{"id":"https://openalex.org/W4414526606","doi":"https://doi.org/10.1101/2025.09.24.676662","title":"Targeting Amygdala-Brainstem Synapses to Reverse Prepulse Inhibition Deficits","display_name":"Targeting Amygdala-Brainstem Synapses to Reverse Prepulse Inhibition Deficits","publication_year":2025,"publication_date":"2025-09-25","ids":{"openalex":"https://openalex.org/W4414526606","doi":"https://doi.org/10.1101/2025.09.24.676662"},"language":"en","primary_location":{"id":"doi:10.1101/2025.09.24.676662","doi":"https://doi.org/10.1101/2025.09.24.676662","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.09.24.676662","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2025/09/25/2025.09.24.676662.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2025/09/25/2025.09.24.676662.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045260690","display_name":"Wanyun Huang","orcid":"https://orcid.org/0009-0003-9134-8669","observed_orcids":["https://orcid.org/0009-0003-9134-8669"]},"institutions":[{"id":"https://openalex.org/I24603500","display_name":"University of Massachusetts Amherst","ror":"https://ror.org/0072zz521","country_code":"US","type":"education","lineage":["https://openalex.org/I24603500"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wanyun Huang","raw_affiliation_strings":["Biology Department, University of Massachusetts Amherst, Life Science Laboratories","University of Massachusetts Amherst"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biology Department, University of Massachusetts Amherst, Life Science Laboratories","institution_ids":["https://openalex.org/I24603500"]},{"raw_affiliation_string":"University of Massachusetts Amherst","institution_ids":["https://openalex.org/I24603500"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109659822","display_name":"Michelle Kha","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177605424","display_name":"Amherst College","ror":"https://ror.org/028vqfs63","country_code":"US","type":"education","lineage":["https://openalex.org/I177605424"]},{"id":"https://openalex.org/I24603500","display_name":"University of Massachusetts Amherst","ror":"https://ror.org/0072zz521","country_code":"US","type":"education","lineage":["https://openalex.org/I24603500"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michelle Kha","raw_affiliation_strings":["Amherst College","Biology Department, University of Massachusetts Amherst, Life Science Laboratories","University of Massachusetts Amherst"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Amherst College","institution_ids":["https://openalex.org/I177605424"]},{"raw_affiliation_string":"Biology Department, University of Massachusetts Amherst, Life Science Laboratories","institution_ids":["https://openalex.org/I24603500"]},{"raw_affiliation_string":"University of Massachusetts Amherst","institution_ids":["https://openalex.org/I24603500"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032807210","display_name":"Adolfo Ernesto Cuadra","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24603500","display_name":"University of Massachusetts Amherst","ror":"https://ror.org/0072zz521","country_code":"US","type":"education","lineage":["https://openalex.org/I24603500"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adolfo E. Cuadra","raw_affiliation_strings":["Biology Department, University of Massachusetts Amherst, Life Science Laboratories","University of Massachusetts Amherst"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biology Department, University of Massachusetts Amherst, Life Science Laboratories","institution_ids":["https://openalex.org/I24603500"]},{"raw_affiliation_string":"University of Massachusetts Amherst","institution_ids":["https://openalex.org/I24603500"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5119735393","display_name":"Okoh Frimpong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24603500","display_name":"University of Massachusetts Amherst","ror":"https://ror.org/0072zz521","country_code":"US","type":"education","lineage":["https://openalex.org/I24603500"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Okoh Frimpong","raw_affiliation_strings":["Biology