{"id":"https://openalex.org/W4414523665","doi":"https://doi.org/10.1101/2025.09.23.677935","title":"Multiple Epigenetic Mechanisms Functionally Cooperate to Silence Expression of Somatostatin Receptor Type 2 in Pancreatic Neuroendocrine Tumors","display_name":"Multiple Epigenetic Mechanisms Functionally Cooperate to Silence Expression of Somatostatin Receptor Type 2 in Pancreatic Neuroendocrine Tumors","publication_year":2025,"publication_date":"2025-09-25","ids":{"openalex":"https://openalex.org/W4414523665","doi":"https://doi.org/10.1101/2025.09.23.677935","pmid":"https://pubmed.ncbi.nlm.nih.gov/41040380","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12485957"},"language":"en","primary_location":{"id":"doi:10.1101/2025.09.23.677935","doi":"https://doi.org/10.1101/2025.09.23.677935","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.09.23.677935","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2025/09/25/2025.09.23.677935.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2025/09/25/2025.09.23.677935.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014881195","display_name":"James P. Madigan","orcid":"https://orcid.org/0000-0002-0503-3704","observed_orcids":["https://orcid.org/0000-0002-0503-3704"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James P. Madigan","raw_affiliation_strings":["Neuroendocrine Cancer Therapy Section, Surgical Oncology Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892","Surgical Oncology Program, National Cancer Institute, National Institutes of Health"],"raw_orcid":"https://orcid.org/0000-0002-0503-3704","affiliations":[{"raw_affiliation_string":"Neuroendocrine Cancer Therapy Section, Surgical Oncology Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]},{"raw_affiliation_string":"Surgical Oncology Program, National Cancer Institute, National Institutes of Health","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112346707","display_name":"Stephen G. Andrews","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen G. Andrews","raw_affiliation_strings":["Neuroendocrine Cancer Therapy Section, Surgical Oncology Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892","Surgical Oncology Program, National Cancer Institute, National Institutes of Health"],"raw_orcid":"https://orcid.org/0009-0006-4614-2743","affiliations":[{"raw_affiliation_string":"Neuroendocrine Cancer Therapy Section, Surgical Oncology Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]},{"raw_affiliation_string":"Surgical Oncology Program, National Cancer Institute, National Institutes of Health","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Rivka B. Farrell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rivka B. Farrell","raw_affiliation_strings":["Neuroendocrine Cancer Therapy Section, Surgical Oncology Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892","Surgical Oncology Program, National Cancer Institute, National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroendocrine Cancer Therapy Section, Surgical Oncology Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]},{"raw_affiliation_string":"Surgical Oncology Program, National Cancer Institute, National Institutes of Health","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Steven D. Forsythe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven D. Forsythe","raw_affiliation_strings":["Neuroendocrine Cancer Therapy Section, Surgical Oncology Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892","Surgical Oncology Program, National Cancer Institute, National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroendocrine Cancer Therapy Section, Surgical Oncology Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]},{"raw_affiliation_string":"Surgical Oncology Program, National Cancer Institute, National Institutes of Health","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101737246","display_name":"Rupali Sharma","orcid":"https://orcid.org/0000-0002-0733-1270","observed_orcids":["https://orcid.org/0000-0002-0733-1270"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210148682","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210148682"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rupali Sharma","raw_affiliation_strings":["Neuroendocrine Cancer Therapy Section, Surgical Oncology Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892","Precision Therapeutics and Translational Technologies, National Center for Advancing Translational Sciences, National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroendocrine Cancer Therapy Section, Surgical Oncology Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]},{"raw_affiliation_string":"Precision Therapeutics and Translational