docking","display_name":"molecular docking","score":0.8830000162124634},{"id":"https://openalex.org/keywords/admet-properties","display_name":"ADMET properties","score":0.7319999933242798},{"id":"https://openalex.org/keywords/drug-likeness-prediction","display_name":"drug-likeness prediction","score":0.8299999833106995}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9473000168800354},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.358599990606308},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.31779998540878296},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.28450000286102295},{"id":"https://openalex.org/C134121241","wikidata":"https://www.wikidata.org/wiki/Q899301","display_name":"Yield (engineering)","level":2,"score":0.27900001406669617},{"id":"https://openalex.org/C94412978","wikidata":"https://www.wikidata.org/wiki/Q103135","display_name":"Hydrolysis","level":2,"score":0.2711000144481659},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.2361000031232834},{"id":"https://openalex.org/C2779530757","wikidata":"https://www.wikidata.org/wiki/Q1207505","display_name":"Quality (philosophy)","level":2,"score":0.22540000081062317},{"id":"https://openalex.org/C116073593","wikidata":"https://www.wikidata.org/wiki/Q864491","display_name":"Biological activity","level":3,"score":0.2150000035762787},{"id":"https://openalex.org/C179998833","wikidata":"https://www.wikidata.org/wiki/Q381233","display_name":"High-performance liquid chromatography","level":2,"score":0.21150000393390656}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1080/22297928.2025.2564845","doi":"https://doi.org/10.1080/22297928.2025.2564845","is_oa":false,"landing_page_url":"https://doi.org/10.1080/22297928.2025.2564845","pdf_url":null,"source":{"id":"https://openalex.org/S2764633598","display_name":"Analytical Chemistry Letters","issn_l":"2229-7928","issn":["2229-7928","2230-7532"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical Chemistry Letters","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W1971048984","https://openalex.org/W1978767679","https://openalex.org/W1983789627","https://openalex.org/W2044628864","https://openalex.org/W2055559046","https://openalex.org/W2341046893","https://openalex.org/W2348117559","https://openalex.org/W2483019733","https://openalex.org/W2506547651","https://openalex.org/W2735899580","https://openalex.org/W2744353305","https://openalex.org/W2769728168","https://openalex.org/W2782509615","https://openalex.org/W2802786739","https://openalex.org/W2806417285","https://openalex.org/W2884762656","https://openalex.org/W2896733577","https://openalex.org/W2920317658","https://openalex.org/W3011856332","https://openalex.org/W3173048853","https://openalex.org/W3177235522","https://openalex.org/W4200207022","https://openalex.org/W4210589250","https://openalex.org/W4327968826","https://openalex.org/W4380082781","https://openalex.org/W4381617180","https://openalex.org/W4390708268","https://openalex.org/W4400852771","https://openalex.org/W4403764975","https://openalex.org/W4404629326"],"related_works":["https://openalex.org/W4410246539","https://openalex.org/W7133504353","https://openalex.org/W4381617180","https://openalex.org/W7121447076","https://openalex.org/W4412630148","https://openalex.org/W4396517923","https://openalex.org/W4406775562","https://openalex.org/W7203828830","https://openalex.org/W4400606044","https://openalex.org/W4394851719"],"abstract_inverted_index":{"Alzheimer\u2019s":[0],"disease":[1],"is":[2,131,190],"a":[3,16,44,59,215],"progressive":[4],"neurodegenerative":[5],"disorder":[6],"marked":[7],"by":[8,33,51,103],"cognitive":[9],"decline,":[10],"in":[11,123,164,210],"which":[12,130,189],"cholinergic":[13],"dysfunction":[14],"plays":[15],"central":[17],"role.":[18],"Current":[19],"acetylcholinesterase":[20],"(AChE)":[21],"inhibitors":[22],"such":[23],"as":[24,230],"donepezil":[25,57,100,138],"provide":[26],"only":[27],"symptomatic":[28],"relief":[29],"and":[30,36,72,101,105,111],"are":[31],"limited":[32],"adverse":[34],"effects":[35,208],"reduced":[37],"long-term":[38],"efficacy.":[39],"To":[40],"address":[41],"these":[42],"limitations,":[43],"series":[45],"of":[46,56,99,146,153,175,181],"N-(5-styryl-1,3,4-oxadiazol-2-yl)methanimine":[47],"derivatives":[48,223],"was":[49,121,149,184],"designed":[50],"replacing":[52],"the":[53,135,154,178,193],"indanone":[54],"moiety":[55],"with":[58,87,205],"1,3,4-oxadiazole":[60],"scaffold.":[61],"The":[62,114,143,173,196],"compounds":[63,160,198],"were":[64,161],"evaluated":[65],"using":[66],"in-silico":[67],"drug-likeness":[68],"prediction,":[69],"ADMET":[70],"profiling,":[71],"molecular":[73],"docking":[74,81,88],"against":[75,167],"AChE":[76],"(PDB":[77],"ID:":[78],"4EY6).":[79],"Molecular":[80],"results":[82],"revealed":[83],"strong":[84],"binding":[85],"affinities,":[86],"scores":[89],"ranging":[90],"from":[91],"-8.2":[92],"to":[93,97,134,151,186,192,201],"-10.1":[94],"kcal/mol,":[95],"comparable":[96,191],"that":[98,152,220],"followed":[102],"synthesis":[104],"structural":[106],"confirmation":[107],"through":[108],"IR,":[109],"NMR,":[110],"mass":[112],"spectrometry.":[113],"most":[115],"potent":[116],"cholinesterase":[117],"catalytic":[118],"domain":[119],"inhibition":[120],"observed":[122,209],"compound":[124,147,182],"2":[125,148,183],"(IC50":[126,139],"=":[127,140],"25.71\u00b10.26":[128],"\u03bcM),":[129],"nearly":[132],"equivalent":[133],"reference":[136],"standard,":[137],"24.71":[141],"\u03bcM).":[142],"inhibitory":[144],"action":[145],"superior":[150],"other":[155],"examined":[156],"compounds.":[157],"All":[158],"synthesized":[159],"screened":[162],"for":[163,214,227],"vitro":[165],"cytotoxicity":[166],"human":[168],"SH-SY5Y":[169],"neuroblastoma":[170],"cell":[171],"lines.":[172],"viability":[174],"cells":[176],"at":[177],"maximum":[179],"concentration":[180],"found":[185],"be":[187],"91.29%,":[188],"standard":[194],"(93.35%).":[195],"remaining":[197],"exhibited":[199],"moderate":[200],"good":[202],"neuroprotective":[203,207],"activity,":[204],"concentration-dependent":[206],"all":[211],"compounds,":[212],"except":[213],"few.":[216],"These":[217],"findings":[218],"suggest":[219],"oxadiazolyl":[221],"methanimine":[222],"represent":[224],"promising":[225],"scaffolds":[226],"further":[228],"development":[229],"potential":[231],"anti-Alzheimer\u2019s":[232],"agents.":[233]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-10-10T00:00:00"}