Department, University of Massachusetts Amherst, Life Science Laboratories","University of Massachusetts Amherst"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biology Department, University of Massachusetts Amherst, Life Science Laboratories","institution_ids":["https://openalex.org/I24603500"]},{"raw_affiliation_string":"University of Massachusetts Amherst","institution_ids":["https://openalex.org/I24603500"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5119735394","display_name":"Laura Snow","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24603500","display_name":"University of Massachusetts Amherst","ror":"https://ror.org/0072zz521","country_code":"US","type":"education","lineage":["https://openalex.org/I24603500"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laura Snow","raw_affiliation_strings":["Biology Department, University of Massachusetts Amherst, Life Science Laboratories","University of Massachusetts Amherst"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biology Department, University of Massachusetts Amherst, Life Science Laboratories","institution_ids":["https://openalex.org/I24603500"]},{"raw_affiliation_string":"University of Massachusetts Amherst","institution_ids":["https://openalex.org/I24603500"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Andrea Gouin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24603500","display_name":"University of Massachusetts Amherst","ror":"https://ror.org/0072zz521","country_code":"US","type":"education","lineage":["https://openalex.org/I24603500"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrea Gouin","raw_affiliation_strings":["Biology Department, University of Massachusetts Amherst, Life Science Laboratories","University of Massachusetts Amherst"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biology Department, University of Massachusetts Amherst, Life Science Laboratories","institution_ids":["https://openalex.org/I24603500"]},{"raw_affiliation_string":"University of Massachusetts Amherst","institution_ids":["https://openalex.org/I24603500"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107095096","display_name":"St\u00e9phanie L. Padilla","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24603500","display_name":"University of Massachusetts Amherst","ror":"https://ror.org/0072zz521","country_code":"US","type":"education","lineage":["https://openalex.org/I24603500"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephanie Padilla","raw_affiliation_strings":["Biology Department, University of Massachusetts Amherst, Life Science Laboratories","University of Massachusetts Amherst"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biology Department, University of Massachusetts Amherst, Life Science Laboratories","institution_ids":["https://openalex.org/I24603500"]},{"raw_affiliation_string":"University of Massachusetts Amherst","institution_ids":["https://openalex.org/I24603500"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091314913","display_name":"Karine F\u00e9nelon","orcid":"https://orcid.org/0000-0003-3605-5540","observed_orcids":["https://orcid.org/0000-0003-3605-5540"]},"institutions":[{"id":"https://openalex.org/I24603500","display_name":"University of Massachusetts Amherst","ror":"https://ror.org/0072zz521","country_code":"US","type":"education","lineage":["https://openalex.org/I24603500"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Karine F\u00e9nelon","raw_affiliation_strings":["Biology Department, University of Massachusetts Amherst, Life Science Laboratories","University of Massachusetts Amherst"],"raw_orcid":"https://orcid.org/0000-0003-3605-5540","affiliations":[{"raw_affiliation_string":"Biology Department, University of Massachusetts Amherst, Life Science Laboratories","institution_ids":["https://openalex.org/I24603500"]},{"raw_affiliation_string":"University of Massachusetts Amherst","institution_ids":["https://openalex.org/I24603500"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5091314913"],"corresponding_institution_ids":["https://openalex.org/I24603500"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.5073000192642212,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.5073000192642212,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.42899999022483826,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.029200000688433647,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prepulse-inhibition","display_name":"prepulse