Technologies, National Center for Advancing Translational Sciences, National Institutes of Health","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210148682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045917555","display_name":"Michele Ceribelli","orcid":"https://orcid.org/0000-0001-9857-9521","observed_orcids":["https://orcid.org/0000-0001-9857-9521"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210148682","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210148682"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michele Ceribelli","raw_affiliation_strings":["Precision Therapeutics and Translational Technologies, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850","National Center for Advancing Translational Sciences, National Institutes of Health"],"raw_orcid":"https://orcid.org/0000-0001-9857-9521","affiliations":[{"raw_affiliation_string":"Precision Therapeutics and Translational Technologies, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210148682"]},{"raw_affiliation_string":"National Center for Advancing Translational Sciences, National Institutes of Health","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210148682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014278257","display_name":"Craig J. Thomas","orcid":"https://orcid.org/0000-0001-9386-9001","observed_orcids":["https://orcid.org/0000-0001-9386-9001"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210148682","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210148682"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Craig J. Thomas","raw_affiliation_strings":["Precision Therapeutics and Translational Technologies, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850","Functional Genomics Laboratory, National Center for Advancing Translational Sciences, National Institutes of Health"],"raw_orcid":"https://orcid.org/0000-0001-9386-9001","affiliations":[{"raw_affiliation_string":"Precision Therapeutics and Translational Technologies, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210148682"]},{"raw_affiliation_string":"Functional Genomics Laboratory, National Center for Advancing Translational Sciences, National Institutes of Health","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210148682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5119734332","display_name":"Kimia N Shamsian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210148682","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210148682"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kimia N. Shamsian","raw_affiliation_strings":["Functional Genomics Laboratory, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850","Functional Genomics Laboratory, National Center for Advancing Translational Sciences, National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Functional Genomics Laboratory, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210148682"]},{"raw_affiliation_string":"Functional Genomics Laboratory, National Center for Advancing Translational Sciences, National Institutes of Health","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210148682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048354597","display_name":"Shinjen Lin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210148682","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210148682"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shinjen Lin","raw_affiliation_strings":["Functional Genomics Laboratory, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850","Functional Genomics Laboratory, National Center for Advancing Translational Sciences, National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Functional Genomics Laboratory, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210148682"]},{"raw_affiliation_string":"Functional Genomics Laboratory, National Center for Advancing Translational Sciences, National Institutes of Health","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210148682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037178716","display_name":"Ken Chih-Chien Cheng","orcid":"https://orcid.org/0000-0003-0437-5697","observed_orcids":["https://orcid.org/0000-0003-0437-5697","https://orcid.org/0000-0001-5764-0648"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210148682","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210148682"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ken Chih-Chien Cheng","raw_affiliation_strings":["Functional Genomics Laboratory, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850","Surgical Oncology Program, National Cancer Institute, National Institutes of Health"],"raw_orcid":"https://orcid.org/0000-0001-5764-0648","affiliations":[{"raw_affiliation_string":"Functional