inhibition","score":0.8259999752044678},{"id":"https://openalex.org/keywords/sensorimotor-gating","display_name":"sensorimotor gating","score":0.9670000076293945},{"id":"https://openalex.org/keywords/central-nucleus-of-the-amygdala","display_name":"central amygdala","score":0.9070000052452087},{"id":"https://openalex.org/keywords/caudal-pontine-reticular-nucleus","display_name":"caudal pontine reticular nucleus","score":0.9670000076293945},{"id":"https://openalex.org/keywords/glutamatergic-synapses","display_name":"glutamatergic synapses","score":0.9810000061988831},{"id":"https://openalex.org/keywords/glycinergic-neurons","display_name":"glycinergic neurons","score":0.9480000138282776},{"id":"https://openalex.org/keywords/proline-dehydrogenase","display_name":"proline dehydrogenase","score":0.9399999976158142},{"id":"https://openalex.org/keywords/schizophrenia-endophenotype","display_name":"schizophrenia endophenotype","score":0.8640000224113464},{"id":"https://openalex.org/keywords/acoustic-startle-response","display_name":"acoustic startle response","score":0.8100000023841858}],"concepts":[{"id":"https://openalex.org/C141421786","wikidata":"https://www.wikidata.org/wiki/Q1128897","display_name":"Prepulse inhibition","level":3,"score":0.9350000023841858},{"id":"https://openalex.org/C2780648746","wikidata":"https://www.wikidata.org/wiki/Q28208871","display_name":"Glutamatergic","level":4,"score":0.8773999810218811},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.7939000129699707},{"id":"https://openalex.org/C187869287","wikidata":"https://www.wikidata.org/wiki/Q2032061","display_name":"Endophenotype","level":3,"score":0.6585999727249146},{"id":"https://openalex.org/C2777845764","wikidata":"https://www.wikidata.org/wiki/Q430986","display_name":"Startle response","level":2,"score":0.4970000088214874},{"id":"https://openalex.org/C2779144063","wikidata":"https://www.wikidata.org/wiki/Q338924","display_name":"Amygdala","level":2,"score":0.48739999532699585},{"id":"https://openalex.org/C2909172351","wikidata":"https://www.wikidata.org/wiki/Q430986","display_name":"Startle reaction","level":3,"score":0.46779999136924744},{"id":"https://openalex.org/C2776412080","wikidata":"https://www.wikidata.org/wiki/Q7431605","display_name":"Schizophrenia (object-oriented programming)","level":2,"score":0.39730000495910645},{"id":"https://openalex.org/C200170125","wikidata":"https://www.wikidata.org/wiki/Q969316","display_name":"Neurotransmission","level":3,"score":0.3610999882221222},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3310000002384186},{"id":"https://openalex.org/C2778135649","wikidata":"https://www.wikidata.org/wiki/Q1432371","display_name":"Thalamic reticular nucleus","level":3,"score":0.31290000677108765},{"id":"https://openalex.org/C2780959517","wikidata":"https://www.wikidata.org/wiki/Q6806092","display_name":"Medial vestibular nucleus","level":4,"score":0.3082999885082245},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.30329999327659607},{"id":"https://openalex.org/C74254510","wikidata":"https://www.wikidata.org/wiki/Q7240508","display_name":"Premovement neuronal activity","level":2,"score":0.30309998989105225},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.2985000014305115},{"id":"https://openalex.org/C127445978","wikidata":"https://www.wikidata.org/wiki/Q187181","display_name":"Synapse","level":2,"score":0.2854999899864197},{"id":"https://openalex.org/C50610925","wikidata":"https://www.wikidata.org/wiki/Q1136816","display_name":"Habituation","level":2,"score":0.28189998865127563},{"id":"https://openalex.org/C35599011","wikidata":"https://www.wikidata.org/wiki/Q426887","display_name":"Glycine receptor","level":4,"score":0.27799999713897705},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.2685999870300293},{"id":"https://openalex.org/C2777426569","wikidata":"https://www.wikidata.org/wiki/Q5062126","display_name":"Central nucleus of the amygdala","level":3,"score":0.2671999931335449},{"id":"https://openalex.org/C551621295","wikidata":"https://www.wikidata.org/wiki/Q182228","display_name":"Brainstem","level":2,"score":0.2648000121116638}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1101/2025.09.24.676662","doi":"https://doi.org/10.1101/2025.09.24.676662","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.09.24.676662","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2025/09/25/2025.09.24.676662.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1101/2025.09.24.676662","doi":"https://doi.org/10.1101/2025.09.24.676662","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.09.24.676662","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2025/09/25/2025.09.24.676662.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4414526606.pdf","grobid_xml":"https://content.openalex.org/works/W4414526606.grobid-xml"},"referenced_works_count":117,"referenced_works":["https://openalex.org/W824928685","https://openalex.org/W1480043204","https://openalex.org/W1511255435","https://openalex.org/W1534457860","https://openalex.org/W1544982068","https://openalex.org/W1545972494","https://openalex.org/W1594690678","https://openalex.org/W1604789895","https://openalex.org/W1644117706","https://openalex.org/W1757694062","https://openalex.org/W1968524760","https://openalex.org/W1973143170","https://openalex.org/W1973947372","https://openalex.org/W1974003946","https://openalex.org/W1978141916","https://openalex.org/W1980967004","https://openalex.org/W1984305433","https://openalex.org/W1984415186","https://openalex.org/W1985299336","https://openalex.org/W1986550451","https://openalex.org/W1989629454","https://openalex.org/W1990230732","https://openalex.org/W1993544884","https://openalex.org/W1993823352","https://openalex.org/W1994677962","https://openalex.org/W1998979210","https://openalex.org/W2004559917","https://openalex.org/W2006395252","https://openalex.org/W2006473457","https://openalex.org/W2008106418","https://openalex.org/W2010589854","https://openalex.org/W2013030084","https://openalex.org/W2022180773","https://openalex.org/W2022258955","https://openalex.org/W2023875149","https://openalex.org/W2028337484","https://openalex.org/W2028889380","https://openalex.org/W2030283288","https://openalex.org/W2031260481","https://openalex.org/W2035883255","https://openalex.org/W2038073160","https://openalex.org/W2040090469","https://openalex.org/W2041279145","https://openalex.org/W2042021963","https://openalex.org/W2042593835","https://openalex.org/W2047424348","https://openalex.org/W2048088283","https://openalex.org/W2049193892","https://openalex.org/W2057647435","https://openalex.org/W2059655841","https://openalex.org/W2060163004","https://openalex.org/W2060884332","https://openalex.org/W2062611403","https://openalex.org/W2068526512","https://openalex.org/W2070660294","https://openalex.org/W2072969178","https://openalex.org/W2073113115","https://openalex.org/W2074029439","https://openalex.org/W2074942168","https://openalex.org/W2075312117","https://openalex.org/W2075752641","https://openalex.org/W2077512500","https://openalex.org/W2079730191","https://openalex.org/W2081628874","https://openalex.org/W2085659432","https://openalex.org/W2087103819","https://openalex.org/W2094450187","https://openalex.org/W2095119525","https://openalex.org/W2102170600","https://openalex.org/W2103092890","https://openalex.org/W2107388867","https://openalex.org/W2109182895","https://openalex.org/W2110017656","https://openalex.org/W2115109681","https://openalex.org/W2115487032","https://openalex.org/W2120532948","https://openalex.org/W2123250120","https://openalex.org/W2123503539","https://openalex.org/W2125407190","https://openalex.org/W2125948416","https://openalex.org/W2133921373","https://openalex.org/W2140862460","https://openalex.org/W2142997789","https://openalex.org/W2150126423","https://openalex.org/W2158765009","https://openalex.org/W2160643155","https://openalex.org/W2163147213","https://openalex.org/W2165970680","https://openalex.org/W2167982093","https://openalex.org/W2168731009","https://openalex.org/W2172394129","https://openalex.org/W2180456503","https://openalex.org/W2181