Genomics Laboratory, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210148682"]},{"raw_affiliation_string":"Surgical Oncology Program, National Cancer Institute, National Institutes of Health","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050780818","display_name":"Samira Mercedes Sadowski","orcid":"https://orcid.org/0000-0002-7538-9431","observed_orcids":["https://orcid.org/0000-0002-7538-9431"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Samira M. Sadowski","raw_affiliation_strings":["Neuroendocrine Cancer Therapy Section, Surgical Oncology Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892"],"raw_orcid":"https://orcid.org/0000-0002-7538-9431","affiliations":[{"raw_affiliation_string":"Neuroendocrine Cancer Therapy Section, Surgical Oncology Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5050780818"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.6523000001907349,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.6523000001907349,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10754","display_name":"Neuroendocrine Tumor Research Advances","score":0.26030001044273376,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.009600000455975533,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/somatostatin-receptor-2","display_name":"somatostatin receptor 2","score":0.9670000076293945},{"id":"https://openalex.org/keywords/pancreatic-neuroendocrine-tumors","display_name":"pancreatic neuroendocrine tumors","score":0.996999979019165},{"id":"https://openalex.org/keywords/epigenetic-silencing","display_name":"epigenetic silencing","score":0.9020000100135803},{"id":"https://openalex.org/keywords/dnmt3b","display_name":"DNMT3B","score":0.9129999876022339},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.9330000281333923},{"id":"https://openalex.org/keywords/polycomb-repressive-complex-1","display_name":"PRC1","score":0.8059999942779541},{"id":"https://openalex.org/keywords/polycomb-repressive-complex-2","display_name":"polycomb repressive complex 2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/histone-demethylase","display_name":"histone demethylase","score":0.8289999961853027},{"id":"https://openalex.org/keywords/h3k4-demethylation","display_name":"H3K4 demethylation","score":0.902999997138977},{"id":"https://openalex.org/keywords/chromatin-remodeling","display_name":"chromatin remodeling","score":0.9860000014305115},{"id":"https://openalex.org/keywords/histone-deacetylase","display_name":"histone deacetylase","score":0.8709999918937683},{"id":"https://openalex.org/keywords/transcriptional-repression","display_name":"transcriptional repression","score":0.7039999961853027},{"id":"https://openalex.org/keywords/tumor-grade","display_name":"tumor grade","score":0.36399999260902405}],"concepts":[{"id":"https://openalex.org/C150008808","wikidata":"https://www.wikidata.org/wiki/Q18031731","display_name":"Somatostatin receptor 2","level":4,"score":0.6787999868392944},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.6775000095367432},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6765000224113464},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.6104000210762024},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5906000137329102},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.5364999771118164},{"id":"https://openalex.org/C63016187","wikidata":"https://www.wikidata.org/wiki/Q17162664","display_name":"Epigenetic regulation of neurogenesis","level":5,"score":0.4422000050544739},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.43369999527931213},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.41999998688697815},{"id":"https://openalex.org/C64980429","wikidata":"https://www.wikidata.org/wiki/Q18031730","display_name":"Somatostatin receptor 1","level":5,"score":0.4171999990940094},{"id":"https://openalex.org/C80115893","wikidata":"https://www.wikidata.org/wiki/Q2067077","display_name":"Somatostatin receptor","level":3,"score":0.412200003862381},{"id":"https://openalex.org/C150425827","wikidata":"https://www.wikidata.org/wiki/Q2560317","display_name":"Histone methyltransferase","level":4,"score":0.39809998869895935},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.39100000262260437},{"id":"https://openalex.org/C167227067","wikidata":"https://www.wikidata.org/wiki/Q5113739","display_name":"Chromatin remodeling","level":4,"score":0.3889000117778778},{"id":"https://openalex.org/C121912465","wikidata":"https://www.wikidata.org/wiki/Q3589153","display_name":"Epigenomics","level":5,"score":0.3456999957561493},{"id":"https://openalex.org/C114691636","wikidata":"https://www.wikidata.org/wiki/Q5031434","display_name":"Cancer