055835","https://openalex.org/W2420398402","https://openalex.org/W2425126086","https://openalex.org/W2468003764","https://openalex.org/W2470294221","https://openalex.org/W2529536607","https://openalex.org/W2533914879","https://openalex.org/W2556758390","https://openalex.org/W2582737854","https://openalex.org/W2603656259","https://openalex.org/W2607435947","https://openalex.org/W2713490841","https://openalex.org/W2790021031","https://openalex.org/W2889246970","https://openalex.org/W2938961713","https://openalex.org/W2949956332","https://openalex.org/W2989479224","https://openalex.org/W3123064267","https://openalex.org/W3164440721","https://openalex.org/W4239024596","https://openalex.org/W4245746501","https://openalex.org/W4289262037","https://openalex.org/W4311824095","https://openalex.org/W4323928485","https://openalex.org/W4394761643"],"related_works":["https://openalex.org/W6959206411","https://openalex.org/W6958954122","https://openalex.org/W3124415284","https://openalex.org/W4409035635","https://openalex.org/W6977805807","https://openalex.org/W4394761643","https://openalex.org/W2083667924","https://openalex.org/W2060163004","https://openalex.org/W1966080862","https://openalex.org/W2132592438"],"abstract_inverted_index":{"Abstract":[0],"Sensorimotor":[1],"gating,":[2],"a":[3,20,55,126,168],"fundamental":[4],"pre-attentive":[5],"process,":[6],"can":[7],"be":[8],"assessed":[9],"using":[10,131],"the":[11,63,89,93,100,111,211],"acoustic":[12,150],"prepulse":[13],"inhibition":[14],"(PPI)":[15],"assay.":[16],"PPI":[17,46,69,108,120,153,188,192,216],"deficits":[18,47,70],"are":[19,26],"hallmark":[21],"endophenotype":[22],"of":[23,45,92,113],"schizophrenia":[24],"and":[25,40,65,145,152,174,186],"observed":[27],"across":[28],"various":[29],"neuropsychiatric":[30],"disorders,":[31],"often":[32],"predicting":[33],"symptoms":[34],"such":[35],"as":[36,54],"attention":[37],"impairments,":[38],"psychosis,":[39],"other":[41],"cognitive/motor":[42],"dysfunctions.":[43],"Reversal":[44],"is":[48],"routinely":[49],"tested":[50],"in":[51,82,88,99,116,134,165,201],"disease":[52],"models":[53],"preclinical":[56],"trial":[57],"for":[58,221],"antipsychotic":[59],"drug":[60],"screening.":[61],"However,":[62],"cellular":[64],"circuit-level":[66],"mechanisms":[67],"underlying":[68],"remain":[71],"unclear,":[72],"limiting":[73],"therapeutic":[74,128,222],"progress.":[75],"We":[76],"recently":[77],"identified":[78,143],"an":[79,133],"uncharted":[80],"pathway":[81],"mice,":[83],"by":[84,193],"which":[85],"glutamatergic":[86,123,196],"neurons":[87,98,147],"central":[90],"nucleus":[91,104],"amygdala":[94,114],"(CeA)":[95],"activate":[96],"glycinergic":[97],"caudal":[101],"pontine":[102],"reticular":[103],"(PnC),":[105],"contributing":[106],"to":[107],"regulation.":[109],"Given":[110],"prevalence":[112],"dys-function":[115],"disorders":[117],"associated":[118],"with":[119,154],"deficits,":[121,217],"CeA-PnC":[122,195],"synapses":[124],"represent":[125],"novel":[127],"target.":[129],"Here,":[130],"\u201cCal-Light,\u201d":[132],"vivo":[135],"Ca2":[136],"+":[137],"-dependent":[138],"photo-tagging":[139],"approach,":[140],"we":[141,159,190],"precisely":[142],"CeA":[144,183],"PnC":[146],"active":[148],"during":[149],"startle":[151],"high":[155],"spatiotemporal":[156],"resolution.":[157],"Furthermore,":[158],"used":[160],"mice":[161,180],"carrying":[162],"homozygous":[163],"deficiency":[164],"PRODH":[166],",":[167],"schizophrenia-relevant":[169],"gene":[170],"encoding":[171],"proline":[172],"dehydrogenase":[173],"modulating":[175],"PPI.":[176],"While":[177],"Prodh":[178],"\u2212/\u2212":[179],"showed":[181],"aberrant":[182],"neuronal":[184],"properties":[185],"reduced":[187],"levels,":[189],"restored":[191],"photo-activating":[194],"synapses,":[197],"underscoring":[198],"their":[199],"involvement":[200],"pathological":[202],"states.":[203],"These":[204],"findings":[205],"provide":[206],"new":[207,219],"mechanistic":[208],"insights":[209],"into":[210],"amygdala-brainstem":[212],"circuitry":[213],"that":[214],"underlies":[215],"offering":[218],"potential":[220],"interventions.":[223]},"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2025-10-10T00:00:00"}