epigenetics","level":5,"score":0.31119999289512634},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.3107999861240387},{"id":"https://openalex.org/C179138559","wikidata":"https://www.wikidata.org/wiki/Q24740158","display_name":"Chromodomain","level":5,"score":0.30160000920295715},{"id":"https://openalex.org/C140173407","wikidata":"https://www.wikidata.org/wiki/Q1138358","display_name":"CpG site","level":5,"score":0.2944999933242798},{"id":"https://openalex.org/C2781364455","wikidata":"https://www.wikidata.org/wiki/Q2531584","display_name":"Demethylase","level":4,"score":0.29409998655319214},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2890999913215637},{"id":"https://openalex.org/C22709980","wikidata":"https://www.wikidata.org/wiki/Q4117777","display_name":"Histone methylation","level":5,"score":0.28870001435279846},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.28780001401901245},{"id":"https://openalex.org/C2777142704","wikidata":"https://www.wikidata.org/wiki/Q15313456","display_name":"DNMT3B","level":5,"score":0.26809999346733093},{"id":"https://openalex.org/C2779066768","wikidata":"https://www.wikidata.org/wiki/Q1981276","display_name":"Neuroendocrine tumors","level":2,"score":0.2581999897956848},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.2500999867916107}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1101/2025.09.23.677935","doi":"https://doi.org/10.1101/2025.09.23.677935","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.09.23.677935","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2025/09/25/2025.09.23.677935.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:41040380","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41040380","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12485957","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12485957/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv","raw_type":"Text"},{"id":"pmh:oai:europepmc.org:11297912","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12485957","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1101/2025.09.23.677935","doi":"https://doi.org/10.1101/2025.09.23.677935","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.09.23.677935","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2025/09/25/2025.09.23.677935.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4414523665.pdf","grobid_xml":"https://content.openalex.org/works/W4414523665.grobid-xml"},"referenced_works_count":73,"referenced_works":["https://openalex.org/W1462996166","https://openalex.org/W1510180204","https://openalex.org/W1969594608","https://openalex.org/W1969670934","https://openalex.org/W1973477569","https://openalex.org/W1973672022","https://openalex.org/W1975046046","https://openalex.org/W1976457281","https://openalex.org/W1984066790","https://openalex.org/W2002826921","https://openalex.org/W2011263116","https://openalex.org/W2034156554","https://openalex.org/W2050723217","https://openalex.org/W2053421436","https://openalex.org/W2072027812","https://openalex.org/W2075421336","https://openalex.org/W2079012552","https://openalex.org/W2084277707","https://openalex.org/W2089191378","https://openalex.org/W2109897362","https://openalex.org/W2110567963","https://openalex.org/W2118699447","https://openalex.org/W2128235491","https://openalex.org/W2128879247","https://openalex.org/W2136376958","https://openalex.org/W2137857624","https://openalex.org/W2145589035","https://openalex.org/W2154234231","https://openalex.org/W2156731811","https://openalex.org/W2161841622","https://openalex.org/W2166478307","https://openalex.org/W2167674777","https://openalex.org/W2170210082","https://openalex.org/W2211232874","https://openalex.org/W2414993363","https://openalex.org/W2463708289","https://openalex.org/W2507604217","https://openalex.org/W2558874878","https://openalex.org/W2573369749","https://openalex.org/W2582256585","https://openalex.org/W2754886024","https://openalex.org/W2756216109","https://openalex.org/W2782857952","https://openalex.org/W2887245558","https://openalex.org/W2888064284","https://openalex.org/W2967972605","https://openalex.org/W2969542839","https://openalex.org/W2991430679","https://openalex.org/W2994125457","https://openalex.org/W3011290602","https://openalex.org/W3092334961","https://openalex.org/W3094440986","https://openalex.org/W3109203358","https://openalex.org/W3111400820","https://openalex.org/W3118427946","https://openalex.org/W3155543161","https://openalex.org/W3193447048","https://openalex.org/W3201918854","https://openalex.org/W3203480491","https://openalex.org/W3207552523","https://openalex.org/W4205249282","https://openalex.org/W4206180415","https://openalex.org/W4212766227","https://openalex.org/W4283360296","https://openalex.org/W4286797705","https://openalex.org/W4302022854","https://openalex.org/W4319000656","https://openalex.org/W4385212580","https://openalex.org/W4386408014","https://openalex.org/W4387747103","https://openalex.org/W4388006650","https://openalex.org/W4403141262","https://openalex.org/W4409161738"],"related_works":["https://openalex.org/W4318940698","https://openalex.org/W7167366250","https://openalex.org/W4375866855","https://openalex.org/W2921972134","https://openalex.org/W3094440986","https://openalex.org/W2400120669","https://openalex.org/W4367148642","https://openalex.org/W3203006866","https://openalex.org/W4366087158","https://openalex.org/W2953728543"],"abstract_inverted_index":{"ABSTRACT":[0],"Pancreatic":[1],"neuroendocrine":[2],"tumors":[3,17],"(PNETs)":[4],"are":[5,18,303],"a":[6,37,126,281],"rare":[7],"and":[8,43,53,84,97,121,148,151,227,275,294],"understudied":[9],"set":[10],"of":[11,28,80,93,133,180,214,223,249,300,316],"cancers,":[12],"with":[13,49,59,130,313],"increasing":[14,322],"incidence.":[15],"Neuroendocrine":[16],"unique":[19],"in":[20,156,240,253,280,307,325],"the":[21,29,81,106,131,199,245,256,314],"fact":[22],"that":[23,105,143,167,192,265],"they":[24],"express":[25],"high":[26],"levels":[27],"somatostatin":[30],"receptor":[31],"type":[32],"2":[33,149],"(SSTR2),":[34],"which":[35,302],"represents":[36],"target":[38],"for":[39,91,116,177],"both":[40,220],"tumor":[41,51,55],"imaging":[42,96],"therapeutics.":[44],"PNET":[45,95],"grade":[46,56],"inversely":[47],"correlates":[48],"SSTR2":[50,67,87,117,195,215,236,266,323],"staining":[52],"higher":[54],"is":[57,69,114,269],"associated":[58],"poor":[60],"patient":[61],"prognosis.":[62],"With":[63],"no":[64],"known":[65],"mutations,":[66],"expression":[68,88,179,268,299,324],"believed":[70],"to":[71,174,209,229,244,296],"be":[72,175],"lost":[73],"through":[74,272],"aberrant":[75],"epigenetic":[76,82,138,216,257,277],"mechanisms.":[77],"Enhanced":[78],"knowledge":[79,213],"biology":[83],"players":[85],"controlling":[86],"may":[89],"allow":[90],"identification":[92],"novel":[94,290],"treatment":[98],"modalities.":[99],"Through":[100],"in-depth":[101],"studies,":[102],"we":[103,140,160,204],"found":[104,161],"specific":[107],"de":[108],"novo":[109],"DNA":[110],"methyltransferase":[111],"(DNMT),":[112],"DNMT3B,":[113],"responsible":[115],"gene":[118,267],"CpG":[119],"methylation":[120,172],"silencing.":[122],"Using":[123],"DNMT3B":[124],"as":[125,189],"starting":[127],"point,":[128],"along":[129],"concept":[132],"functional":[134,206],"crosstalk":[135],"between":[136],"various":[137,273],"mechanisms,":[139],"further":[141,210],"discovered":[142],"Polycomb":[144],"Repressor":[145],"Complexes":[146],"1":[147],"(PRC1":[150],"PRC2)":[152],"play":[153],"important":[154],"roles":[155],"silencing":[157,178,232,258],"SSTR2.":[158,181],"Moreover,":[159],"several":[162,185,222],"histone":[163,170],"lysine":[164],"demethylases,":[165],"enzymes":[166],"remove":[168],"activating":[169],"H3K4":[171],"marks,":[173],"critical":[176],"We":[182],"additionally":[183],"identified":[184],"chromatin":[186,285],"remodeling":[187],"enzymes/complexes":[188],"cellular":[190],"factors":[191],"negatively":[193],"regulate":[194],"expression.":[196,237],"Finally,":[197],"using":[198],"HiBiT":[200],"luminescent":[201],"reporter":[202],"system,":[203],"exploited":[205],"chemo-genomic":[207],"screens":[208,219],"expand":[211],"our":[212,224,241,262,311],"control.":[217],"These":[218],"reinforced":[221],"initial":[225],"findings":[226,242],"helped":[228],"identify":[230],"additional":[231],"mechanism":[233],"potentially":[234],"regulating":[235],"A":[238],"commonality":[239],"point":[243],"presence,":[246],"or":[247],"necessity,":[248],"Class":[250],"I":[251],"HDACs":[252],"nearly":[254],"all":[255],"mechanisms":[259],"characterized.":[260],"Overall,":[261],"work":[263],"demonstrates":[264],"likely":[270],"silenced":[271],"dynamic":[274],"interconnected":[276],"events,":[278],"resulting":[279],"compacted,":[282],"transcriptionally":[283],"repressed":[284],"environment.":[286],"Our":[287],"study":[288],"offers":[289],"potential":[291],"therapeutic":[292],"targets":[293],"combinations":[295],"best":[297],"increase":[298],"SSTR2,":[301],"currently":[304],"being":[305],"tested":[306],"pre-clinical":[308],"studies":[309],"from":[310],"group,":[312],"goal":[315],"future":[317],"clinical":[318],"trials":[319],"aimed":[320],"at":[321],"high-grade,":[326],"SSTR2-low":[327],"NET":[328],"patients.":[329]},"counts_by_year":[{"year":2026,"cited_by_count":2}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2025-10-10T00:00:00"}